Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X1Q3_LEIDO

TriTrypDb:

LdBPK_282010.1 , LdCL_280025100 , LDHU3_28.2630

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0016020	membrane	2	10
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	10

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Expansion

Sequence features

A0A3S7X1Q3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1Q3

Function

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Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006897	endocytosis	5	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016409	palmitoyltransferase activity	5	10
GO:0016417	S-acyltransferase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016746	acyltransferase activity	3	10
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	10
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	10
GO:0019707	protein-cysteine S-acyltransferase activity	3	10
GO:0140096	catalytic activity, acting on a protein	2	10

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.471
CLV_NRD_NRD_1	159	161	PF00675	0.280
CLV_NRD_NRD_1	279	281	PF00675	0.242
CLV_NRD_NRD_1	321	323	PF00675	0.245
CLV_NRD_NRD_1	424	426	PF00675	0.380
CLV_PCSK_KEX2_1	102	104	PF00082	0.483
CLV_PCSK_KEX2_1	161	163	PF00082	0.435
CLV_PCSK_KEX2_1	320	322	PF00082	0.258
CLV_PCSK_KEX2_1	405	407	PF00082	0.357
CLV_PCSK_KEX2_1	424	426	PF00082	0.378

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P832	Leptomonas seymouri	63%	99%
A0A1X0NSC8	Trypanosomatidae	39%	92%
A0A3S5ISD2	Trypanosoma rangeli	42%	100%
A4HGP2	Leishmania braziliensis	77%	100%
A4I3R5	Leishmania infantum	100%	100%
D0A893	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	97%
E9B008	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q877	Leishmania major	95%	100%

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