X-pro, dipeptidyl-peptidase,serine peptidase, Clan SC, family S15, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

X-pro, dipeptidyl-peptidase,serine peptidase, Clan SC, family S15, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X1Q1_LEIDO

TriTrypDb:

LdBPK_282080.1 , LdCL_280025800 , LDHU3_28.2750

Length:

686

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X1Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1Q1

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0008233	peptidase activity	3	9
GO:0008238	exopeptidase activity	4	9
GO:0008239	dipeptidyl-peptidase activity	5	9
GO:0016787	hydrolase activity	2	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:0004721	phosphoprotein phosphatase activity	3	2
GO:0004725	protein tyrosine phosphatase activity	4	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.546
CLV_NRD_NRD_1	139	141	PF00675	0.366
CLV_NRD_NRD_1	2	4	PF00675	0.606
CLV_NRD_NRD_1	53	55	PF00675	0.336
CLV_NRD_NRD_1	612	614	PF00675	0.482
CLV_NRD_NRD_1	679	681	PF00675	0.448
CLV_NRD_NRD_1	682	684	PF00675	0.441
CLV_PCSK_FUR_1	680	684	PF00082	0.552
CLV_PCSK_KEX2_1	139	141	PF00082	0.367
CLV_PCSK_KEX2_1	2	4	PF00082	0.606
CLV_PCSK_KEX2_1	55	57	PF00082	0.332
CLV_PCSK_KEX2_1	612	614	PF00082	0.458
CLV_PCSK_KEX2_1	679	681	PF00082	0.448
CLV_PCSK_KEX2_1	682	684	PF00082	0.441
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.330
CLV_PCSK_SKI1_1	290	294	PF00082	0.458
CLV_PCSK_SKI1_1	301	305	PF00082	0.462
CLV_PCSK_SKI1_1	439	443	PF00082	0.344
CLV_PCSK_SKI1_1	613	617	PF00082	0.562
DEG_Nend_UBRbox_1	1	4	PF02207	0.623
DEG_SIAH_1	270	278	PF03145	0.567
DOC_CKS1_1	376	381	PF01111	0.541
DOC_CKS1_1	557	562	PF01111	0.545
DOC_CYCLIN_RxL_1	609	621	PF00134	0.457
DOC_MAPK_MEF2A_6	145	152	PF00069	0.551
DOC_MAPK_NFAT4_5	145	153	PF00069	0.610
DOC_PP2B_LxvP_1	261	264	PF13499	0.524
DOC_PP2B_LxvP_1	32	35	PF13499	0.541
DOC_PP4_FxxP_1	534	537	PF00568	0.519
DOC_USP7_MATH_1	500	504	PF00917	0.615
DOC_USP7_MATH_1	85	89	PF00917	0.606
DOC_USP7_UBL2_3	262	266	PF12436	0.576
DOC_WW_Pin1_4	278	283	PF00397	0.513
DOC_WW_Pin1_4	375	380	PF00397	0.548
DOC_WW_Pin1_4	516	521	PF00397	0.533
DOC_WW_Pin1_4	556	561	PF00397	0.500
LIG_14-3-3_CanoR_1	156	163	PF00244	0.536
LIG_14-3-3_CanoR_1	2	11	PF00244	0.578
LIG_14-3-3_CanoR_1	457	461	PF00244	0.534
LIG_14-3-3_CanoR_1	571	576	PF00244	0.489
LIG_APCC_ABBA_1	314	319	PF00400	0.500
LIG_deltaCOP1_diTrp_1	109	116	PF00928	0.533
LIG_deltaCOP1_diTrp_1	194	200	PF00928	0.533
LIG_deltaCOP1_diTrp_1	294	299	PF00928	0.516
LIG_EH1_1	459	467	PF00400	0.614
LIG_eIF4E_1	460	466	PF01652	0.614
LIG_FHA_1	10	16	PF00498	0.577
LIG_FHA_1	116	122	PF00498	0.614
LIG_FHA_1	156	162	PF00498	0.533
LIG_FHA_1	249	255	PF00498	0.539
LIG_FHA_1	303	309	PF00498	0.427
LIG_FHA_1	369	375	PF00498	0.622
LIG_FHA_1	426	432	PF00498	0.524
LIG_FHA_1	457	463	PF00498	0.606
LIG_FHA_1	521	527	PF00498	0.557
LIG_FHA_1	584	590	PF00498	0.463
LIG_FHA_2	19	25	PF00498	0.548
LIG_FHA_2	302	308	PF00498	0.556
LIG_FHA_2	392	398	PF00498	0.562
LIG_FHA_2	603	609	PF00498	0.457
LIG_GBD_Chelix_1	349	357	PF00786	0.254
LIG_HCF-1_HBM_1	16	19	PF13415	0.535
LIG_HCF-1_HBM_1	41	44	PF13415	0.610
LIG_LIR_Apic_2	531	537	PF02991	0.479
LIG_LIR_Gen_1	16	26	PF02991	0.469
LIG_LIR_Gen_1	231	241	PF02991	0.533
LIG_LIR_Gen_1	572	579	PF02991	0.473
LIG_LIR_Gen_1	580	589	PF02991	0.406
LIG_LIR_Gen_1	653	663	PF02991	0.437
LIG_LIR_Nem_3	127	131	PF02991	0.533
LIG_LIR_Nem_3	16	22	PF02991	0.443
LIG_LIR_Nem_3	231	236	PF02991	0.555
LIG_LIR_Nem_3	294	298	PF02991	0.576
LIG_LIR_Nem_3	310	314	PF02991	0.419
LIG_LIR_Nem_3	386	392	PF02991	0.673
LIG_LIR_Nem_3	41	47	PF02991	0.555
LIG_LIR_Nem_3	49	53	PF02991	0.510
LIG_LIR_Nem_3	490	496	PF02991	0.580
LIG_LIR_Nem_3	572	578	PF02991	0.475
LIG_LIR_Nem_3	580	585	PF02991	0.396
LIG_LIR_Nem_3	653	659	PF02991	0.442
LIG_LYPXL_yS_3	44	47	PF13949	0.614
LIG_MYND_1	537	541	PF01753	0.510
LIG_NRBOX	253	259	PF00104	0.614
LIG_PDZ_Class_3	681	686	PF00595	0.482
LIG_Pex14_1	246	250	PF04695	0.533
LIG_Pex14_1	272	276	PF04695	0.533
LIG_Pex14_2	673	677	PF04695	0.477
LIG_PTB_Apo_2	167	174	PF02174	0.533
LIG_PTB_Apo_2	249	256	PF02174	0.533
LIG_SH2_CRK	233	237	PF00017	0.533
LIG_SH2_CRK	496	500	PF00017	0.614
LIG_SH2_GRB2like	250	253	PF00017	0.533
LIG_SH2_NCK_1	233	237	PF00017	0.533
LIG_SH2_NCK_1	412	416	PF00017	0.614
LIG_SH2_PTP2	19	22	PF00017	0.529
LIG_SH2_PTP2	75	78	PF00017	0.611
LIG_SH2_SRC	575	578	PF00017	0.493
LIG_SH2_SRC	656	659	PF00017	0.452
LIG_SH2_STAP1	220	224	PF00017	0.533
LIG_SH2_STAP1	250	254	PF00017	0.533
LIG_SH2_STAP1	575	579	PF00017	0.520
LIG_SH2_STAT3	96	99	PF00017	0.533
LIG_SH2_STAT5	19	22	PF00017	0.529
LIG_SH2_STAT5	250	253	PF00017	0.533
LIG_SH2_STAT5	317	320	PF00017	0.533
LIG_SH2_STAT5	412	415	PF00017	0.614
LIG_SH2_STAT5	496	499	PF00017	0.601
LIG_SH2_STAT5	50	53	PF00017	0.534
LIG_SH2_STAT5	627	630	PF00017	0.546
LIG_SH2_STAT5	656	659	PF00017	0.429
LIG_SH2_STAT5	75	78	PF00017	0.579
LIG_SH2_STAT5	96	99	PF00017	0.533
LIG_SH3_3	373	379	PF00018	0.605
LIG_SH3_3	535	541	PF00018	0.518
LIG_SH3_3	543	549	PF00018	0.437
LIG_SH3_3	554	560	PF00018	0.584
LIG_SH3_3	632	638	PF00018	0.567
LIG_SUMO_SIM_anti_2	102	109	PF11976	0.551
LIG_SUMO_SIM_par_1	238	244	PF11976	0.614
LIG_SUMO_SIM_par_1	371	378	PF11976	0.630
LIG_SUMO_SIM_par_1	522	528	PF11976	0.579
LIG_TRAF2_1	228	231	PF00917	0.614
LIG_TYR_ITIM	573	578	PF00017	0.492
LIG_UBA3_1	254	262	PF00899	0.390
LIG_UBA3_1	358	364	PF00899	0.338
LIG_UBA3_1	47	55	PF00899	0.376
MOD_CDK_SPxxK_3	278	285	PF00069	0.562
MOD_CK2_1	225	231	PF00069	0.386
MOD_CK2_1	301	307	PF00069	0.359
MOD_CK2_1	391	397	PF00069	0.430
MOD_CK2_1	548	554	PF00069	0.600
MOD_CK2_1	564	570	PF00069	0.597
MOD_CK2_1	602	608	PF00069	0.464
MOD_CMANNOS	296	299	PF00535	0.411
MOD_GlcNHglycan	385	388	PF01048	0.413
MOD_GlcNHglycan	413	416	PF01048	0.487
MOD_GlcNHglycan	541	544	PF01048	0.628
MOD_GlcNHglycan	623	626	PF01048	0.472
MOD_GSK3_1	366	373	PF00069	0.439
MOD_GSK3_1	411	418	PF00069	0.462
MOD_GSK3_1	425	432	PF00069	0.349
MOD_GSK3_1	500	507	PF00069	0.390
MOD_GSK3_1	516	523	PF00069	0.390
MOD_GSK3_1	555	562	PF00069	0.517
MOD_GSK3_1	603	610	PF00069	0.578
MOD_GSK3_1	621	628	PF00069	0.506
MOD_N-GLC_1	56	61	PF02516	0.489
MOD_N-GLC_1	644	649	PF02516	0.546
MOD_NEK2_1	124	129	PF00069	0.388
MOD_NEK2_1	150	155	PF00069	0.485
MOD_NEK2_1	408	413	PF00069	0.543
MOD_NEK2_1	429	434	PF00069	0.491
MOD_NEK2_1	615	620	PF00069	0.451
MOD_NEK2_1	633	638	PF00069	0.444
MOD_NEK2_1	673	678	PF00069	0.554
MOD_PIKK_1	646	652	PF00454	0.547
MOD_PIKK_1	9	15	PF00454	0.578
MOD_PKA_2	155	161	PF00069	0.380
MOD_PKA_2	456	462	PF00069	0.379
MOD_PKB_1	54	62	PF00069	0.376
MOD_Plk_1	231	237	PF00069	0.489
MOD_Plk_1	318	324	PF00069	0.499
MOD_Plk_1	521	527	PF00069	0.492
MOD_Plk_1	569	575	PF00069	0.462
MOD_Plk_1	603	609	PF00069	0.504
MOD_Plk_1	613	619	PF00069	0.559
MOD_Plk_1	673	679	PF00069	0.552
MOD_Plk_4	345	351	PF00069	0.479
MOD_Plk_4	370	376	PF00069	0.489
MOD_Plk_4	521	527	PF00069	0.496
MOD_Plk_4	559	565	PF00069	0.539
MOD_ProDKin_1	278	284	PF00069	0.514
MOD_ProDKin_1	375	381	PF00069	0.396
MOD_ProDKin_1	516	522	PF00069	0.376
MOD_ProDKin_1	556	562	PF00069	0.501
MOD_SUMO_for_1	97	100	PF00179	0.489
TRG_DiLeu_BaEn_1	87	92	PF01217	0.376
TRG_ENDOCYTIC_2	19	22	PF00928	0.529
TRG_ENDOCYTIC_2	233	236	PF00928	0.376
TRG_ENDOCYTIC_2	44	47	PF00928	0.489
TRG_ENDOCYTIC_2	512	515	PF00928	0.489
TRG_ENDOCYTIC_2	575	578	PF00928	0.493
TRG_ENDOCYTIC_2	656	659	PF00928	0.427
TRG_ENDOCYTIC_2	75	78	PF00928	0.436
TRG_ER_diArg_1	1	3	PF00400	0.639
TRG_ER_diArg_1	139	141	PF00400	0.424
TRG_ER_diArg_1	53	56	PF00400	0.379
TRG_ER_diArg_1	611	613	PF00400	0.472
TRG_ER_diArg_1	679	682	PF00400	0.454
TRG_NLS_MonoExtN_4	52	58	PF00514	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I036	Leptomonas seymouri	80%	100%
A0A1X0NRA9	Trypanosomatidae	55%	100%
A0A422N0C2	Trypanosoma rangeli	56%	100%
A4I3S2	Leishmania infantum	100%	100%
E9B014	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q871	Leishmania major	96%	100%
Q82MI6	Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)	22%	100%
Q9L9D7	Rhodococcus sp. (strain MB1 Bresler)	23%	100%
V5BL63	Trypanosoma cruzi	56%	100%