Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X213_LEIDO

TriTrypDb:

LdBPK_283080.1 , LdCL_280036100 , LDHU3_28.4090

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3S7X213

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X213

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	1
GO:0005488	binding	1	1
GO:0005524	ATP binding	5	1
GO:0017076	purine nucleotide binding	4	1
GO:0030554	adenyl nucleotide binding	5	1
GO:0032553	ribonucleotide binding	3	1
GO:0032555	purine ribonucleotide binding	4	1
GO:0032559	adenyl ribonucleotide binding	5	1
GO:0035639	purine ribonucleoside triphosphate binding	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	326	330	PF00656	0.615
CLV_NRD_NRD_1	123	125	PF00675	0.594
CLV_NRD_NRD_1	16	18	PF00675	0.614
CLV_NRD_NRD_1	233	235	PF00675	0.479
CLV_NRD_NRD_1	435	437	PF00675	0.704
CLV_NRD_NRD_1	93	95	PF00675	0.459
CLV_PCSK_KEX2_1	123	125	PF00082	0.523
CLV_PCSK_KEX2_1	151	153	PF00082	0.672
CLV_PCSK_KEX2_1	16	18	PF00082	0.606
CLV_PCSK_KEX2_1	233	235	PF00082	0.479
CLV_PCSK_KEX2_1	297	299	PF00082	0.484
CLV_PCSK_KEX2_1	434	436	PF00082	0.686
CLV_PCSK_KEX2_1	93	95	PF00082	0.442
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.694
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.521
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.694
CLV_PCSK_PC7_1	119	125	PF00082	0.582
CLV_PCSK_SKI1_1	123	127	PF00082	0.573
CLV_PCSK_SKI1_1	297	301	PF00082	0.458
CLV_PCSK_SKI1_1	93	97	PF00082	0.573
CLV_Separin_Metazoa	222	226	PF03568	0.553
DEG_APCC_DBOX_1	92	100	PF00400	0.557
DOC_ANK_TNKS_1	224	231	PF00023	0.533
DOC_CDC14_PxL_1	174	182	PF14671	0.534
DOC_CDC14_PxL_1	408	416	PF14671	0.491
DOC_CYCLIN_RxL_1	133	145	PF00134	0.541
DOC_CYCLIN_RxL_1	90	101	PF00134	0.579
DOC_CYCLIN_yCln2_LP_2	165	171	PF00134	0.499
DOC_CYCLIN_yCln2_LP_2	266	272	PF00134	0.470
DOC_CYCLIN_yCln2_LP_2	287	293	PF00134	0.454
DOC_CYCLIN_yCln2_LP_2	338	344	PF00134	0.675
DOC_MAPK_gen_1	123	129	PF00069	0.564
DOC_MAPK_gen_1	281	291	PF00069	0.456
DOC_MAPK_MEF2A_6	281	289	PF00069	0.523
DOC_PP1_RVXF_1	184	191	PF00149	0.405
DOC_PP2B_LxvP_1	163	166	PF13499	0.530
DOC_PP2B_LxvP_1	266	269	PF13499	0.465
DOC_PP2B_LxvP_1	287	290	PF13499	0.487
DOC_PP4_FxxP_1	74	77	PF00568	0.549
DOC_USP7_MATH_1	193	197	PF00917	0.649
DOC_USP7_MATH_1	344	348	PF00917	0.747
DOC_USP7_UBL2_3	434	438	PF12436	0.713
DOC_WW_Pin1_4	1	6	PF00397	0.682
DOC_WW_Pin1_4	155	160	PF00397	0.632
DOC_WW_Pin1_4	259	264	PF00397	0.698
DOC_WW_Pin1_4	337	342	PF00397	0.677
DOC_WW_Pin1_4	351	356	PF00397	0.706
DOC_WW_Pin1_4	52	57	PF00397	0.703
LIG_14-3-3_CanoR_1	124	130	PF00244	0.546
LIG_14-3-3_CanoR_1	16	24	PF00244	0.581
LIG_Actin_WH2_2	282	299	PF00022	0.529
LIG_APCC_ABBA_1	140	145	PF00400	0.499
LIG_BIR_II_1	1	5	PF00653	0.596
LIG_BIR_III_4	329	333	PF00653	0.644
LIG_BRCT_BRCA1_1	81	85	PF00533	0.533
LIG_CSL_BTD_1	287	290	PF09270	0.521
LIG_DLG_GKlike_1	23	30	PF00625	0.522
LIG_FHA_1	137	143	PF00498	0.517
LIG_FHA_1	333	339	PF00498	0.721
LIG_FHA_1	37	43	PF00498	0.638
LIG_FHA_1	385	391	PF00498	0.479
LIG_FHA_2	179	185	PF00498	0.433
LIG_FHA_2	347	353	PF00498	0.697
LIG_FHA_2	370	376	PF00498	0.706
LIG_FHA_2	387	393	PF00498	0.460
LIG_FHA_2	425	431	PF00498	0.738
LIG_LIR_Apic_2	245	250	PF02991	0.616
LIG_LIR_Gen_1	22	30	PF02991	0.558
LIG_LIR_Gen_1	271	279	PF02991	0.402
LIG_LIR_Gen_1	402	412	PF02991	0.512
LIG_LIR_LC3C_4	239	243	PF02991	0.480
LIG_LIR_Nem_3	22	27	PF02991	0.537
LIG_LIR_Nem_3	271	275	PF02991	0.391
LIG_LYPXL_S_1	381	385	PF13949	0.536
LIG_LYPXL_yS_3	382	385	PF13949	0.508
LIG_NRBOX	198	204	PF00104	0.509
LIG_SH2_CRK	308	312	PF00017	0.429
LIG_SH2_STAT5	179	182	PF00017	0.427
LIG_SH2_STAT5	201	204	PF00017	0.458
LIG_SH2_STAT5	247	250	PF00017	0.656
LIG_SH2_STAT5	272	275	PF00017	0.520
LIG_SH3_1	246	252	PF00018	0.531
LIG_SH3_3	103	109	PF00018	0.460
LIG_SH3_3	246	252	PF00018	0.574
LIG_SH3_CIN85_PxpxPR_1	52	57	PF14604	0.625
LIG_SUMO_SIM_anti_2	103	108	PF11976	0.507
LIG_SUMO_SIM_par_1	138	145	PF11976	0.535
LIG_SUMO_SIM_par_1	389	395	PF11976	0.528
LIG_SUMO_SIM_par_1	4	10	PF11976	0.674
LIG_SUMO_SIM_par_1	59	65	PF11976	0.577
LIG_TYR_ITIM	306	311	PF00017	0.440
LIG_WRC_WIRS_1	126	131	PF05994	0.450
LIG_WRC_WIRS_1	24	29	PF05994	0.553
MOD_CDK_SPK_2	52	57	PF00069	0.625
MOD_CDK_SPxxK_3	351	358	PF00069	0.692
MOD_CK1_1	115	121	PF00069	0.526
MOD_CK1_1	19	25	PF00069	0.561
MOD_CK1_1	254	260	PF00069	0.723
MOD_CK1_1	262	268	PF00069	0.609
MOD_CK1_1	351	357	PF00069	0.690
MOD_CK1_1	360	366	PF00069	0.580
MOD_CK1_1	424	430	PF00069	0.708
MOD_CK1_1	79	85	PF00069	0.460
MOD_CK2_1	261	267	PF00069	0.608
MOD_CK2_1	346	352	PF00069	0.726
MOD_CK2_1	369	375	PF00069	0.583
MOD_CK2_1	424	430	PF00069	0.718
MOD_Cter_Amidation	14	17	PF01082	0.688
MOD_GlcNHglycan	1	4	PF01048	0.599
MOD_GlcNHglycan	11	14	PF01048	0.539
MOD_GlcNHglycan	114	117	PF01048	0.553
MOD_GlcNHglycan	258	261	PF01048	0.675
MOD_GlcNHglycan	303	306	PF01048	0.580
MOD_GlcNHglycan	346	349	PF01048	0.744
MOD_GlcNHglycan	359	362	PF01048	0.648
MOD_GlcNHglycan	375	378	PF01048	0.545
MOD_GlcNHglycan	423	426	PF01048	0.641
MOD_GlcNHglycan	81	84	PF01048	0.536
MOD_GSK3_1	1	8	PF00069	0.613
MOD_GSK3_1	125	132	PF00069	0.460
MOD_GSK3_1	19	26	PF00069	0.547
MOD_GSK3_1	250	257	PF00069	0.700
MOD_GSK3_1	321	328	PF00069	0.506
MOD_GSK3_1	332	339	PF00069	0.661
MOD_GSK3_1	344	351	PF00069	0.663
MOD_GSK3_1	365	372	PF00069	0.572
MOD_N-GLC_1	236	241	PF02516	0.521
MOD_N-GLC_2	418	420	PF02516	0.544
MOD_NEK2_1	129	134	PF00069	0.389
MOD_NEK2_1	85	90	PF00069	0.510
MOD_NEK2_1	9	14	PF00069	0.615
MOD_OFUCOSY	320	325	PF10250	0.535
MOD_PIKK_1	172	178	PF00454	0.513
MOD_PIKK_1	193	199	PF00454	0.589
MOD_PKA_1	16	22	PF00069	0.605
MOD_PKA_2	118	124	PF00069	0.587
MOD_PKA_2	16	22	PF00069	0.634
MOD_PKA_2	357	363	PF00069	0.706
MOD_PKA_2	79	85	PF00069	0.588
MOD_Plk_1	236	242	PF00069	0.519
MOD_Plk_4	237	243	PF00069	0.492
MOD_Plk_4	386	392	PF00069	0.440
MOD_ProDKin_1	1	7	PF00069	0.677
MOD_ProDKin_1	155	161	PF00069	0.627
MOD_ProDKin_1	259	265	PF00069	0.679
MOD_ProDKin_1	337	343	PF00069	0.678
MOD_ProDKin_1	351	357	PF00069	0.706
MOD_ProDKin_1	52	58	PF00069	0.697
MOD_SUMO_for_1	150	153	PF00179	0.672
TRG_ENDOCYTIC_2	272	275	PF00928	0.493
TRG_ENDOCYTIC_2	308	311	PF00928	0.482
TRG_ENDOCYTIC_2	382	385	PF00928	0.508
TRG_ENDOCYTIC_2	404	407	PF00928	0.488
TRG_ER_diArg_1	122	124	PF00400	0.577
TRG_ER_diArg_1	232	234	PF00400	0.506
TRG_ER_diArg_1	92	94	PF00400	0.454
TRG_NES_CRM1_1	409	421	PF08389	0.487
TRG_NLS_MonoCore_2	432	437	PF00514	0.670
TRG_NLS_MonoExtC_3	433	438	PF00514	0.674
TRG_NLS_MonoExtN_4	433	438	PF00514	0.771

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4Z3	Leptomonas seymouri	46%	93%
A0A0S4IUX7	Bodo saltans	25%	98%
A0A1X0NQH2	Trypanosomatidae	28%	100%
A0A422N0P3	Trypanosoma rangeli	28%	99%
A4HGY8	Leishmania braziliensis	77%	100%
A4I420	Leishmania infantum	100%	100%
D0A8Y9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	98%
E9B0A7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q7X7	Leishmania major	94%	100%
V5ATM8	Trypanosoma cruzi	29%	100%