FHA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X221_LEIDO

TriTrypDb:

LdBPK_290310.1 , LdCL_290007900 , LDHU3_29.0410

Length:

337

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X221

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X221

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	315	319	PF00656	0.477
CLV_C14_Caspase3-7	62	66	PF00656	0.630
CLV_NRD_NRD_1	173	175	PF00675	0.510
CLV_NRD_NRD_1	328	330	PF00675	0.454
CLV_NRD_NRD_1	56	58	PF00675	0.582
CLV_NRD_NRD_1	99	101	PF00675	0.445
CLV_PCSK_KEX2_1	108	110	PF00082	0.647
CLV_PCSK_KEX2_1	56	58	PF00082	0.582
CLV_PCSK_KEX2_1	99	101	PF00082	0.466
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.682
CLV_PCSK_SKI1_1	216	220	PF00082	0.442
CLV_PCSK_SKI1_1	25	29	PF00082	0.611
CLV_PCSK_SKI1_1	36	40	PF00082	0.472
CLV_PCSK_SKI1_1	86	90	PF00082	0.468
DEG_APCC_DBOX_1	120	128	PF00400	0.445
DEG_Nend_UBRbox_2	1	3	PF02207	0.640
DEG_SIAH_1	245	253	PF03145	0.305
DEG_SPOP_SBC_1	69	73	PF00917	0.606
DOC_CYCLIN_RxL_1	22	32	PF00134	0.644
DOC_MAPK_gen_1	108	116	PF00069	0.710
DOC_PP1_RVXF_1	34	41	PF00149	0.582
DOC_PP2B_LxvP_1	26	29	PF13499	0.715
DOC_PP2B_LxvP_1	45	48	PF13499	0.398
DOC_PP4_FxxP_1	160	163	PF00568	0.503
DOC_USP7_MATH_1	151	155	PF00917	0.697
DOC_USP7_MATH_1	204	208	PF00917	0.355
DOC_USP7_MATH_1	259	263	PF00917	0.480
DOC_USP7_MATH_1	274	278	PF00917	0.232
DOC_USP7_MATH_1	29	33	PF00917	0.720
DOC_USP7_MATH_1	63	67	PF00917	0.541
DOC_USP7_MATH_2	200	206	PF00917	0.434
DOC_USP7_UBL2_3	171	175	PF12436	0.581
DOC_WW_Pin1_4	234	239	PF00397	0.402
DOC_WW_Pin1_4	242	247	PF00397	0.375
LIG_14-3-3_CanoR_1	109	116	PF00244	0.701
LIG_BRCT_BRCA1_1	156	160	PF00533	0.592
LIG_eIF4E_1	6	12	PF01652	0.643
LIG_FHA_1	109	115	PF00498	0.739
LIG_FHA_1	127	133	PF00498	0.249
LIG_FHA_1	157	163	PF00498	0.481
LIG_FHA_1	228	234	PF00498	0.405
LIG_FHA_1	255	261	PF00498	0.383
LIG_FHA_1	285	291	PF00498	0.447
LIG_FHA_1	312	318	PF00498	0.337
LIG_FHA_1	7	13	PF00498	0.538
LIG_FHA_2	313	319	PF00498	0.335
LIG_FHA_2	87	93	PF00498	0.467
LIG_LIR_Apic_2	157	163	PF02991	0.532
LIG_LIR_Gen_1	178	187	PF02991	0.469
LIG_LIR_Gen_1	265	275	PF02991	0.402
LIG_LIR_Gen_1	328	337	PF02991	0.414
LIG_LIR_Gen_1	83	91	PF02991	0.481
LIG_LIR_Nem_3	125	131	PF02991	0.550
LIG_LIR_Nem_3	178	182	PF02991	0.462
LIG_LIR_Nem_3	183	187	PF02991	0.445
LIG_LIR_Nem_3	265	271	PF02991	0.402
LIG_LIR_Nem_3	83	87	PF02991	0.461
LIG_LYPXL_yS_3	41	44	PF13949	0.558
LIG_MLH1_MIPbox_1	157	161	PF16413	0.577
LIG_SH2_CRK	128	132	PF00017	0.485
LIG_SH2_CRK	165	169	PF00017	0.464
LIG_SH2_CRK	179	183	PF00017	0.405
LIG_SH2_GRB2like	179	182	PF00017	0.511
LIG_SH2_NCK_1	179	183	PF00017	0.433
LIG_SH2_SRC	179	182	PF00017	0.472
LIG_SH2_STAT5	128	131	PF00017	0.545
LIG_SH2_STAT5	228	231	PF00017	0.480
LIG_SH2_STAT5	331	334	PF00017	0.376
LIG_SH2_STAT5	84	87	PF00017	0.489
LIG_SH3_3	18	24	PF00018	0.697
LIG_SH3_3	235	241	PF00018	0.447
LIG_SUMO_SIM_par_1	291	298	PF11976	0.335
LIG_TRAF2_2	48	53	PF00917	0.526
LIG_TYR_ITIM	82	87	PF00017	0.498
LIG_UBA3_1	167	175	PF00899	0.516
MOD_CK1_1	141	147	PF00069	0.634
MOD_CK1_1	154	160	PF00069	0.588
MOD_CK1_1	262	268	PF00069	0.480
MOD_CK1_1	43	49	PF00069	0.409
MOD_CK1_1	74	80	PF00069	0.588
MOD_CK2_1	86	92	PF00069	0.468
MOD_CMANNOS	98	101	PF00535	0.541
MOD_GlcNHglycan	124	127	PF01048	0.580
MOD_GlcNHglycan	140	143	PF01048	0.536
MOD_GlcNHglycan	147	150	PF01048	0.616
MOD_GlcNHglycan	206	209	PF01048	0.312
MOD_GlcNHglycan	276	279	PF01048	0.441
MOD_GlcNHglycan	31	34	PF01048	0.612
MOD_GSK3_1	122	129	PF00069	0.539
MOD_GSK3_1	141	148	PF00069	0.515
MOD_GSK3_1	151	158	PF00069	0.645
MOD_GSK3_1	294	301	PF00069	0.274
MOD_GSK3_1	312	319	PF00069	0.368
MOD_GSK3_1	6	13	PF00069	0.632
MOD_GSK3_1	69	76	PF00069	0.658
MOD_N-GLC_1	180	185	PF02516	0.512
MOD_N-GLC_1	298	303	PF02516	0.335
MOD_NEK2_1	11	16	PF00069	0.658
MOD_NEK2_1	253	258	PF00069	0.480
MOD_NEK2_1	295	300	PF00069	0.335
MOD_NEK2_1	311	316	PF00069	0.395
MOD_NEK2_1	324	329	PF00069	0.316
MOD_PIKK_1	254	260	PF00454	0.383
MOD_PKA_1	108	114	PF00069	0.696
MOD_PKA_2	108	114	PF00069	0.671
MOD_Plk_1	180	186	PF00069	0.552
MOD_Plk_1	311	317	PF00069	0.480
MOD_Plk_2-3	312	318	PF00069	0.408
MOD_Plk_4	156	162	PF00069	0.550
MOD_Plk_4	312	318	PF00069	0.335
MOD_Plk_4	40	46	PF00069	0.439
MOD_Plk_4	77	83	PF00069	0.498
MOD_ProDKin_1	234	240	PF00069	0.402
MOD_ProDKin_1	242	248	PF00069	0.375
MOD_SUMO_rev_2	226	236	PF00179	0.188
TRG_DiLeu_BaEn_4	231	237	PF01217	0.169
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.736
TRG_ENDOCYTIC_2	128	131	PF00928	0.486
TRG_ENDOCYTIC_2	165	168	PF00928	0.468
TRG_ENDOCYTIC_2	179	182	PF00928	0.412
TRG_ENDOCYTIC_2	331	334	PF00928	0.376
TRG_ENDOCYTIC_2	41	44	PF00928	0.558
TRG_ENDOCYTIC_2	84	87	PF00928	0.421
TRG_ER_diArg_1	23	26	PF00400	0.715
TRG_ER_diArg_1	55	57	PF00400	0.566
TRG_ER_diArg_1	98	100	PF00400	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9L3	Leptomonas seymouri	57%	99%
A0A1X0NZG4	Trypanosomatidae	34%	100%
A0A422N067	Trypanosoma rangeli	36%	100%
A4HH57	Leishmania braziliensis	80%	100%
A4I483	Leishmania infantum	99%	100%
C9ZKP7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ADN2	Leishmania major	93%	100%
E9AM48	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BPX7	Trypanosoma cruzi	33%	100%