Glycerophosphoryl diester phosphodiesterase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycerophosphoryl diester phosphodiesterase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X1Q6_LEIDO

TriTrypDb:

LdBPK_282250.1 , LdCL_280027600 , LDHU3_28.3040

Length:

349

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3S7X1Q6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1Q6

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0008152	metabolic process	1	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:0006644	phospholipid metabolic process	4	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0009056	catabolic process	2	1
GO:0009395	phospholipid catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0016042	lipid catabolic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044242	cellular lipid catabolic process	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046475	glycerophospholipid catabolic process	6	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0046503	glycerolipid catabolic process	5	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008081	phosphoric diester hydrolase activity	5	11
GO:0008889	glycerophosphodiester phosphodiesterase activity	6	5
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0042578	phosphoric ester hydrolase activity	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.470
CLV_C14_Caspase3-7	81	85	PF00656	0.487
CLV_NRD_NRD_1	221	223	PF00675	0.320
CLV_NRD_NRD_1	30	32	PF00675	0.384
CLV_PCSK_KEX2_1	125	127	PF00082	0.300
CLV_PCSK_KEX2_1	223	225	PF00082	0.301
CLV_PCSK_KEX2_1	30	32	PF00082	0.381
CLV_PCSK_KEX2_1	339	341	PF00082	0.581
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.321
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.317
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.367
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.581
CLV_PCSK_SKI1_1	135	139	PF00082	0.214
CLV_PCSK_SKI1_1	232	236	PF00082	0.300
CLV_PCSK_SKI1_1	32	36	PF00082	0.362
DEG_Nend_UBRbox_1	1	4	PF02207	0.355
DEG_SPOP_SBC_1	260	264	PF00917	0.357
DOC_MAPK_FxFP_2	39	42	PF00069	0.560
DOC_MAPK_gen_1	125	132	PF00069	0.466
DOC_MAPK_gen_1	162	169	PF00069	0.448
DOC_MAPK_gen_1	339	348	PF00069	0.328
DOC_MAPK_gen_1	80	89	PF00069	0.516
DOC_MAPK_MEF2A_6	125	132	PF00069	0.521
DOC_MAPK_MEF2A_6	162	171	PF00069	0.514
DOC_MAPK_MEF2A_6	178	187	PF00069	0.383
DOC_MAPK_MEF2A_6	339	348	PF00069	0.382
DOC_MAPK_NFAT4_5	125	133	PF00069	0.521
DOC_MAPK_RevD_3	15	30	PF00069	0.423
DOC_PP4_FxxP_1	228	231	PF00568	0.490
DOC_PP4_FxxP_1	256	259	PF00568	0.269
DOC_PP4_FxxP_1	285	288	PF00568	0.376
DOC_PP4_FxxP_1	39	42	PF00568	0.560
DOC_USP7_MATH_1	142	146	PF00917	0.451
DOC_USP7_MATH_1	25	29	PF00917	0.562
DOC_USP7_UBL2_3	115	119	PF12436	0.516
DOC_USP7_UBL2_3	174	178	PF12436	0.519
DOC_USP7_UBL2_3	32	36	PF12436	0.587
DOC_WW_Pin1_4	284	289	PF00397	0.311
LIG_14-3-3_CanoR_1	31	35	PF00244	0.512
LIG_APCC_ABBA_1	167	172	PF00400	0.446
LIG_BRCT_BRCA1_1	17	21	PF00533	0.309
LIG_BRCT_BRCA1_1	176	180	PF00533	0.496
LIG_BRCT_BRCA1_1	194	198	PF00533	0.413
LIG_CaM_IQ_9	19	34	PF13499	0.499
LIG_FHA_1	125	131	PF00498	0.470
LIG_FHA_1	132	138	PF00498	0.453
LIG_FHA_1	149	155	PF00498	0.468
LIG_FHA_1	235	241	PF00498	0.419
LIG_FHA_2	105	111	PF00498	0.476
LIG_LIR_Apic_2	254	259	PF02991	0.264
LIG_LIR_Gen_1	177	188	PF02991	0.441
LIG_LIR_Gen_1	18	26	PF02991	0.253
LIG_LIR_Gen_1	237	246	PF02991	0.318
LIG_LIR_Gen_1	250	261	PF02991	0.253
LIG_LIR_Gen_1	59	69	PF02991	0.493
LIG_LIR_LC3C_4	109	113	PF02991	0.479
LIG_LIR_Nem_3	177	183	PF02991	0.597
LIG_LIR_Nem_3	233	238	PF02991	0.304
LIG_LIR_Nem_3	250	256	PF02991	0.203
LIG_LIR_Nem_3	272	276	PF02991	0.345
LIG_PCNA_yPIPBox_3	317	330	PF02747	0.339
LIG_PTB_Apo_2	208	215	PF02174	0.558
LIG_SH2_CRK	103	107	PF00017	0.512
LIG_SH2_CRK	242	246	PF00017	0.370
LIG_SH2_CRK	273	277	PF00017	0.343
LIG_SH2_PTP2	14	17	PF00017	0.309
LIG_SH2_STAT5	14	17	PF00017	0.271
LIG_SH2_STAT5	213	216	PF00017	0.525
LIG_SH2_STAT5	238	241	PF00017	0.290
LIG_SH2_STAT5	242	245	PF00017	0.282
LIG_SH2_STAT5	248	251	PF00017	0.387
LIG_SH2_STAT5	293	296	PF00017	0.313
LIG_SH2_STAT5	61	64	PF00017	0.480
LIG_SH3_1	162	168	PF00018	0.470
LIG_SH3_3	162	168	PF00018	0.432
LIG_SUMO_SIM_anti_2	179	185	PF11976	0.450
LIG_SUMO_SIM_anti_2	308	314	PF11976	0.386
LIG_SUMO_SIM_par_1	126	131	PF11976	0.516
LIG_SUMO_SIM_par_1	5	10	PF11976	0.380
LIG_SUMO_SIM_par_1	73	78	PF11976	0.446
LIG_TYR_ITIM	240	245	PF00017	0.346
LIG_TYR_ITIM	246	251	PF00017	0.435
LIG_WRC_WIRS_1	60	65	PF05994	0.480
MOD_CK2_1	104	110	PF00069	0.488
MOD_GlcNHglycan	9	12	PF01048	0.302
MOD_GSK3_1	194	201	PF00069	0.498
MOD_GSK3_1	37	44	PF00069	0.617
MOD_GSK3_1	91	98	PF00069	0.497
MOD_NEK2_1	198	203	PF00069	0.484
MOD_NEK2_1	234	239	PF00069	0.423
MOD_NEK2_1	240	245	PF00069	0.392
MOD_NEK2_1	261	266	PF00069	0.384
MOD_NEK2_1	283	288	PF00069	0.359
MOD_NEK2_1	95	100	PF00069	0.476
MOD_NEK2_2	56	61	PF00069	0.424
MOD_PK_1	2	8	PF00069	0.180
MOD_PKA_1	30	36	PF00069	0.591
MOD_PKA_1	37	43	PF00069	0.575
MOD_PKA_2	192	198	PF00069	0.498
MOD_PKA_2	30	36	PF00069	0.545
MOD_PKA_2	79	85	PF00069	0.492
MOD_Plk_1	149	155	PF00069	0.474
MOD_Plk_1	56	62	PF00069	0.424
MOD_Plk_1	91	97	PF00069	0.463
MOD_Plk_4	2	8	PF00069	0.313
MOD_Plk_4	234	240	PF00069	0.412
MOD_Plk_4	30	36	PF00069	0.605
MOD_Plk_4	49	55	PF00069	0.403
MOD_Plk_4	56	62	PF00069	0.413
MOD_ProDKin_1	284	290	PF00069	0.306
MOD_SUMO_for_1	173	176	PF00179	0.472
MOD_SUMO_rev_2	172	180	PF00179	0.525
TRG_DiLeu_BaEn_2	175	181	PF01217	0.550
TRG_DiLeu_BaEn_2	193	199	PF01217	0.378
TRG_DiLeu_BaLyEn_6	285	290	PF01217	0.355
TRG_ENDOCYTIC_2	103	106	PF00928	0.517
TRG_ENDOCYTIC_2	14	17	PF00928	0.373
TRG_ENDOCYTIC_2	225	228	PF00928	0.483
TRG_ENDOCYTIC_2	238	241	PF00928	0.222
TRG_ENDOCYTIC_2	242	245	PF00928	0.209
TRG_ENDOCYTIC_2	248	251	PF00928	0.403
TRG_ENDOCYTIC_2	253	256	PF00928	0.300
TRG_ENDOCYTIC_2	273	276	PF00928	0.344
TRG_ENDOCYTIC_2	61	64	PF00928	0.516
TRG_ER_diArg_1	221	224	PF00400	0.518
TRG_NLS_MonoCore_2	28	33	PF00514	0.562
TRG_NLS_MonoExtC_3	221	226	PF00514	0.538
TRG_NLS_MonoExtN_4	219	226	PF00514	0.569
TRG_NLS_MonoExtN_4	27	34	PF00514	0.652
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.259
TRG_Pf-PMV_PEXEL_1	332	336	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8E4	Leptomonas seymouri	56%	99%
A0A0S4IJ80	Bodo saltans	35%	85%
A0A1X0NRF0	Trypanosomatidae	46%	98%
A0A3R7NHN9	Trypanosoma rangeli	44%	99%
A4HGR4	Leishmania braziliensis	79%	100%
A4I3T9	Leishmania infantum	99%	100%
D0A869	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B031	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q0VGK4	Rattus norvegicus	29%	100%
Q4Q855	Leishmania major	91%	100%
Q7L5L3	Homo sapiens	27%	100%
Q8N9F7	Homo sapiens	30%	100%
Q99LY2	Mus musculus	27%	100%
Q9CRY7	Mus musculus	28%	100%