Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X1Y4_LEIDO

TriTrypDb:

LdBPK_283030.1 , LdCL_280035700 , LDHU3_28.4050

Length:

208

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X1Y4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1Y4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.817
CLV_NRD_NRD_1	132	134	PF00675	0.433
CLV_NRD_NRD_1	180	182	PF00675	0.570
CLV_PCSK_KEX2_1	13	15	PF00082	0.817
CLV_PCSK_KEX2_1	134	136	PF00082	0.435
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.493
CLV_PCSK_SKI1_1	138	142	PF00082	0.510
CLV_PCSK_SKI1_1	181	185	PF00082	0.574
CLV_PCSK_SKI1_1	69	73	PF00082	0.558
DEG_SPOP_SBC_1	85	89	PF00917	0.621
DOC_MAPK_gen_1	133	142	PF00069	0.490
DOC_MAPK_gen_1	143	149	PF00069	0.488
DOC_PP1_RVXF_1	102	108	PF00149	0.492
DOC_PP1_RVXF_1	136	142	PF00149	0.486
DOC_PP1_SILK_1	156	161	PF00149	0.535
DOC_PP4_MxPP_1	1	4	PF00568	0.626
DOC_USP7_MATH_1	154	158	PF00917	0.476
DOC_USP7_MATH_1	170	174	PF00917	0.514
DOC_USP7_MATH_1	45	49	PF00917	0.626
DOC_USP7_MATH_1	52	56	PF00917	0.650
DOC_USP7_MATH_1	86	90	PF00917	0.633
DOC_WW_Pin1_4	107	112	PF00397	0.477
DOC_WW_Pin1_4	97	102	PF00397	0.516
LIG_14-3-3_CanoR_1	8	13	PF00244	0.675
LIG_CaM_IQ_9	158	174	PF13499	0.533
LIG_FHA_1	100	106	PF00498	0.538
LIG_FHA_1	154	160	PF00498	0.475
LIG_FHA_2	148	154	PF00498	0.561
LIG_FHA_2	60	66	PF00498	0.577
LIG_Integrin_isoDGR_2	136	138	PF01839	0.491
LIG_LIR_Gen_1	7	16	PF02991	0.645
LIG_LIR_Nem_3	7	12	PF02991	0.637
LIG_PDZ_Class_3	203	208	PF00595	0.654
LIG_Pex14_2	120	124	PF04695	0.501
LIG_SH2_CRK	9	13	PF00017	0.693
LIG_SH3_1	13	19	PF00018	0.644
LIG_SH3_3	13	19	PF00018	0.705
LIG_UBA3_1	158	166	PF00899	0.474
LIG_UBA3_1	190	198	PF00899	0.544
LIG_WW_3	3	7	PF00397	0.614
MOD_CDK_SPxxK_3	97	104	PF00069	0.509
MOD_CK1_1	55	61	PF00069	0.572
MOD_CK1_1	89	95	PF00069	0.604
MOD_CK2_1	147	153	PF00069	0.628
MOD_CK2_1	59	65	PF00069	0.587
MOD_CK2_1	84	90	PF00069	0.662
MOD_Cter_Amidation	37	40	PF01082	0.686
MOD_GlcNHglycan	41	44	PF01048	0.649
MOD_GlcNHglycan	47	50	PF01048	0.596
MOD_GlcNHglycan	52	55	PF01048	0.564
MOD_GSK3_1	55	62	PF00069	0.539
MOD_GSK3_1	85	92	PF00069	0.633
MOD_N-GLC_1	97	102	PF02516	0.717
MOD_NEK2_1	147	152	PF00069	0.585
MOD_NEK2_1	194	199	PF00069	0.494
MOD_PK_1	8	14	PF00069	0.695
MOD_PKA_1	39	45	PF00069	0.695
MOD_PKA_2	122	128	PF00069	0.583
MOD_PKB_1	6	14	PF00069	0.675
MOD_Plk_1	89	95	PF00069	0.681
MOD_Plk_4	154	160	PF00069	0.484
MOD_ProDKin_1	107	113	PF00069	0.478
MOD_ProDKin_1	97	103	PF00069	0.506
MOD_SUMO_for_1	183	186	PF00179	0.541
TRG_ENDOCYTIC_2	9	12	PF00928	0.688
TRG_ER_diArg_1	12	14	PF00400	0.655
TRG_NLS_Bipartite_1	133	147	PF00514	0.438
TRG_NLS_MonoExtC_3	180	186	PF00514	0.549
TRG_Pf-PMV_PEXEL_1	181	186	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE59	Leptomonas seymouri	62%	100%
A0A422N0N6	Trypanosoma rangeli	37%	100%
A4HGY4	Leishmania braziliensis	78%	96%
A4I416	Leishmania infantum	98%	100%
E9B0A3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q7Y1	Leishmania major	94%	100%