Methyltransferase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative methyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X1M1_LEIDO

TriTrypDb:

LdBPK_281990.1 , LdCL_280024900 , LDHU3_28.2600

Length:

671

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X1M1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1M1

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	375	379	PF00656	0.732
CLV_C14_Caspase3-7	431	435	PF00656	0.429
CLV_NRD_NRD_1	75	77	PF00675	0.620
CLV_PCSK_KEX2_1	531	533	PF00082	0.408
CLV_PCSK_KEX2_1	74	76	PF00082	0.632
CLV_PCSK_PC1ET2_1	531	533	PF00082	0.408
CLV_PCSK_SKI1_1	226	230	PF00082	0.730
CLV_PCSK_SKI1_1	468	472	PF00082	0.369
CLV_PCSK_SKI1_1	665	669	PF00082	0.637
CLV_PCSK_SKI1_1	79	83	PF00082	0.488
DEG_Nend_UBRbox_2	1	3	PF02207	0.700
DEG_SCF_FBW7_1	143	149	PF00400	0.632
DEG_SCF_TRCP1_1	627	633	PF00400	0.569
DEG_SPOP_SBC_1	152	156	PF00917	0.629
DEG_SPOP_SBC_1	333	337	PF00917	0.651
DEG_SPOP_SBC_1	381	385	PF00917	0.627
DEG_SPOP_SBC_1	98	102	PF00917	0.601
DOC_CKS1_1	143	148	PF01111	0.704
DOC_CKS1_1	168	173	PF01111	0.765
DOC_CKS1_1	359	364	PF01111	0.725
DOC_CYCLIN_RxL_1	17	28	PF00134	0.478
DOC_MAPK_gen_1	529	537	PF00069	0.498
DOC_PP2B_LxvP_1	328	331	PF13499	0.548
DOC_PP2B_PxIxI_1	216	222	PF00149	0.625
DOC_PP4_FxxP_1	135	138	PF00568	0.490
DOC_USP7_MATH_1	138	142	PF00917	0.551
DOC_USP7_MATH_1	147	151	PF00917	0.635
DOC_USP7_MATH_1	152	156	PF00917	0.822
DOC_USP7_MATH_1	169	173	PF00917	0.667
DOC_USP7_MATH_1	183	187	PF00917	0.825
DOC_USP7_MATH_1	230	234	PF00917	0.791
DOC_USP7_MATH_1	333	337	PF00917	0.692
DOC_USP7_MATH_1	338	342	PF00917	0.723
DOC_USP7_MATH_1	367	371	PF00917	0.812
DOC_USP7_MATH_1	381	385	PF00917	0.628
DOC_USP7_MATH_1	48	52	PF00917	0.563
DOC_USP7_MATH_1	522	526	PF00917	0.729
DOC_USP7_MATH_1	98	102	PF00917	0.613
DOC_WW_Pin1_4	142	147	PF00397	0.673
DOC_WW_Pin1_4	153	158	PF00397	0.749
DOC_WW_Pin1_4	167	172	PF00397	0.620
DOC_WW_Pin1_4	179	184	PF00397	0.697
DOC_WW_Pin1_4	185	190	PF00397	0.851
DOC_WW_Pin1_4	208	213	PF00397	0.708
DOC_WW_Pin1_4	233	238	PF00397	0.825
DOC_WW_Pin1_4	242	247	PF00397	0.741
DOC_WW_Pin1_4	265	270	PF00397	0.765
DOC_WW_Pin1_4	340	345	PF00397	0.730
DOC_WW_Pin1_4	358	363	PF00397	0.680
DOC_WW_Pin1_4	389	394	PF00397	0.454
DOC_WW_Pin1_4	403	408	PF00397	0.388
DOC_WW_Pin1_4	460	465	PF00397	0.515
DOC_WW_Pin1_4	5	10	PF00397	0.540
LIG_14-3-3_CanoR_1	118	122	PF00244	0.541
LIG_14-3-3_CanoR_1	184	189	PF00244	0.773
LIG_14-3-3_CanoR_1	198	206	PF00244	0.599
LIG_14-3-3_CanoR_1	289	295	PF00244	0.626
LIG_14-3-3_CanoR_1	437	447	PF00244	0.299
LIG_14-3-3_CanoR_1	518	522	PF00244	0.450
LIG_Actin_WH2_2	649	667	PF00022	0.486
LIG_CtBP_PxDLS_1	362	366	PF00389	0.738
LIG_EH_1	136	140	PF12763	0.598
LIG_EH1_1	306	314	PF00400	0.458
LIG_FHA_1	143	149	PF00498	0.712
LIG_FHA_1	205	211	PF00498	0.757
LIG_FHA_1	30	36	PF00498	0.493
LIG_FHA_1	319	325	PF00498	0.496
LIG_FHA_1	461	467	PF00498	0.513
LIG_FHA_1	499	505	PF00498	0.430
LIG_FHA_1	508	514	PF00498	0.335
LIG_FHA_1	6	12	PF00498	0.671
LIG_FHA_1	649	655	PF00498	0.460
LIG_FHA_2	100	106	PF00498	0.623
LIG_FHA_2	633	639	PF00498	0.685
LIG_GBD_Chelix_1	507	515	PF00786	0.411
LIG_GSK3_LRP6_1	237	242	PF00069	0.752
LIG_IRF3_LxIS_1	568	575	PF10401	0.543
LIG_LIR_Apic_2	134	138	PF02991	0.486
LIG_LIR_Gen_1	114	122	PF02991	0.625
LIG_LIR_Gen_1	283	290	PF02991	0.500
LIG_LIR_Gen_1	293	302	PF02991	0.566
LIG_LIR_Gen_1	561	569	PF02991	0.477
LIG_LIR_Nem_3	114	119	PF02991	0.605
LIG_LIR_Nem_3	134	139	PF02991	0.497
LIG_LIR_Nem_3	283	288	PF02991	0.501
LIG_LIR_Nem_3	293	298	PF02991	0.557
LIG_LIR_Nem_3	555	559	PF02991	0.433
LIG_LIR_Nem_3	561	565	PF02991	0.379
LIG_NRP_CendR_1	668	671	PF00754	0.524
LIG_Pex14_1	303	307	PF04695	0.468
LIG_Pex14_2	135	139	PF04695	0.505
LIG_Pex14_2	14	18	PF04695	0.535
LIG_PTB_Apo_2	432	439	PF02174	0.411
LIG_SH2_CRK	562	566	PF00017	0.465
LIG_SH2_GRB2like	85	88	PF00017	0.482
LIG_SH2_SRC	409	412	PF00017	0.524
LIG_SH2_SRC	428	431	PF00017	0.213
LIG_SH2_SRC	85	88	PF00017	0.482
LIG_SH2_STAP1	499	503	PF00017	0.411
LIG_SH2_STAP1	650	654	PF00017	0.540
LIG_SH2_STAP1	93	97	PF00017	0.428
LIG_SH2_STAT5	409	412	PF00017	0.513
LIG_SH2_STAT5	523	526	PF00017	0.574
LIG_SH2_STAT5	650	653	PF00017	0.487
LIG_SH2_STAT5	85	88	PF00017	0.458
LIG_SH3_1	235	241	PF00018	0.748
LIG_SH3_3	140	146	PF00018	0.630
LIG_SH3_3	155	161	PF00018	0.691
LIG_SH3_3	224	230	PF00018	0.755
LIG_SH3_3	231	237	PF00018	0.768
LIG_SH3_3	255	261	PF00018	0.844
LIG_SH3_3	459	465	PF00018	0.436
LIG_SH3_3	60	66	PF00018	0.574
LIG_SUMO_SIM_anti_2	490	496	PF11976	0.407
LIG_SUMO_SIM_par_1	31	36	PF11976	0.490
LIG_SUMO_SIM_par_1	55	60	PF11976	0.416
LIG_TRAF2_1	88	91	PF00917	0.479
LIG_UBA3_1	309	318	PF00899	0.452
LIG_WRC_WIRS_1	11	16	PF05994	0.590
LIG_WRC_WIRS_1	132	137	PF05994	0.484
LIG_WRC_WIRS_1	420	425	PF05994	0.411
LIG_WRC_WIRS_1	553	558	PF05994	0.576
LIG_WW_3	71	75	PF00397	0.509
MOD_CDC14_SPxK_1	392	395	PF00782	0.299
MOD_CDK_SPK_2	179	184	PF00069	0.726
MOD_CDK_SPK_2	242	247	PF00069	0.793
MOD_CDK_SPxK_1	389	395	PF00069	0.299
MOD_CDK_SPxxK_3	237	244	PF00069	0.855
MOD_CK1_1	10	16	PF00069	0.695
MOD_CK1_1	100	106	PF00069	0.600
MOD_CK1_1	159	165	PF00069	0.804
MOD_CK1_1	196	202	PF00069	0.820
MOD_CK1_1	204	210	PF00069	0.732
MOD_CK1_1	233	239	PF00069	0.700
MOD_CK1_1	242	248	PF00069	0.619
MOD_CK1_1	340	346	PF00069	0.820
MOD_CK1_1	372	378	PF00069	0.784
MOD_CK1_1	380	386	PF00069	0.650
MOD_CK1_1	552	558	PF00069	0.500
MOD_CK1_1	617	623	PF00069	0.591
MOD_CK2_1	184	190	PF00069	0.592
MOD_CK2_1	199	205	PF00069	0.595
MOD_CK2_1	632	638	PF00069	0.692
MOD_CK2_1	85	91	PF00069	0.552
MOD_CK2_1	99	105	PF00069	0.515
MOD_GlcNHglycan	140	143	PF01048	0.559
MOD_GlcNHglycan	149	152	PF01048	0.684
MOD_GlcNHglycan	158	161	PF01048	0.603
MOD_GlcNHglycan	165	168	PF01048	0.599
MOD_GlcNHglycan	27	30	PF01048	0.536
MOD_GlcNHglycan	270	273	PF01048	0.683
MOD_GlcNHglycan	340	343	PF01048	0.733
MOD_GlcNHglycan	35	38	PF01048	0.532
MOD_GlcNHglycan	378	382	PF01048	0.685
MOD_GlcNHglycan	384	387	PF01048	0.615
MOD_GlcNHglycan	50	53	PF01048	0.365
MOD_GlcNHglycan	524	527	PF01048	0.623
MOD_GlcNHglycan	576	581	PF01048	0.515
MOD_GlcNHglycan	619	622	PF01048	0.676
MOD_GlcNHglycan	627	630	PF01048	0.684
MOD_GSK3_1	10	17	PF00069	0.607
MOD_GSK3_1	138	145	PF00069	0.601
MOD_GSK3_1	147	154	PF00069	0.744
MOD_GSK3_1	159	166	PF00069	0.721
MOD_GSK3_1	169	176	PF00069	0.760
MOD_GSK3_1	179	186	PF00069	0.744
MOD_GSK3_1	192	199	PF00069	0.611
MOD_GSK3_1	204	211	PF00069	0.638
MOD_GSK3_1	233	240	PF00069	0.749
MOD_GSK3_1	25	32	PF00069	0.445
MOD_GSK3_1	284	291	PF00069	0.538
MOD_GSK3_1	333	340	PF00069	0.775
MOD_GSK3_1	361	368	PF00069	0.748
MOD_GSK3_1	369	376	PF00069	0.669
MOD_GSK3_1	377	384	PF00069	0.662
MOD_GSK3_1	419	426	PF00069	0.411
MOD_GSK3_1	513	520	PF00069	0.429
MOD_GSK3_1	548	555	PF00069	0.588
MOD_GSK3_1	568	575	PF00069	0.290
MOD_GSK3_1	97	104	PF00069	0.590
MOD_N-GLC_1	338	343	PF02516	0.683
MOD_N-GLC_1	438	443	PF02516	0.299
MOD_N-GLC_1	630	635	PF02516	0.686
MOD_N-GLC_2	388	390	PF02516	0.548
MOD_NEK2_1	14	19	PF00069	0.527
MOD_NEK2_1	25	30	PF00069	0.404
MOD_NEK2_1	347	352	PF00069	0.726
MOD_NEK2_1	507	512	PF00069	0.372
MOD_NEK2_1	513	518	PF00069	0.341
MOD_NEK2_1	549	554	PF00069	0.500
MOD_NEK2_1	649	654	PF00069	0.535
MOD_NEK2_1	99	104	PF00069	0.587
MOD_NEK2_2	131	136	PF00069	0.590
MOD_NEK2_2	230	235	PF00069	0.795
MOD_NEK2_2	369	374	PF00069	0.679
MOD_PIKK_1	169	175	PF00454	0.773
MOD_PIKK_1	193	199	PF00454	0.773
MOD_PIKK_1	239	245	PF00454	0.684
MOD_PIKK_1	41	47	PF00454	0.455
MOD_PKA_2	117	123	PF00069	0.593
MOD_PKA_2	183	189	PF00069	0.772
MOD_PKA_2	288	294	PF00069	0.516
MOD_PKA_2	331	337	PF00069	0.768
MOD_PKA_2	373	379	PF00069	0.653
MOD_PKA_2	517	523	PF00069	0.465
MOD_PKA_2	572	578	PF00069	0.621
MOD_Plk_1	14	20	PF00069	0.525
MOD_Plk_1	489	495	PF00069	0.436
MOD_Plk_1	542	548	PF00069	0.515
MOD_Plk_4	117	123	PF00069	0.633
MOD_Plk_4	131	137	PF00069	0.353
MOD_Plk_4	29	35	PF00069	0.388
MOD_Plk_4	298	304	PF00069	0.549
MOD_Plk_4	419	425	PF00069	0.390
MOD_Plk_4	428	434	PF00069	0.411
MOD_Plk_4	489	495	PF00069	0.436
MOD_Plk_4	649	655	PF00069	0.515
MOD_ProDKin_1	142	148	PF00069	0.682
MOD_ProDKin_1	153	159	PF00069	0.748
MOD_ProDKin_1	167	173	PF00069	0.693
MOD_ProDKin_1	179	185	PF00069	0.724
MOD_ProDKin_1	208	214	PF00069	0.708
MOD_ProDKin_1	233	239	PF00069	0.826
MOD_ProDKin_1	242	248	PF00069	0.740
MOD_ProDKin_1	265	271	PF00069	0.761
MOD_ProDKin_1	340	346	PF00069	0.731
MOD_ProDKin_1	358	364	PF00069	0.680
MOD_ProDKin_1	389	395	PF00069	0.454
MOD_ProDKin_1	403	409	PF00069	0.388
MOD_ProDKin_1	460	466	PF00069	0.515
MOD_ProDKin_1	5	11	PF00069	0.535
MOD_SUMO_rev_2	223	228	PF00179	0.577
TRG_DiLeu_BaLyEn_6	343	348	PF01217	0.827
TRG_ENDOCYTIC_2	136	139	PF00928	0.597
TRG_ENDOCYTIC_2	562	565	PF00928	0.457
TRG_ENDOCYTIC_2	650	653	PF00928	0.487
TRG_ER_diArg_1	73	76	PF00400	0.518
TRG_NLS_MonoCore_2	528	533	PF00514	0.428
TRG_NLS_MonoExtN_4	529	534	PF00514	0.430
TRG_Pf-PMV_PEXEL_1	280	284	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I298	Leptomonas seymouri	48%	90%
A4HGP0	Leishmania braziliensis	69%	100%
A4I3R3	Leishmania infantum	99%	100%
E9B006	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4Q879	Leishmania major	87%	100%