Double-stranded_DNA-binding_domain_containing_pro tein_putative/Pfam:PF01984

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Double-stranded DNA-binding domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X1M4_LEIDO

TriTrypDb:

LdBPK_282040.1 , LdCL_280025500 , LDHU3_28.2690

Length:

113

Annotations

Annotations by Jardim et al.

Nucleic acid binding, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7X1M4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1M4

PDB structure(s): 6vmt_A

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.201
CLV_PCSK_FUR_1	47	51	PF00082	0.280
CLV_PCSK_KEX2_1	107	109	PF00082	0.443
CLV_PCSK_KEX2_1	49	51	PF00082	0.280
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.443
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.280
CLV_PCSK_PC7_1	45	51	PF00082	0.280
CLV_PCSK_SKI1_1	85	89	PF00082	0.201
DEG_APCC_DBOX_1	44	52	PF00400	0.201
DEG_APCC_DBOX_1	84	92	PF00400	0.201
DEG_APCC_KENBOX_2	31	35	PF00400	0.332
DOC_PP4_MxPP_1	75	78	PF00568	0.332
DOC_USP7_MATH_1	38	42	PF00917	0.233
LIG_14-3-3_CanoR_1	106	113	PF00244	0.535
LIG_Actin_WH2_2	33	51	PF00022	0.280
LIG_BIR_II_1	1	5	PF00653	0.453
LIG_FHA_2	107	113	PF00498	0.552
LIG_FHA_2	81	87	PF00498	0.245
LIG_TRAF2_1	20	23	PF00917	0.209
LIG_TRAF2_1	27	30	PF00917	0.257
LIG_TRAF2_1	92	95	PF00917	0.332
MOD_CK1_1	100	106	PF00069	0.240
MOD_CK1_1	80	86	PF00069	0.221
MOD_CK2_1	80	86	PF00069	0.280
MOD_GlcNHglycan	40	43	PF01048	0.246
MOD_PIKK_1	97	103	PF00454	0.165
MOD_PKA_1	106	112	PF00069	0.532
MOD_Plk_1	80	86	PF00069	0.245
TRG_Pf-PMV_PEXEL_1	85	90	PF00026	0.219

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P828	Leptomonas seymouri	88%	100%
A0A0S4JF96	Bodo saltans	70%	99%
A0A1X0NQU5	Trypanosomatidae	61%	99%
A0A3S5ISD1	Trypanosoma rangeli	73%	100%
A4G031	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	37%	96%
A4HGP5	Leishmania braziliensis	92%	100%
A4I3R8	Leishmania infantum	100%	100%
A5UL35	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	33%	96%
A6URD8	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	33%	100%
A6UVQ4	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	38%	95%
A6VIE7	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	36%	95%
A9A8D7	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	37%	96%
C3MR75	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	31%	96%
C3MXG4	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	31%	96%
C3MZB0	Sulfolobus islandicus (strain M.16.27)	31%	96%
C3N7D0	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	31%	96%
C3NGA4	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	30%	96%
C4KII8	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	31%	96%
D0A890	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9B011	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O13929	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	86%
Q2NGR0	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	36%	96%
Q4J8U0	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	31%	100%
Q4Q874	Leishmania major	97%	100%
Q58103	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	38%	100%
Q6M0W1	Methanococcus maripaludis (strain S2 / LL)	38%	95%
Q980F8	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	31%	96%