Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X1P6_LEIDO

TriTrypDb:

LdBPK_282150.1 , LdCL_280026600 , LDHU3_28.2930

Length:

550

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X1P6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1P6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	408	412	PF00656	0.688
CLV_NRD_NRD_1	16	18	PF00675	0.594
CLV_NRD_NRD_1	204	206	PF00675	0.557
CLV_NRD_NRD_1	290	292	PF00675	0.516
CLV_PCSK_FUR_1	510	514	PF00082	0.481
CLV_PCSK_KEX2_1	16	18	PF00082	0.594
CLV_PCSK_KEX2_1	204	206	PF00082	0.596
CLV_PCSK_KEX2_1	244	246	PF00082	0.369
CLV_PCSK_KEX2_1	290	292	PF00082	0.516
CLV_PCSK_KEX2_1	318	320	PF00082	0.508
CLV_PCSK_KEX2_1	512	514	PF00082	0.541
CLV_PCSK_KEX2_1	544	546	PF00082	0.566
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.369
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.555
CLV_PCSK_PC1ET2_1	512	514	PF00082	0.541
CLV_PCSK_PC1ET2_1	544	546	PF00082	0.566
CLV_PCSK_PC7_1	200	206	PF00082	0.382
CLV_PCSK_PC7_1	286	292	PF00082	0.514
CLV_PCSK_PC7_1	314	320	PF00082	0.385
CLV_PCSK_SKI1_1	176	180	PF00082	0.328
CLV_PCSK_SKI1_1	231	235	PF00082	0.417
DEG_APCC_DBOX_1	3	11	PF00400	0.358
DEG_COP1_1	119	129	PF00400	0.551
DOC_CKS1_1	387	392	PF01111	0.658
DOC_CKS1_1	421	426	PF01111	0.621
DOC_CYCLIN_RxL_1	510	518	PF00134	0.585
DOC_CYCLIN_yCln2_LP_2	234	240	PF00134	0.463
DOC_CYCLIN_yCln2_LP_2	387	393	PF00134	0.735
DOC_MAPK_DCC_7	231	240	PF00069	0.514
DOC_MAPK_gen_1	510	519	PF00069	0.533
DOC_MAPK_HePTP_8	329	341	PF00069	0.434
DOC_MAPK_MEF2A_6	332	341	PF00069	0.582
DOC_MAPK_MEF2A_6	4	11	PF00069	0.486
DOC_MAPK_MEF2A_6	510	519	PF00069	0.533
DOC_MAPK_NFAT4_5	512	520	PF00069	0.548
DOC_PP4_FxxP_1	349	352	PF00568	0.407
DOC_USP7_MATH_1	125	129	PF00917	0.494
DOC_USP7_MATH_1	32	36	PF00917	0.690
DOC_USP7_MATH_1	370	374	PF00917	0.601
DOC_USP7_MATH_1	480	484	PF00917	0.650
DOC_USP7_MATH_1	497	501	PF00917	0.589
DOC_WW_Pin1_4	166	171	PF00397	0.399
DOC_WW_Pin1_4	238	243	PF00397	0.476
DOC_WW_Pin1_4	348	353	PF00397	0.437
DOC_WW_Pin1_4	386	391	PF00397	0.600
DOC_WW_Pin1_4	420	425	PF00397	0.638
LIG_14-3-3_CanoR_1	183	189	PF00244	0.363
LIG_14-3-3_CanoR_1	264	271	PF00244	0.443
LIG_14-3-3_CanoR_1	332	337	PF00244	0.596
LIG_14-3-3_CanoR_1	371	375	PF00244	0.697
LIG_14-3-3_CanoR_1	469	478	PF00244	0.470
LIG_APCC_ABBA_1	450	455	PF00400	0.485
LIG_BIR_III_4	396	400	PF00653	0.596
LIG_BRCT_BRCA1_1	184	188	PF00533	0.349
LIG_BRCT_BRCA1_1	210	214	PF00533	0.428
LIG_BRCT_BRCA1_1	254	258	PF00533	0.582
LIG_BRCT_BRCA1_1	445	449	PF00533	0.573
LIG_BRCT_BRCA1_1	7	11	PF00533	0.483
LIG_Clathr_ClatBox_1	342	346	PF01394	0.360
LIG_CSL_BTD_1	387	390	PF09270	0.654
LIG_deltaCOP1_diTrp_1	134	140	PF00928	0.469
LIG_FHA_1	173	179	PF00498	0.362
LIG_FHA_1	22	28	PF00498	0.404
LIG_FHA_1	387	393	PF00498	0.663
LIG_FHA_1	442	448	PF00498	0.638
LIG_FHA_2	117	123	PF00498	0.568
LIG_FHA_2	172	178	PF00498	0.472
LIG_FHA_2	275	281	PF00498	0.493
LIG_FHA_2	396	402	PF00498	0.614
LIG_FHA_2	406	412	PF00498	0.594
LIG_FHA_2	432	438	PF00498	0.762
LIG_GBD_Chelix_1	339	347	PF00786	0.436
LIG_Integrin_RGD_1	415	417	PF01839	0.606
LIG_LIR_Apic_2	160	166	PF02991	0.460
LIG_LIR_Apic_2	346	352	PF02991	0.383
LIG_LIR_Gen_1	373	382	PF02991	0.531
LIG_LIR_Nem_3	128	132	PF02991	0.443
LIG_LIR_Nem_3	255	261	PF02991	0.459
LIG_LIR_Nem_3	267	273	PF02991	0.426
LIG_LIR_Nem_3	373	379	PF02991	0.660
LIG_LIR_Nem_3	448	453	PF02991	0.491
LIG_LIR_Nem_3	76	81	PF02991	0.494
LIG_NRBOX	338	344	PF00104	0.529
LIG_Pex14_2	140	144	PF04695	0.363
LIG_Pex14_2	449	453	PF04695	0.510
LIG_REV1ctd_RIR_1	447	455	PF16727	0.495
LIG_SH2_CRK	493	497	PF00017	0.628
LIG_SH2_NCK_1	71	75	PF00017	0.517
LIG_SH2_SRC	54	57	PF00017	0.386
LIG_SH2_SRC	71	74	PF00017	0.509
LIG_SH2_STAP1	78	82	PF00017	0.520
LIG_SH2_STAT5	155	158	PF00017	0.415
LIG_SH2_STAT5	173	176	PF00017	0.436
LIG_SH2_STAT5	357	360	PF00017	0.367
LIG_SH2_STAT5	41	44	PF00017	0.531
LIG_SH2_STAT5	462	465	PF00017	0.554
LIG_SH2_STAT5	493	496	PF00017	0.551
LIG_SH2_STAT5	54	57	PF00017	0.327
LIG_SH2_STAT5	81	84	PF00017	0.523
LIG_SH3_3	265	271	PF00018	0.504
LIG_SH3_3	300	306	PF00018	0.563
LIG_SH3_3	349	355	PF00018	0.396
LIG_SH3_3	60	66	PF00018	0.421
LIG_SUMO_SIM_anti_2	338	343	PF11976	0.387
LIG_SUMO_SIM_par_1	341	346	PF11976	0.381
LIG_TRAF2_1	44	47	PF00917	0.423
LIG_TRAF2_1	74	77	PF00917	0.611
LIG_WRC_WIRS_1	126	131	PF05994	0.474
MOD_CDC14_SPxK_1	241	244	PF00782	0.365
MOD_CDK_SPxK_1	238	244	PF00069	0.350
MOD_CDK_SPxxK_3	238	245	PF00069	0.488
MOD_CK1_1	120	126	PF00069	0.511
MOD_CK1_1	128	134	PF00069	0.442
MOD_CK1_1	225	231	PF00069	0.530
MOD_CK1_1	335	341	PF00069	0.474
MOD_CK1_1	39	45	PF00069	0.604
MOD_CK1_1	431	437	PF00069	0.667
MOD_CK1_1	57	63	PF00069	0.315
MOD_CK2_1	128	134	PF00069	0.444
MOD_CK2_1	135	141	PF00069	0.366
MOD_CK2_1	171	177	PF00069	0.421
MOD_CK2_1	274	280	PF00069	0.458
MOD_CK2_1	395	401	PF00069	0.552
MOD_CMANNOS	385	388	PF00535	0.594
MOD_Cter_Amidation	14	17	PF01082	0.612
MOD_GlcNHglycan	11	14	PF01048	0.526
MOD_GlcNHglycan	110	113	PF01048	0.612
MOD_GlcNHglycan	121	125	PF01048	0.551
MOD_GlcNHglycan	201	204	PF01048	0.391
MOD_GlcNHglycan	224	227	PF01048	0.486
MOD_GlcNHglycan	323	326	PF01048	0.660
MOD_GlcNHglycan	327	332	PF01048	0.623
MOD_GlcNHglycan	33	37	PF01048	0.630
MOD_GlcNHglycan	359	362	PF01048	0.329
MOD_GlcNHglycan	372	375	PF01048	0.498
MOD_GlcNHglycan	499	502	PF01048	0.702
MOD_GlcNHglycan	95	98	PF01048	0.736
MOD_GSK3_1	108	115	PF00069	0.718
MOD_GSK3_1	116	123	PF00069	0.628
MOD_GSK3_1	210	217	PF00069	0.565
MOD_GSK3_1	218	225	PF00069	0.363
MOD_GSK3_1	252	259	PF00069	0.499
MOD_GSK3_1	32	39	PF00069	0.704
MOD_GSK3_1	370	377	PF00069	0.529
MOD_GSK3_1	401	408	PF00069	0.580
MOD_GSK3_1	480	487	PF00069	0.691
MOD_GSK3_1	5	12	PF00069	0.404
MOD_N-GLC_1	183	188	PF02516	0.388
MOD_N-GLC_1	57	62	PF02516	0.475
MOD_N-GLC_1	87	92	PF02516	0.761
MOD_NEK2_1	182	187	PF00069	0.362
MOD_NEK2_1	214	219	PF00069	0.446
MOD_NEK2_1	222	227	PF00069	0.523
MOD_NEK2_1	256	261	PF00069	0.570
MOD_NEK2_1	298	303	PF00069	0.469
MOD_NEK2_1	470	475	PF00069	0.600
MOD_NEK2_2	135	140	PF00069	0.358
MOD_NEK2_2	21	26	PF00069	0.396
MOD_PIKK_1	380	386	PF00454	0.600
MOD_PIKK_1	417	423	PF00454	0.610
MOD_PKA_2	182	188	PF00069	0.357
MOD_PKA_2	199	205	PF00069	0.441
MOD_PKA_2	263	269	PF00069	0.438
MOD_PKA_2	370	376	PF00069	0.696
MOD_Plk_1	214	220	PF00069	0.337
MOD_Plk_1	298	304	PF00069	0.354
MOD_Plk_1	36	42	PF00069	0.479
MOD_Plk_1	380	386	PF00069	0.576
MOD_Plk_1	57	63	PF00069	0.407
MOD_Plk_4	135	141	PF00069	0.489
MOD_Plk_4	269	275	PF00069	0.523
MOD_Plk_4	5	11	PF00069	0.397
MOD_Plk_4	77	83	PF00069	0.516
MOD_ProDKin_1	166	172	PF00069	0.387
MOD_ProDKin_1	238	244	PF00069	0.483
MOD_ProDKin_1	348	354	PF00069	0.441
MOD_ProDKin_1	386	392	PF00069	0.601
MOD_ProDKin_1	420	426	PF00069	0.641
TRG_DiLeu_BaEn_1	177	182	PF01217	0.447
TRG_DiLeu_BaEn_1	293	298	PF01217	0.393
TRG_DiLeu_BaEn_1	499	504	PF01217	0.557
TRG_DiLeu_BaEn_3	529	535	PF01217	0.588
TRG_DiLeu_BaLyEn_6	387	392	PF01217	0.658
TRG_ENDOCYTIC_2	493	496	PF00928	0.570
TRG_ER_diArg_1	290	292	PF00400	0.510
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	513	518	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	536	540	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL93	Leptomonas seymouri	60%	100%
A0A1X0NQS9	Trypanosomatidae	35%	100%
A0A422NBH7	Trypanosoma rangeli	39%	100%
A4HGQ5	Leishmania braziliensis	76%	100%
A4I3S9	Leishmania infantum	99%	100%
D0A878	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B021	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q865	Leishmania major	88%	100%
V5DCT5	Trypanosoma cruzi	37%	100%