Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X1N8_LEIDO

TriTrypDb:

LdBPK_281840.1 , LdCL_280023400 , LDHU3_28.2440

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X1N8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1N8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	568	572	PF00656	0.647
CLV_MEL_PAP_1	494	500	PF00089	0.569
CLV_PCSK_KEX2_1	24	26	PF00082	0.534
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.534
CLV_PCSK_SKI1_1	333	337	PF00082	0.646
CLV_PCSK_SKI1_1	597	601	PF00082	0.516
DEG_APCC_DBOX_1	496	504	PF00400	0.543
DEG_SCF_FBW7_1	251	258	PF00400	0.592
DEG_SPOP_SBC_1	438	442	PF00917	0.663
DEG_SPOP_SBC_1	70	74	PF00917	0.637
DOC_CKS1_1	252	257	PF01111	0.605
DOC_MAPK_MEF2A_6	285	294	PF00069	0.540
DOC_MAPK_MEF2A_6	490	498	PF00069	0.584
DOC_PP1_RVXF_1	294	300	PF00149	0.562
DOC_PP2B_LxvP_1	604	607	PF13499	0.508
DOC_PP4_MxPP_1	172	175	PF00568	0.564
DOC_SPAK_OSR1_1	468	472	PF12202	0.487
DOC_USP7_MATH_1	121	125	PF00917	0.632
DOC_USP7_MATH_1	132	136	PF00917	0.592
DOC_USP7_MATH_1	152	156	PF00917	0.486
DOC_USP7_MATH_1	178	182	PF00917	0.709
DOC_USP7_MATH_1	192	196	PF00917	0.537
DOC_USP7_MATH_1	233	237	PF00917	0.723
DOC_USP7_MATH_1	255	259	PF00917	0.660
DOC_USP7_MATH_1	270	274	PF00917	0.644
DOC_USP7_MATH_1	279	283	PF00917	0.691
DOC_USP7_MATH_1	39	43	PF00917	0.589
DOC_USP7_MATH_1	438	442	PF00917	0.732
DOC_USP7_MATH_1	45	49	PF00917	0.581
DOC_USP7_MATH_1	452	456	PF00917	0.499
DOC_USP7_MATH_1	70	74	PF00917	0.593
DOC_USP7_MATH_1	88	92	PF00917	0.503
DOC_USP7_MATH_2	233	239	PF00917	0.724
DOC_WW_Pin1_4	202	207	PF00397	0.603
DOC_WW_Pin1_4	251	256	PF00397	0.736
DOC_WW_Pin1_4	271	276	PF00397	0.548
DOC_WW_Pin1_4	299	304	PF00397	0.565
DOC_WW_Pin1_4	402	407	PF00397	0.665
DOC_WW_Pin1_4	430	435	PF00397	0.594
DOC_WW_Pin1_4	439	444	PF00397	0.625
DOC_WW_Pin1_4	531	536	PF00397	0.512
DOC_WW_Pin1_4	56	61	PF00397	0.611
DOC_WW_Pin1_4	99	104	PF00397	0.644
LIG_14-3-3_CanoR_1	468	474	PF00244	0.489
LIG_14-3-3_CanoR_1	497	501	PF00244	0.560
LIG_14-3-3_CanoR_1	56	60	PF00244	0.609
LIG_14-3-3_CanoR_1	611	617	PF00244	0.581
LIG_Actin_WH2_2	482	499	PF00022	0.564
LIG_Actin_WH2_2	585	603	PF00022	0.521
LIG_BIR_II_1	1	5	PF00653	0.632
LIG_BRCT_BRCA1_1	1	5	PF00533	0.632
LIG_BRCT_BRCA1_1	235	239	PF00533	0.732
LIG_BRCT_BRCA1_1	391	395	PF00533	0.579
LIG_BRCT_BRCA1_1	556	560	PF00533	0.654
LIG_FHA_1	362	368	PF00498	0.681
LIG_FHA_1	370	376	PF00498	0.609
LIG_FHA_1	455	461	PF00498	0.488
LIG_FHA_1	542	548	PF00498	0.591
LIG_FHA_2	11	17	PF00498	0.559
LIG_FHA_2	344	350	PF00498	0.672
LIG_LIR_Apic_2	525	530	PF02991	0.490
LIG_LIR_Gen_1	123	134	PF02991	0.610
LIG_LIR_Gen_1	302	311	PF02991	0.617
LIG_LIR_Gen_1	512	519	PF02991	0.460
LIG_LIR_Gen_1	558	569	PF02991	0.724
LIG_LIR_Nem_3	258	263	PF02991	0.623
LIG_LIR_Nem_3	302	308	PF02991	0.617
LIG_LIR_Nem_3	512	517	PF02991	0.456
LIG_LIR_Nem_3	558	564	PF02991	0.654
LIG_PCNA_yPIPBox_3	19	30	PF02747	0.537
LIG_PCNA_yPIPBox_3	508	520	PF02747	0.468
LIG_Pex14_2	560	564	PF04695	0.604
LIG_PTB_Apo_2	206	213	PF02174	0.601
LIG_PTB_Phospho_1	206	212	PF10480	0.602
LIG_SH2_CRK	252	256	PF00017	0.606
LIG_SH2_GRB2like	582	585	PF00017	0.566
LIG_SH2_NCK_1	153	157	PF00017	0.558
LIG_SH2_PTP2	514	517	PF00017	0.414
LIG_SH2_SRC	291	294	PF00017	0.582
LIG_SH2_STAP1	93	97	PF00017	0.611
LIG_SH2_STAT5	291	294	PF00017	0.582
LIG_SH2_STAT5	356	359	PF00017	0.707
LIG_SH2_STAT5	466	469	PF00017	0.494
LIG_SH2_STAT5	514	517	PF00017	0.475
LIG_SH2_STAT5	582	585	PF00017	0.566
LIG_SH3_3	444	450	PF00018	0.734
LIG_SH3_3	456	462	PF00018	0.439
LIG_SH3_3	495	501	PF00018	0.564
LIG_SH3_3	529	535	PF00018	0.508
LIG_SH3_3	607	613	PF00018	0.487
LIG_TRAF2_1	102	105	PF00917	0.587
LIG_TYR_ITIM	289	294	PF00017	0.581
MOD_CK1_1	130	136	PF00069	0.661
MOD_CK1_1	140	146	PF00069	0.581
MOD_CK1_1	185	191	PF00069	0.681
MOD_CK1_1	199	205	PF00069	0.540
MOD_CK1_1	265	271	PF00069	0.719
MOD_CK1_1	273	279	PF00069	0.661
MOD_CK1_1	363	369	PF00069	0.670
MOD_CK1_1	389	395	PF00069	0.600
MOD_CK1_1	439	445	PF00069	0.631
MOD_CK1_1	455	461	PF00069	0.497
MOD_CK1_1	567	573	PF00069	0.660
MOD_CK1_1	91	97	PF00069	0.605
MOD_CK1_1	99	105	PF00069	0.604
MOD_CK2_1	121	127	PF00069	0.609
MOD_CK2_1	165	171	PF00069	0.657
MOD_CK2_1	343	349	PF00069	0.675
MOD_CK2_1	445	451	PF00069	0.692
MOD_CK2_1	5	11	PF00069	0.575
MOD_CK2_1	99	105	PF00069	0.594
MOD_DYRK1A_RPxSP_1	56	60	PF00069	0.609
MOD_GlcNHglycan	115	118	PF01048	0.565
MOD_GlcNHglycan	131	135	PF01048	0.582
MOD_GlcNHglycan	146	149	PF01048	0.542
MOD_GlcNHglycan	154	157	PF01048	0.591
MOD_GlcNHglycan	158	161	PF01048	0.555
MOD_GlcNHglycan	167	170	PF01048	0.579
MOD_GlcNHglycan	176	179	PF01048	0.621
MOD_GlcNHglycan	184	187	PF01048	0.575
MOD_GlcNHglycan	196	199	PF01048	0.501
MOD_GlcNHglycan	209	212	PF01048	0.558
MOD_GlcNHglycan	235	238	PF01048	0.705
MOD_GlcNHglycan	242	246	PF01048	0.618
MOD_GlcNHglycan	264	267	PF01048	0.693
MOD_GlcNHglycan	281	284	PF01048	0.666
MOD_GlcNHglycan	428	431	PF01048	0.697
MOD_GlcNHglycan	47	50	PF01048	0.615
MOD_GlcNHglycan	576	581	PF01048	0.637
MOD_GlcNHglycan	73	76	PF01048	0.610
MOD_GlcNHglycan	83	86	PF01048	0.537
MOD_GSK3_1	121	128	PF00069	0.625
MOD_GSK3_1	130	137	PF00069	0.601
MOD_GSK3_1	140	147	PF00069	0.551
MOD_GSK3_1	152	159	PF00069	0.570
MOD_GSK3_1	174	181	PF00069	0.704
MOD_GSK3_1	192	199	PF00069	0.512
MOD_GSK3_1	215	222	PF00069	0.552
MOD_GSK3_1	231	238	PF00069	0.713
MOD_GSK3_1	251	258	PF00069	0.578
MOD_GSK3_1	262	269	PF00069	0.706
MOD_GSK3_1	343	350	PF00069	0.700
MOD_GSK3_1	356	363	PF00069	0.560
MOD_GSK3_1	394	401	PF00069	0.706
MOD_GSK3_1	426	433	PF00069	0.687
MOD_GSK3_1	437	444	PF00069	0.710
MOD_GSK3_1	52	59	PF00069	0.590
MOD_GSK3_1	555	562	PF00069	0.601
MOD_GSK3_1	563	570	PF00069	0.613
MOD_GSK3_1	612	619	PF00069	0.551
MOD_GSK3_1	91	98	PF00069	0.621
MOD_N-GLC_1	386	391	PF02516	0.589
MOD_N-GLC_1	5	10	PF02516	0.555
MOD_N-GLC_1	95	100	PF02516	0.658
MOD_N-GLC_2	522	524	PF02516	0.503
MOD_NEK2_1	207	212	PF00069	0.618
MOD_NEK2_1	367	372	PF00069	0.730
MOD_NEK2_1	469	474	PF00069	0.593
MOD_NEK2_1	477	482	PF00069	0.544
MOD_NEK2_1	496	501	PF00069	0.629
MOD_NEK2_1	5	10	PF00069	0.594
MOD_NEK2_1	541	546	PF00069	0.534
MOD_NEK2_1	564	569	PF00069	0.726
MOD_NEK2_1	600	605	PF00069	0.524
MOD_NEK2_1	69	74	PF00069	0.605
MOD_NEK2_1	95	100	PF00069	0.607
MOD_PIKK_1	146	152	PF00454	0.638
MOD_PIKK_1	441	447	PF00454	0.711
MOD_PIKK_1	586	592	PF00454	0.470
MOD_PKA_2	350	356	PF00069	0.709
MOD_PKA_2	496	502	PF00069	0.554
MOD_PKA_2	539	545	PF00069	0.528
MOD_PKA_2	55	61	PF00069	0.572
MOD_PKA_2	600	606	PF00069	0.521
MOD_Plk_1	5	11	PF00069	0.588
MOD_Plk_1	586	592	PF00069	0.522
MOD_Plk_1	91	97	PF00069	0.603
MOD_Plk_4	215	221	PF00069	0.657
MOD_Plk_4	363	369	PF00069	0.690
MOD_Plk_4	455	461	PF00069	0.553
MOD_Plk_4	533	539	PF00069	0.516
MOD_Plk_4	600	606	PF00069	0.485
MOD_ProDKin_1	202	208	PF00069	0.605
MOD_ProDKin_1	251	257	PF00069	0.735
MOD_ProDKin_1	271	277	PF00069	0.544
MOD_ProDKin_1	299	305	PF00069	0.565
MOD_ProDKin_1	402	408	PF00069	0.661
MOD_ProDKin_1	430	436	PF00069	0.598
MOD_ProDKin_1	439	445	PF00069	0.626
MOD_ProDKin_1	531	537	PF00069	0.508
MOD_ProDKin_1	56	62	PF00069	0.612
MOD_ProDKin_1	99	105	PF00069	0.645
TRG_DiLeu_BaEn_2	586	592	PF01217	0.522
TRG_ENDOCYTIC_2	291	294	PF00928	0.624
TRG_ENDOCYTIC_2	466	469	PF00928	0.494
TRG_ENDOCYTIC_2	514	517	PF00928	0.466
TRG_ENDOCYTIC_2	561	564	PF00928	0.734
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HGM5	Leishmania braziliensis	68%	98%
A4I3P9	Leishmania infantum	99%	100%
E9AZZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%