U5 snRNP-specific 40 kDa protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U5 snRNP-specific 40 kDa protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X1X9_LEIDO

TriTrypDb:

LdBPK_283190.1 , LdCL_280037200 , LDHU3_28.4250

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S7X1X9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1X9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0030627	pre-mRNA 5'-splice site binding	6	1
GO:0036002	pre-mRNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	67	71	PF00656	0.389
CLV_NRD_NRD_1	45	47	PF00675	0.417
CLV_NRD_NRD_1	85	87	PF00675	0.469
CLV_PCSK_FUR_1	85	89	PF00082	0.417
CLV_PCSK_KEX2_1	269	271	PF00082	0.498
CLV_PCSK_KEX2_1	45	47	PF00082	0.417
CLV_PCSK_KEX2_1	84	86	PF00082	0.474
CLV_PCSK_KEX2_1	87	89	PF00082	0.448
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.498
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.411
CLV_PCSK_PC7_1	41	47	PF00082	0.411
CLV_PCSK_PC7_1	81	87	PF00082	0.411
CLV_PCSK_SKI1_1	109	113	PF00082	0.419
CLV_PCSK_SKI1_1	14	18	PF00082	0.415
CLV_PCSK_SKI1_1	336	340	PF00082	0.486
CLV_PCSK_SKI1_1	373	377	PF00082	0.398
DEG_APCC_DBOX_1	108	116	PF00400	0.444
DEG_APCC_DBOX_1	19	27	PF00400	0.401
DEG_Nend_UBRbox_4	1	3	PF02207	0.409
DEG_SPOP_SBC_1	130	134	PF00917	0.525
DEG_SPOP_SBC_1	355	359	PF00917	0.433
DOC_CYCLIN_yCln2_LP_2	107	113	PF00134	0.417
DOC_CYCLIN_yCln2_LP_2	31	37	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	4	10	PF00134	0.406
DOC_MAPK_DCC_7	9	17	PF00069	0.409
DOC_MAPK_gen_1	18	26	PF00069	0.447
DOC_MAPK_gen_1	269	276	PF00069	0.435
DOC_MAPK_gen_1	45	51	PF00069	0.405
DOC_MAPK_MEF2A_6	9	17	PF00069	0.409
DOC_PP1_RVXF_1	12	18	PF00149	0.411
DOC_PP1_RVXF_1	58	65	PF00149	0.369
DOC_PP2B_LxvP_1	4	7	PF13499	0.403
DOC_SPAK_OSR1_1	232	236	PF12202	0.352
DOC_USP7_MATH_1	251	255	PF00917	0.348
DOC_USP7_MATH_1	283	287	PF00917	0.347
DOC_USP7_MATH_1	355	359	PF00917	0.516
DOC_USP7_UBL2_3	269	273	PF12436	0.448
DOC_WW_Pin1_4	114	119	PF00397	0.376
DOC_WW_Pin1_4	30	35	PF00397	0.380
DOC_WW_Pin1_4	96	101	PF00397	0.372
LIG_14-3-3_CanoR_1	103	108	PF00244	0.414
LIG_14-3-3_CanoR_1	18	24	PF00244	0.401
LIG_14-3-3_CanoR_1	336	341	PF00244	0.458
LIG_14-3-3_CanoR_1	46	52	PF00244	0.401
LIG_14-3-3_CanoR_1	75	79	PF00244	0.446
LIG_Actin_WH2_2	214	230	PF00022	0.471
LIG_BIR_III_4	70	74	PF00653	0.465
LIG_BRCT_BRCA1_1	253	257	PF00533	0.416
LIG_BRCT_BRCA1_1	26	30	PF00533	0.408
LIG_CSL_BTD_1	380	383	PF09270	0.481
LIG_FHA_1	164	170	PF00498	0.416
LIG_FHA_1	203	209	PF00498	0.462
LIG_FHA_1	324	330	PF00498	0.488
LIG_FHA_1	343	349	PF00498	0.417
LIG_FHA_1	408	414	PF00498	0.407
LIG_FHA_1	57	63	PF00498	0.373
LIG_FHA_2	215	221	PF00498	0.446
LIG_Integrin_isoDGR_2	91	93	PF01839	0.393
LIG_LIR_Gen_1	27	36	PF02991	0.397
LIG_LIR_Gen_1	289	299	PF02991	0.438
LIG_LIR_Nem_3	141	147	PF02991	0.418
LIG_LIR_Nem_3	27	31	PF02991	0.408
LIG_LIR_Nem_3	289	295	PF02991	0.463
LIG_LIR_Nem_3	302	308	PF02991	0.420
LIG_LYPXL_S_1	4	8	PF13949	0.405
LIG_SH2_CRK	28	32	PF00017	0.392
LIG_SH2_GRB2like	144	147	PF00017	0.435
LIG_SH2_STAP1	28	32	PF00017	0.392
LIG_SH2_STAT5	263	266	PF00017	0.435
LIG_SH2_STAT5	432	435	PF00017	0.444
LIG_SH2_STAT5	78	81	PF00017	0.404
LIG_SH2_STAT5	96	99	PF00017	0.361
LIG_SH3_3	385	391	PF00018	0.461
LIG_SH3_3	4	10	PF00018	0.406
LIG_SUMO_SIM_anti_2	22	27	PF11976	0.402
LIG_SUMO_SIM_par_1	22	27	PF11976	0.402
LIG_SUMO_SIM_par_1	396	401	PF11976	0.439
LIG_TRFH_1	30	34	PF08558	0.401
LIG_TYR_ITIM	26	31	PF00017	0.392
LIG_WRPW_2	8	11	PF00400	0.411
LIG_WW_3	11	15	PF00397	0.408
MOD_CDK_SPxxK_3	96	103	PF00069	0.378
MOD_CK1_1	114	120	PF00069	0.393
MOD_CK1_1	134	140	PF00069	0.577
MOD_CK1_1	202	208	PF00069	0.420
MOD_CK1_1	286	292	PF00069	0.416
MOD_CK1_1	327	333	PF00069	0.509
MOD_CK1_1	417	423	PF00069	0.426
MOD_CK1_1	99	105	PF00069	0.393
MOD_GlcNHglycan	133	136	PF01048	0.516
MOD_GlcNHglycan	201	204	PF01048	0.524
MOD_GlcNHglycan	285	288	PF01048	0.482
MOD_GlcNHglycan	321	324	PF01048	0.498
MOD_GlcNHglycan	342	345	PF01048	0.519
MOD_GlcNHglycan	400	403	PF01048	0.520
MOD_GlcNHglycan	419	422	PF01048	0.418
MOD_GlcNHglycan	435	438	PF01048	0.331
MOD_GSK3_1	126	133	PF00069	0.488
MOD_GSK3_1	247	254	PF00069	0.420
MOD_GSK3_1	26	33	PF00069	0.389
MOD_GSK3_1	282	289	PF00069	0.382
MOD_GSK3_1	319	326	PF00069	0.406
MOD_GSK3_1	336	343	PF00069	0.403
MOD_GSK3_1	47	54	PF00069	0.401
MOD_GSK3_1	99	106	PF00069	0.409
MOD_N-GLC_1	422	427	PF02516	0.438
MOD_NEK2_1	111	116	PF00069	0.598
MOD_NEK2_1	126	131	PF00069	0.451
MOD_NEK2_1	24	29	PF00069	0.405
MOD_NEK2_1	342	347	PF00069	0.384
MOD_NEK2_1	35	40	PF00069	0.348
MOD_NEK2_1	354	359	PF00069	0.415
MOD_NEK2_1	422	427	PF00069	0.438
MOD_NEK2_1	64	69	PF00069	0.356
MOD_NEK2_2	409	414	PF00069	0.463
MOD_PIKK_1	121	127	PF00454	0.388
MOD_PIKK_1	348	354	PF00454	0.478
MOD_PKA_2	19	25	PF00069	0.419
MOD_PKA_2	251	257	PF00069	0.410
MOD_PKA_2	47	53	PF00069	0.392
MOD_PKA_2	74	80	PF00069	0.436
MOD_PKB_1	226	234	PF00069	0.464
MOD_Plk_1	422	428	PF00069	0.488
MOD_Plk_4	116	122	PF00069	0.578
MOD_Plk_4	19	25	PF00069	0.400
MOD_Plk_4	214	220	PF00069	0.409
MOD_Plk_4	251	257	PF00069	0.416
MOD_Plk_4	26	32	PF00069	0.389
MOD_Plk_4	324	330	PF00069	0.360
MOD_Plk_4	74	80	PF00069	0.418
MOD_ProDKin_1	114	120	PF00069	0.374
MOD_ProDKin_1	30	36	PF00069	0.376
MOD_ProDKin_1	96	102	PF00069	0.374
TRG_DiLeu_BaEn_1	170	175	PF01217	0.269
TRG_DiLeu_BaEn_1	372	377	PF01217	0.512
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.389
TRG_DiLeu_BaLyEn_6	358	363	PF01217	0.411
TRG_ENDOCYTIC_2	144	147	PF00928	0.435
TRG_ENDOCYTIC_2	28	31	PF00928	0.392
TRG_ENDOCYTIC_2	5	8	PF00928	0.404
TRG_ER_diArg_1	17	20	PF00400	0.447
TRG_ER_diArg_1	44	46	PF00400	0.414
TRG_ER_diArg_1	84	86	PF00400	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5J8	Leptomonas seymouri	61%	100%
A0A1X0NQJ3	Trypanosomatidae	34%	100%
A0A422NG23	Trypanosoma rangeli	37%	100%
A4HGZ9	Leishmania braziliensis	85%	100%
A4I431	Leishmania infantum	100%	100%
E9B0B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O94620	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q4Q7W6	Leishmania major	90%	100%