Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X1X0_LEIDO

TriTrypDb:

LdBPK_282770.1 , LdCL_280032800 , LDHU3_28.3750

Length:

226

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X1X0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1X0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.749
CLV_C14_Caspase3-7	129	133	PF00656	0.797
CLV_NRD_NRD_1	10	12	PF00675	0.610
CLV_PCSK_KEX2_1	10	12	PF00082	0.610
CLV_PCSK_KEX2_1	125	127	PF00082	0.741
CLV_PCSK_KEX2_1	93	95	PF00082	0.770
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.802
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.770
CLV_Separin_Metazoa	117	121	PF03568	0.573
CLV_Separin_Metazoa	205	209	PF03568	0.555
DEG_SCF_FBW7_1	182	187	PF00400	0.517
DEG_SCF_SKP2-CKS1_1	70	77	PF00560	0.787
DEG_SPOP_SBC_1	36	40	PF00917	0.584
DOC_CYCLIN_RxL_1	50	62	PF00134	0.615
DOC_MAPK_MEF2A_6	208	216	PF00069	0.549
DOC_USP7_MATH_1	137	141	PF00917	0.797
DOC_USP7_MATH_1	147	151	PF00917	0.637
DOC_USP7_MATH_1	173	177	PF00917	0.676
DOC_USP7_MATH_1	184	188	PF00917	0.630
DOC_WW_Pin1_4	112	117	PF00397	0.740
DOC_WW_Pin1_4	140	145	PF00397	0.720
DOC_WW_Pin1_4	180	185	PF00397	0.549
DOC_WW_Pin1_4	22	27	PF00397	0.752
DOC_WW_Pin1_4	71	76	PF00397	0.726
LIG_14-3-3_CanoR_1	126	134	PF00244	0.626
LIG_14-3-3_CanoR_1	160	164	PF00244	0.702
LIG_14-3-3_CanoR_1	27	33	PF00244	0.658
LIG_14-3-3_CanoR_1	37	44	PF00244	0.660
LIG_14-3-3_CanoR_1	50	57	PF00244	0.523
LIG_FHA_1	129	135	PF00498	0.585
LIG_FHA_1	183	189	PF00498	0.628
LIG_FHA_1	199	205	PF00498	0.385
LIG_FHA_1	23	29	PF00498	0.732
LIG_FHA_1	49	55	PF00498	0.654
LIG_FHA_2	67	73	PF00498	0.764
LIG_LIR_Gen_1	187	197	PF02991	0.666
LIG_LIR_Nem_3	187	192	PF02991	0.573
LIG_PDZ_Class_2	221	226	PF00595	0.671
LIG_PDZ_Wminus1_1	224	226	PF00595	0.690
LIG_REV1ctd_RIR_1	6	15	PF16727	0.629
LIG_SH2_CRK	12	16	PF00017	0.557
LIG_SH2_NCK_1	12	16	PF00017	0.557
LIG_SH2_PTP2	189	192	PF00017	0.534
LIG_SH2_STAP1	12	16	PF00017	0.616
LIG_SH2_STAP1	194	198	PF00017	0.546
LIG_SH2_STAT5	12	15	PF00017	0.637
LIG_SH2_STAT5	189	192	PF00017	0.512
LIG_SH2_STAT5	218	221	PF00017	0.536
LIG_SH3_3	113	119	PF00018	0.664
LIG_SH3_3	131	137	PF00018	0.587
LIG_SH3_3	206	212	PF00018	0.577
LIG_UBA3_1	56	63	PF00899	0.597
LIG_WW_3	117	121	PF00397	0.573
MOD_CDK_SPK_2	22	27	PF00069	0.752
MOD_CDK_SPxK_1	71	77	PF00069	0.789
MOD_CK1_1	112	118	PF00069	0.718
MOD_CK1_1	140	146	PF00069	0.641
MOD_CK1_1	176	182	PF00069	0.616
MOD_CK1_1	31	37	PF00069	0.709
MOD_CK1_1	43	49	PF00069	0.566
MOD_CK1_1	66	72	PF00069	0.767
MOD_CK1_1	84	90	PF00069	0.499
MOD_CK2_1	103	109	PF00069	0.629
MOD_CK2_1	70	76	PF00069	0.785
MOD_GlcNHglycan	104	108	PF01048	0.791
MOD_GlcNHglycan	134	137	PF01048	0.734
MOD_GlcNHglycan	139	143	PF01048	0.690
MOD_GlcNHglycan	149	152	PF01048	0.628
MOD_GlcNHglycan	45	48	PF01048	0.655
MOD_GlcNHglycan	78	81	PF01048	0.632
MOD_GlcNHglycan	83	86	PF01048	0.576
MOD_GSK3_1	108	115	PF00069	0.742
MOD_GSK3_1	128	135	PF00069	0.722
MOD_GSK3_1	138	145	PF00069	0.669
MOD_GSK3_1	173	180	PF00069	0.624
MOD_GSK3_1	31	38	PF00069	0.613
MOD_GSK3_1	39	46	PF00069	0.576
MOD_GSK3_1	59	66	PF00069	0.424
MOD_GSK3_1	67	74	PF00069	0.611
MOD_GSK3_1	76	83	PF00069	0.550
MOD_GSK3_1	84	91	PF00069	0.644
MOD_GSK3_1	99	106	PF00069	0.576
MOD_NEK2_1	108	113	PF00069	0.601
MOD_NEK2_1	220	225	PF00069	0.563
MOD_NEK2_1	88	93	PF00069	0.595
MOD_NEK2_2	184	189	PF00069	0.612
MOD_PIKK_1	63	69	PF00454	0.552
MOD_PKA_1	10	16	PF00069	0.615
MOD_PKA_2	10	16	PF00069	0.615
MOD_PKA_2	159	165	PF00069	0.702
MOD_PKA_2	36	42	PF00069	0.619
MOD_PKA_2	49	55	PF00069	0.626
MOD_PKB_1	126	134	PF00069	0.684
MOD_Plk_1	103	109	PF00069	0.574
MOD_Plk_4	184	190	PF00069	0.694
MOD_Plk_4	220	226	PF00069	0.538
MOD_ProDKin_1	112	118	PF00069	0.730
MOD_ProDKin_1	140	146	PF00069	0.723
MOD_ProDKin_1	180	186	PF00069	0.548
MOD_ProDKin_1	22	28	PF00069	0.752
MOD_ProDKin_1	71	77	PF00069	0.728
MOD_SUMO_for_1	153	156	PF00179	0.710
MOD_SUMO_rev_2	117	127	PF00179	0.723
TRG_ENDOCYTIC_2	12	15	PF00928	0.554
TRG_ENDOCYTIC_2	189	192	PF00928	0.484
TRG_ER_diArg_1	9	11	PF00400	0.610
TRG_NLS_MonoExtC_3	124	130	PF00514	0.727

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P417	Leptomonas seymouri	44%	100%
A4HGW0	Leishmania braziliensis	70%	100%
A4I3Z0	Leishmania infantum	99%	100%
E9B080	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q805	Leishmania major	90%	100%