Kelch motif/Galactose oxidase, central domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Galactose oxidase, central domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X1L8_LEIDO

TriTrypDb:

LdBPK_281720.1 , LdCL_280022100 , LDHU3_28.2250

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X1L8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1L8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	349	353	PF00656	0.350
CLV_NRD_NRD_1	157	159	PF00675	0.506
CLV_NRD_NRD_1	41	43	PF00675	0.567
CLV_PCSK_KEX2_1	157	159	PF00082	0.506
CLV_PCSK_KEX2_1	41	43	PF00082	0.567
CLV_PCSK_SKI1_1	371	375	PF00082	0.507
CLV_PCSK_SKI1_1	396	400	PF00082	0.455
CLV_PCSK_SKI1_1	87	91	PF00082	0.464
DEG_APCC_DBOX_1	157	165	PF00400	0.490
DEG_MDM2_SWIB_1	275	283	PF02201	0.469
DEG_Nend_UBRbox_2	1	3	PF02207	0.486
DEG_SPOP_SBC_1	23	27	PF00917	0.541
DOC_CKS1_1	185	190	PF01111	0.363
DOC_CKS1_1	408	413	PF01111	0.570
DOC_CYCLIN_RxL_1	242	250	PF00134	0.485
DOC_MAPK_MEF2A_6	245	253	PF00069	0.421
DOC_PP2B_LxvP_1	21	24	PF13499	0.642
DOC_PP4_FxxP_1	253	256	PF00568	0.403
DOC_USP7_MATH_1	131	135	PF00917	0.653
DOC_USP7_MATH_1	234	238	PF00917	0.366
DOC_USP7_MATH_1	24	28	PF00917	0.702
DOC_USP7_MATH_1	376	380	PF00917	0.528
DOC_USP7_MATH_1	63	67	PF00917	0.476
DOC_WW_Pin1_4	121	126	PF00397	0.538
DOC_WW_Pin1_4	170	175	PF00397	0.532
DOC_WW_Pin1_4	184	189	PF00397	0.273
DOC_WW_Pin1_4	232	237	PF00397	0.385
DOC_WW_Pin1_4	238	243	PF00397	0.260
DOC_WW_Pin1_4	297	302	PF00397	0.706
DOC_WW_Pin1_4	371	376	PF00397	0.594
DOC_WW_Pin1_4	385	390	PF00397	0.420
DOC_WW_Pin1_4	407	412	PF00397	0.590
DOC_WW_Pin1_4	59	64	PF00397	0.639
DOC_WW_Pin1_4	79	84	PF00397	0.362
LIG_14-3-3_CanoR_1	157	162	PF00244	0.490
LIG_14-3-3_CanoR_1	245	250	PF00244	0.473
LIG_14-3-3_CanoR_1	273	281	PF00244	0.460
LIG_14-3-3_CanoR_1	329	337	PF00244	0.567
LIG_APCC_ABBA_1	164	169	PF00400	0.487
LIG_BIR_III_2	122	126	PF00653	0.644
LIG_BIR_III_2	171	175	PF00653	0.524
LIG_BRCT_BRCA1_1	249	253	PF00533	0.467
LIG_deltaCOP1_diTrp_1	277	281	PF00928	0.464
LIG_DLG_GKlike_1	245	252	PF00625	0.387
LIG_FHA_1	111	117	PF00498	0.493
LIG_FHA_1	255	261	PF00498	0.470
LIG_FHA_1	372	378	PF00498	0.548
LIG_FHA_1	386	392	PF00498	0.424
LIG_FHA_1	415	421	PF00498	0.524
LIG_FHA_1	51	57	PF00498	0.441
LIG_FHA_1	80	86	PF00498	0.505
LIG_FHA_2	185	191	PF00498	0.473
LIG_FHA_2	298	304	PF00498	0.734
LIG_LIR_Apic_2	250	256	PF02991	0.472
LIG_LIR_Gen_1	274	283	PF02991	0.464
LIG_LIR_Gen_1	285	296	PF02991	0.475
LIG_LIR_Gen_1	65	74	PF02991	0.443
LIG_LIR_Nem_3	257	262	PF02991	0.454
LIG_LIR_Nem_3	274	278	PF02991	0.334
LIG_LIR_Nem_3	285	291	PF02991	0.372
LIG_LIR_Nem_3	65	70	PF02991	0.435
LIG_LYPXL_S_1	50	54	PF13949	0.350
LIG_LYPXL_yS_3	51	54	PF13949	0.363
LIG_Pex14_2	275	279	PF04695	0.464
LIG_SH2_GRB2like	74	77	PF00017	0.563
LIG_SH2_STAP1	162	166	PF00017	0.480
LIG_SH2_STAT5	146	149	PF00017	0.429
LIG_SH2_STAT5	205	208	PF00017	0.380
LIG_SH2_STAT5	221	224	PF00017	0.228
LIG_SH2_STAT5	336	339	PF00017	0.477
LIG_SH2_STAT5	387	390	PF00017	0.430
LIG_SH3_3	17	23	PF00018	0.605
LIG_SH3_3	287	293	PF00018	0.528
LIG_SH3_3	311	317	PF00018	0.550
LIG_SH3_3	405	411	PF00018	0.653
LIG_SH3_3	46	52	PF00018	0.494
LIG_SH3_3	6	12	PF00018	0.500
LIG_SH3_3	94	100	PF00018	0.504
LIG_SH3_CIN85_PxpxPR_1	240	245	PF14604	0.362
LIG_SUMO_SIM_anti_2	248	253	PF11976	0.446
LIG_SUMO_SIM_anti_2	25	40	PF11976	0.627
LIG_SUMO_SIM_par_1	245	250	PF11976	0.484
LIG_SUMO_SIM_par_1	414	419	PF11976	0.513
LIG_SUMO_SIM_par_1	53	59	PF11976	0.574
LIG_TRAF2_1	301	304	PF00917	0.649
LIG_TRAF2_2	293	298	PF00917	0.583
LIG_WRC_WIRS_1	272	277	PF05994	0.490
MOD_CDK_SPK_2	59	64	PF00069	0.483
MOD_CDK_SPxxK_3	238	245	PF00069	0.433
MOD_CK1_1	132	138	PF00069	0.633
MOD_CK1_1	235	241	PF00069	0.366
MOD_CK1_1	419	425	PF00069	0.537
MOD_CK1_1	59	65	PF00069	0.624
MOD_CK1_1	75	81	PF00069	0.505
MOD_CK2_1	184	190	PF00069	0.544
MOD_CK2_1	22	28	PF00069	0.674
MOD_CK2_1	297	303	PF00069	0.732
MOD_CK2_1	59	65	PF00069	0.530
MOD_GlcNHglycan	116	119	PF01048	0.635
MOD_GlcNHglycan	131	134	PF01048	0.684
MOD_GlcNHglycan	332	335	PF01048	0.592
MOD_GlcNHglycan	378	381	PF01048	0.676
MOD_GlcNHglycan	411	414	PF01048	0.524
MOD_GlcNHglycan	421	424	PF01048	0.474
MOD_GlcNHglycan	46	49	PF01048	0.516
MOD_GlcNHglycan	57	61	PF01048	0.549
MOD_GlcNHglycan	79	82	PF01048	0.554
MOD_GSK3_1	110	117	PF00069	0.541
MOD_GSK3_1	129	136	PF00069	0.532
MOD_GSK3_1	210	217	PF00069	0.448
MOD_GSK3_1	234	241	PF00069	0.394
MOD_GSK3_1	282	289	PF00069	0.475
MOD_GSK3_1	328	335	PF00069	0.574
MOD_GSK3_1	387	394	PF00069	0.455
MOD_GSK3_1	59	66	PF00069	0.578
MOD_GSK3_1	75	82	PF00069	0.446
MOD_N-GLC_1	345	350	PF02516	0.546
MOD_N-GLC_1	75	80	PF02516	0.545
MOD_NEK2_1	247	252	PF00069	0.405
MOD_NEK2_1	330	335	PF00069	0.493
MOD_NEK2_1	414	419	PF00069	0.516
MOD_PIKK_1	210	216	PF00454	0.430
MOD_PKA_1	157	163	PF00069	0.463
MOD_PKA_2	157	163	PF00069	0.487
MOD_PKA_2	328	334	PF00069	0.586
MOD_PKA_2	63	69	PF00069	0.523
MOD_Plk_2-3	271	277	PF00069	0.392
MOD_Plk_4	111	117	PF00069	0.547
MOD_Plk_4	157	163	PF00069	0.487
MOD_Plk_4	247	253	PF00069	0.413
MOD_Plk_4	255	261	PF00069	0.472
MOD_Plk_4	332	338	PF00069	0.532
MOD_Plk_4	387	393	PF00069	0.461
MOD_Plk_4	63	69	PF00069	0.558
MOD_ProDKin_1	121	127	PF00069	0.539
MOD_ProDKin_1	170	176	PF00069	0.532
MOD_ProDKin_1	184	190	PF00069	0.277
MOD_ProDKin_1	232	238	PF00069	0.385
MOD_ProDKin_1	297	303	PF00069	0.710
MOD_ProDKin_1	371	377	PF00069	0.596
MOD_ProDKin_1	385	391	PF00069	0.413
MOD_ProDKin_1	407	413	PF00069	0.577
MOD_ProDKin_1	59	65	PF00069	0.624
MOD_ProDKin_1	79	85	PF00069	0.359
TRG_DiLeu_BaEn_1	395	400	PF01217	0.512
TRG_DiLeu_BaEn_1	65	70	PF01217	0.439
TRG_DiLeu_BaLyEn_6	242	247	PF01217	0.306
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.503
TRG_ENDOCYTIC_2	51	54	PF00928	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P824	Leptomonas seymouri	52%	100%
A0A1X0NSF3	Trypanosomatidae	35%	100%
A0A3R7MSX4	Trypanosoma rangeli	39%	100%
A4HGL2	Leishmania braziliensis	84%	100%
A4I3N8	Leishmania infantum	99%	100%
D0A8C6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AZX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q8A6	Leishmania major	94%	100%
V5AVA5	Trypanosoma cruzi	37%	100%