Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X1T5_LEIDO

TriTrypDb:

LdBPK_282330.1 , LdCL_280028400 , LDHU3_28.3160

Length:

245

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X1T5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1T5

PDB structure(s): 7ane_ap

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.659
CLV_C14_Caspase3-7	27	31	PF00656	0.626
CLV_NRD_NRD_1	138	140	PF00675	0.402
CLV_NRD_NRD_1	8	10	PF00675	0.441
CLV_PCSK_KEX2_1	138	140	PF00082	0.402
CLV_PCSK_KEX2_1	8	10	PF00082	0.441
CLV_PCSK_SKI1_1	206	210	PF00082	0.522
CLV_PCSK_SKI1_1	81	85	PF00082	0.350
DEG_APCC_DBOX_1	80	88	PF00400	0.368
DEG_Nend_UBRbox_2	1	3	PF02207	0.614
DEG_SCF_FBW7_2	29	36	PF00400	0.564
DEG_SCF_FBW7_2	63	69	PF00400	0.599
DEG_SPOP_SBC_1	122	126	PF00917	0.439
DOC_CKS1_1	63	68	PF01111	0.509
DOC_MAPK_HePTP_8	89	101	PF00069	0.517
DOC_MAPK_MEF2A_6	81	89	PF00069	0.358
DOC_MAPK_MEF2A_6	92	101	PF00069	0.391
DOC_PP1_RVXF_1	204	210	PF00149	0.504
DOC_PP2B_LxvP_1	85	88	PF13499	0.373
DOC_USP7_MATH_1	122	126	PF00917	0.439
DOC_USP7_MATH_1	88	92	PF00917	0.523
DOC_WW_Pin1_4	25	30	PF00397	0.733
DOC_WW_Pin1_4	62	67	PF00397	0.495
LIG_14-3-3_CanoR_1	110	115	PF00244	0.542
LIG_14-3-3_CanoR_1	123	128	PF00244	0.427
LIG_14-3-3_CanoR_1	220	224	PF00244	0.542
LIG_14-3-3_CanoR_1	48	56	PF00244	0.495
LIG_deltaCOP1_diTrp_1	160	168	PF00928	0.421
LIG_DLG_GKlike_1	123	131	PF00625	0.396
LIG_FHA_2	32	38	PF00498	0.719
LIG_FHA_2	63	69	PF00498	0.494
LIG_LIR_Gen_1	147	156	PF02991	0.376
LIG_LIR_Gen_1	225	234	PF02991	0.438
LIG_NRBOX	78	84	PF00104	0.483
LIG_PCNA_PIPBox_1	114	123	PF02747	0.510
LIG_Pex14_1	164	168	PF04695	0.420
LIG_Pex14_1	233	237	PF04695	0.462
LIG_Pex14_2	168	172	PF04695	0.578
LIG_SH2_SRC	127	130	PF00017	0.483
LIG_SH2_STAP1	127	131	PF00017	0.466
LIG_SH2_STAT3	154	157	PF00017	0.375
LIG_SH3_1	60	66	PF00018	0.503
LIG_SH3_3	60	66	PF00018	0.481
LIG_Sin3_3	95	102	PF02671	0.407
LIG_SUMO_SIM_anti_2	80	86	PF11976	0.363
LIG_TRAF2_1	20	23	PF00917	0.598
LIG_TRAF2_1	34	37	PF00917	0.589
LIG_TRAF2_1	44	47	PF00917	0.586
LIG_TRAF2_1	66	69	PF00917	0.586
LIG_TRFH_1	59	63	PF08558	0.398
LIG_WRC_WIRS_1	223	228	PF05994	0.571
MOD_CDK_SPK_2	62	67	PF00069	0.495
MOD_CK1_1	113	119	PF00069	0.422
MOD_CK1_1	222	228	PF00069	0.552
MOD_CK1_1	28	34	PF00069	0.735
MOD_CK2_1	123	129	PF00069	0.402
MOD_CK2_1	172	178	PF00069	0.577
MOD_CK2_1	222	228	PF00069	0.553
MOD_CK2_1	239	245	PF00069	0.583
MOD_CK2_1	31	37	PF00069	0.728
MOD_CK2_1	62	68	PF00069	0.485
MOD_GlcNHglycan	104	107	PF01048	0.522
MOD_GSK3_1	215	222	PF00069	0.586
MOD_GSK3_1	24	31	PF00069	0.714
MOD_NEK2_1	102	107	PF00069	0.523
MOD_NEK2_1	121	126	PF00069	0.470
MOD_NEK2_1	137	142	PF00069	0.383
MOD_NEK2_1	152	157	PF00069	0.279
MOD_NEK2_1	172	177	PF00069	0.609
MOD_PIKK_1	215	221	PF00454	0.593
MOD_PKA_2	122	128	PF00069	0.552
MOD_PKA_2	137	143	PF00069	0.495
MOD_PKA_2	219	225	PF00069	0.549
MOD_PKA_2	47	53	PF00069	0.415
MOD_ProDKin_1	25	31	PF00069	0.734
MOD_ProDKin_1	62	68	PF00069	0.504
MOD_SUMO_rev_2	193	202	PF00179	0.534
MOD_SUMO_rev_2	211	218	PF00179	0.586
MOD_SUMO_rev_2	36	45	PF00179	0.662
TRG_DiLeu_BaLyEn_6	78	83	PF01217	0.362
TRG_ENDOCYTIC_2	149	152	PF00928	0.378
TRG_ER_diArg_1	137	139	PF00400	0.398
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	9	13	PF00026	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCE2	Leptomonas seymouri	76%	74%
A0A0S4IX75	Bodo saltans	45%	80%
A0A1X0NQT5	Trypanosomatidae	54%	83%
A0A3R7N764	Trypanosoma rangeli	54%	88%
A4HGS2	Leishmania braziliensis	90%	100%
A4I3U7	Leishmania infantum	100%	100%
D0A916	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	87%
E9B039	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q847	Leishmania major	96%	100%
V5B8A1	Trypanosoma cruzi	52%	88%