LeishMANIAdb
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C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
C3H1-type domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X224_LEIDO
TriTrypDb:
LdBPK_283180.1 , LdCL_280037100 , LDHU3_28.4240
Length:
336

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X224
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X224

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 12
GO:0043167 ion binding 2 12
GO:0043169 cation binding 3 12
GO:0046872 metal ion binding 4 12
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 178 182 PF00656 0.630
CLV_NRD_NRD_1 12 14 PF00675 0.654
CLV_NRD_NRD_1 59 61 PF00675 0.575
CLV_PCSK_FUR_1 9 13 PF00082 0.753
CLV_PCSK_KEX2_1 11 13 PF00082 0.686
CLV_PCSK_KEX2_1 43 45 PF00082 0.469
CLV_PCSK_PC1ET2_1 43 45 PF00082 0.501
CLV_PCSK_PC7_1 7 13 PF00082 0.750
CLV_PCSK_SKI1_1 216 220 PF00082 0.623
CLV_PCSK_SKI1_1 43 47 PF00082 0.407
CLV_PCSK_SKI1_1 68 72 PF00082 0.530
DEG_Nend_UBRbox_1 1 4 PF02207 0.697
DOC_ANK_TNKS_1 12 19 PF00023 0.730
DOC_CYCLIN_RxL_1 40 50 PF00134 0.451
DOC_CYCLIN_yCln2_LP_2 218 224 PF00134 0.717
DOC_MAPK_gen_1 43 49 PF00069 0.515
DOC_PP2B_LxvP_1 218 221 PF13499 0.710
DOC_PP2B_LxvP_1 45 48 PF13499 0.382
DOC_USP7_MATH_1 153 157 PF00917 0.575
DOC_USP7_MATH_1 258 262 PF00917 0.741
DOC_USP7_MATH_1 305 309 PF00917 0.671
DOC_USP7_MATH_1 324 328 PF00917 0.446
DOC_USP7_MATH_1 48 52 PF00917 0.471
DOC_USP7_MATH_2 15 21 PF00917 0.766
DOC_WW_Pin1_4 180 185 PF00397 0.588
DOC_WW_Pin1_4 247 252 PF00397 0.752
DOC_WW_Pin1_4 272 277 PF00397 0.607
DOC_WW_Pin1_4 288 293 PF00397 0.623
DOC_WW_Pin1_4 301 306 PF00397 0.642
LIG_14-3-3_CanoR_1 209 213 PF00244 0.535
LIG_14-3-3_CanoR_1 309 319 PF00244 0.587
LIG_BRCT_BRCA1_1 307 311 PF00533 0.717
LIG_EVH1_2 276 280 PF00568 0.686
LIG_EVH1_2 31 35 PF00568 0.556
LIG_FHA_1 112 118 PF00498 0.554
LIG_FHA_1 142 148 PF00498 0.456
LIG_FHA_1 168 174 PF00498 0.471
LIG_FHA_1 209 215 PF00498 0.511
LIG_FHA_1 217 223 PF00498 0.588
LIG_FHA_1 25 31 PF00498 0.558
LIG_FHA_1 273 279 PF00498 0.668
LIG_FHA_2 236 242 PF00498 0.653
LIG_IBAR_NPY_1 323 325 PF08397 0.586
LIG_LIR_Gen_1 191 202 PF02991 0.385
LIG_LIR_Gen_1 230 240 PF02991 0.581
LIG_LIR_Nem_3 191 197 PF02991 0.375
LIG_LIR_Nem_3 230 236 PF02991 0.581
LIG_SH2_STAP1 233 237 PF00017 0.517
LIG_SH3_3 163 169 PF00018 0.414
LIG_SH3_3 259 265 PF00018 0.726
LIG_SH3_3 271 277 PF00018 0.708
LIG_SH3_3 34 40 PF00018 0.407
LIG_UBA3_1 34 43 PF00899 0.463
MOD_CDK_SPxxK_3 180 187 PF00069 0.580
MOD_CDK_SPxxK_3 272 279 PF00069 0.682
MOD_CK1_1 112 118 PF00069 0.512
MOD_CK1_1 247 253 PF00069 0.768
MOD_CK1_1 260 266 PF00069 0.673
MOD_CK1_1 310 316 PF00069 0.583
MOD_CK1_1 328 334 PF00069 0.627
MOD_CK2_1 329 335 PF00069 0.634
MOD_GlcNHglycan 113 117 PF01048 0.590
MOD_GlcNHglycan 155 158 PF01048 0.516
MOD_GlcNHglycan 170 173 PF01048 0.342
MOD_GlcNHglycan 177 180 PF01048 0.481
MOD_GlcNHglycan 246 249 PF01048 0.635
MOD_GlcNHglycan 268 271 PF01048 0.718
MOD_GlcNHglycan 315 318 PF01048 0.648
MOD_GSK3_1 253 260 PF00069 0.754
MOD_GSK3_1 301 308 PF00069 0.656
MOD_GSK3_1 309 316 PF00069 0.579
MOD_GSK3_1 324 331 PF00069 0.524
MOD_GSK3_1 48 55 PF00069 0.449
MOD_N-GLC_1 325 330 PF02516 0.639
MOD_NEK2_1 244 249 PF00069 0.642
MOD_NEK2_1 266 271 PF00069 0.687
MOD_NEK2_1 285 290 PF00069 0.738
MOD_NEK2_1 307 312 PF00069 0.614
MOD_NEK2_1 52 57 PF00069 0.435
MOD_PIKK_1 253 259 PF00454 0.720
MOD_PKA_2 208 214 PF00069 0.561
MOD_PKB_1 74 82 PF00069 0.499
MOD_Plk_2-3 235 241 PF00069 0.733
MOD_Plk_4 138 144 PF00069 0.537
MOD_Plk_4 235 241 PF00069 0.655
MOD_Plk_4 329 335 PF00069 0.619
MOD_Plk_4 48 54 PF00069 0.539
MOD_ProDKin_1 180 186 PF00069 0.575
MOD_ProDKin_1 247 253 PF00069 0.753
MOD_ProDKin_1 272 278 PF00069 0.606
MOD_ProDKin_1 288 294 PF00069 0.622
MOD_ProDKin_1 301 307 PF00069 0.639
MOD_SUMO_for_1 212 215 PF00179 0.633
TRG_DiLeu_BaLyEn_6 119 124 PF01217 0.368
TRG_ENDOCYTIC_2 233 236 PF00928 0.517
TRG_ER_diArg_1 9 12 PF00400 0.687
TRG_Pf-PMV_PEXEL_1 97 101 PF00026 0.495

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HY30 Leptomonas seymouri 30% 81%
A0A0N1I3L5 Leptomonas seymouri 68% 100%
A0A1X0NQH6 Trypanosomatidae 41% 100%
A0A3R7R5S5 Trypanosoma rangeli 32% 76%
A0A3S5IR49 Trypanosoma rangeli 39% 100%
A4HGZ8 Leishmania braziliensis 83% 100%
A4I430 Leishmania infantum 99% 100%
E9B0B7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q7W7 Leishmania major 95% 100%
V5BI47 Trypanosoma cruzi 42% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS