Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X1Q3_LEIDO

TriTrypDb:

LdBPK_282010.1 , LdCL_280025100 , LDHU3_28.2630

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7X1Q3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1Q3

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006897	endocytosis	5	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016409	palmitoyltransferase activity	5	10
GO:0016417	S-acyltransferase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016746	acyltransferase activity	3	10
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	10
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	10
GO:0019707	protein-cysteine S-acyltransferase activity	3	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.471
CLV_NRD_NRD_1	159	161	PF00675	0.280
CLV_NRD_NRD_1	279	281	PF00675	0.242
CLV_NRD_NRD_1	321	323	PF00675	0.245
CLV_NRD_NRD_1	424	426	PF00675	0.380
CLV_PCSK_KEX2_1	102	104	PF00082	0.483
CLV_PCSK_KEX2_1	161	163	PF00082	0.435
CLV_PCSK_KEX2_1	320	322	PF00082	0.258
CLV_PCSK_KEX2_1	405	407	PF00082	0.357
CLV_PCSK_KEX2_1	424	426	PF00082	0.378
CLV_PCSK_KEX2_1	437	439	PF00082	0.368
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.483
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.470
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.382
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.372
CLV_PCSK_PC7_1	157	163	PF00082	0.446
CLV_PCSK_SKI1_1	115	119	PF00082	0.397
CLV_PCSK_SKI1_1	411	415	PF00082	0.305
CLV_PCSK_SKI1_1	438	442	PF00082	0.364
CLV_PCSK_SKI1_1	7	11	PF00082	0.435
DEG_SPOP_SBC_1	174	178	PF00917	0.467
DOC_CYCLIN_yClb5_NLxxxL_5	415	421	PF00134	0.510
DOC_CYCLIN_yCln2_LP_2	132	138	PF00134	0.541
DOC_MAPK_gen_1	157	165	PF00069	0.592
DOC_MAPK_gen_1	437	443	PF00069	0.541
DOC_PP4_FxxP_1	190	193	PF00568	0.488
DOC_USP7_UBL2_3	148	152	PF12436	0.568
LIG_14-3-3_CanoR_1	226	232	PF00244	0.517
LIG_14-3-3_CanoR_1	280	288	PF00244	0.442
LIG_14-3-3_CanoR_1	425	431	PF00244	0.604
LIG_AP2alpha_1	431	435	PF02296	0.530
LIG_BIR_II_1	1	5	PF00653	0.670
LIG_BRCT_BRCA1_1	130	134	PF00533	0.567
LIG_BRCT_BRCA1_1	184	188	PF00533	0.387
LIG_EH1_1	364	372	PF00400	0.221
LIG_eIF4E_1	209	215	PF01652	0.336
LIG_FHA_1	11	17	PF00498	0.615
LIG_FHA_1	135	141	PF00498	0.556
LIG_FHA_1	339	345	PF00498	0.333
LIG_FHA_1	354	360	PF00498	0.245
LIG_FHA_1	65	71	PF00498	0.611
LIG_FHA_2	255	261	PF00498	0.578
LIG_FHA_2	348	354	PF00498	0.325
LIG_FHA_2	52	58	PF00498	0.682
LIG_GBD_Chelix_1	362	370	PF00786	0.297
LIG_IBAR_NPY_1	407	409	PF08397	0.547
LIG_LIR_Apic_2	177	183	PF02991	0.335
LIG_LIR_Apic_2	187	193	PF02991	0.337
LIG_LIR_Apic_2	231	237	PF02991	0.480
LIG_LIR_Gen_1	141	150	PF02991	0.535
LIG_LIR_Gen_1	185	194	PF02991	0.343
LIG_LIR_Gen_1	26	35	PF02991	0.567
LIG_LIR_Gen_1	267	278	PF02991	0.549
LIG_LIR_Gen_1	324	333	PF02991	0.529
LIG_LIR_Gen_1	350	360	PF02991	0.391
LIG_LIR_Gen_1	383	392	PF02991	0.471
LIG_LIR_Nem_3	13	17	PF02991	0.593
LIG_LIR_Nem_3	131	136	PF02991	0.527
LIG_LIR_Nem_3	141	145	PF02991	0.502
LIG_LIR_Nem_3	185	191	PF02991	0.308
LIG_LIR_Nem_3	26	30	PF02991	0.541
LIG_LIR_Nem_3	267	273	PF02991	0.560
LIG_LIR_Nem_3	324	329	PF02991	0.529
LIG_LIR_Nem_3	350	355	PF02991	0.391
LIG_LIR_Nem_3	383	388	PF02991	0.493
LIG_MLH1_MIPbox_1	130	134	PF16413	0.605
LIG_PCNA_PIPBox_1	342	351	PF02747	0.297
LIG_PDZ_Class_1	452	457	PF00595	0.662
LIG_Pex14_1	205	209	PF04695	0.322
LIG_Pex14_2	130	134	PF04695	0.567
LIG_Pex14_2	186	190	PF04695	0.243
LIG_Pex14_2	431	435	PF04695	0.530
LIG_PTB_Apo_2	413	420	PF02174	0.571
LIG_PTB_Phospho_1	413	419	PF10480	0.574
LIG_REV1ctd_RIR_1	411	419	PF16727	0.506
LIG_SH2_CRK	14	18	PF00017	0.517
LIG_SH2_CRK	150	154	PF00017	0.588
LIG_SH2_CRK	166	170	PF00017	0.517
LIG_SH2_CRK	180	184	PF00017	0.231
LIG_SH2_CRK	221	225	PF00017	0.319
LIG_SH2_CRK	419	423	PF00017	0.542
LIG_SH2_GRB2like	168	171	PF00017	0.584
LIG_SH2_NCK_1	150	154	PF00017	0.588
LIG_SH2_NCK_1	229	233	PF00017	0.470
LIG_SH2_PTP2	168	171	PF00017	0.590
LIG_SH2_PTP2	234	237	PF00017	0.566
LIG_SH2_SRC	168	171	PF00017	0.590
LIG_SH2_STAP1	221	225	PF00017	0.278
LIG_SH2_STAP1	75	79	PF00017	0.642
LIG_SH2_STAT5	142	145	PF00017	0.537
LIG_SH2_STAT5	168	171	PF00017	0.527
LIG_SH2_STAT5	221	224	PF00017	0.296
LIG_SH2_STAT5	234	237	PF00017	0.539
LIG_SH2_STAT5	298	301	PF00017	0.452
LIG_SH3_3	13	19	PF00018	0.530
LIG_SH3_3	34	40	PF00018	0.584
LIG_SH3_4	148	155	PF00018	0.528
LIG_Sin3_3	364	371	PF02671	0.221
LIG_TRAF2_1	252	255	PF00917	0.614
LIG_TYR_ITIM	12	17	PF00017	0.566
LIG_TYR_ITIM	219	224	PF00017	0.341
LIG_TYR_ITIM	417	422	PF00017	0.537
LIG_WRC_WIRS_1	326	331	PF05994	0.305
MOD_CK1_1	2	8	PF00069	0.678
MOD_CK1_1	331	337	PF00069	0.495
MOD_CK2_1	265	271	PF00069	0.544
MOD_CK2_1	347	353	PF00069	0.393
MOD_CK2_1	390	396	PF00069	0.513
MOD_CK2_1	93	99	PF00069	0.645
MOD_CMANNOS	349	352	PF00535	0.457
MOD_Cter_Amidation	145	148	PF01082	0.339
MOD_Cter_Amidation	318	321	PF01082	0.243
MOD_GlcNHglycan	118	121	PF01048	0.343
MOD_GlcNHglycan	180	183	PF01048	0.376
MOD_GlcNHglycan	75	78	PF01048	0.435
MOD_GlcNHglycan	85	88	PF01048	0.402
MOD_GSK3_1	174	181	PF00069	0.444
MOD_GSK3_1	324	331	PF00069	0.506
MOD_GSK3_1	371	378	PF00069	0.401
MOD_GSK3_1	380	387	PF00069	0.395
MOD_GSK3_1	51	58	PF00069	0.682
MOD_GSK3_1	79	86	PF00069	0.622
MOD_N-GLC_2	170	172	PF02516	0.349
MOD_NEK2_1	1	6	PF00069	0.706
MOD_NEK2_1	219	224	PF00069	0.379
MOD_NEK2_1	325	330	PF00069	0.448
MOD_NEK2_1	377	382	PF00069	0.311
MOD_NEK2_1	384	389	PF00069	0.483
MOD_NEK2_1	85	90	PF00069	0.643
MOD_PIKK_1	386	392	PF00454	0.457
MOD_PIKK_1	64	70	PF00454	0.607
MOD_PKA_2	265	271	PF00069	0.544
MOD_Plk_1	254	260	PF00069	0.628
MOD_Plk_2-3	254	260	PF00069	0.617
MOD_Plk_4	105	111	PF00069	0.737
MOD_Plk_4	219	225	PF00069	0.370
MOD_Plk_4	265	271	PF00069	0.628
MOD_Plk_4	325	331	PF00069	0.547
MOD_Plk_4	340	346	PF00069	0.305
MOD_Plk_4	371	377	PF00069	0.354
MOD_Plk_4	380	386	PF00069	0.378
MOD_Plk_4	426	432	PF00069	0.514
TRG_ENDOCYTIC_2	14	17	PF00928	0.523
TRG_ENDOCYTIC_2	142	145	PF00928	0.532
TRG_ENDOCYTIC_2	150	153	PF00928	0.529
TRG_ENDOCYTIC_2	166	169	PF00928	0.499
TRG_ENDOCYTIC_2	221	224	PF00928	0.307
TRG_ENDOCYTIC_2	418	421	PF00928	0.574
TRG_ER_diArg_1	159	162	PF00400	0.587
TRG_ER_diArg_1	320	322	PF00400	0.524
TRG_ER_diArg_1	424	426	PF00400	0.581
TRG_NES_CRM1_1	267	279	PF08389	0.600
TRG_NLS_Bipartite_1	147	164	PF00514	0.523
TRG_NLS_MonoExtC_3	159	164	PF00514	0.594
TRG_NLS_MonoExtN_4	157	164	PF00514	0.587
TRG_Pf-PMV_PEXEL_1	195	200	PF00026	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P832	Leptomonas seymouri	63%	99%
A0A1X0NSC8	Trypanosomatidae	39%	92%
A0A3S5ISD2	Trypanosoma rangeli	42%	100%
A4HGP2	Leishmania braziliensis	77%	100%
A4I3R5	Leishmania infantum	100%	100%
D0A893	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	97%
E9B008	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q877	Leishmania major	95%	100%