Zinc transporter 3, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc transporter 3, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X1N7_LEIDO

TriTrypDb:

LdBPK_282050.1 , LdCL_280025600 , LDHU3_28.2710

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 33
NetGPI	no	yes: 0, no: 33

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	34
GO:0110165	cellular anatomical entity	1	34
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	4

Expansion

Sequence features

A0A3S7X1N7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1N7

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	4
GO:0006810	transport	3	4
GO:0006811	monoatomic ion transport	4	4
GO:0006812	monoatomic cation transport	5	4
GO:0006829	zinc ion transport	8	4
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006875	obsolete intracellular metal ion homeostasis	6	1
GO:0006882	intracellular zinc ion homeostasis	7	1
GO:0009987	cellular process	1	4
GO:0019725	cellular homeostasis	2	1
GO:0030001	metal ion transport	6	4
GO:0030003	intracellular monoatomic cation homeostasis	5	1
GO:0034220	monoatomic ion transmembrane transport	3	4
GO:0042592	homeostatic process	3	1
GO:0046916	obsolete intracellular transition metal ion homeostasis	7	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0051179	localization	1	4
GO:0051234	establishment of localization	2	4
GO:0055065	obsolete metal ion homeostasis	7	1
GO:0055069	obsolete zinc ion homeostasis	8	1
GO:0055076	obsolete transition metal ion homeostasis	8	1
GO:0055080	monoatomic cation homeostasis	6	1
GO:0055082	intracellular chemical homeostasis	3	1
GO:0055085	transmembrane transport	2	4
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071577	zinc ion transmembrane transport	6	4
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	1
GO:0072507	obsolete divalent inorganic cation homeostasis	7	1
GO:0098655	monoatomic cation transmembrane transport	4	4
GO:0098660	inorganic ion transmembrane transport	4	4
GO:0098662	inorganic cation transmembrane transport	5	4
GO:0098771	inorganic ion homeostasis	6	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	34
GO:0008324	monoatomic cation transmembrane transporter activity	4	34
GO:0015075	monoatomic ion transmembrane transporter activity	3	34
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	34
GO:0022857	transmembrane transporter activity	2	34
GO:0022890	inorganic cation transmembrane transporter activity	4	34
GO:0046873	metal ion transmembrane transporter activity	5	34
GO:0005385	zinc ion transmembrane transporter activity	7	4
GO:0046915	transition metal ion transmembrane transporter activity	6	4
GO:0005381	iron ion transmembrane transporter activity	7	1
GO:0015093	ferrous iron transmembrane transporter activity	8	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	55	59	PF00656	0.617
CLV_C14_Caspase3-7	79	83	PF00656	0.670
CLV_C14_Caspase3-7	91	95	PF00656	0.622
CLV_NRD_NRD_1	245	247	PF00675	0.411
CLV_PCSK_KEX2_1	139	141	PF00082	0.351
CLV_PCSK_KEX2_1	442	444	PF00082	0.289
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.351
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.322
CLV_PCSK_SKI1_1	389	393	PF00082	0.622
DOC_CYCLIN_yCln2_LP_2	372	378	PF00134	0.383
DOC_MAPK_gen_1	139	146	PF00069	0.637
DOC_MAPK_gen_1	24	31	PF00069	0.441
DOC_MAPK_MEF2A_6	139	146	PF00069	0.486
DOC_MAPK_MEF2A_6	332	340	PF00069	0.333
DOC_MAPK_MEF2A_6	359	368	PF00069	0.615
DOC_MAPK_NFAT4_5	359	367	PF00069	0.551
DOC_PP2B_LxvP_1	372	375	PF13499	0.452
DOC_USP7_MATH_1	34	38	PF00917	0.487
DOC_USP7_MATH_1	354	358	PF00917	0.569
DOC_USP7_MATH_1	398	402	PF00917	0.338
DOC_USP7_MATH_2	28	34	PF00917	0.466
DOC_WW_Pin1_4	42	47	PF00397	0.440
LIG_14-3-3_CanoR_1	61	67	PF00244	0.701
LIG_BIR_II_1	1	5	PF00653	0.455
LIG_BIR_III_1	1	5	PF00653	0.455
LIG_BIR_III_3	1	5	PF00653	0.455
LIG_BRCT_BRCA1_1	174	178	PF00533	0.282
LIG_Clathr_ClatBox_1	419	423	PF01394	0.501
LIG_deltaCOP1_diTrp_1	192	198	PF00928	0.285
LIG_eIF4E_1	414	420	PF01652	0.391
LIG_FHA_1	157	163	PF00498	0.434
LIG_FHA_1	380	386	PF00498	0.352
LIG_FHA_1	394	400	PF00498	0.319
LIG_FHA_2	53	59	PF00498	0.493
LIG_GBD_Chelix_1	302	310	PF00786	0.259
LIG_GBD_Chelix_1	364	372	PF00786	0.374
LIG_LIR_Gen_1	192	202	PF02991	0.280
LIG_LIR_Gen_1	395	404	PF02991	0.402
LIG_LIR_Nem_3	192	197	PF02991	0.340
LIG_LIR_Nem_3	316	321	PF02991	0.423
LIG_LIR_Nem_3	395	400	PF02991	0.428
LIG_PDZ_Wminus1_1	462	464	PF00595	0.418
LIG_Pex14_1	194	198	PF04695	0.532
LIG_Pex14_2	31	35	PF04695	0.443
LIG_Pex14_2	340	344	PF04695	0.451
LIG_Pex14_2	417	421	PF04695	0.439
LIG_PTB_Apo_2	237	244	PF02174	0.459
LIG_SH2_CRK	397	401	PF00017	0.285
LIG_SH2_NCK_1	397	401	PF00017	0.285
LIG_SH2_SRC	149	152	PF00017	0.587
LIG_SH2_SRC	66	69	PF00017	0.495
LIG_SH2_STAT5	149	152	PF00017	0.568
LIG_SH2_STAT5	414	417	PF00017	0.368
LIG_SH3_1	227	233	PF00018	0.482
LIG_SH3_3	227	233	PF00018	0.586
LIG_SH3_3	270	276	PF00018	0.539
LIG_SH3_3	287	293	PF00018	0.641
LIG_SUMO_SIM_anti_2	363	368	PF11976	0.515
LIG_SxIP_EBH_1	127	140	PF03271	0.408
LIG_TYR_ITSM	393	400	PF00017	0.285
LIG_UBA3_1	133	139	PF00899	0.310
MOD_CK1_1	393	399	PF00069	0.380
MOD_CK1_1	76	82	PF00069	0.634
MOD_CK1_1	88	94	PF00069	0.607
MOD_CK2_1	183	189	PF00069	0.302
MOD_CK2_1	62	68	PF00069	0.691
MOD_Cter_Amidation	137	140	PF01082	0.397
MOD_GlcNHglycan	32	35	PF01048	0.790
MOD_GlcNHglycan	36	39	PF01048	0.776
MOD_GlcNHglycan	372	375	PF01048	0.436
MOD_GlcNHglycan	392	395	PF01048	0.542
MOD_GlcNHglycan	400	403	PF01048	0.383
MOD_GlcNHglycan	68	71	PF01048	0.865
MOD_GlcNHglycan	78	81	PF01048	0.825
MOD_GlcNHglycan	90	93	PF01048	0.856
MOD_GSK3_1	125	132	PF00069	0.368
MOD_GSK3_1	30	37	PF00069	0.507
MOD_GSK3_1	354	361	PF00069	0.594
MOD_GSK3_1	38	45	PF00069	0.534
MOD_GSK3_1	381	388	PF00069	0.394
MOD_GSK3_1	62	69	PF00069	0.677
MOD_N-GLC_2	240	242	PF02516	0.282
MOD_NEK2_1	125	130	PF00069	0.398
MOD_NEK2_1	310	315	PF00069	0.410
MOD_NEK2_1	323	328	PF00069	0.355
MOD_NEK2_1	368	373	PF00069	0.410
MOD_NEK2_1	392	397	PF00069	0.359
MOD_NEK2_2	354	359	PF00069	0.515
MOD_PKA_2	218	224	PF00069	0.588
MOD_PKA_2	62	68	PF00069	0.691
MOD_Plk_1	354	360	PF00069	0.494
MOD_Plk_4	125	131	PF00069	0.390
MOD_Plk_4	172	178	PF00069	0.299
MOD_Plk_4	313	319	PF00069	0.402
MOD_Plk_4	381	387	PF00069	0.420
MOD_ProDKin_1	42	48	PF00069	0.442
TRG_DiLeu_BaEn_2	191	197	PF01217	0.324
TRG_ENDOCYTIC_2	397	400	PF00928	0.380
TRG_ENDOCYTIC_2	414	417	PF00928	0.377
TRG_ENDOCYTIC_2	447	450	PF00928	0.450
TRG_ER_diArg_1	61	64	PF00400	0.523
TRG_Pf-PMV_PEXEL_1	10	15	PF00026	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCU5	Leptomonas seymouri	40%	100%
A0A1X0NR51	Trypanosomatidae	46%	100%
A0A1X0NSB9	Trypanosomatidae	37%	100%
A0A1X0NSI7	Trypanosomatidae	38%	100%
A0A3R7LZX6	Trypanosoma rangeli	41%	100%
A0A3S7X501	Leishmania donovani	40%	100%
A0A3S7X7B0	Leishmania donovani	35%	100%
A0A422MUI2	Trypanosoma rangeli	37%	100%
A4HGP7	Leishmania braziliensis	80%	100%
A4HJU9	Leishmania braziliensis	41%	100%
A4HJV0	Leishmania braziliensis	41%	100%
A4HJV1	Leishmania braziliensis	36%	99%
A4HM27	Leishmania braziliensis	33%	94%
A4I3R9	Leishmania infantum	99%	100%
A4I7B1	Leishmania infantum	41%	100%
A4I9G1	Leishmania infantum	35%	92%
D0A885	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
D0A886	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A887	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A888	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A889	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B012	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	97%
E9B2A5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9B2A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9B4F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	93%
O04089	Arabidopsis thaliana	27%	100%
O23039	Arabidopsis thaliana	29%	100%
O64738	Arabidopsis thaliana	26%	100%
O81123	Arabidopsis thaliana	24%	100%
O81850	Arabidopsis thaliana	25%	100%
O82643	Arabidopsis thaliana	27%	100%
O94639	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
P32804	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
Q38856	Arabidopsis thaliana	24%	100%
Q4Q3L6	Leishmania major	33%	92%
Q4Q5V0	Leishmania major	39%	100%
Q4Q5V1	Leishmania major	39%	100%
Q4Q873	Leishmania major	84%	96%
Q6L8G0	Oryza sativa subsp. japonica	28%	100%
Q6L8G1	Oryza sativa subsp. japonica	28%	100%
Q75HB1	Oryza sativa subsp. japonica	29%	100%
Q7XLD4	Oryza sativa subsp. japonica	26%	100%
Q8S3W4	Arabidopsis thaliana	22%	100%
Q8W245	Arabidopsis thaliana	21%	100%
Q8W246	Arabidopsis thaliana	28%	100%
Q9FIS2	Arabidopsis thaliana	26%	100%
Q9SLG3	Arabidopsis thaliana	29%	100%
V5AWN3	Trypanosoma cruzi	38%	100%
V5BC34	Trypanosoma cruzi	36%	100%
V5DCU2	Trypanosoma cruzi	44%	100%