Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X1X5_LEIDO

TriTrypDb:

LdBPK_282520.1 , LdCL_280030300 , LDHU3_28.3410

Length:

244

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X1X5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1X5

PDB structure(s): 7aih_Ag , 7am2_Ag , 7ane_Ag

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	208	210	PF00675	0.436
CLV_PCSK_KEX2_1	184	186	PF00082	0.433
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.391
CLV_PCSK_SKI1_1	184	188	PF00082	0.409
CLV_PCSK_SKI1_1	209	213	PF00082	0.385
CLV_PCSK_SKI1_1	239	243	PF00082	0.441
CLV_PCSK_SKI1_1	84	88	PF00082	0.381
DEG_SCF_SKP2-CKS1_1	19	26	PF00560	0.526
DOC_MAPK_gen_1	166	175	PF00069	0.367
DOC_MAPK_MEF2A_6	9	18	PF00069	0.635
DOC_PP1_RVXF_1	192	199	PF00149	0.470
DOC_WW_Pin1_4	10	15	PF00397	0.563
DOC_WW_Pin1_4	20	25	PF00397	0.529
LIG_14-3-3_CanoR_1	107	114	PF00244	0.417
LIG_14-3-3_CanoR_1	215	220	PF00244	0.407
LIG_14-3-3_CanoR_1	49	53	PF00244	0.418
LIG_14-3-3_CanoR_1	75	83	PF00244	0.504
LIG_BIR_II_1	1	5	PF00653	0.676
LIG_deltaCOP1_diTrp_1	137	140	PF00928	0.406
LIG_deltaCOP1_diTrp_1	54	63	PF00928	0.532
LIG_FHA_1	11	17	PF00498	0.636
LIG_FHA_1	160	166	PF00498	0.537
LIG_FHA_1	20	26	PF00498	0.485
LIG_FHA_1	233	239	PF00498	0.440
LIG_FHA_1	94	100	PF00498	0.504
LIG_FHA_2	146	152	PF00498	0.423
LIG_FHA_2	155	161	PF00498	0.417
LIG_FHA_2	49	55	PF00498	0.410
LIG_Integrin_isoDGR_2	41	43	PF01839	0.505
LIG_LIR_Apic_2	148	153	PF02991	0.432
LIG_LIR_Gen_1	170	180	PF02991	0.380
LIG_LIR_Gen_1	192	201	PF02991	0.513
LIG_LIR_Nem_3	119	124	PF02991	0.310
LIG_LIR_Nem_3	170	175	PF02991	0.426
LIG_LIR_Nem_3	192	198	PF02991	0.428
LIG_Pex14_1	117	121	PF04695	0.320
LIG_SH2_GRB2like	118	121	PF00017	0.341
LIG_SH2_NCK_1	78	82	PF00017	0.465
LIG_SH2_SRC	150	153	PF00017	0.434
LIG_SH2_STAP1	118	122	PF00017	0.337
LIG_SH2_STAP1	78	82	PF00017	0.507
LIG_SH2_STAT3	129	132	PF00017	0.428
LIG_SH2_STAT5	118	121	PF00017	0.469
LIG_SH2_STAT5	156	159	PF00017	0.499
LIG_SH2_STAT5	195	198	PF00017	0.572
LIG_SH2_STAT5	27	30	PF00017	0.402
LIG_SH3_2	100	105	PF14604	0.411
LIG_SH3_3	96	102	PF00018	0.398
LIG_TRAF2_1	189	192	PF00917	0.395
LIG_UBA3_1	31	38	PF00899	0.493
MOD_CDK_SPxK_1	20	26	PF00069	0.525
MOD_CK2_1	154	160	PF00069	0.475
MOD_CK2_1	186	192	PF00069	0.467
MOD_CK2_1	48	54	PF00069	0.420
MOD_GlcNHglycan	226	229	PF01048	0.500
MOD_GlcNHglycan	6	9	PF01048	0.604
MOD_GlcNHglycan	78	81	PF01048	0.574
MOD_GSK3_1	116	123	PF00069	0.344
MOD_N-GLC_1	175	180	PF02516	0.388
MOD_NEK2_1	159	164	PF00069	0.433
MOD_NEK2_1	3	8	PF00069	0.545
MOD_PKA_2	3	9	PF00069	0.609
MOD_PKA_2	48	54	PF00069	0.415
MOD_PKA_2	76	82	PF00069	0.537
MOD_PKB_1	105	113	PF00069	0.447
MOD_PKB_1	143	151	PF00069	0.452
MOD_Plk_1	175	181	PF00069	0.392
MOD_Plk_1	53	59	PF00069	0.384
MOD_Plk_4	201	207	PF00069	0.397
MOD_Plk_4	53	59	PF00069	0.384
MOD_ProDKin_1	10	16	PF00069	0.564
MOD_ProDKin_1	20	26	PF00069	0.525
MOD_SUMO_rev_2	158	165	PF00179	0.413
TRG_DiLeu_BaEn_4	191	197	PF01217	0.470
TRG_ENDOCYTIC_2	121	124	PF00928	0.301
TRG_ENDOCYTIC_2	156	159	PF00928	0.548
TRG_ENDOCYTIC_2	195	198	PF00928	0.430
TRG_ER_diArg_1	143	146	PF00400	0.450
TRG_ER_diArg_1	168	171	PF00400	0.363
TRG_ER_diArg_1	74	77	PF00400	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWA3	Leptomonas seymouri	90%	100%
A0A0S4IVR2	Bodo saltans	70%	100%
A0A1X0NR03	Trypanosomatidae	74%	100%
A0A422N0C3	Trypanosoma rangeli	76%	100%
A4HGT9	Leishmania braziliensis	95%	100%
A4I3W6	Leishmania infantum	100%	100%
D0A934	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	100%
E9B056	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4Q829	Leishmania major	98%	100%
V5B9U4	Trypanosoma cruzi	74%	100%