Leucine-rich repeat protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine rich repeat protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X1U4_LEIDO

TriTrypDb:

LdBPK_282790.1 , LdCL_280033000 , LDHU3_28.3770

Length:

886

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3S7X1U4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1U4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0019900	kinase binding	4	1
GO:0019901	protein kinase binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	821	825	PF00656	0.684
CLV_NRD_NRD_1	280	282	PF00675	0.550
CLV_NRD_NRD_1	319	321	PF00675	0.542
CLV_NRD_NRD_1	344	346	PF00675	0.589
CLV_NRD_NRD_1	354	356	PF00675	0.568
CLV_NRD_NRD_1	511	513	PF00675	0.686
CLV_NRD_NRD_1	531	533	PF00675	0.377
CLV_NRD_NRD_1	657	659	PF00675	0.286
CLV_NRD_NRD_1	706	708	PF00675	0.649
CLV_NRD_NRD_1	747	749	PF00675	0.614
CLV_PCSK_KEX2_1	280	282	PF00082	0.550
CLV_PCSK_KEX2_1	319	321	PF00082	0.542
CLV_PCSK_KEX2_1	354	356	PF00082	0.605
CLV_PCSK_KEX2_1	531	533	PF00082	0.547
CLV_PCSK_KEX2_1	657	659	PF00082	0.288
CLV_PCSK_SKI1_1	111	115	PF00082	0.515
CLV_PCSK_SKI1_1	237	241	PF00082	0.560
CLV_PCSK_SKI1_1	28	32	PF00082	0.565
CLV_PCSK_SKI1_1	296	300	PF00082	0.457
CLV_PCSK_SKI1_1	544	548	PF00082	0.316
CLV_PCSK_SKI1_1	65	69	PF00082	0.466
CLV_PCSK_SKI1_1	678	682	PF00082	0.705
CLV_PCSK_SKI1_1	721	725	PF00082	0.688
DEG_APCC_DBOX_1	219	227	PF00400	0.458
DEG_APCC_DBOX_1	27	35	PF00400	0.527
DEG_APCC_DBOX_1	295	303	PF00400	0.376
DEG_APCC_DBOX_1	543	551	PF00400	0.497
DEG_Nend_Nbox_1	1	3	PF02207	0.706
DEG_SCF_TRCP1_1	598	604	PF00400	0.572
DEG_SPOP_SBC_1	152	156	PF00917	0.713
DOC_CDC14_PxL_1	189	197	PF14671	0.453
DOC_CKS1_1	1	6	PF01111	0.587
DOC_CKS1_1	359	364	PF01111	0.539
DOC_MAPK_gen_1	111	121	PF00069	0.494
DOC_MAPK_gen_1	319	327	PF00069	0.609
DOC_MAPK_gen_1	531	539	PF00069	0.334
DOC_MAPK_gen_1	654	663	PF00069	0.335
DOC_MAPK_JIP1_4	296	302	PF00069	0.413
DOC_MAPK_MEF2A_6	196	203	PF00069	0.478
DOC_MAPK_MEF2A_6	237	245	PF00069	0.432
DOC_PP1_RVXF_1	115	122	PF00149	0.540
DOC_PP1_RVXF_1	162	168	PF00149	0.637
DOC_PP2B_LxvP_1	686	689	PF13499	0.537
DOC_PP4_FxxP_1	258	261	PF00568	0.514
DOC_USP7_MATH_1	170	174	PF00917	0.621
DOC_USP7_MATH_1	230	234	PF00917	0.429
DOC_USP7_MATH_1	461	465	PF00917	0.663
DOC_USP7_MATH_1	483	487	PF00917	0.621
DOC_USP7_MATH_1	587	591	PF00917	0.760
DOC_USP7_MATH_1	85	89	PF00917	0.444
DOC_USP7_MATH_1	850	854	PF00917	0.656
DOC_WW_Pin1_4	147	152	PF00397	0.706
DOC_WW_Pin1_4	358	363	PF00397	0.536
DOC_WW_Pin1_4	424	429	PF00397	0.714
DOC_WW_Pin1_4	445	450	PF00397	0.678
DOC_WW_Pin1_4	479	484	PF00397	0.604
DOC_WW_Pin1_4	52	57	PF00397	0.527
DOC_WW_Pin1_4	771	776	PF00397	0.718
DOC_WW_Pin1_4	841	846	PF00397	0.748
LIG_14-3-3_CanoR_1	164	170	PF00244	0.691
LIG_14-3-3_CanoR_1	237	242	PF00244	0.492
LIG_14-3-3_CanoR_1	259	265	PF00244	0.520
LIG_14-3-3_CanoR_1	354	363	PF00244	0.659
LIG_14-3-3_CanoR_1	463	471	PF00244	0.673
LIG_14-3-3_CanoR_1	605	614	PF00244	0.708
LIG_14-3-3_CanoR_1	65	70	PF00244	0.431
LIG_14-3-3_CanoR_1	698	706	PF00244	0.549
LIG_14-3-3_CanoR_1	836	842	PF00244	0.775
LIG_14-3-3_CanoR_1	857	863	PF00244	0.586
LIG_Actin_RPEL_3	524	543	PF02755	0.362
LIG_Actin_WH2_2	222	239	PF00022	0.490
LIG_Actin_WH2_2	500	517	PF00022	0.593
LIG_Actin_WH2_2	56	73	PF00022	0.489
LIG_Actin_WH2_2	85	102	PF00022	0.483
LIG_APCC_ABBA_1	324	329	PF00400	0.556
LIG_BIR_III_4	103	107	PF00653	0.451
LIG_BIR_III_4	391	395	PF00653	0.657
LIG_BRCT_BRCA1_1	558	562	PF00533	0.606
LIG_CaM_IQ_9	536	551	PF13499	0.482
LIG_CaM_IQ_9	660	675	PF13499	0.477
LIG_Clathr_ClatBox_1	306	310	PF01394	0.479
LIG_deltaCOP1_diTrp_1	290	301	PF00928	0.557
LIG_EH_1	259	263	PF12763	0.513
LIG_eIF4E_1	123	129	PF01652	0.449
LIG_FHA_1	236	242	PF00498	0.472
LIG_FHA_1	502	508	PF00498	0.668
LIG_FHA_1	602	608	PF00498	0.723
LIG_FHA_1	701	707	PF00498	0.506
LIG_FHA_1	846	852	PF00498	0.690
LIG_FHA_1	862	868	PF00498	0.567
LIG_FHA_2	313	319	PF00498	0.434
LIG_FHA_2	428	434	PF00498	0.774
LIG_LIR_Apic_2	255	261	PF02991	0.320
LIG_LIR_Apic_2	291	297	PF02991	0.490
LIG_LIR_Apic_2	339	343	PF02991	0.577
LIG_LIR_Apic_2	430	434	PF02991	0.729
LIG_LIR_Gen_1	120	131	PF02991	0.419
LIG_LIR_Gen_1	639	650	PF02991	0.701
LIG_LIR_Nem_3	292	298	PF02991	0.469
LIG_LIR_Nem_3	382	386	PF02991	0.631
LIG_LIR_Nem_3	559	565	PF02991	0.554
LIG_LIR_Nem_3	639	645	PF02991	0.698
LIG_LIR_Nem_3	84	89	PF02991	0.414
LIG_MYND_1	612	616	PF01753	0.625
LIG_NRBOX	719	725	PF00104	0.637
LIG_PCNA_TLS_4	346	353	PF02747	0.551
LIG_PCNA_yPIPBox_3	632	642	PF02747	0.625
LIG_Pex14_1	294	298	PF04695	0.452
LIG_Pex14_2	258	262	PF04695	0.511
LIG_SH2_CRK	340	344	PF00017	0.603
LIG_SH2_CRK	383	387	PF00017	0.636
LIG_SH2_GRB2like	340	343	PF00017	0.598
LIG_SH2_NCK_1	736	740	PF00017	0.579
LIG_SH2_PTP2	66	69	PF00017	0.414
LIG_SH2_SRC	736	739	PF00017	0.544
LIG_SH2_STAT3	565	568	PF00017	0.622
LIG_SH2_STAT5	352	355	PF00017	0.461
LIG_SH2_STAT5	66	69	PF00017	0.414
LIG_SH2_STAT5	764	767	PF00017	0.642
LIG_SH3_3	166	172	PF00018	0.572
LIG_SH3_3	238	244	PF00018	0.427
LIG_SH3_3	469	475	PF00018	0.709
LIG_SH3_3	800	806	PF00018	0.574
LIG_SUMO_SIM_anti_2	518	525	PF11976	0.593
LIG_SUMO_SIM_anti_2	88	93	PF11976	0.441
LIG_SUMO_SIM_par_1	173	180	PF11976	0.561
LIG_SUMO_SIM_par_1	222	228	PF11976	0.423
LIG_SUMO_SIM_par_1	303	308	PF11976	0.526
LIG_SUMO_SIM_par_1	48	55	PF11976	0.441
LIG_SUMO_SIM_par_1	90	95	PF11976	0.331
LIG_TRAF2_1	35	38	PF00917	0.566
LIG_TRAF2_1	379	382	PF00917	0.590
LIG_TRAF2_1	516	519	PF00917	0.594
LIG_TRAF2_1	633	636	PF00917	0.656
LIG_TYR_ITIM	64	69	PF00017	0.545
LIG_UBA3_1	109	114	PF00899	0.500
LIG_WRC_WIRS_1	503	508	PF05994	0.630
LIG_WRPW_2	295	298	PF00400	0.451
MOD_CK1_1	140	146	PF00069	0.704
MOD_CK1_1	156	162	PF00069	0.682
MOD_CK1_1	225	231	PF00069	0.451
MOD_CK1_1	427	433	PF00069	0.818
MOD_CK1_1	462	468	PF00069	0.567
MOD_CK1_1	482	488	PF00069	0.786
MOD_CK1_1	502	508	PF00069	0.646
MOD_CK1_1	51	57	PF00069	0.553
MOD_CK1_1	530	536	PF00069	0.362
MOD_CK1_1	601	607	PF00069	0.693
MOD_CK1_1	630	636	PF00069	0.659
MOD_CK1_1	768	774	PF00069	0.748
MOD_CK1_1	853	859	PF00069	0.766
MOD_CK1_1	861	867	PF00069	0.742
MOD_CK2_1	312	318	PF00069	0.398
MOD_CK2_1	333	339	PF00069	0.603
MOD_CK2_1	376	382	PF00069	0.678
MOD_CK2_1	513	519	PF00069	0.592
MOD_CK2_1	630	636	PF00069	0.629
MOD_CK2_1	777	783	PF00069	0.770
MOD_GlcNHglycan	133	136	PF01048	0.636
MOD_GlcNHglycan	142	145	PF01048	0.698
MOD_GlcNHglycan	155	158	PF01048	0.676
MOD_GlcNHglycan	161	164	PF01048	0.600
MOD_GlcNHglycan	196	199	PF01048	0.505
MOD_GlcNHglycan	382	386	PF01048	0.747
MOD_GlcNHglycan	407	410	PF01048	0.664
MOD_GlcNHglycan	418	421	PF01048	0.573
MOD_GlcNHglycan	465	468	PF01048	0.684
MOD_GlcNHglycan	485	488	PF01048	0.459
MOD_GlcNHglycan	573	576	PF01048	0.647
MOD_GlcNHglycan	582	585	PF01048	0.601
MOD_GlcNHglycan	589	592	PF01048	0.737
MOD_GlcNHglycan	598	601	PF01048	0.693
MOD_GlcNHglycan	788	791	PF01048	0.779
MOD_GlcNHglycan	827	830	PF01048	0.687
MOD_GlcNHglycan	873	876	PF01048	0.807
MOD_GSK3_1	105	112	PF00069	0.451
MOD_GSK3_1	115	122	PF00069	0.480
MOD_GSK3_1	136	143	PF00069	0.746
MOD_GSK3_1	147	154	PF00069	0.725
MOD_GSK3_1	159	166	PF00069	0.579
MOD_GSK3_1	248	255	PF00069	0.391
MOD_GSK3_1	260	267	PF00069	0.508
MOD_GSK3_1	269	276	PF00069	0.597
MOD_GSK3_1	329	336	PF00069	0.521
MOD_GSK3_1	354	361	PF00069	0.651
MOD_GSK3_1	416	423	PF00069	0.797
MOD_GSK3_1	459	466	PF00069	0.601
MOD_GSK3_1	477	484	PF00069	0.768
MOD_GSK3_1	48	55	PF00069	0.437
MOD_GSK3_1	601	608	PF00069	0.629
MOD_GSK3_1	708	715	PF00069	0.537
MOD_GSK3_1	765	772	PF00069	0.760
MOD_GSK3_1	773	780	PF00069	0.735
MOD_GSK3_1	827	834	PF00069	0.792
MOD_GSK3_1	837	844	PF00069	0.729
MOD_GSK3_1	846	853	PF00069	0.761
MOD_GSK3_1	858	865	PF00069	0.830
MOD_N-GLC_1	131	136	PF02516	0.550
MOD_N-GLC_1	182	187	PF02516	0.457
MOD_N-GLC_1	274	279	PF02516	0.636
MOD_N-GLC_1	329	334	PF02516	0.513
MOD_N-GLC_1	42	47	PF02516	0.443
MOD_N-GLC_1	420	425	PF02516	0.793
MOD_N-GLC_1	596	601	PF02516	0.716
MOD_N-GLC_1	768	773	PF02516	0.689
MOD_NEK2_1	109	114	PF00069	0.500
MOD_NEK2_1	131	136	PF00069	0.621
MOD_NEK2_1	153	158	PF00069	0.649
MOD_NEK2_1	165	170	PF00069	0.635
MOD_NEK2_1	177	182	PF00069	0.453
MOD_NEK2_1	248	253	PF00069	0.396
MOD_NEK2_1	26	31	PF00069	0.631
MOD_NEK2_1	264	269	PF00069	0.536
MOD_NEK2_1	289	294	PF00069	0.567
MOD_NEK2_1	333	338	PF00069	0.580
MOD_NEK2_1	42	47	PF00069	0.411
MOD_NEK2_1	50	55	PF00069	0.435
MOD_NEK2_1	724	729	PF00069	0.548
MOD_NEK2_1	827	832	PF00069	0.751
MOD_NEK2_1	862	867	PF00069	0.678
MOD_NEK2_1	9	14	PF00069	0.447
MOD_NEK2_1	92	97	PF00069	0.348
MOD_NEK2_2	222	227	PF00069	0.483
MOD_NEK2_2	269	274	PF00069	0.618
MOD_PIKK_1	252	258	PF00454	0.310
MOD_PIKK_1	605	611	PF00454	0.575
MOD_PIKK_1	769	775	PF00454	0.783
MOD_PIKK_1	839	845	PF00454	0.788
MOD_PK_1	513	519	PF00069	0.580
MOD_PKA_1	354	360	PF00069	0.581
MOD_PKA_2	140	146	PF00069	0.770
MOD_PKA_2	163	169	PF00069	0.692
MOD_PKA_2	273	279	PF00069	0.692
MOD_PKA_2	354	360	PF00069	0.649
MOD_PKA_2	462	468	PF00069	0.712
MOD_PKA_2	530	536	PF00069	0.421
MOD_PKA_2	858	864	PF00069	0.638
MOD_PKA_2	865	871	PF00069	0.607
MOD_Plk_1	119	125	PF00069	0.426
MOD_Plk_1	26	32	PF00069	0.520
MOD_Plk_1	289	295	PF00069	0.545
MOD_Plk_1	376	382	PF00069	0.562
MOD_Plk_1	9	15	PF00069	0.468
MOD_Plk_2-3	777	783	PF00069	0.655
MOD_Plk_4	105	111	PF00069	0.407
MOD_Plk_4	237	243	PF00069	0.421
MOD_Plk_4	289	295	PF00069	0.546
MOD_Plk_4	502	508	PF00069	0.580
MOD_Plk_4	65	71	PF00069	0.518
MOD_Plk_4	777	783	PF00069	0.665
MOD_Plk_4	873	879	PF00069	0.705
MOD_ProDKin_1	147	153	PF00069	0.709
MOD_ProDKin_1	358	364	PF00069	0.544
MOD_ProDKin_1	424	430	PF00069	0.714
MOD_ProDKin_1	445	451	PF00069	0.678
MOD_ProDKin_1	479	485	PF00069	0.607
MOD_ProDKin_1	52	58	PF00069	0.521
MOD_ProDKin_1	771	777	PF00069	0.720
MOD_ProDKin_1	841	847	PF00069	0.750
TRG_DiLeu_BaEn_1	719	724	PF01217	0.638
TRG_DiLeu_BaEn_2	557	563	PF01217	0.597
TRG_DiLeu_BaEn_4	37	43	PF01217	0.531
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.467
TRG_DiLeu_BaLyEn_6	301	306	PF01217	0.498
TRG_ENDOCYTIC_2	123	126	PF00928	0.437
TRG_ENDOCYTIC_2	383	386	PF00928	0.631
TRG_ENDOCYTIC_2	648	651	PF00928	0.635
TRG_ENDOCYTIC_2	66	69	PF00928	0.546
TRG_ER_diArg_1	319	321	PF00400	0.544
TRG_ER_diArg_1	353	355	PF00400	0.482
TRG_ER_diArg_1	495	498	PF00400	0.607
TRG_ER_diArg_1	531	534	PF00400	0.543
TRG_ER_diArg_1	670	673	PF00400	0.494
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	515	519	PF00026	0.652
TRG_Pf-PMV_PEXEL_1	632	636	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	721	725	PF00026	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0J5	Leptomonas seymouri	51%	100%
A0A0S4IJ40	Bodo saltans	23%	100%
A0A3R7LYV2	Trypanosoma rangeli	29%	100%
A4HGW2	Leishmania braziliensis	65%	98%
A4I3Z2	Leishmania infantum	100%	100%
E9B082	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q803	Leishmania major	93%	100%
V5BL83	Trypanosoma cruzi	29%	100%