Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X226_LEIDO

TriTrypDb:

LdBPK_283230.1 , LdCL_280037800 , LDHU3_28.4300

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X226

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X226

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.422
CLV_NRD_NRD_1	165	167	PF00675	0.577
CLV_NRD_NRD_1	17	19	PF00675	0.645
CLV_NRD_NRD_1	176	178	PF00675	0.427
CLV_PCSK_FUR_1	145	149	PF00082	0.420
CLV_PCSK_KEX2_1	147	149	PF00082	0.438
CLV_PCSK_KEX2_1	165	167	PF00082	0.502
CLV_PCSK_KEX2_1	17	19	PF00082	0.612
CLV_PCSK_KEX2_1	176	178	PF00082	0.427
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.422
CLV_PCSK_SKI1_1	105	109	PF00082	0.522
CLV_PCSK_SKI1_1	193	197	PF00082	0.641
CLV_Separin_Metazoa	228	232	PF03568	0.499
DEG_APCC_DBOX_1	66	74	PF00400	0.577
DOC_ANK_TNKS_1	52	59	PF00023	0.564
DOC_CDC14_PxL_1	7	15	PF14671	0.410
DOC_USP7_MATH_1	221	225	PF00917	0.546
DOC_USP7_UBL2_3	135	139	PF12436	0.382
DOC_WW_Pin1_4	186	191	PF00397	0.670
DOC_WW_Pin1_4	195	200	PF00397	0.716
DOC_WW_Pin1_4	72	77	PF00397	0.497
LIG_14-3-3_CterR_2	231	234	PF00244	0.512
LIG_CaM_IQ_9	39	55	PF13499	0.512
LIG_FHA_1	23	29	PF00498	0.652
LIG_FHA_1	52	58	PF00498	0.588
LIG_FHA_2	109	115	PF00498	0.446
LIG_FHA_2	39	45	PF00498	0.526
LIG_LIR_Gen_1	91	100	PF02991	0.441
LIG_LIR_Nem_3	130	136	PF02991	0.455
LIG_LIR_Nem_3	91	97	PF02991	0.496
LIG_NRBOX	225	231	PF00104	0.484
LIG_SH2_STAT5	161	164	PF00017	0.514
LIG_SH2_STAT5	64	67	PF00017	0.578
LIG_SH3_2	100	105	PF14604	0.500
LIG_SH3_3	184	190	PF00018	0.672
LIG_SH3_3	97	103	PF00018	0.482
LIG_SUMO_SIM_par_1	181	186	PF11976	0.622
LIG_TRAF2_1	111	114	PF00917	0.447
LIG_TRAF2_1	115	118	PF00917	0.431
LIG_TRAF2_1	208	211	PF00917	0.530
LIG_TRAF2_1	41	44	PF00917	0.520
LIG_TRAF2_2	199	204	PF00917	0.600
MOD_CDK_SPxxK_3	186	193	PF00069	0.658
MOD_CK1_1	205	211	PF00069	0.516
MOD_CK2_1	108	114	PF00069	0.454
MOD_CK2_1	205	211	PF00069	0.549
MOD_CK2_1	221	227	PF00069	0.434
MOD_CK2_1	38	44	PF00069	0.524
MOD_CK2_1	68	74	PF00069	0.576
MOD_GlcNHglycan	20	23	PF01048	0.590
MOD_GlcNHglycan	207	210	PF01048	0.546
MOD_GSK3_1	18	25	PF00069	0.636
MOD_GSK3_1	30	37	PF00069	0.480
MOD_GSK3_1	47	54	PF00069	0.396
MOD_GSK3_1	68	75	PF00069	0.570
MOD_N-GLC_1	221	226	PF02516	0.462
MOD_NEK2_1	34	39	PF00069	0.521
MOD_PIKK_1	152	158	PF00454	0.390
MOD_PKA_2	5	11	PF00069	0.566
MOD_PKB_1	169	177	PF00069	0.426
MOD_Plk_1	203	209	PF00069	0.576
MOD_Plk_1	221	227	PF00069	0.455
MOD_Plk_1	68	74	PF00069	0.576
MOD_Plk_4	24	30	PF00069	0.474
MOD_Plk_4	34	40	PF00069	0.530
MOD_Plk_4	5	11	PF00069	0.619
MOD_ProDKin_1	186	192	PF00069	0.674
MOD_ProDKin_1	195	201	PF00069	0.715
MOD_ProDKin_1	72	78	PF00069	0.490
MOD_SUMO_for_1	115	118	PF00179	0.459
MOD_SUMO_rev_2	83	90	PF00179	0.529
TRG_DiLeu_BaEn_4	214	220	PF01217	0.374
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.409
TRG_ER_diArg_1	17	19	PF00400	0.622
TRG_ER_diArg_1	176	178	PF00400	0.554
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYA2	Leptomonas seymouri	59%	95%
A4HH02	Leishmania braziliensis	76%	100%
A4I434	Leishmania infantum	99%	100%
D0A8X4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B0C1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q7W3	Leishmania major	89%	100%