NOL1/NOP2/sun family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NOL1/NOP2/sun family, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X1L9_LEIDO

TriTrypDb:

LdBPK_281860.1 , LdCL_280023600 , LDHU3_28.2460

Length:

588

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X1L9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1L9

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0032259	methylation	2	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000154	rRNA modification	6	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0031167	rRNA methylation	5	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1
GO:0070475	rRNA base methylation	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	86	90	PF00656	0.555
CLV_NRD_NRD_1	109	111	PF00675	0.551
CLV_NRD_NRD_1	139	141	PF00675	0.760
CLV_NRD_NRD_1	174	176	PF00675	0.484
CLV_NRD_NRD_1	179	181	PF00675	0.555
CLV_NRD_NRD_1	210	212	PF00675	0.685
CLV_NRD_NRD_1	26	28	PF00675	0.460
CLV_NRD_NRD_1	309	311	PF00675	0.602
CLV_NRD_NRD_1	428	430	PF00675	0.620
CLV_NRD_NRD_1	492	494	PF00675	0.253
CLV_PCSK_FUR_1	136	140	PF00082	0.719
CLV_PCSK_FUR_1	172	176	PF00082	0.464
CLV_PCSK_KEX2_1	138	140	PF00082	0.760
CLV_PCSK_KEX2_1	174	176	PF00082	0.472
CLV_PCSK_KEX2_1	181	183	PF00082	0.549
CLV_PCSK_KEX2_1	206	208	PF00082	0.705
CLV_PCSK_KEX2_1	210	212	PF00082	0.692
CLV_PCSK_KEX2_1	355	357	PF00082	0.264
CLV_PCSK_KEX2_1	428	430	PF00082	0.669
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.721
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.564
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.762
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.274
CLV_PCSK_SKI1_1	206	210	PF00082	0.731
CLV_PCSK_SKI1_1	284	288	PF00082	0.673
CLV_PCSK_SKI1_1	381	385	PF00082	0.270
CLV_PCSK_SKI1_1	493	497	PF00082	0.253
CLV_PCSK_SKI1_1	526	530	PF00082	0.253
CLV_PCSK_SKI1_1	93	97	PF00082	0.533
CLV_Separin_Metazoa	523	527	PF03568	0.539
DEG_APCC_DBOX_1	309	317	PF00400	0.426
DEG_Nend_UBRbox_2	1	3	PF02207	0.401
DOC_ANK_TNKS_1	138	145	PF00023	0.733
DOC_CYCLIN_RxL_1	19	29	PF00134	0.418
DOC_CYCLIN_RxL_1	487	499	PF00134	0.496
DOC_MAPK_gen_1	155	164	PF00069	0.380
DOC_MAPK_MEF2A_6	158	166	PF00069	0.411
DOC_PP2B_LxvP_1	151	154	PF13499	0.529
DOC_PP2B_LxvP_1	333	336	PF13499	0.450
DOC_PP2B_PxIxI_1	335	341	PF00149	0.530
DOC_USP7_MATH_1	145	149	PF00917	0.581
DOC_USP7_MATH_1	193	197	PF00917	0.760
DOC_USP7_MATH_1	246	250	PF00917	0.450
DOC_USP7_MATH_1	280	284	PF00917	0.716
DOC_USP7_MATH_1	391	395	PF00917	0.453
DOC_USP7_UBL2_3	28	32	PF12436	0.437
DOC_USP7_UBL2_3	284	288	PF12436	0.766
DOC_USP7_UBL2_3	550	554	PF12436	0.468
LIG_14-3-3_CanoR_1	158	163	PF00244	0.377
LIG_14-3-3_CanoR_1	210	215	PF00244	0.731
LIG_14-3-3_CanoR_1	257	265	PF00244	0.365
LIG_14-3-3_CanoR_1	356	361	PF00244	0.465
LIG_14-3-3_CanoR_1	381	389	PF00244	0.539
LIG_14-3-3_CanoR_1	428	434	PF00244	0.650
LIG_14-3-3_CanoR_1	93	102	PF00244	0.547
LIG_Actin_WH2_2	159	176	PF00022	0.442
LIG_BIR_III_2	268	272	PF00653	0.519
LIG_BRCT_BRCA1_1	369	373	PF00533	0.475
LIG_Clathr_ClatBox_1	500	504	PF01394	0.464
LIG_FHA_1	159	165	PF00498	0.411
LIG_FHA_1	325	331	PF00498	0.453
LIG_FHA_1	34	40	PF00498	0.404
LIG_FHA_1	382	388	PF00498	0.469
LIG_FHA_1	511	517	PF00498	0.454
LIG_FHA_2	341	347	PF00498	0.539
LIG_FHA_2	398	404	PF00498	0.464
LIG_FHA_2	84	90	PF00498	0.469
LIG_IRF3_LxIS_1	159	165	PF10401	0.488
LIG_LIR_Gen_1	36	44	PF02991	0.380
LIG_LIR_Gen_1	364	373	PF02991	0.465
LIG_LIR_Nem_3	104	109	PF02991	0.433
LIG_LIR_Nem_3	36	40	PF02991	0.384
LIG_LIR_Nem_3	364	368	PF02991	0.468
LIG_LIR_Nem_3	370	376	PF02991	0.414
LIG_LIR_Nem_3	58	63	PF02991	0.410
LIG_REV1ctd_RIR_1	57	63	PF16727	0.454
LIG_SH2_CRK	156	160	PF00017	0.362
LIG_SH2_CRK	37	41	PF00017	0.395
LIG_SH2_CRK	76	80	PF00017	0.377
LIG_SH2_GRB2like	365	368	PF00017	0.464
LIG_SH2_NCK_1	156	160	PF00017	0.362
LIG_SH2_PTP2	365	368	PF00017	0.478
LIG_SH2_SRC	365	368	PF00017	0.478
LIG_SH2_STAP1	76	80	PF00017	0.377
LIG_SH2_STAT3	62	65	PF00017	0.549
LIG_SH2_STAT5	101	104	PF00017	0.439
LIG_SH2_STAT5	315	318	PF00017	0.446
LIG_SH2_STAT5	365	368	PF00017	0.459
LIG_SH2_STAT5	580	583	PF00017	0.471
LIG_SH3_3	111	117	PF00018	0.532
LIG_SH3_3	213	219	PF00018	0.657
LIG_SH3_3	224	230	PF00018	0.428
LIG_SH3_3	231	237	PF00018	0.448
LIG_SUMO_SIM_par_1	270	276	PF11976	0.550
LIG_SUMO_SIM_par_1	51	58	PF11976	0.535
LIG_TRAF2_1	165	168	PF00917	0.501
LIG_TRAF2_1	449	452	PF00917	0.744
LIG_WRC_WIRS_1	500	505	PF05994	0.464
LIG_WW_3	115	119	PF00397	0.557
MOD_CK1_1	147	153	PF00069	0.648
MOD_CK1_1	183	189	PF00069	0.545
MOD_CK1_1	499	505	PF00069	0.485
MOD_CK1_1	512	518	PF00069	0.396
MOD_CK2_1	162	168	PF00069	0.419
MOD_CK2_1	476	482	PF00069	0.345
MOD_CK2_1	512	518	PF00069	0.478
MOD_Cter_Amidation	136	139	PF01082	0.719
MOD_GlcNHglycan	140	143	PF01048	0.719
MOD_GlcNHglycan	175	178	PF01048	0.551
MOD_GlcNHglycan	189	192	PF01048	0.616
MOD_GlcNHglycan	202	205	PF01048	0.554
MOD_GlcNHglycan	248	251	PF01048	0.444
MOD_GlcNHglycan	393	396	PF01048	0.269
MOD_GlcNHglycan	465	468	PF01048	0.755
MOD_GlcNHglycan	97	100	PF01048	0.470
MOD_GSK3_1	143	150	PF00069	0.660
MOD_GSK3_1	158	165	PF00069	0.482
MOD_GSK3_1	183	190	PF00069	0.672
MOD_GSK3_1	206	213	PF00069	0.744
MOD_GSK3_1	286	293	PF00069	0.790
MOD_GSK3_1	389	396	PF00069	0.444
MOD_GSK3_1	505	512	PF00069	0.454
MOD_GSK3_1	83	90	PF00069	0.467
MOD_GSK3_1	93	100	PF00069	0.432
MOD_N-GLC_1	17	22	PF02516	0.491
MOD_N-GLC_1	302	307	PF02516	0.717
MOD_N-GLC_1	324	329	PF02516	0.253
MOD_N-GLC_1	87	92	PF02516	0.575
MOD_NEK2_1	496	501	PF00069	0.511
MOD_NEK2_1	563	568	PF00069	0.453
MOD_PIKK_1	221	227	PF00454	0.574
MOD_PIKK_1	325	331	PF00454	0.478
MOD_PIKK_1	420	426	PF00454	0.584
MOD_PIKK_1	93	99	PF00454	0.522
MOD_PKA_1	138	144	PF00069	0.795
MOD_PKA_1	180	186	PF00069	0.556
MOD_PKA_1	206	212	PF00069	0.762
MOD_PKA_1	33	39	PF00069	0.410
MOD_PKA_1	428	434	PF00069	0.672
MOD_PKA_2	138	144	PF00069	0.737
MOD_PKA_2	173	179	PF00069	0.597
MOD_PKA_2	183	189	PF00069	0.688
MOD_PKA_2	206	212	PF00069	0.747
MOD_PKA_2	256	262	PF00069	0.366
MOD_PKA_2	428	434	PF00069	0.672
MOD_PKA_2	539	545	PF00069	0.548
MOD_PKB_1	458	466	PF00069	0.572
MOD_Plk_1	476	482	PF00069	0.376
MOD_Plk_4	496	502	PF00069	0.514
MOD_Plk_4	97	103	PF00069	0.506
MOD_SUMO_for_1	129	132	PF00179	0.568
MOD_SUMO_for_1	480	483	PF00179	0.530
TRG_ENDOCYTIC_2	106	109	PF00928	0.429
TRG_ENDOCYTIC_2	156	159	PF00928	0.365
TRG_ENDOCYTIC_2	365	368	PF00928	0.475
TRG_ENDOCYTIC_2	37	40	PF00928	0.394
TRG_ENDOCYTIC_2	47	50	PF00928	0.360
TRG_ENDOCYTIC_2	76	79	PF00928	0.369
TRG_ER_diArg_1	172	175	PF00400	0.458
TRG_ER_diArg_1	428	430	PF00400	0.647
TRG_NLS_MonoExtC_3	137	143	PF00514	0.715
TRG_NLS_MonoExtC_3	179	184	PF00514	0.638
TRG_NLS_MonoExtN_4	136	142	PF00514	0.715
TRG_NLS_MonoExtN_4	284	291	PF00514	0.698
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I291	Leptomonas seymouri	71%	100%
A0A0S4JC42	Bodo saltans	53%	100%
A0A1X0NQY2	Trypanosomatidae	58%	100%
A0A422NZ09	Trypanosoma rangeli	58%	100%
A4HGM7	Leishmania braziliensis	83%	99%
A4I3Q1	Leishmania infantum	98%	100%
D0A8B0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AZZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O14039	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q4Q892	Leishmania major	92%	100%
Q8GYE8	Arabidopsis thaliana	27%	100%
Q8K4F6	Mus musculus	27%	100%
Q9NAA7	Caenorhabditis elegans	23%	100%
V5BAN7	Trypanosoma cruzi	58%	100%