Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X1Y8_LEIDO

TriTrypDb:

LdBPK_282620.1 , LdCL_280031300 , LDHU3_28.3550

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005851	eukaryotic translation initiation factor 2B complex	2	1
GO:0032045	guanyl-nucleotide exchange factor complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1

Expansion

Sequence features

A0A3S7X1Y8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1Y8

Function

Biological processes
Term	Name	Level	Count
GO:0002183	cytoplasmic translational initiation	4	1
GO:0006413	translational initiation	3	1
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1
GO:0009058	biosynthetic process	2	6

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003743	translation initiation factor activity	4	1
GO:0003824	catalytic activity	1	7
GO:0005085	guanyl-nucleotide exchange factor activity	3	1
GO:0005488	binding	1	1
GO:0008135	translation factor activity, RNA binding	3	1
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016779	nucleotidyltransferase activity	4	7
GO:0030234	enzyme regulator activity	2	1
GO:0030695	GTPase regulator activity	4	1
GO:0045182	translation regulator activity	1	1
GO:0060589	nucleoside-triphosphatase regulator activity	3	1
GO:0090079	translation regulator activity, nucleic acid binding	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1
GO:0140678	molecular function inhibitor activity	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:0008879	glucose-1-phosphate thymidylyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.657
CLV_C14_Caspase3-7	269	273	PF00656	0.491
CLV_C14_Caspase3-7	362	366	PF00656	0.332
CLV_C14_Caspase3-7	450	454	PF00656	0.515
CLV_C14_Caspase3-7	589	593	PF00656	0.582
CLV_NRD_NRD_1	228	230	PF00675	0.608
CLV_NRD_NRD_1	353	355	PF00675	0.400
CLV_NRD_NRD_1	390	392	PF00675	0.501
CLV_PCSK_KEX2_1	230	232	PF00082	0.691
CLV_PCSK_KEX2_1	353	355	PF00082	0.400
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.691
CLV_PCSK_PC7_1	226	232	PF00082	0.619
CLV_PCSK_SKI1_1	110	114	PF00082	0.462
CLV_PCSK_SKI1_1	190	194	PF00082	0.354
CLV_PCSK_SKI1_1	33	37	PF00082	0.321
CLV_PCSK_SKI1_1	373	377	PF00082	0.469
CLV_PCSK_SKI1_1	392	396	PF00082	0.440
CLV_PCSK_SKI1_1	524	528	PF00082	0.583
CLV_PCSK_SKI1_1	57	61	PF00082	0.377
DEG_APCC_DBOX_1	372	380	PF00400	0.464
DEG_APCC_DBOX_1	523	531	PF00400	0.594
DEG_SCF_FBW7_2	48	53	PF00400	0.398
DEG_SPOP_SBC_1	285	289	PF00917	0.595
DOC_CKS1_1	413	418	PF01111	0.495
DOC_MAPK_gen_1	108	115	PF00069	0.449
DOC_MAPK_gen_1	353	359	PF00069	0.396
DOC_MAPK_gen_1	391	397	PF00069	0.502
DOC_MAPK_gen_1	419	426	PF00069	0.537
DOC_MAPK_MEF2A_6	341	348	PF00069	0.452
DOC_MAPK_MEF2A_6	419	426	PF00069	0.537
DOC_PP1_RVXF_1	39	46	PF00149	0.460
DOC_PP4_FxxP_1	413	416	PF00568	0.418
DOC_PP4_FxxP_1	446	449	PF00568	0.434
DOC_PP4_FxxP_1	525	528	PF00568	0.630
DOC_USP7_MATH_1	160	164	PF00917	0.675
DOC_USP7_MATH_1	273	277	PF00917	0.557
DOC_USP7_MATH_1	281	285	PF00917	0.632
DOC_USP7_MATH_1	286	290	PF00917	0.632
DOC_USP7_MATH_1	383	387	PF00917	0.491
DOC_USP7_MATH_1	491	495	PF00917	0.591
DOC_USP7_MATH_1	526	530	PF00917	0.764
DOC_USP7_MATH_1	555	559	PF00917	0.624
DOC_USP7_MATH_1	563	567	PF00917	0.529
DOC_USP7_MATH_1	633	637	PF00917	0.360
DOC_USP7_MATH_1	644	648	PF00917	0.277
DOC_USP7_UBL2_3	104	108	PF12436	0.415
DOC_WW_Pin1_4	142	147	PF00397	0.736
DOC_WW_Pin1_4	295	300	PF00397	0.526
DOC_WW_Pin1_4	310	315	PF00397	0.570
DOC_WW_Pin1_4	412	417	PF00397	0.499
DOC_WW_Pin1_4	46	51	PF00397	0.441
LIG_14-3-3_CanoR_1	182	189	PF00244	0.530
LIG_14-3-3_CanoR_1	212	218	PF00244	0.516
LIG_14-3-3_CanoR_1	345	349	PF00244	0.439
LIG_14-3-3_CanoR_1	617	624	PF00244	0.448
LIG_Actin_WH2_2	100	116	PF00022	0.500
LIG_BIR_II_1	1	5	PF00653	0.623
LIG_BRCT_BRCA1_1	74	78	PF00533	0.562
LIG_Clathr_ClatBox_1	201	205	PF01394	0.496
LIG_EVH1_2	596	600	PF00568	0.542
LIG_FHA_1	197	203	PF00498	0.407
LIG_FHA_1	219	225	PF00498	0.475
LIG_FHA_1	258	264	PF00498	0.606
LIG_FHA_1	269	275	PF00498	0.531
LIG_FHA_1	450	456	PF00498	0.482
LIG_FHA_1	47	53	PF00498	0.364
LIG_FHA_1	517	523	PF00498	0.638
LIG_FHA_1	600	606	PF00498	0.437
LIG_FHA_1	617	623	PF00498	0.315
LIG_FHA_1	640	646	PF00498	0.364
LIG_FHA_2	118	124	PF00498	0.532
LIG_FHA_2	26	32	PF00498	0.426
LIG_FHA_2	413	419	PF00498	0.473
LIG_FHA_2	458	464	PF00498	0.363
LIG_FHA_2	572	578	PF00498	0.620
LIG_FHA_2	96	102	PF00498	0.351
LIG_LIR_Apic_2	410	416	PF02991	0.447
LIG_LIR_Gen_1	211	222	PF02991	0.465
LIG_LIR_Gen_1	65	74	PF02991	0.408
LIG_LIR_Gen_1	82	92	PF02991	0.322
LIG_LIR_Nem_3	211	217	PF02991	0.484
LIG_LIR_Nem_3	479	484	PF02991	0.359
LIG_LIR_Nem_3	53	59	PF02991	0.379
LIG_LIR_Nem_3	65	70	PF02991	0.337
LIG_LIR_Nem_3	75	81	PF02991	0.399
LIG_LIR_Nem_3	82	88	PF02991	0.281
LIG_MAD2	651	659	PF02301	0.363
LIG_MYND_1	528	532	PF01753	0.624
LIG_Pex14_1	374	378	PF04695	0.379
LIG_Pex14_2	56	60	PF04695	0.466
LIG_SH2_CRK	214	218	PF00017	0.409
LIG_SH2_CRK	225	229	PF00017	0.403
LIG_SH2_CRK	481	485	PF00017	0.496
LIG_SH2_CRK	67	71	PF00017	0.368
LIG_SH2_GRB2like	334	337	PF00017	0.455
LIG_SH2_PTP2	85	88	PF00017	0.474
LIG_SH2_SRC	334	337	PF00017	0.493
LIG_SH2_STAP1	214	218	PF00017	0.477
LIG_SH2_STAP1	259	263	PF00017	0.469
LIG_SH2_STAT5	106	109	PF00017	0.352
LIG_SH2_STAT5	259	262	PF00017	0.498
LIG_SH2_STAT5	334	337	PF00017	0.473
LIG_SH2_STAT5	369	372	PF00017	0.301
LIG_SH2_STAT5	73	76	PF00017	0.364
LIG_SH2_STAT5	85	88	PF00017	0.346
LIG_SH3_3	566	572	PF00018	0.530
LIG_SH3_3	591	597	PF00018	0.566
LIG_SUMO_SIM_anti_2	20	26	PF11976	0.481
LIG_SUMO_SIM_par_1	198	205	PF11976	0.448
LIG_SUMO_SIM_par_1	570	577	PF11976	0.612
LIG_TRAF2_1	267	270	PF00917	0.366
LIG_TRFH_1	85	89	PF08558	0.357
LIG_TYR_ITAM	211	228	PF00017	0.440
LIG_WRC_WIRS_1	206	211	PF05994	0.474
LIG_WRC_WIRS_1	587	592	PF05994	0.517
MOD_CDK_SPxxK_3	412	419	PF00069	0.497
MOD_CK1_1	134	140	PF00069	0.557
MOD_CK1_1	147	153	PF00069	0.554
MOD_CK1_1	196	202	PF00069	0.322
MOD_CK1_1	2	8	PF00069	0.550
MOD_CK1_1	216	222	PF00069	0.227
MOD_CK1_1	251	257	PF00069	0.732
MOD_CK1_1	284	290	PF00069	0.734
MOD_CK1_1	386	392	PF00069	0.425
MOD_CK1_1	401	407	PF00069	0.343
MOD_CK1_1	436	442	PF00069	0.571
MOD_CK2_1	117	123	PF00069	0.522
MOD_CK2_1	147	153	PF00069	0.650
MOD_CK2_1	205	211	PF00069	0.510
MOD_CK2_1	25	31	PF00069	0.496
MOD_CK2_1	310	316	PF00069	0.667
MOD_CK2_1	412	418	PF00069	0.451
MOD_CK2_1	444	450	PF00069	0.647
MOD_CK2_1	457	463	PF00069	0.315
MOD_CK2_1	571	577	PF00069	0.609
MOD_CK2_1	667	673	PF00069	0.549
MOD_GlcNHglycan	133	136	PF01048	0.747
MOD_GlcNHglycan	139	143	PF01048	0.700
MOD_GlcNHglycan	160	163	PF01048	0.803
MOD_GlcNHglycan	184	187	PF01048	0.602
MOD_GlcNHglycan	250	253	PF01048	0.723
MOD_GlcNHglycan	283	286	PF01048	0.677
MOD_GlcNHglycan	295	298	PF01048	0.724
MOD_GlcNHglycan	305	308	PF01048	0.767
MOD_GlcNHglycan	381	384	PF01048	0.430
MOD_GlcNHglycan	434	438	PF01048	0.643
MOD_GlcNHglycan	489	492	PF01048	0.509
MOD_GlcNHglycan	503	506	PF01048	0.468
MOD_GlcNHglycan	519	522	PF01048	0.606
MOD_GlcNHglycan	551	554	PF01048	0.586
MOD_GlcNHglycan	557	560	PF01048	0.438
MOD_GlcNHglycan	646	649	PF01048	0.342
MOD_GSK3_1	134	141	PF00069	0.716
MOD_GSK3_1	166	173	PF00069	0.730
MOD_GSK3_1	251	258	PF00069	0.643
MOD_GSK3_1	280	287	PF00069	0.672
MOD_GSK3_1	293	300	PF00069	0.581
MOD_GSK3_1	379	386	PF00069	0.393
MOD_GSK3_1	398	405	PF00069	0.434
MOD_GSK3_1	487	494	PF00069	0.568
MOD_GSK3_1	586	593	PF00069	0.487
MOD_GSK3_1	635	642	PF00069	0.350
MOD_N-GLC_1	131	136	PF02516	0.520
MOD_N-GLC_1	665	670	PF02516	0.562
MOD_NEK2_1	303	308	PF00069	0.632
MOD_NEK2_1	398	403	PF00069	0.372
MOD_NEK2_1	590	595	PF00069	0.442
MOD_PIKK_1	297	303	PF00454	0.731
MOD_PIKK_1	398	404	PF00454	0.378
MOD_PIKK_1	491	497	PF00454	0.599
MOD_PK_1	144	150	PF00069	0.593
MOD_PKA_2	344	350	PF00069	0.481
MOD_PKA_2	616	622	PF00069	0.358
MOD_Plk_1	131	137	PF00069	0.595
MOD_Plk_1	255	261	PF00069	0.615
MOD_Plk_1	355	361	PF00069	0.386
MOD_Plk_1	386	392	PF00069	0.516
MOD_Plk_2-3	117	123	PF00069	0.522
MOD_Plk_2-3	205	211	PF00069	0.510
MOD_Plk_4	144	150	PF00069	0.610
MOD_Plk_4	196	202	PF00069	0.322
MOD_Plk_4	205	211	PF00069	0.367
MOD_Plk_4	31	37	PF00069	0.454
MOD_Plk_4	457	463	PF00069	0.337
MOD_Plk_4	526	532	PF00069	0.762
MOD_Plk_4	563	569	PF00069	0.490
MOD_Plk_4	586	592	PF00069	0.482
MOD_Plk_4	618	624	PF00069	0.376
MOD_Plk_4	635	641	PF00069	0.322
MOD_Plk_4	652	658	PF00069	0.356
MOD_Plk_4	667	673	PF00069	0.416
MOD_ProDKin_1	142	148	PF00069	0.736
MOD_ProDKin_1	295	301	PF00069	0.527
MOD_ProDKin_1	310	316	PF00069	0.571
MOD_ProDKin_1	412	418	PF00069	0.500
MOD_ProDKin_1	46	52	PF00069	0.450
MOD_SUMO_for_1	178	181	PF00179	0.658
MOD_SUMO_rev_2	337	342	PF00179	0.371
TRG_DiLeu_BaEn_4	269	275	PF01217	0.467
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.414
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.450
TRG_DiLeu_BaLyEn_6	498	503	PF01217	0.494
TRG_ENDOCYTIC_2	214	217	PF00928	0.390
TRG_ENDOCYTIC_2	225	228	PF00928	0.384
TRG_ENDOCYTIC_2	481	484	PF00928	0.395
TRG_ENDOCYTIC_2	67	70	PF00928	0.363
TRG_ENDOCYTIC_2	85	88	PF00928	0.346
TRG_ER_diArg_1	228	231	PF00400	0.631
TRG_ER_diArg_1	353	355	PF00400	0.400
TRG_NLS_MonoExtN_4	226	233	PF00514	0.615
TRG_Pf-PMV_PEXEL_1	482	487	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCH8	Leptomonas seymouri	66%	100%
A0A0S4IV50	Bodo saltans	34%	100%
A0A1X0NS55	Trypanosomatidae	38%	100%
A0A3R7REE6	Trypanosoma rangeli	34%	100%
A4HGU7	Leishmania braziliensis	83%	100%
A4I3X5	Leishmania infantum	100%	100%
D0A943	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B065	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q820	Leishmania major	95%	100%
V5BC43	Trypanosoma cruzi	36%	100%