WD domain, G-beta repeat, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X1Z8_LEIDO

TriTrypDb:

LdBPK_290100.1 , LdCL_290005900 , LDHU3_29.0150

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005868	cytoplasmic dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0030286	dynein complex	3	1
GO:0030990	intraciliary transport particle	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A0A3S7X1Z8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1Z8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1
GO:0010970	transport along microtubule	4	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0042073	intraciliary transport	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0099111	microtubule-based transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045503	dynein light chain binding	3	1
GO:0045504	dynein heavy chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	521	525	PF00656	0.526
CLV_NRD_NRD_1	121	123	PF00675	0.583
CLV_NRD_NRD_1	300	302	PF00675	0.481
CLV_NRD_NRD_1	438	440	PF00675	0.437
CLV_NRD_NRD_1	65	67	PF00675	0.576
CLV_PCSK_FUR_1	298	302	PF00082	0.543
CLV_PCSK_KEX2_1	300	302	PF00082	0.509
CLV_PCSK_KEX2_1	438	440	PF00082	0.437
CLV_PCSK_KEX2_1	65	67	PF00082	0.576
CLV_PCSK_SKI1_1	106	110	PF00082	0.426
CLV_PCSK_SKI1_1	287	291	PF00082	0.527
CLV_PCSK_SKI1_1	384	388	PF00082	0.425
CLV_PCSK_SKI1_1	439	443	PF00082	0.493
CLV_PCSK_SKI1_1	506	510	PF00082	0.550
DEG_APCC_DBOX_1	403	411	PF00400	0.419
DEG_APCC_DBOX_1	437	445	PF00400	0.435
DOC_CYCLIN_RxL_1	381	392	PF00134	0.417
DOC_CYCLIN_yCln2_LP_2	288	294	PF00134	0.434
DOC_MAPK_gen_1	122	129	PF00069	0.531
DOC_MAPK_gen_1	172	178	PF00069	0.481
DOC_MAPK_gen_1	298	307	PF00069	0.404
DOC_MAPK_gen_1	341	349	PF00069	0.530
DOC_MAPK_gen_1	438	444	PF00069	0.412
DOC_MAPK_MEF2A_6	298	307	PF00069	0.425
DOC_USP7_MATH_1	108	112	PF00917	0.506
DOC_USP7_MATH_1	259	263	PF00917	0.536
DOC_USP7_MATH_1	273	277	PF00917	0.483
DOC_USP7_MATH_1	373	377	PF00917	0.390
DOC_USP7_MATH_1	434	438	PF00917	0.324
DOC_USP7_MATH_1	458	462	PF00917	0.446
DOC_USP7_MATH_1	471	475	PF00917	0.385
DOC_USP7_MATH_1	508	512	PF00917	0.457
DOC_USP7_MATH_2	348	354	PF00917	0.608
DOC_USP7_UBL2_3	36	40	PF12436	0.666
DOC_WW_Pin1_4	114	119	PF00397	0.609
DOC_WW_Pin1_4	132	137	PF00397	0.450
DOC_WW_Pin1_4	280	285	PF00397	0.412
DOC_WW_Pin1_4	377	382	PF00397	0.328
DOC_WW_Pin1_4	402	407	PF00397	0.446
DOC_WW_Pin1_4	423	428	PF00397	0.353
LIG_14-3-3_CanoR_1	106	116	PF00244	0.519
LIG_14-3-3_CanoR_1	122	131	PF00244	0.513
LIG_14-3-3_CanoR_1	190	196	PF00244	0.548
LIG_14-3-3_CanoR_1	300	306	PF00244	0.483
LIG_14-3-3_CanoR_1	341	346	PF00244	0.568
LIG_14-3-3_CanoR_1	397	406	PF00244	0.453
LIG_14-3-3_CanoR_1	438	442	PF00244	0.382
LIG_14-3-3_CanoR_1	510	514	PF00244	0.621
LIG_14-3-3_CanoR_1	65	69	PF00244	0.624
LIG_Actin_WH2_2	174	189	PF00022	0.441
LIG_Actin_WH2_2	437	455	PF00022	0.308
LIG_Actin_WH2_2	494	512	PF00022	0.545
LIG_BIR_II_1	1	5	PF00653	0.611
LIG_BIR_III_4	484	488	PF00653	0.435
LIG_BRCT_BRCA1_1	109	113	PF00533	0.434
LIG_BRCT_BRCA1_1	202	206	PF00533	0.412
LIG_BRCT_BRCA1_1	379	383	PF00533	0.311
LIG_Clathr_ClatBox_1	331	335	PF01394	0.433
LIG_Clathr_ClatBox_1	407	411	PF01394	0.509
LIG_FHA_1	10	16	PF00498	0.545
LIG_FHA_1	107	113	PF00498	0.566
LIG_FHA_1	245	251	PF00498	0.466
LIG_FHA_1	32	38	PF00498	0.548
LIG_FHA_1	342	348	PF00498	0.548
LIG_FHA_1	455	461	PF00498	0.514
LIG_FHA_1	517	523	PF00498	0.649
LIG_FHA_1	524	530	PF00498	0.526
LIG_FHA_2	23	29	PF00498	0.627
LIG_FHA_2	388	394	PF00498	0.471
LIG_FHA_2	473	479	PF00498	0.477
LIG_FHA_2	500	506	PF00498	0.413
LIG_FHA_2	89	95	PF00498	0.545
LIG_LIR_Apic_2	344	348	PF02991	0.638
LIG_LIR_Nem_3	110	116	PF02991	0.437
LIG_LIR_Nem_3	311	315	PF02991	0.502
LIG_LIR_Nem_3	380	386	PF02991	0.317
LIG_LIR_Nem_3	422	428	PF02991	0.447
LIG_MLH1_MIPbox_1	379	383	PF16413	0.311
LIG_PDZ_Class_1	531	536	PF00595	0.599
LIG_Pex14_2	383	387	PF04695	0.455
LIG_REV1ctd_RIR_1	380	388	PF16727	0.404
LIG_SH2_CRK	312	316	PF00017	0.521
LIG_SH2_CRK	79	83	PF00017	0.552
LIG_SH2_PTP2	175	178	PF00017	0.439
LIG_SH2_STAP1	237	241	PF00017	0.562
LIG_SH2_STAP1	456	460	PF00017	0.485
LIG_SH2_STAT5	131	134	PF00017	0.470
LIG_SH2_STAT5	175	178	PF00017	0.439
LIG_SH2_STAT5	237	240	PF00017	0.545
LIG_SH2_STAT5	268	271	PF00017	0.404
LIG_SH2_STAT5	419	422	PF00017	0.509
LIG_SH2_STAT5	456	459	PF00017	0.532
LIG_SH2_STAT5	77	80	PF00017	0.467
LIG_SH3_1	424	430	PF00018	0.456
LIG_SH3_3	205	211	PF00018	0.540
LIG_SH3_3	253	259	PF00018	0.494
LIG_SH3_3	424	430	PF00018	0.356
LIG_SUMO_SIM_anti_2	125	132	PF11976	0.514
LIG_SUMO_SIM_anti_2	14	19	PF11976	0.477
LIG_SUMO_SIM_anti_2	247	254	PF11976	0.509
LIG_SUMO_SIM_anti_2	327	333	PF11976	0.394
LIG_SUMO_SIM_anti_2	431	437	PF11976	0.370
LIG_SUMO_SIM_par_1	212	218	PF11976	0.414
LIG_SUMO_SIM_par_1	360	365	PF11976	0.469
LIG_SUMO_SIM_par_1	405	416	PF11976	0.520
LIG_SUMO_SIM_par_1	431	437	PF11976	0.370
LIG_TRAF2_1	137	140	PF00917	0.421
LIG_TRAF2_1	412	415	PF00917	0.400
LIG_TYR_ITIM	310	315	PF00017	0.496
LIG_WRC_WIRS_1	89	94	PF05994	0.505
MOD_CDC14_SPxK_1	426	429	PF00782	0.338
MOD_CDK_SPxK_1	423	429	PF00069	0.341
MOD_CDK_SPxxK_3	280	287	PF00069	0.454
MOD_CDK_SPxxK_3	377	384	PF00069	0.426
MOD_CK1_1	239	245	PF00069	0.458
MOD_CK1_1	296	302	PF00069	0.455
MOD_CK1_1	392	398	PF00069	0.333
MOD_CK1_1	41	47	PF00069	0.583
MOD_CK1_1	413	419	PF00069	0.403
MOD_CK1_1	437	443	PF00069	0.352
MOD_CK1_1	499	505	PF00069	0.487
MOD_CK1_1	512	518	PF00069	0.512
MOD_CK2_1	22	28	PF00069	0.667
MOD_CK2_1	237	243	PF00069	0.443
MOD_CK2_1	397	403	PF00069	0.417
MOD_CK2_1	409	415	PF00069	0.467
MOD_CK2_1	472	478	PF00069	0.486
MOD_CK2_1	499	505	PF00069	0.402
MOD_CK2_1	515	521	PF00069	0.540
MOD_CK2_1	88	94	PF00069	0.483
MOD_GlcNHglycan	165	169	PF01048	0.534
MOD_GlcNHglycan	219	222	PF01048	0.344
MOD_GlcNHglycan	239	242	PF01048	0.557
MOD_GlcNHglycan	271	274	PF01048	0.320
MOD_GlcNHglycan	275	278	PF01048	0.343
MOD_GlcNHglycan	377	380	PF01048	0.471
MOD_GlcNHglycan	393	397	PF01048	0.255
MOD_GlcNHglycan	460	463	PF01048	0.503
MOD_GSK3_1	114	121	PF00069	0.587
MOD_GSK3_1	125	132	PF00069	0.509
MOD_GSK3_1	196	203	PF00069	0.423
MOD_GSK3_1	235	242	PF00069	0.440
MOD_GSK3_1	244	251	PF00069	0.396
MOD_GSK3_1	269	276	PF00069	0.481
MOD_GSK3_1	27	34	PF00069	0.644
MOD_GSK3_1	301	308	PF00069	0.461
MOD_GSK3_1	314	321	PF00069	0.552
MOD_GSK3_1	373	380	PF00069	0.388
MOD_GSK3_1	388	395	PF00069	0.152
MOD_GSK3_1	402	409	PF00069	0.386
MOD_GSK3_1	454	461	PF00069	0.445
MOD_GSK3_1	508	515	PF00069	0.546
MOD_GSK3_1	60	67	PF00069	0.576
MOD_N-GLC_1	106	111	PF02516	0.558
MOD_N-GLC_1	227	232	PF02516	0.419
MOD_N-GLC_1	472	477	PF02516	0.427
MOD_NEK2_1	146	151	PF00069	0.376
MOD_NEK2_1	163	168	PF00069	0.525
MOD_NEK2_1	186	191	PF00069	0.561
MOD_NEK2_1	386	391	PF00069	0.307
MOD_NEK2_1	472	477	PF00069	0.400
MOD_NEK2_1	509	514	PF00069	0.602
MOD_NEK2_1	531	536	PF00069	0.599
MOD_NEK2_1	93	98	PF00069	0.427
MOD_NEK2_2	108	113	PF00069	0.549
MOD_NEK2_2	293	298	PF00069	0.502
MOD_PIKK_1	16	22	PF00454	0.671
MOD_PIKK_1	271	277	PF00454	0.420
MOD_PIKK_1	29	35	PF00454	0.571
MOD_PIKK_1	314	320	PF00454	0.589
MOD_PIKK_1	350	356	PF00454	0.666
MOD_PIKK_1	41	47	PF00454	0.579
MOD_PIKK_1	496	502	PF00454	0.466
MOD_PIKK_1	509	515	PF00454	0.552
MOD_PK_1	301	307	PF00069	0.497
MOD_PKA_1	122	128	PF00069	0.493
MOD_PKA_1	22	28	PF00069	0.599
MOD_PKA_2	186	192	PF00069	0.555
MOD_PKA_2	318	324	PF00069	0.561
MOD_PKA_2	428	434	PF00069	0.347
MOD_PKA_2	437	443	PF00069	0.339
MOD_PKA_2	509	515	PF00069	0.497
MOD_PKA_2	64	70	PF00069	0.613
MOD_Plk_1	46	52	PF00069	0.606
MOD_Plk_1	496	502	PF00069	0.492
MOD_Plk_1	523	529	PF00069	0.469
MOD_Plk_1	93	99	PF00069	0.573
MOD_Plk_4	108	114	PF00069	0.466
MOD_Plk_4	125	131	PF00069	0.530
MOD_Plk_4	248	254	PF00069	0.461
MOD_Plk_4	355	361	PF00069	0.519
MOD_Plk_4	428	434	PF00069	0.351
MOD_Plk_4	88	94	PF00069	0.485
MOD_ProDKin_1	114	120	PF00069	0.610
MOD_ProDKin_1	132	138	PF00069	0.446
MOD_ProDKin_1	280	286	PF00069	0.417
MOD_ProDKin_1	377	383	PF00069	0.328
MOD_ProDKin_1	402	408	PF00069	0.445
MOD_ProDKin_1	423	429	PF00069	0.350
TRG_DiLeu_LyEn_5	403	408	PF01217	0.494
TRG_ENDOCYTIC_2	161	164	PF00928	0.364
TRG_ENDOCYTIC_2	175	178	PF00928	0.439
TRG_ENDOCYTIC_2	312	315	PF00928	0.510
TRG_ENDOCYTIC_2	399	402	PF00928	0.354
TRG_ENDOCYTIC_2	79	82	PF00928	0.487
TRG_ER_diArg_1	297	300	PF00400	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P997	Leptomonas seymouri	24%	89%
A0A0N1HUS1	Leptomonas seymouri	67%	100%
A0A0S4KLW0	Bodo saltans	41%	96%
A0A1X0P0W1	Trypanosomatidae	47%	100%
A0A3S5IRX8	Trypanosoma rangeli	47%	100%
A0A3S7X5B2	Leishmania donovani	24%	89%
A2AC93	Mus musculus	25%	86%
A4HH18	Leishmania braziliensis	81%	100%
A4I447	Leishmania infantum	99%	100%
A4I7S3	Leishmania infantum	24%	89%
C9ZKR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D0A9Y1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	89%
E9ADL2	Leishmania major	95%	100%
E9AM69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9PYY5	Mus musculus	23%	66%
Q16959	Heliocidaris crassispina	24%	76%
Q16960	Heliocidaris crassispina	25%	90%
Q24246	Drosophila melanogaster	26%	81%
Q32KS2	Bos taurus	22%	76%
Q39578	Chlamydomonas reinhardtii	25%	78%
Q4Q5H6	Leishmania major	23%	89%
Q4QR00	Xenopus laevis	24%	91%
Q4V8G4	Rattus norvegicus	22%	67%
Q5U4F6	Mus musculus	29%	100%
Q5XIL8	Rattus norvegicus	21%	76%
Q66HC9	Rattus norvegicus	23%	87%
Q8C0M8	Mus musculus	21%	76%
Q96EX3	Homo sapiens	30%	100%
Q9UI46	Homo sapiens	22%	77%
V5B145	Trypanosoma cruzi	24%	89%
V5BUI1	Trypanosoma cruzi	49%	100%