Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X216_LEIDO

TriTrypDb:

LdBPK_283150.1 , LdCL_280036800 , LDHU3_28.4200

Length:

179

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X216

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X216

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	43	47	PF00082	0.398
DEG_Nend_UBRbox_2	1	3	PF02207	0.551
DOC_CKS1_1	53	58	PF01111	0.496
DOC_MAPK_gen_1	133	142	PF00069	0.504
DOC_MAPK_gen_1	63	71	PF00069	0.470
DOC_MAPK_MEF2A_6	109	118	PF00069	0.408
DOC_MAPK_MEF2A_6	136	144	PF00069	0.421
DOC_MAPK_MEF2A_6	15	24	PF00069	0.431
DOC_MAPK_MEF2A_6	63	71	PF00069	0.470
DOC_PP1_RVXF_1	13	20	PF00149	0.436
DOC_PP1_RVXF_1	66	72	PF00149	0.438
DOC_PP2B_LxvP_1	96	99	PF13499	0.509
DOC_PP4_FxxP_1	118	121	PF00568	0.345
DOC_PP4_FxxP_1	81	84	PF00568	0.466
DOC_USP7_MATH_1	100	104	PF00917	0.585
DOC_USP7_MATH_1	107	111	PF00917	0.745
DOC_USP7_MATH_1	121	125	PF00917	0.475
DOC_WW_Pin1_4	142	147	PF00397	0.437
DOC_WW_Pin1_4	52	57	PF00397	0.560
LIG_14-3-3_CanoR_1	109	114	PF00244	0.459
LIG_14-3-3_CanoR_1	166	174	PF00244	0.483
LIG_14-3-3_CanoR_1	25	29	PF00244	0.390
LIG_Actin_WH2_2	10	27	PF00022	0.433
LIG_ActinCP_TwfCPI_2	118	125	PF01115	0.394
LIG_FHA_1	125	131	PF00498	0.402
LIG_LIR_Gen_1	147	157	PF02991	0.497
LIG_LIR_Gen_1	42	53	PF02991	0.431
LIG_LIR_Nem_3	147	152	PF02991	0.562
LIG_LIR_Nem_3	18	22	PF02991	0.477
LIG_LIR_Nem_3	42	48	PF02991	0.424
LIG_PDZ_Class_2	174	179	PF00595	0.515
LIG_Pex14_2	71	75	PF04695	0.341
LIG_SH2_STAP1	4	8	PF00017	0.455
LIG_SH3_3	14	20	PF00018	0.449
LIG_SH3_3	50	56	PF00018	0.491
LIG_SUMO_SIM_anti_2	86	91	PF11976	0.311
MOD_CK1_1	124	130	PF00069	0.555
MOD_CK1_1	153	159	PF00069	0.361
MOD_CK1_1	3	9	PF00069	0.571
MOD_CK2_1	107	113	PF00069	0.617
MOD_CK2_1	157	163	PF00069	0.484
MOD_GlcNHglycan	102	105	PF01048	0.623
MOD_GlcNHglycan	109	112	PF01048	0.610
MOD_GSK3_1	153	160	PF00069	0.497
MOD_GSK3_1	43	50	PF00069	0.456
MOD_NEK2_1	24	29	PF00069	0.388
MOD_NEK2_1	71	76	PF00069	0.477
MOD_PKA_2	24	30	PF00069	0.393
MOD_Plk_1	6	12	PF00069	0.472
MOD_Plk_4	24	30	PF00069	0.399
MOD_ProDKin_1	142	148	PF00069	0.441
MOD_ProDKin_1	52	58	PF00069	0.567
MOD_SUMO_rev_2	38	45	PF00179	0.575
TRG_DiLeu_BaEn_1	18	23	PF01217	0.423
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKA8	Leptomonas seymouri	47%	99%
A0A1X0NR08	Trypanosomatidae	35%	87%
A0A3R7KM85	Trypanosoma rangeli	33%	100%
A4HGZ5	Leishmania braziliensis	79%	100%
A4I427	Leishmania infantum	100%	100%
D0A8Y0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B0B4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q7X0	Leishmania major	95%	99%