Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X1Y7_LEIDO

TriTrypDb:

LdBPK_283120.1 , LdCL_280036500 , LDHU3_28.4130

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X1Y7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1Y7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	354	358	PF00656	0.485
CLV_C14_Caspase3-7	364	368	PF00656	0.529
CLV_NRD_NRD_1	180	182	PF00675	0.449
CLV_NRD_NRD_1	273	275	PF00675	0.462
CLV_NRD_NRD_1	98	100	PF00675	0.553
CLV_PCSK_FUR_1	55	59	PF00082	0.597
CLV_PCSK_KEX2_1	115	117	PF00082	0.364
CLV_PCSK_KEX2_1	125	127	PF00082	0.507
CLV_PCSK_KEX2_1	180	182	PF00082	0.452
CLV_PCSK_KEX2_1	273	275	PF00082	0.462
CLV_PCSK_KEX2_1	57	59	PF00082	0.686
CLV_PCSK_KEX2_1	98	100	PF00082	0.647
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.512
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.614
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.686
CLV_PCSK_SKI1_1	208	212	PF00082	0.495
CLV_PCSK_SKI1_1	234	238	PF00082	0.404
CLV_PCSK_SKI1_1	273	277	PF00082	0.433
DEG_APCC_DBOX_1	207	215	PF00400	0.475
DEG_APCC_DBOX_1	273	281	PF00400	0.443
DEG_APCC_DBOX_1	57	65	PF00400	0.558
DEG_SPOP_SBC_1	5	9	PF00917	0.559
DOC_PP1_RVXF_1	71	78	PF00149	0.379
DOC_USP7_MATH_1	179	183	PF00917	0.612
DOC_USP7_MATH_1	344	348	PF00917	0.511
DOC_USP7_MATH_1	351	355	PF00917	0.510
DOC_USP7_MATH_2	14	20	PF00917	0.551
DOC_WW_Pin1_4	362	367	PF00397	0.665
LIG_14-3-3_CanoR_1	180	184	PF00244	0.484
LIG_14-3-3_CanoR_1	189	193	PF00244	0.383
LIG_14-3-3_CanoR_1	299	305	PF00244	0.481
LIG_14-3-3_CanoR_1	51	59	PF00244	0.566
LIG_Actin_WH2_2	102	120	PF00022	0.489
LIG_Actin_WH2_2	214	230	PF00022	0.434
LIG_APCC_ABBA_1	214	219	PF00400	0.447
LIG_BIR_II_1	1	5	PF00653	0.642
LIG_BIR_III_2	219	223	PF00653	0.427
LIG_BIR_III_4	357	361	PF00653	0.577
LIG_BRCT_BRCA1_1	317	321	PF00533	0.429
LIG_Clathr_ClatBox_1	146	150	PF01394	0.439
LIG_Clathr_ClatBox_1	172	176	PF01394	0.436
LIG_FHA_1	131	137	PF00498	0.382
LIG_FHA_1	167	173	PF00498	0.481
LIG_FHA_1	295	301	PF00498	0.466
LIG_FHA_1	368	374	PF00498	0.570
LIG_FHA_1	51	57	PF00498	0.529
LIG_FHA_1	77	83	PF00498	0.473
LIG_FHA_2	262	268	PF00498	0.475
LIG_FHA_2	301	307	PF00498	0.502
LIG_LIR_Gen_1	142	151	PF02991	0.521
LIG_LIR_Gen_1	322	328	PF02991	0.516
LIG_LIR_Nem_3	142	146	PF02991	0.479
LIG_LIR_Nem_3	269	275	PF02991	0.413
LIG_LIR_Nem_3	287	293	PF02991	0.412
LIG_LIR_Nem_3	303	307	PF02991	0.507
LIG_LIR_Nem_3	318	324	PF02991	0.357
LIG_LIR_Nem_3	69	75	PF02991	0.538
LIG_RPA_C_Fungi	46	58	PF08784	0.562
LIG_SH2_CRK	162	166	PF00017	0.380
LIG_SH2_CRK	293	297	PF00017	0.460
LIG_SH2_NCK_1	187	191	PF00017	0.431
LIG_SH2_NCK_1	293	297	PF00017	0.460
LIG_SH2_STAP1	143	147	PF00017	0.470
LIG_SH2_STAP1	317	321	PF00017	0.453
LIG_SH2_STAP1	34	38	PF00017	0.646
LIG_SH2_STAP1	78	82	PF00017	0.483
LIG_SH2_STAT3	317	320	PF00017	0.454
LIG_SH2_STAT3	34	37	PF00017	0.528
LIG_SH2_STAT5	290	293	PF00017	0.426
LIG_SH2_STAT5	34	37	PF00017	0.528
LIG_SH2_STAT5	38	41	PF00017	0.486
LIG_SH2_STAT5	67	70	PF00017	0.486
LIG_SH2_STAT5	78	81	PF00017	0.409
LIG_SH3_1	118	124	PF00018	0.552
LIG_SH3_2	121	126	PF14604	0.581
LIG_SH3_3	118	124	PF00018	0.576
LIG_SH3_3	369	375	PF00018	0.632
LIG_SUMO_SIM_anti_2	129	136	PF11976	0.528
LIG_SUMO_SIM_anti_2	24	31	PF11976	0.474
LIG_SUMO_SIM_par_1	145	150	PF11976	0.444
LIG_TYR_ITIM	291	296	PF00017	0.444
LIG_UBA3_1	146	152	PF00899	0.397
LIG_WW_3	12	16	PF00397	0.676
MOD_CK1_1	19	25	PF00069	0.515
MOD_CK1_1	76	82	PF00069	0.497
MOD_CK1_1	91	97	PF00069	0.456
MOD_CK2_1	18	24	PF00069	0.593
MOD_CK2_1	240	246	PF00069	0.703
MOD_CK2_1	261	267	PF00069	0.481
MOD_CK2_1	300	306	PF00069	0.501
MOD_CK2_1	59	65	PF00069	0.526
MOD_GlcNHglycan	18	21	PF01048	0.506
MOD_GlcNHglycan	353	356	PF01048	0.537
MOD_GlcNHglycan	79	82	PF01048	0.481
MOD_GlcNHglycan	8	11	PF01048	0.628
MOD_GSK3_1	18	25	PF00069	0.666
MOD_GSK3_1	240	247	PF00069	0.499
MOD_GSK3_1	32	39	PF00069	0.419
MOD_GSK3_1	73	80	PF00069	0.495
MOD_GSK3_1	84	91	PF00069	0.446
MOD_N-GLC_1	360	365	PF02516	0.593
MOD_N-GLC_1	5	10	PF02516	0.606
MOD_NEK2_1	300	305	PF00069	0.420
MOD_NEK2_1	77	82	PF00069	0.481
MOD_NEK2_2	161	166	PF00069	0.405
MOD_PIKK_1	32	38	PF00454	0.514
MOD_PIKK_1	329	335	PF00454	0.467
MOD_PIKK_1	59	65	PF00454	0.502
MOD_PKA_2	179	185	PF00069	0.523
MOD_PKA_2	188	194	PF00069	0.383
MOD_PKA_2	300	306	PF00069	0.481
MOD_PKA_2	50	56	PF00069	0.517
MOD_Plk_1	315	321	PF00069	0.451
MOD_Plk_1	73	79	PF00069	0.498
MOD_Plk_2-3	263	269	PF00069	0.521
MOD_Plk_4	130	136	PF00069	0.435
MOD_Plk_4	161	167	PF00069	0.394
MOD_Plk_4	22	28	PF00069	0.515
MOD_Plk_4	240	246	PF00069	0.583
MOD_Plk_4	73	79	PF00069	0.462
MOD_ProDKin_1	362	368	PF00069	0.665
MOD_SUMO_rev_2	145	154	PF00179	0.440
TRG_DiLeu_BaEn_1	142	147	PF01217	0.439
TRG_DiLeu_BaEn_1	206	211	PF01217	0.375
TRG_DiLeu_BaEn_2	149	155	PF01217	0.467
TRG_DiLeu_BaEn_2	305	311	PF01217	0.502
TRG_DiLeu_BaLyEn_6	205	210	PF01217	0.377
TRG_DiLeu_BaLyEn_6	225	230	PF01217	0.317
TRG_ENDOCYTIC_2	143	146	PF00928	0.586
TRG_ENDOCYTIC_2	162	165	PF00928	0.282
TRG_ENDOCYTIC_2	293	296	PF00928	0.476
TRG_ENDOCYTIC_2	304	307	PF00928	0.480
TRG_ER_diArg_1	109	112	PF00400	0.399
TRG_ER_diArg_1	272	274	PF00400	0.483
TRG_ER_diArg_1	334	337	PF00400	0.491
TRG_ER_diArg_1	97	99	PF00400	0.670
TRG_NES_CRM1_1	219	233	PF08389	0.385
TRG_NLS_Bipartite_1	98	119	PF00514	0.452
TRG_NLS_MonoExtN_4	112	119	PF00514	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5J9	Leptomonas seymouri	48%	100%
A4HGZ2	Leishmania braziliensis	72%	100%
A4I424	Leishmania infantum	99%	100%
E9B0B1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q7X3	Leishmania major	92%	100%
V5B930	Trypanosoma cruzi	25%	100%