Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X1S1_LEIDO

TriTrypDb:

LdBPK_282470.1 , LdCL_280029700 , LDHU3_28.3330

Length:

645

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X1S1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1S1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.511
CLV_C14_Caspase3-7	364	368	PF00656	0.556
CLV_MEL_PAP_1	144	150	PF00089	0.429
CLV_NRD_NRD_1	109	111	PF00675	0.427
CLV_NRD_NRD_1	153	155	PF00675	0.416
CLV_NRD_NRD_1	191	193	PF00675	0.501
CLV_NRD_NRD_1	205	207	PF00675	0.646
CLV_NRD_NRD_1	307	309	PF00675	0.597
CLV_NRD_NRD_1	311	313	PF00675	0.602
CLV_NRD_NRD_1	379	381	PF00675	0.670
CLV_NRD_NRD_1	478	480	PF00675	0.691
CLV_NRD_NRD_1	589	591	PF00675	0.438
CLV_NRD_NRD_1	82	84	PF00675	0.406
CLV_PCSK_FUR_1	377	381	PF00082	0.610
CLV_PCSK_FUR_1	79	83	PF00082	0.419
CLV_PCSK_KEX2_1	109	111	PF00082	0.427
CLV_PCSK_KEX2_1	152	154	PF00082	0.415
CLV_PCSK_KEX2_1	191	193	PF00082	0.501
CLV_PCSK_KEX2_1	205	207	PF00082	0.627
CLV_PCSK_KEX2_1	306	308	PF00082	0.596
CLV_PCSK_KEX2_1	311	313	PF00082	0.600
CLV_PCSK_KEX2_1	379	381	PF00082	0.646
CLV_PCSK_KEX2_1	477	479	PF00082	0.701
CLV_PCSK_KEX2_1	589	591	PF00082	0.438
CLV_PCSK_KEX2_1	81	83	PF00082	0.427
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.543
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.402
CLV_PCSK_PC7_1	307	313	PF00082	0.573
CLV_PCSK_PC7_1	474	480	PF00082	0.639
CLV_PCSK_SKI1_1	110	114	PF00082	0.425
CLV_PCSK_SKI1_1	619	623	PF00082	0.632
DEG_APCC_DBOX_1	108	116	PF00400	0.424
DEG_APCC_DBOX_1	618	626	PF00400	0.615
DEG_Nend_Nbox_1	1	3	PF02207	0.565
DEG_SPOP_SBC_1	38	42	PF00917	0.562
DEG_SPOP_SBC_1	395	399	PF00917	0.550
DEG_SPOP_SBC_1	455	459	PF00917	0.553
DEG_SPOP_SBC_1	65	69	PF00917	0.466
DOC_ANK_TNKS_1	537	544	PF00023	0.594
DOC_CKS1_1	389	394	PF01111	0.569
DOC_PP2B_LxvP_1	534	537	PF13499	0.639
DOC_USP7_MATH_1	146	150	PF00917	0.458
DOC_USP7_MATH_1	21	25	PF00917	0.606
DOC_USP7_MATH_1	264	268	PF00917	0.622
DOC_USP7_MATH_1	288	292	PF00917	0.623
DOC_USP7_MATH_1	38	42	PF00917	0.512
DOC_USP7_MATH_1	395	399	PF00917	0.629
DOC_USP7_MATH_1	456	460	PF00917	0.677
DOC_USP7_MATH_1	514	518	PF00917	0.822
DOC_USP7_MATH_1	52	56	PF00917	0.523
DOC_WW_Pin1_4	13	18	PF00397	0.546
DOC_WW_Pin1_4	260	265	PF00397	0.569
DOC_WW_Pin1_4	278	283	PF00397	0.642
DOC_WW_Pin1_4	301	306	PF00397	0.615
DOC_WW_Pin1_4	321	326	PF00397	0.436
DOC_WW_Pin1_4	327	332	PF00397	0.511
DOC_WW_Pin1_4	371	376	PF00397	0.710
DOC_WW_Pin1_4	388	393	PF00397	0.593
DOC_WW_Pin1_4	401	406	PF00397	0.746
DOC_WW_Pin1_4	417	422	PF00397	0.564
DOC_WW_Pin1_4	425	430	PF00397	0.647
DOC_WW_Pin1_4	431	436	PF00397	0.581
DOC_WW_Pin1_4	465	470	PF00397	0.694
DOC_WW_Pin1_4	479	484	PF00397	0.561
DOC_WW_Pin1_4	489	494	PF00397	0.568
DOC_WW_Pin1_4	53	58	PF00397	0.660
LIG_14-3-3_CanoR_1	205	209	PF00244	0.655
LIG_14-3-3_CanoR_1	221	226	PF00244	0.386
LIG_14-3-3_CanoR_1	275	279	PF00244	0.667
LIG_14-3-3_CanoR_1	289	293	PF00244	0.478
LIG_14-3-3_CanoR_1	327	331	PF00244	0.538
LIG_14-3-3_CanoR_1	380	390	PF00244	0.648
LIG_14-3-3_CanoR_1	554	563	PF00244	0.534
LIG_Actin_WH2_2	176	193	PF00022	0.454
LIG_Actin_WH2_2	215	232	PF00022	0.598
LIG_BRCT_BRCA1_1	487	491	PF00533	0.683
LIG_CtBP_PxDLS_1	74	78	PF00389	0.530
LIG_DLG_GKlike_1	221	229	PF00625	0.510
LIG_EH1_1	333	341	PF00400	0.578
LIG_FHA_1	111	117	PF00498	0.426
LIG_FHA_1	256	262	PF00498	0.640
LIG_FHA_1	331	337	PF00498	0.520
LIG_FHA_1	65	71	PF00498	0.538
LIG_FHA_1	82	88	PF00498	0.509
LIG_FHA_2	493	499	PF00498	0.621
LIG_FHA_2	66	72	PF00498	0.521
LIG_LIR_Gen_1	185	195	PF02991	0.502
LIG_LIR_Gen_1	291	299	PF02991	0.546
LIG_LIR_Gen_1	59	65	PF02991	0.459
LIG_LIR_Gen_1	633	643	PF02991	0.466
LIG_LIR_Nem_3	185	190	PF02991	0.497
LIG_LIR_Nem_3	410	414	PF02991	0.608
LIG_LIR_Nem_3	59	64	PF02991	0.461
LIG_LIR_Nem_3	633	639	PF02991	0.397
LIG_RPA_C_Fungi	121	133	PF08784	0.463
LIG_SH2_CRK	355	359	PF00017	0.647
LIG_SH2_CRK	61	65	PF00017	0.557
LIG_SH2_CRK	94	98	PF00017	0.420
LIG_SH2_STAP1	61	65	PF00017	0.458
LIG_SH2_STAP1	636	640	PF00017	0.464
LIG_SH2_STAT5	292	295	PF00017	0.544
LIG_SH2_STAT5	348	351	PF00017	0.573
LIG_SH2_STAT5	631	634	PF00017	0.404
LIG_SH3_1	387	393	PF00018	0.628
LIG_SH3_2	533	538	PF14604	0.622
LIG_SH3_3	11	17	PF00018	0.560
LIG_SH3_3	258	264	PF00018	0.592
LIG_SH3_3	313	319	PF00018	0.577
LIG_SH3_3	386	392	PF00018	0.688
LIG_SH3_3	480	486	PF00018	0.647
LIG_SH3_3	507	513	PF00018	0.705
LIG_SH3_3	529	535	PF00018	0.672
LIG_SH3_CIN85_PxpxPR_1	533	538	PF14604	0.600
LIG_SUMO_SIM_anti_2	637	645	PF11976	0.436
LIG_SUMO_SIM_par_1	71	78	PF11976	0.542
LIG_TRAF2_1	104	107	PF00917	0.394
LIG_TRAF2_1	200	203	PF00917	0.509
LIG_TYR_ITIM	353	358	PF00017	0.646
LIG_TYR_ITIM	92	97	PF00017	0.469
LIG_UBA3_1	591	598	PF00899	0.418
LIG_WW_3	404	408	PF00397	0.578
LIG_WW_3	535	539	PF00397	0.597
MOD_CDC14_SPxK_1	304	307	PF00782	0.590
MOD_CDC14_SPxK_1	324	327	PF00782	0.431
MOD_CDC14_SPxK_1	374	377	PF00782	0.639
MOD_CDC14_SPxK_1	482	485	PF00782	0.612
MOD_CDK_SPK_2	260	265	PF00069	0.556
MOD_CDK_SPK_2	301	306	PF00069	0.530
MOD_CDK_SPK_2	489	494	PF00069	0.658
MOD_CDK_SPxK_1	301	307	PF00069	0.616
MOD_CDK_SPxK_1	321	327	PF00069	0.434
MOD_CDK_SPxK_1	371	377	PF00069	0.640
MOD_CDK_SPxK_1	401	407	PF00069	0.605
MOD_CDK_SPxK_1	479	485	PF00069	0.616
MOD_CDK_SPxxK_3	301	308	PF00069	0.569
MOD_CDK_SPxxK_3	465	472	PF00069	0.657
MOD_CDK_SPxxK_3	489	496	PF00069	0.597
MOD_CK1_1	16	22	PF00069	0.709
MOD_CK1_1	23	29	PF00069	0.594
MOD_CK1_1	273	279	PF00069	0.709
MOD_CK1_1	32	38	PF00069	0.523
MOD_CK1_1	330	336	PF00069	0.538
MOD_CK1_1	399	405	PF00069	0.560
MOD_CK1_1	40	46	PF00069	0.536
MOD_CK1_1	424	430	PF00069	0.639
MOD_CK1_1	443	449	PF00069	0.705
MOD_CK1_1	465	471	PF00069	0.655
MOD_CK1_1	47	53	PF00069	0.617
MOD_CK1_1	492	498	PF00069	0.598
MOD_CK1_1	517	523	PF00069	0.681
MOD_CK1_1	56	62	PF00069	0.476
MOD_CK2_1	197	203	PF00069	0.514
MOD_CK2_1	260	266	PF00069	0.677
MOD_CK2_1	492	498	PF00069	0.618
MOD_CK2_1	65	71	PF00069	0.520
MOD_DYRK1A_RPxSP_1	327	331	PF00069	0.538
MOD_GlcNHglycan	25	28	PF01048	0.709
MOD_GlcNHglycan	31	34	PF01048	0.607
MOD_GlcNHglycan	316	319	PF01048	0.588
MOD_GlcNHglycan	401	404	PF01048	0.598
MOD_GlcNHglycan	429	432	PF01048	0.640
MOD_GlcNHglycan	44	47	PF01048	0.495
MOD_GlcNHglycan	450	453	PF01048	0.622
MOD_GlcNHglycan	458	461	PF01048	0.562
MOD_GlcNHglycan	469	472	PF01048	0.523
MOD_GlcNHglycan	506	509	PF01048	0.646
MOD_GlcNHglycan	58	61	PF01048	0.503
MOD_GSK3_1	12	19	PF00069	0.611
MOD_GSK3_1	217	224	PF00069	0.593
MOD_GSK3_1	251	258	PF00069	0.710
MOD_GSK3_1	260	267	PF00069	0.684
MOD_GSK3_1	270	277	PF00069	0.617
MOD_GSK3_1	278	285	PF00069	0.509
MOD_GSK3_1	326	333	PF00069	0.548
MOD_GSK3_1	37	44	PF00069	0.605
MOD_GSK3_1	395	402	PF00069	0.638
MOD_GSK3_1	417	424	PF00069	0.661
MOD_GSK3_1	425	432	PF00069	0.688
MOD_GSK3_1	434	441	PF00069	0.704
MOD_GSK3_1	442	449	PF00069	0.622
MOD_GSK3_1	463	470	PF00069	0.666
MOD_GSK3_1	48	55	PF00069	0.733
MOD_GSK3_1	485	492	PF00069	0.626
MOD_GSK3_1	514	521	PF00069	0.678
MOD_GSK3_1	578	585	PF00069	0.495
MOD_LATS_1	108	114	PF00433	0.426
MOD_N-GLC_1	549	554	PF02516	0.483
MOD_NEK2_1	134	139	PF00069	0.422
MOD_NEK2_1	176	181	PF00069	0.588
MOD_NEK2_1	20	25	PF00069	0.639
MOD_NEK2_1	423	428	PF00069	0.638
MOD_NEK2_1	549	554	PF00069	0.597
MOD_NEK2_1	64	69	PF00069	0.513
MOD_NEK2_1	75	80	PF00069	0.509
MOD_PIKK_1	110	116	PF00454	0.423
MOD_PIKK_1	501	507	PF00454	0.625
MOD_PIKK_1	582	588	PF00454	0.442
MOD_PKA_1	81	87	PF00069	0.385
MOD_PKA_2	146	152	PF00069	0.504
MOD_PKA_2	166	172	PF00069	0.526
MOD_PKA_2	204	210	PF00069	0.513
MOD_PKA_2	274	280	PF00069	0.684
MOD_PKA_2	288	294	PF00069	0.502
MOD_PKA_2	326	332	PF00069	0.540
MOD_PKA_2	81	87	PF00069	0.432
MOD_PKB_1	219	227	PF00069	0.504
MOD_PKB_1	499	507	PF00069	0.581
MOD_Plk_1	110	116	PF00069	0.423
MOD_Plk_1	176	182	PF00069	0.523
MOD_Plk_1	65	71	PF00069	0.465
MOD_Plk_2-3	66	72	PF00069	0.624
MOD_Plk_4	32	38	PF00069	0.578
MOD_ProDKin_1	13	19	PF00069	0.549
MOD_ProDKin_1	260	266	PF00069	0.566
MOD_ProDKin_1	278	284	PF00069	0.639
MOD_ProDKin_1	301	307	PF00069	0.616
MOD_ProDKin_1	321	327	PF00069	0.434
MOD_ProDKin_1	371	377	PF00069	0.712
MOD_ProDKin_1	388	394	PF00069	0.595
MOD_ProDKin_1	401	407	PF00069	0.748
MOD_ProDKin_1	417	423	PF00069	0.567
MOD_ProDKin_1	425	431	PF00069	0.647
MOD_ProDKin_1	465	471	PF00069	0.693
MOD_ProDKin_1	479	485	PF00069	0.560
MOD_ProDKin_1	489	495	PF00069	0.569
MOD_ProDKin_1	53	59	PF00069	0.657
MOD_SUMO_for_1	625	628	PF00179	0.341
MOD_SUMO_rev_2	594	600	PF00179	0.472
MOD_SUMO_rev_2	620	627	PF00179	0.357
TRG_DiLeu_BaEn_1	111	116	PF01217	0.424
TRG_DiLeu_BaEn_4	185	191	PF01217	0.500
TRG_ENDOCYTIC_2	292	295	PF00928	0.544
TRG_ENDOCYTIC_2	355	358	PF00928	0.646
TRG_ENDOCYTIC_2	411	414	PF00928	0.614
TRG_ENDOCYTIC_2	61	64	PF00928	0.462
TRG_ENDOCYTIC_2	636	639	PF00928	0.400
TRG_ENDOCYTIC_2	94	97	PF00928	0.422
TRG_ER_diArg_1	152	154	PF00400	0.456
TRG_ER_diArg_1	190	192	PF00400	0.513
TRG_ER_diArg_1	218	221	PF00400	0.466
TRG_ER_diArg_1	307	309	PF00400	0.571
TRG_ER_diArg_1	310	312	PF00400	0.577
TRG_ER_diArg_1	349	352	PF00400	0.577
TRG_ER_diArg_1	376	379	PF00400	0.683
TRG_ER_diArg_1	477	479	PF00400	0.697
TRG_ER_diArg_1	484	487	PF00400	0.608
TRG_ER_diArg_1	493	496	PF00400	0.558
TRG_ER_diArg_1	588	590	PF00400	0.441
TRG_ER_diArg_1	616	619	PF00400	0.622
TRG_ER_diArg_1	82	85	PF00400	0.375
TRG_NLS_MonoExtC_3	305	310	PF00514	0.542
TRG_NLS_MonoExtC_3	80	85	PF00514	0.380
TRG_NLS_MonoExtN_4	303	310	PF00514	0.538
TRG_NLS_MonoExtN_4	79	85	PF00514	0.390
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	181	185	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	554	559	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	572	576	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	589	594	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAD1	Leptomonas seymouri	45%	100%
A4HGT4	Leishmania braziliensis	73%	100%
A4I3W1	Leishmania infantum	99%	100%
E9B051	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q834	Leishmania major	89%	100%