Cyclin dependent kinase-binding protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclin dependent kinase-binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X1Q4_LEIDO

TriTrypDb:

LdBPK_282390.1 , LdCL_280029000 , LDHU3_28.3230

Length:

924

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X1Q4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1Q4

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0044237	cellular metabolic process	2	6
GO:0050789	regulation of biological process	2	6
GO:0050794	regulation of cellular process	3	6
GO:0051726	regulation of cell cycle	4	6
GO:0065007	biological regulation	1	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.674
CLV_C14_Caspase3-7	532	536	PF00656	0.573
CLV_C14_Caspase3-7	571	575	PF00656	0.727
CLV_C14_Caspase3-7	590	594	PF00656	0.715
CLV_C14_Caspase3-7	65	69	PF00656	0.772
CLV_C14_Caspase3-7	95	99	PF00656	0.722
CLV_NRD_NRD_1	190	192	PF00675	0.781
CLV_NRD_NRD_1	203	205	PF00675	0.557
CLV_NRD_NRD_1	223	225	PF00675	0.516
CLV_NRD_NRD_1	352	354	PF00675	0.682
CLV_NRD_NRD_1	447	449	PF00675	0.700
CLV_NRD_NRD_1	557	559	PF00675	0.691
CLV_NRD_NRD_1	599	601	PF00675	0.728
CLV_NRD_NRD_1	645	647	PF00675	0.742
CLV_NRD_NRD_1	665	667	PF00675	0.535
CLV_NRD_NRD_1	697	699	PF00675	0.568
CLV_NRD_NRD_1	744	746	PF00675	0.461
CLV_NRD_NRD_1	787	789	PF00675	0.460
CLV_NRD_NRD_1	820	822	PF00675	0.518
CLV_PCSK_FUR_1	201	205	PF00082	0.650
CLV_PCSK_FUR_1	221	225	PF00082	0.518
CLV_PCSK_FUR_1	374	378	PF00082	0.847
CLV_PCSK_FUR_1	445	449	PF00082	0.688
CLV_PCSK_FUR_1	642	646	PF00082	0.847
CLV_PCSK_FUR_1	818	822	PF00082	0.496
CLV_PCSK_KEX2_1	189	191	PF00082	0.793
CLV_PCSK_KEX2_1	203	205	PF00082	0.544
CLV_PCSK_KEX2_1	220	222	PF00082	0.747
CLV_PCSK_KEX2_1	223	225	PF00082	0.516
CLV_PCSK_KEX2_1	334	336	PF00082	0.689
CLV_PCSK_KEX2_1	352	354	PF00082	0.526
CLV_PCSK_KEX2_1	376	378	PF00082	0.763
CLV_PCSK_KEX2_1	445	447	PF00082	0.709
CLV_PCSK_KEX2_1	453	455	PF00082	0.648
CLV_PCSK_KEX2_1	511	513	PF00082	0.721
CLV_PCSK_KEX2_1	557	559	PF00082	0.634
CLV_PCSK_KEX2_1	599	601	PF00082	0.728
CLV_PCSK_KEX2_1	644	646	PF00082	0.752
CLV_PCSK_KEX2_1	696	698	PF00082	0.568
CLV_PCSK_KEX2_1	820	822	PF00082	0.518
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.747
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.772
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.847
CLV_PCSK_PC1ET2_1	453	455	PF00082	0.644
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.721
CLV_PCSK_SKI1_1	104	108	PF00082	0.715
CLV_PCSK_SKI1_1	52	56	PF00082	0.700
CLV_PCSK_SKI1_1	666	670	PF00082	0.633
CLV_PCSK_SKI1_1	716	720	PF00082	0.514
CLV_PCSK_SKI1_1	737	741	PF00082	0.500
CLV_PCSK_SKI1_1	745	749	PF00082	0.457
CLV_PCSK_SKI1_1	83	87	PF00082	0.733
DEG_APCC_DBOX_1	338	346	PF00400	0.673
DEG_APCC_DBOX_1	82	90	PF00400	0.726
DEG_Nend_Nbox_1	1	3	PF02207	0.687
DEG_SCF_TRCP1_1	574	579	PF00400	0.728
DEG_SPOP_SBC_1	110	114	PF00917	0.708
DEG_SPOP_SBC_1	141	145	PF00917	0.600
DEG_SPOP_SBC_1	567	571	PF00917	0.735
DOC_ANK_TNKS_1	400	407	PF00023	0.583
DOC_CKS1_1	180	185	PF01111	0.751
DOC_CYCLIN_RxL_1	424	436	PF00134	0.719
DOC_CYCLIN_RxL_1	885	898	PF00134	0.479
DOC_MAPK_gen_1	334	342	PF00069	0.764
DOC_MAPK_gen_1	696	703	PF00069	0.512
DOC_MAPK_gen_1	745	753	PF00069	0.456
DOC_PP1_RVXF_1	339	345	PF00149	0.673
DOC_PP4_FxxP_1	116	119	PF00568	0.575
DOC_PP4_FxxP_1	907	910	PF00568	0.515
DOC_USP7_MATH_1	111	115	PF00917	0.706
DOC_USP7_MATH_1	131	135	PF00917	0.573
DOC_USP7_MATH_1	157	161	PF00917	0.603
DOC_USP7_MATH_1	22	26	PF00917	0.657
DOC_USP7_MATH_1	273	277	PF00917	0.838
DOC_USP7_MATH_1	50	54	PF00917	0.720
DOC_USP7_MATH_1	500	504	PF00917	0.729
DOC_USP7_UBL2_3	376	380	PF12436	0.842
DOC_USP7_UBL2_3	716	720	PF12436	0.514
DOC_USP7_UBL2_3	785	789	PF12436	0.477
DOC_WW_Pin1_4	179	184	PF00397	0.718
DOC_WW_Pin1_4	246	251	PF00397	0.748
DOC_WW_Pin1_4	375	380	PF00397	0.773
DOC_WW_Pin1_4	412	417	PF00397	0.702
DOC_WW_Pin1_4	463	468	PF00397	0.626
DOC_WW_Pin1_4	906	911	PF00397	0.633
LIG_14-3-3_CanoR_1	109	119	PF00244	0.713
LIG_14-3-3_CanoR_1	29	37	PF00244	0.791
LIG_14-3-3_CanoR_1	428	433	PF00244	0.678
LIG_14-3-3_CanoR_1	480	485	PF00244	0.779
LIG_14-3-3_CanoR_1	578	583	PF00244	0.708
LIG_14-3-3_CanoR_1	605	614	PF00244	0.744
LIG_14-3-3_CanoR_1	698	704	PF00244	0.552
LIG_14-3-3_CanoR_1	707	711	PF00244	0.492
LIG_Actin_WH2_2	732	747	PF00022	0.495
LIG_BIR_III_4	535	539	PF00653	0.607
LIG_BRCT_BRCA1_1	112	116	PF00533	0.569
LIG_BRCT_BRCA1_1	522	526	PF00533	0.559
LIG_BRCT_BRCA1_1	903	907	PF00533	0.535
LIG_FHA_1	105	111	PF00498	0.772
LIG_FHA_1	153	159	PF00498	0.630
LIG_FHA_1	29	35	PF00498	0.788
LIG_FHA_1	562	568	PF00498	0.707
LIG_FHA_1	577	583	PF00498	0.678
LIG_FHA_1	686	692	PF00498	0.648
LIG_FHA_1	803	809	PF00498	0.497
LIG_FHA_2	473	479	PF00498	0.738
LIG_FHA_2	588	594	PF00498	0.729
LIG_FHA_2	690	696	PF00498	0.560
LIG_FHA_2	77	83	PF00498	0.806
LIG_FHA_2	884	890	PF00498	0.441
LIG_FHA_2	896	902	PF00498	0.395
LIG_FHA_2	93	99	PF00498	0.541
LIG_LIR_Apic_2	113	119	PF02991	0.570
LIG_LIR_Apic_2	904	910	PF02991	0.530
LIG_LIR_Gen_1	537	545	PF02991	0.706
LIG_LIR_Gen_1	872	877	PF02991	0.429
LIG_LIR_LC3C_4	775	779	PF02991	0.439
LIG_LIR_Nem_3	537	543	PF02991	0.652
LIG_LIR_Nem_3	664	668	PF02991	0.576
LIG_LIR_Nem_3	862	868	PF02991	0.456
LIG_LIR_Nem_3	872	876	PF02991	0.432
LIG_Pex14_2	194	198	PF04695	0.704
LIG_Pex14_2	815	819	PF04695	0.469
LIG_PTB_Apo_2	543	550	PF02174	0.702
LIG_PTB_Apo_2	674	681	PF02174	0.573
LIG_PTB_Phospho_1	543	549	PF10480	0.701
LIG_PTB_Phospho_1	918	924	PF10480	0.577
LIG_SH2_CRK	665	669	PF00017	0.577
LIG_SH2_CRK	919	923	PF00017	0.578
LIG_SH2_GRB2like	912	915	PF00017	0.556
LIG_SH2_GRB2like	919	922	PF00017	0.584
LIG_SH2_PTP2	868	871	PF00017	0.453
LIG_SH2_SRC	912	915	PF00017	0.556
LIG_SH2_STAP1	769	773	PF00017	0.428
LIG_SH2_STAP1	903	907	PF00017	0.535
LIG_SH2_STAP1	919	923	PF00017	0.578
LIG_SH2_STAT3	202	205	PF00017	0.667
LIG_SH2_STAT5	549	552	PF00017	0.707
LIG_SH2_STAT5	684	687	PF00017	0.459
LIG_SH2_STAT5	728	731	PF00017	0.492
LIG_SH2_STAT5	773	776	PF00017	0.373
LIG_SH2_STAT5	814	817	PF00017	0.474
LIG_SH2_STAT5	868	871	PF00017	0.453
LIG_SH2_STAT5	912	915	PF00017	0.556
LIG_SH3_3	167	173	PF00018	0.681
LIG_SH3_3	487	493	PF00018	0.695
LIG_SH3_4	324	331	PF00018	0.793
LIG_SUMO_SIM_par_1	699	705	PF11976	0.554
LIG_SUMO_SIM_par_1	760	767	PF11976	0.447
LIG_SxIP_EBH_1	162	176	PF03271	0.683
LIG_TRAF2_1	898	901	PF00917	0.513
LIG_TRFH_1	873	877	PF08558	0.479
LIG_UBA3_1	797	801	PF00899	0.437
LIG_UBA3_1	808	816	PF00899	0.478
LIG_WRC_WIRS_1	710	715	PF05994	0.514
MOD_CDK_SPK_2	375	380	PF00069	0.842
MOD_CK1_1	129	135	PF00069	0.808
MOD_CK1_1	179	185	PF00069	0.750
MOD_CK1_1	211	217	PF00069	0.757
MOD_CK1_1	227	233	PF00069	0.705
MOD_CK1_1	234	240	PF00069	0.748
MOD_CK1_1	246	252	PF00069	0.671
MOD_CK1_1	254	260	PF00069	0.818
MOD_CK1_1	290	296	PF00069	0.796
MOD_CK1_1	318	324	PF00069	0.643
MOD_CK1_1	354	360	PF00069	0.752
MOD_CK1_1	361	367	PF00069	0.716
MOD_CK1_1	370	376	PF00069	0.696
MOD_CK1_1	420	426	PF00069	0.729
MOD_CK1_1	431	437	PF00069	0.800
MOD_CK1_1	440	446	PF00069	0.717
MOD_CK1_1	463	469	PF00069	0.616
MOD_CK1_1	498	504	PF00069	0.727
MOD_CK1_1	505	511	PF00069	0.728
MOD_CK1_1	513	519	PF00069	0.476
MOD_CK1_1	520	526	PF00069	0.684
MOD_CK1_1	569	575	PF00069	0.692
MOD_CK1_1	581	587	PF00069	0.630
MOD_CK1_1	59	65	PF00069	0.805
MOD_CK1_1	592	598	PF00069	0.667
MOD_CK1_1	603	609	PF00069	0.818
MOD_CK1_1	610	616	PF00069	0.656
MOD_CK1_1	617	623	PF00069	0.702
MOD_CK1_1	624	630	PF00069	0.762
MOD_CK1_1	631	637	PF00069	0.716
MOD_CK1_1	702	708	PF00069	0.533
MOD_CK1_1	709	715	PF00069	0.508
MOD_CK2_1	111	117	PF00069	0.714
MOD_CK2_1	236	242	PF00069	0.826
MOD_CK2_1	472	478	PF00069	0.726
MOD_CK2_1	689	695	PF00069	0.535
MOD_CK2_1	76	82	PF00069	0.807
MOD_CK2_1	883	889	PF00069	0.441
MOD_CK2_1	895	901	PF00069	0.393
MOD_Cter_Amidation	374	377	PF01082	0.852
MOD_GlcNHglycan	11	14	PF01048	0.664
MOD_GlcNHglycan	113	116	PF01048	0.738
MOD_GlcNHglycan	128	131	PF01048	0.636
MOD_GlcNHglycan	135	138	PF01048	0.691
MOD_GlcNHglycan	24	27	PF01048	0.530
MOD_GlcNHglycan	245	248	PF01048	0.812
MOD_GlcNHglycan	253	256	PF01048	0.710
MOD_GlcNHglycan	266	269	PF01048	0.618
MOD_GlcNHglycan	275	278	PF01048	0.832
MOD_GlcNHglycan	288	292	PF01048	0.665
MOD_GlcNHglycan	320	323	PF01048	0.713
MOD_GlcNHglycan	34	37	PF01048	0.678
MOD_GlcNHglycan	367	370	PF01048	0.792
MOD_GlcNHglycan	411	415	PF01048	0.685
MOD_GlcNHglycan	462	465	PF01048	0.607
MOD_GlcNHglycan	57	61	PF01048	0.799
MOD_GlcNHglycan	574	577	PF01048	0.725
MOD_GlcNHglycan	656	659	PF01048	0.807
MOD_GlcNHglycan	7	10	PF01048	0.717
MOD_GlcNHglycan	825	828	PF01048	0.592
MOD_GSK3_1	129	136	PF00069	0.798
MOD_GSK3_1	140	147	PF00069	0.650
MOD_GSK3_1	208	215	PF00069	0.674
MOD_GSK3_1	224	231	PF00069	0.743
MOD_GSK3_1	232	239	PF00069	0.742
MOD_GSK3_1	246	253	PF00069	0.788
MOD_GSK3_1	28	35	PF00069	0.786
MOD_GSK3_1	351	358	PF00069	0.740
MOD_GSK3_1	360	367	PF00069	0.713
MOD_GSK3_1	418	425	PF00069	0.720
MOD_GSK3_1	426	433	PF00069	0.739
MOD_GSK3_1	436	443	PF00069	0.785
MOD_GSK3_1	495	502	PF00069	0.716
MOD_GSK3_1	5	12	PF00069	0.582
MOD_GSK3_1	506	513	PF00069	0.732
MOD_GSK3_1	514	521	PF00069	0.722
MOD_GSK3_1	52	59	PF00069	0.803
MOD_GSK3_1	562	569	PF00069	0.702
MOD_GSK3_1	572	579	PF00069	0.706
MOD_GSK3_1	581	588	PF00069	0.741
MOD_GSK3_1	589	596	PF00069	0.610
MOD_GSK3_1	599	606	PF00069	0.791
MOD_GSK3_1	609	616	PF00069	0.603
MOD_GSK3_1	617	624	PF00069	0.618
MOD_GSK3_1	62	69	PF00069	0.597
MOD_GSK3_1	627	634	PF00069	0.628
MOD_GSK3_1	685	692	PF00069	0.649
MOD_GSK3_1	702	709	PF00069	0.351
MOD_LATS_1	222	228	PF00433	0.762
MOD_LATS_1	597	603	PF00433	0.721
MOD_LATS_1	623	629	PF00433	0.613
MOD_N-GLC_1	104	109	PF02516	0.717
MOD_N-GLC_1	141	146	PF02516	0.637
MOD_N-GLC_1	225	230	PF02516	0.735
MOD_N-GLC_1	251	256	PF02516	0.801
MOD_N-GLC_1	498	503	PF02516	0.723
MOD_N-GLC_1	603	608	PF02516	0.715
MOD_N-GLC_1	689	694	PF02516	0.554
MOD_N-GLC_1	823	828	PF02516	0.570
MOD_N-GLC_1	895	900	PF02516	0.497
MOD_NEK2_1	165	170	PF00069	0.764
MOD_NEK2_1	208	213	PF00069	0.722
MOD_NEK2_1	251	256	PF00069	0.680
MOD_NEK2_1	419	424	PF00069	0.718
MOD_NEK2_1	426	431	PF00069	0.753
MOD_NEK2_1	432	437	PF00069	0.732
MOD_NEK2_1	582	587	PF00069	0.725
MOD_NEK2_1	685	690	PF00069	0.645
MOD_NEK2_1	70	75	PF00069	0.829
MOD_NEK2_1	762	767	PF00069	0.450
MOD_NEK2_1	871	876	PF00069	0.475
MOD_NEK2_2	196	201	PF00069	0.765
MOD_NEK2_2	99	104	PF00069	0.716
MOD_PIKK_1	129	135	PF00454	0.820
MOD_PIKK_1	176	182	PF00454	0.832
MOD_PIKK_1	307	313	PF00454	0.710
MOD_PIKK_1	603	609	PF00454	0.839
MOD_PIKK_1	896	902	PF00454	0.602
MOD_PKA_1	352	358	PF00069	0.828
MOD_PKA_1	446	452	PF00069	0.637
MOD_PKA_1	510	516	PF00069	0.782
MOD_PKA_1	599	605	PF00069	0.725
MOD_PKA_2	28	34	PF00069	0.783
MOD_PKA_2	315	321	PF00069	0.839
MOD_PKA_2	351	357	PF00069	0.821
MOD_PKA_2	365	371	PF00069	0.602
MOD_PKA_2	400	406	PF00069	0.685
MOD_PKA_2	446	452	PF00069	0.687
MOD_PKA_2	479	485	PF00069	0.696
MOD_PKA_2	503	509	PF00069	0.727
MOD_PKA_2	511	517	PF00069	0.587
MOD_PKA_2	599	605	PF00069	0.749
MOD_PKA_2	617	623	PF00069	0.737
MOD_PKA_2	624	630	PF00069	0.761
MOD_PKA_2	631	637	PF00069	0.653
MOD_PKA_2	706	712	PF00069	0.503
MOD_PKB_1	446	454	PF00069	0.629
MOD_Plk_1	104	110	PF00069	0.716
MOD_Plk_1	196	202	PF00069	0.764
MOD_Plk_1	561	567	PF00069	0.812
MOD_Plk_1	757	763	PF00069	0.509
MOD_Plk_1	871	877	PF00069	0.474
MOD_Plk_2-3	757	763	PF00069	0.509
MOD_Plk_4	422	428	PF00069	0.731
MOD_Plk_4	469	475	PF00069	0.605
MOD_Plk_4	480	486	PF00069	0.683
MOD_Plk_4	522	528	PF00069	0.667
MOD_Plk_4	562	568	PF00069	0.731
MOD_Plk_4	578	584	PF00069	0.778
MOD_Plk_4	706	712	PF00069	0.453
MOD_Plk_4	757	763	PF00069	0.469
MOD_ProDKin_1	179	185	PF00069	0.719
MOD_ProDKin_1	246	252	PF00069	0.746
MOD_ProDKin_1	375	381	PF00069	0.774
MOD_ProDKin_1	412	418	PF00069	0.701
MOD_ProDKin_1	463	469	PF00069	0.622
MOD_ProDKin_1	906	912	PF00069	0.636
MOD_SUMO_for_1	333	336	PF00179	0.664
MOD_SUMO_for_1	747	750	PF00179	0.455
MOD_SUMO_rev_2	709	719	PF00179	0.512
MOD_SUMO_rev_2	733	742	PF00179	0.507
TRG_DiLeu_BaEn_1	757	762	PF01217	0.510
TRG_DiLeu_BaEn_1	804	809	PF01217	0.602
TRG_DiLeu_BaEn_2	538	544	PF01217	0.646
TRG_DiLeu_BaLyEn_6	887	892	PF01217	0.461
TRG_ENDOCYTIC_2	346	349	PF00928	0.804
TRG_ENDOCYTIC_2	540	543	PF00928	0.706
TRG_ENDOCYTIC_2	665	668	PF00928	0.575
TRG_ENDOCYTIC_2	771	774	PF00928	0.426
TRG_ENDOCYTIC_2	868	871	PF00928	0.396
TRG_ENDOCYTIC_2	919	922	PF00928	0.525
TRG_ER_diArg_1	189	191	PF00400	0.778
TRG_ER_diArg_1	202	204	PF00400	0.567
TRG_ER_diArg_1	221	224	PF00400	0.613
TRG_ER_diArg_1	314	317	PF00400	0.840
TRG_ER_diArg_1	339	342	PF00400	0.666
TRG_ER_diArg_1	445	448	PF00400	0.705
TRG_ER_diArg_1	642	645	PF00400	0.744
TRG_ER_diArg_1	696	698	PF00400	0.568
TRG_ER_diArg_1	819	821	PF00400	0.504
TRG_NLS_Bipartite_1	203	224	PF00514	0.794
TRG_NLS_MonoExtC_3	219	224	PF00514	0.847
TRG_NLS_MonoExtC_3	744	750	PF00514	0.458
TRG_NLS_MonoExtN_4	217	224	PF00514	0.843
TRG_NLS_MonoExtN_4	450	456	PF00514	0.570
TRG_Pf-PMV_PEXEL_1	531	535	PF00026	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2Z2	Leptomonas seymouri	61%	100%
A4HGS7	Leishmania braziliensis	79%	100%
E9B044	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q841	Leishmania major	91%	100%