Membrane-bound acid phosphatase, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

membrane-bound acid phosphatase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X1W4_LEIDO

TriTrypDb:

LdBPK_282850.1 , LdCL_280033600 , LDHU3_28.3840

Length:

548

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 60

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 31, no: 3
NetGPI	no	yes: 0, no: 34

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	27
GO:0110165	cellular anatomical entity	1	27

Expansion

Sequence features

A0A3S7X1W4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1W4

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0008152	metabolic process	1	4
GO:0009987	cellular process	1	4
GO:0016311	dephosphorylation	5	4
GO:0044237	cellular metabolic process	2	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0003993	acid phosphatase activity	6	1
GO:0016787	hydrolase activity	2	5
GO:0016788	hydrolase activity, acting on ester bonds	3	5
GO:0016791	phosphatase activity	5	5
GO:0042578	phosphoric ester hydrolase activity	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	393	395	PF00675	0.535
CLV_PCSK_KEX2_1	393	395	PF00082	0.509
CLV_PCSK_SKI1_1	6	10	PF00082	0.699
CLV_Separin_Metazoa	542	546	PF03568	0.554
DEG_Kelch_Keap1_1	337	342	PF01344	0.241
DOC_CKS1_1	31	36	PF01111	0.420
DOC_CYCLIN_RxL_1	3	12	PF00134	0.632
DOC_MAPK_MEF2A_6	14	22	PF00069	0.538
DOC_PP1_RVXF_1	392	399	PF00149	0.366
DOC_PP2B_LxvP_1	455	458	PF13499	0.236
DOC_PP4_FxxP_1	162	165	PF00568	0.210
DOC_PP4_FxxP_1	74	77	PF00568	0.180
DOC_PP4_MxPP_1	322	325	PF00568	0.332
DOC_USP7_MATH_1	139	143	PF00917	0.251
DOC_USP7_MATH_1	176	180	PF00917	0.385
DOC_USP7_MATH_1	262	266	PF00917	0.320
DOC_USP7_MATH_1	32	36	PF00917	0.704
DOC_USP7_MATH_1	519	523	PF00917	0.627
DOC_WW_Pin1_4	30	35	PF00397	0.602
DOC_WW_Pin1_4	352	357	PF00397	0.296
DOC_WW_Pin1_4	67	72	PF00397	0.409
LIG_14-3-3_CanoR_1	125	134	PF00244	0.267
LIG_14-3-3_CanoR_1	292	296	PF00244	0.253
LIG_14-3-3_CanoR_1	93	101	PF00244	0.327
LIG_APCC_ABBAyCdc20_2	536	542	PF00400	0.549
LIG_APCC_Cbox_2	187	193	PF00515	0.236
LIG_BRCT_BRCA1_1	262	266	PF00533	0.389
LIG_FHA_1	148	154	PF00498	0.299
LIG_FHA_1	21	27	PF00498	0.552
LIG_FHA_1	211	217	PF00498	0.423
LIG_FHA_1	225	231	PF00498	0.319
LIG_FHA_1	292	298	PF00498	0.293
LIG_FHA_1	327	333	PF00498	0.322
LIG_FHA_1	365	371	PF00498	0.347
LIG_FHA_1	381	387	PF00498	0.373
LIG_FHA_1	412	418	PF00498	0.378
LIG_FHA_1	426	432	PF00498	0.285
LIG_FHA_1	500	506	PF00498	0.310
LIG_FHA_1	61	67	PF00498	0.393
LIG_FHA_2	112	118	PF00498	0.312
LIG_FHA_2	311	317	PF00498	0.307
LIG_FHA_2	420	426	PF00498	0.430
LIG_FHA_2	97	103	PF00498	0.385
LIG_HP1_1	165	169	PF01393	0.202
LIG_LIR_Apic_2	161	165	PF02991	0.336
LIG_LIR_Gen_1	163	174	PF02991	0.326
LIG_LIR_Gen_1	192	201	PF02991	0.349
LIG_LIR_Nem_3	163	169	PF02991	0.290
LIG_LIR_Nem_3	192	196	PF02991	0.346
LIG_LIR_Nem_3	252	257	PF02991	0.282
LIG_LIR_Nem_3	390	395	PF02991	0.291
LIG_PCNA_PIPBox_1	83	92	PF02747	0.299
LIG_PCNA_yPIPBox_3	181	190	PF02747	0.302
LIG_PCNA_yPIPBox_3	328	336	PF02747	0.330
LIG_Pex14_1	166	170	PF04695	0.338
LIG_Pex14_1	204	208	PF04695	0.401
LIG_Pex14_2	162	166	PF04695	0.337
LIG_Pex14_2	360	364	PF04695	0.414
LIG_SH2_NCK_1	223	227	PF00017	0.214
LIG_SH2_NCK_1	447	451	PF00017	0.258
LIG_SH2_SRC	223	226	PF00017	0.308
LIG_SH2_SRC	260	263	PF00017	0.391
LIG_SH2_STAP1	111	115	PF00017	0.299
LIG_SH2_STAP1	326	330	PF00017	0.255
LIG_SH2_STAT5	160	163	PF00017	0.310
LIG_SH2_STAT5	170	173	PF00017	0.271
LIG_SH2_STAT5	189	192	PF00017	0.275
LIG_SH2_STAT5	208	211	PF00017	0.313
LIG_SH2_STAT5	395	398	PF00017	0.351
LIG_SH2_STAT5	453	456	PF00017	0.321
LIG_SH3_3	428	434	PF00018	0.431
LIG_SH3_3	540	546	PF00018	0.647
LIG_SH3_3	98	104	PF00018	0.289
LIG_SH3_5	107	111	PF00018	0.229
LIG_SUMO_SIM_anti_2	112	118	PF11976	0.367
LIG_SUMO_SIM_anti_2	514	519	PF11976	0.405
LIG_SUMO_SIM_par_1	18	23	PF11976	0.528
LIG_SUMO_SIM_par_1	218	224	PF11976	0.304
LIG_SUMO_SIM_par_1	328	333	PF11976	0.326
LIG_SUMO_SIM_par_1	516	522	PF11976	0.528
LIG_TRAF2_1	422	425	PF00917	0.271
LIG_WRC_WIRS_1	159	164	PF05994	0.347
LIG_WRC_WIRS_1	500	505	PF05994	0.333
LIG_WRC_WIRS_1	86	91	PF05994	0.318
MOD_CDK_SPxK_1	30	36	PF00069	0.419
MOD_CK1_1	118	124	PF00069	0.320
MOD_CK1_1	154	160	PF00069	0.398
MOD_CK1_1	210	216	PF00069	0.346
MOD_CK1_1	337	343	PF00069	0.333
MOD_CK1_1	35	41	PF00069	0.443
MOD_CK1_1	375	381	PF00069	0.386
MOD_CK1_1	474	480	PF00069	0.477
MOD_CK1_1	488	494	PF00069	0.466
MOD_CK1_1	499	505	PF00069	0.424
MOD_CK1_1	524	530	PF00069	0.641
MOD_CK2_1	111	117	PF00069	0.300
MOD_CK2_1	336	342	PF00069	0.251
MOD_CK2_1	419	425	PF00069	0.420
MOD_GlcNHglycan	128	131	PF01048	0.462
MOD_GlcNHglycan	178	181	PF01048	0.635
MOD_GlcNHglycan	300	303	PF01048	0.509
MOD_GlcNHglycan	336	339	PF01048	0.527
MOD_GlcNHglycan	411	417	PF01048	0.563
MOD_GlcNHglycan	441	444	PF01048	0.534
MOD_GlcNHglycan	455	458	PF01048	0.524
MOD_GlcNHglycan	465	468	PF01048	0.535
MOD_GlcNHglycan	487	490	PF01048	0.650
MOD_GlcNHglycan	523	526	PF01048	0.441
MOD_GlcNHglycan	55	58	PF01048	0.541
MOD_GSK3_1	111	118	PF00069	0.232
MOD_GSK3_1	147	154	PF00069	0.323
MOD_GSK3_1	207	214	PF00069	0.365
MOD_GSK3_1	260	267	PF00069	0.316
MOD_GSK3_1	360	367	PF00069	0.387
MOD_GSK3_1	453	460	PF00069	0.410
MOD_GSK3_1	481	488	PF00069	0.506
MOD_GSK3_1	53	60	PF00069	0.375
MOD_GSK3_1	85	92	PF00069	0.349
MOD_N-GLC_1	139	144	PF02516	0.473
MOD_N-GLC_1	210	215	PF02516	0.570
MOD_N-GLC_1	375	380	PF02516	0.543
MOD_N-GLC_1	481	486	PF02516	0.588
MOD_N-GLC_1	61	66	PF02516	0.557
MOD_N-GLC_2	385	387	PF02516	0.499
MOD_NEK2_1	115	120	PF00069	0.264
MOD_NEK2_1	169	174	PF00069	0.364
MOD_NEK2_1	298	303	PF00069	0.337
MOD_NEK2_1	334	339	PF00069	0.346
MOD_NEK2_1	439	444	PF00069	0.369
MOD_NEK2_1	521	526	PF00069	0.578
MOD_NEK2_1	89	94	PF00069	0.305
MOD_OFUCOSY	462	469	PF10250	0.644
MOD_OGLYCOS	67	72	PF02709	0.482
MOD_PIKK_1	151	157	PF00454	0.423
MOD_PIKK_1	160	166	PF00454	0.384
MOD_PIKK_1	457	463	PF00454	0.432
MOD_PK_1	534	540	PF00069	0.565
MOD_PKA_2	291	297	PF00069	0.279
MOD_PKA_2	35	41	PF00069	0.363
MOD_PKB_1	91	99	PF00069	0.355
MOD_Plk_1	111	117	PF00069	0.263
MOD_Plk_1	139	145	PF00069	0.318
MOD_Plk_1	303	309	PF00069	0.287
MOD_Plk_1	412	418	PF00069	0.393
MOD_Plk_1	425	431	PF00069	0.380
MOD_Plk_1	481	487	PF00069	0.374
MOD_Plk_1	534	540	PF00069	0.660
MOD_Plk_1	61	67	PF00069	0.340
MOD_Plk_1	96	102	PF00069	0.291
MOD_Plk_4	111	117	PF00069	0.307
MOD_Plk_4	154	160	PF00069	0.334
MOD_Plk_4	326	332	PF00069	0.312
MOD_Plk_4	511	517	PF00069	0.308
MOD_Plk_4	534	540	PF00069	0.659
MOD_Plk_4	85	91	PF00069	0.272
MOD_Plk_4	96	102	PF00069	0.301
MOD_ProDKin_1	30	36	PF00069	0.599
MOD_ProDKin_1	352	358	PF00069	0.298
MOD_ProDKin_1	67	73	PF00069	0.403
TRG_DiLeu_BaEn_1	413	418	PF01217	0.353
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.285
TRG_ENDOCYTIC_2	243	246	PF00928	0.384
TRG_ENDOCYTIC_2	254	257	PF00928	0.297
TRG_ENDOCYTIC_2	295	298	PF00928	0.386
TRG_ER_diArg_1	392	394	PF00400	0.332
TRG_ER_diArg_1	90	93	PF00400	0.302
TRG_Pf-PMV_PEXEL_1	283	287	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y5	Leptomonas seymouri	46%	96%
A0A0N1I756	Leptomonas seymouri	37%	100%
A0A0N1PEH4	Leptomonas seymouri	31%	100%
A0A0S4IRF5	Bodo saltans	24%	82%
A0A0S4IUV8	Bodo saltans	23%	100%
A0A0S4IV77	Bodo saltans	32%	100%
A0A0S4IXN9	Bodo saltans	22%	100%
A0A0S4JEA9	Bodo saltans	25%	100%
A0A0S4JJK3	Bodo saltans	28%	100%
A0A0S4JW09	Bodo saltans	26%	100%
A0A1X0NNY4	Trypanosomatidae	35%	99%
A0A1X0NQL4	Trypanosomatidae	29%	100%
A0A1X0NY34	Trypanosomatidae	26%	100%
A0A1X0P3J2	Trypanosomatidae	22%	100%
A0A1X0P7V5	Trypanosomatidae	38%	100%
A0A3Q8IR23	Leishmania donovani	46%	100%
A0A3R7KGH3	Trypanosoma rangeli	24%	100%
A0A3R7KSH4	Trypanosoma rangeli	26%	100%
A0A3R7MEN7	Trypanosoma rangeli	38%	100%
A0A3R7MHJ7	Trypanosoma rangeli	28%	100%
A0A3S5H827	Leishmania donovani	35%	100%
A0A3S7WXU0	Leishmania donovani	44%	100%
A4HCZ0	Leishmania braziliensis	41%	100%
A4HGW8	Leishmania braziliensis	72%	100%
A4HPC1	Leishmania braziliensis	35%	100%
A4HPC5	Leishmania braziliensis	42%	100%
A4HQG6	Leishmania braziliensis	34%	100%
A4HQG9	Leishmania braziliensis	33%	100%
A4I0H5	Leishmania infantum	44%	100%
A4I3Z8	Leishmania infantum	100%	100%
A4ICA5	Leishmania infantum	34%	100%
A4ICG3	Leishmania infantum	35%	100%
A4ICG5	Leishmania infantum	46%	100%
D0A3E0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
D0A947	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0A948	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
D0A9J5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AT34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AT36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AWD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9B088	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
P11117	Homo sapiens	28%	100%
P20611	Rattus norvegicus	26%	100%
P24638	Mus musculus	28%	100%
Q3KQG9	Xenopus laevis	28%	100%
Q4Q1G2	Leishmania major	45%	100%
Q4Q1G4	Leishmania major	34%	100%
Q4Q7Z7	Leishmania major	94%	100%
Q4QB35	Leishmania major	43%	100%
Q4R5N9	Macaca fascicularis	29%	100%
Q5NVF6	Pongo abelii	28%	100%
V5BCI2	Trypanosoma cruzi	24%	100%
V5BK91	Trypanosoma cruzi	39%	100%
V5BL75	Trypanosoma cruzi	27%	100%