Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X1P3_LEIDO

TriTrypDb:

LdBPK_282160.1 , LdCL_280026700 , LDHU3_28.2940

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	1
GO:0005814	centriole	5	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X1P3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1P3

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	1
GO:0007098	centrosome cycle	3	1
GO:0009987	cellular process	1	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010638	positive regulation of organelle organization	6	1
GO:0010824	regulation of centrosome duplication	6	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0031023	microtubule organizing center organization	3	1
GO:0032886	regulation of microtubule-based process	4	1
GO:0033043	regulation of organelle organization	5	1
GO:0044087	regulation of cellular component biogenesis	4	1
GO:0044089	positive regulation of cellular component biogenesis	5	1
GO:0045787	positive regulation of cell cycle	5	1
GO:0046599	regulation of centriole replication	6	1
GO:0046601	positive regulation of centriole replication	7	1
GO:0046605	regulation of centrosome cycle	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051130	positive regulation of cellular component organization	5	1
GO:0051493	regulation of cytoskeleton organization	6	1
GO:0051495	positive regulation of cytoskeleton organization	7	1
GO:0051726	regulation of cell cycle	4	1
GO:0065007	biological regulation	1	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090068	positive regulation of cell cycle process	6	1
GO:1902115	regulation of organelle assembly	5	1
GO:1902117	positive regulation of organelle assembly	6	1
GO:1903722	regulation of centriole elongation	6	1
GO:1903724	positive regulation of centriole elongation	7	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	441	445	PF00656	0.700
CLV_MEL_PAP_1	152	158	PF00089	0.559
CLV_NRD_NRD_1	125	127	PF00675	0.571
CLV_NRD_NRD_1	168	170	PF00675	0.538
CLV_NRD_NRD_1	238	240	PF00675	0.479
CLV_NRD_NRD_1	256	258	PF00675	0.399
CLV_NRD_NRD_1	268	270	PF00675	0.599
CLV_NRD_NRD_1	412	414	PF00675	0.707
CLV_NRD_NRD_1	421	423	PF00675	0.737
CLV_NRD_NRD_1	50	52	PF00675	0.485
CLV_NRD_NRD_1	529	531	PF00675	0.594
CLV_PCSK_KEX2_1	105	107	PF00082	0.436
CLV_PCSK_KEX2_1	125	127	PF00082	0.287
CLV_PCSK_KEX2_1	167	169	PF00082	0.541
CLV_PCSK_KEX2_1	231	233	PF00082	0.520
CLV_PCSK_KEX2_1	267	269	PF00082	0.633
CLV_PCSK_KEX2_1	421	423	PF00082	0.770
CLV_PCSK_KEX2_1	50	52	PF00082	0.499
CLV_PCSK_KEX2_1	529	531	PF00082	0.594
CLV_PCSK_KEX2_1	90	92	PF00082	0.505
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.481
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.580
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.580
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.487
CLV_PCSK_SKI1_1	105	109	PF00082	0.456
CLV_PCSK_SKI1_1	147	151	PF00082	0.489
CLV_PCSK_SKI1_1	168	172	PF00082	0.483
CLV_PCSK_SKI1_1	42	46	PF00082	0.522
DEG_APCC_DBOX_1	70	78	PF00400	0.469
DEG_SCF_TRCP1_1	427	433	PF00400	0.684
DEG_SPOP_SBC_1	454	458	PF00917	0.669
DOC_CYCLIN_yCln2_LP_2	284	290	PF00134	0.615
DOC_MAPK_gen_1	145	152	PF00069	0.488
DOC_MAPK_MEF2A_6	145	152	PF00069	0.453
DOC_MAPK_MEF2A_6	231	238	PF00069	0.375
DOC_MAPK_NFAT4_5	145	153	PF00069	0.454
DOC_PP2B_LxvP_1	284	287	PF13499	0.648
DOC_USP7_MATH_1	134	138	PF00917	0.506
DOC_USP7_MATH_1	380	384	PF00917	0.767
DOC_USP7_MATH_1	430	434	PF00917	0.759
DOC_USP7_MATH_1	522	526	PF00917	0.606
DOC_USP7_MATH_1	56	60	PF00917	0.589
DOC_WW_Pin1_4	2	7	PF00397	0.713
DOC_WW_Pin1_4	261	266	PF00397	0.740
DOC_WW_Pin1_4	365	370	PF00397	0.752
DOC_WW_Pin1_4	412	417	PF00397	0.616
DOC_WW_Pin1_4	499	504	PF00397	0.609
LIG_14-3-3_CanoR_1	155	163	PF00244	0.499
LIG_14-3-3_CanoR_1	268	273	PF00244	0.680
LIG_14-3-3_CanoR_1	474	479	PF00244	0.717
LIG_BIR_II_1	1	5	PF00653	0.720
LIG_BRCT_BRCA1_1	284	288	PF00533	0.657
LIG_FHA_1	169	175	PF00498	0.558
LIG_FHA_1	386	392	PF00498	0.702
LIG_FHA_1	399	405	PF00498	0.603
LIG_FHA_1	430	436	PF00498	0.733
LIG_FHA_1	455	461	PF00498	0.716
LIG_FHA_1	90	96	PF00498	0.574
LIG_FHA_2	125	131	PF00498	0.518
LIG_FHA_2	343	349	PF00498	0.759
LIG_FHA_2	355	361	PF00498	0.567
LIG_FHA_2	377	383	PF00498	0.799
LIG_FHA_2	395	401	PF00498	0.694
LIG_FHA_2	439	445	PF00498	0.684
LIG_FHA_2	502	508	PF00498	0.683
LIG_LIR_Gen_1	162	170	PF02991	0.480
LIG_LIR_Gen_1	252	259	PF02991	0.606
LIG_LIR_Gen_1	313	322	PF02991	0.618
LIG_LIR_Nem_3	162	166	PF02991	0.475
LIG_LIR_Nem_3	252	256	PF02991	0.548
LIG_LIR_Nem_3	313	319	PF02991	0.562
LIG_LIR_Nem_3	444	450	PF02991	0.544
LIG_LYPXL_yS_3	447	450	PF13949	0.665
LIG_MYND_1	479	483	PF01753	0.647
LIG_SH2_CRK	163	167	PF00017	0.502
LIG_SH2_CRK	241	245	PF00017	0.564
LIG_SH2_CRK	316	320	PF00017	0.547
LIG_SH2_NCK_1	20	24	PF00017	0.434
LIG_SH2_STAP1	20	24	PF00017	0.434
LIG_SH2_STAP1	569	573	PF00017	0.440
LIG_SH2_STAT3	37	40	PF00017	0.558
LIG_SH2_STAT3	572	575	PF00017	0.571
LIG_SH2_STAT5	116	119	PF00017	0.563
LIG_SH2_STAT5	173	176	PF00017	0.535
LIG_SH2_STAT5	572	575	PF00017	0.571
LIG_SH3_3	277	283	PF00018	0.629
LIG_SH3_3	284	290	PF00018	0.500
LIG_SH3_3	344	350	PF00018	0.743
LIG_SH3_3	477	483	PF00018	0.626
LIG_TRAF2_1	127	130	PF00917	0.571
LIG_TRAF2_1	159	162	PF00917	0.562
LIG_TRAF2_1	461	464	PF00917	0.683
LIG_TRAF2_1	504	507	PF00917	0.695
LIG_UBA3_1	318	323	PF00899	0.515
LIG_WRC_WIRS_1	532	537	PF05994	0.505
MOD_CDC14_SPxK_1	264	267	PF00782	0.644
MOD_CDK_SPxK_1	261	267	PF00069	0.628
MOD_CDK_SPxxK_3	2	9	PF00069	0.674
MOD_CDK_SPxxK_3	261	268	PF00069	0.634
MOD_CDK_SPxxK_3	365	372	PF00069	0.742
MOD_CK1_1	219	225	PF00069	0.575
MOD_CK1_1	362	368	PF00069	0.741
MOD_CK1_1	402	408	PF00069	0.616
MOD_CK1_1	442	448	PF00069	0.648
MOD_CK1_1	469	475	PF00069	0.768
MOD_CK2_1	124	130	PF00069	0.568
MOD_CK2_1	342	348	PF00069	0.759
MOD_CK2_1	376	382	PF00069	0.771
MOD_CK2_1	394	400	PF00069	0.686
MOD_CK2_1	425	431	PF00069	0.771
MOD_CK2_1	501	507	PF00069	0.726
MOD_GlcNHglycan	11	14	PF01048	0.579
MOD_GlcNHglycan	157	160	PF01048	0.492
MOD_GlcNHglycan	208	212	PF01048	0.581
MOD_GlcNHglycan	284	287	PF01048	0.706
MOD_GlcNHglycan	290	293	PF01048	0.715
MOD_GlcNHglycan	306	309	PF01048	0.568
MOD_GlcNHglycan	382	385	PF01048	0.766
MOD_GlcNHglycan	404	407	PF01048	0.735
MOD_GlcNHglycan	427	430	PF01048	0.754
MOD_GlcNHglycan	444	447	PF01048	0.575
MOD_GlcNHglycan	520	523	PF01048	0.632
MOD_GlcNHglycan	524	527	PF01048	0.591
MOD_GSK3_1	168	175	PF00069	0.469
MOD_GSK3_1	190	197	PF00069	0.620
MOD_GSK3_1	350	357	PF00069	0.735
MOD_GSK3_1	358	365	PF00069	0.715
MOD_GSK3_1	370	377	PF00069	0.595
MOD_GSK3_1	386	393	PF00069	0.599
MOD_GSK3_1	394	401	PF00069	0.619
MOD_GSK3_1	425	432	PF00069	0.788
MOD_GSK3_1	438	445	PF00069	0.628
MOD_GSK3_1	469	476	PF00069	0.736
MOD_GSK3_1	518	525	PF00069	0.580
MOD_GSK3_1	546	553	PF00069	0.479
MOD_N-GLC_1	177	182	PF02516	0.573
MOD_N-GLC_1	333	338	PF02516	0.698
MOD_NEK2_1	1	6	PF00069	0.693
MOD_NEK2_1	133	138	PF00069	0.550
MOD_NEK2_1	192	197	PF00069	0.569
MOD_NEK2_1	216	221	PF00069	0.492
MOD_NEK2_1	354	359	PF00069	0.741
MOD_NEK2_1	399	404	PF00069	0.709
MOD_NEK2_1	438	443	PF00069	0.692
MOD_NEK2_1	516	521	PF00069	0.669
MOD_NEK2_1	546	551	PF00069	0.465
MOD_NEK2_2	350	355	PF00069	0.574
MOD_PIKK_1	192	198	PF00454	0.567
MOD_PIKK_1	216	222	PF00454	0.516
MOD_PK_1	232	238	PF00069	0.374
MOD_PKA_1	168	174	PF00069	0.386
MOD_PKA_1	268	274	PF00069	0.651
MOD_PKA_2	124	130	PF00069	0.568
MOD_PKA_2	14	20	PF00069	0.482
MOD_PKA_2	154	160	PF00069	0.497
MOD_PKA_2	168	174	PF00069	0.482
MOD_PKA_2	268	274	PF00069	0.651
MOD_PKA_2	334	340	PF00069	0.717
MOD_PKA_2	473	479	PF00069	0.718
MOD_PKA_2	56	62	PF00069	0.595
MOD_Plk_1	395	401	PF00069	0.670
MOD_Plk_1	430	436	PF00069	0.745
MOD_Plk_1	439	445	PF00069	0.659
MOD_Plk_4	232	238	PF00069	0.374
MOD_Plk_4	430	436	PF00069	0.751
MOD_Plk_4	455	461	PF00069	0.685
MOD_Plk_4	531	537	PF00069	0.623
MOD_ProDKin_1	2	8	PF00069	0.710
MOD_ProDKin_1	261	267	PF00069	0.745
MOD_ProDKin_1	365	371	PF00069	0.752
MOD_ProDKin_1	412	418	PF00069	0.620
MOD_ProDKin_1	499	505	PF00069	0.607
MOD_SUMO_for_1	322	325	PF00179	0.570
MOD_SUMO_rev_2	55	64	PF00179	0.557
TRG_DiLeu_BaLyEn_6	445	450	PF01217	0.501
TRG_ENDOCYTIC_2	163	166	PF00928	0.467
TRG_ENDOCYTIC_2	241	244	PF00928	0.442
TRG_ENDOCYTIC_2	316	319	PF00928	0.549
TRG_ENDOCYTIC_2	447	450	PF00928	0.543
TRG_ER_diArg_1	125	128	PF00400	0.572
TRG_ER_diArg_1	166	169	PF00400	0.538
TRG_ER_diArg_1	421	423	PF00400	0.800
TRG_ER_diArg_1	50	52	PF00400	0.543
TRG_NES_CRM1_1	531	544	PF08389	0.517
TRG_NES_CRM1_1	72	86	PF08389	0.458
TRG_NLS_Bipartite_1	257	271	PF00514	0.647
TRG_NLS_Bipartite_1	90	109	PF00514	0.555
TRG_NLS_MonoExtN_4	265	271	PF00514	0.544
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	486	490	PF00026	0.742
TRG_Pf-PMV_PEXEL_1	50	55	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYF9	Leptomonas seymouri	54%	93%
A0A1X0NR42	Trypanosomatidae	31%	98%
A0A3S5IQW4	Trypanosoma rangeli	33%	94%
A4HGQ6	Leishmania braziliensis	81%	100%
A4I3T0	Leishmania infantum	100%	100%
D0A877	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B022	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q864	Leishmania major	95%	100%
V5AWM8	Trypanosoma cruzi	31%	100%