Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X1L5_LEIDO

TriTrypDb:

LdBPK_281870.1 , LdCL_280023700 , LDHU3_28.2470

Length:

940

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X1L5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1L5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	206	210	PF00656	0.634
CLV_C14_Caspase3-7	291	295	PF00656	0.691
CLV_C14_Caspase3-7	381	385	PF00656	0.621
CLV_C14_Caspase3-7	402	406	PF00656	0.714
CLV_C14_Caspase3-7	848	852	PF00656	0.573
CLV_NRD_NRD_1	149	151	PF00675	0.664
CLV_NRD_NRD_1	214	216	PF00675	0.691
CLV_NRD_NRD_1	284	286	PF00675	0.651
CLV_NRD_NRD_1	30	32	PF00675	0.559
CLV_NRD_NRD_1	536	538	PF00675	0.597
CLV_NRD_NRD_1	564	566	PF00675	0.612
CLV_NRD_NRD_1	609	611	PF00675	0.640
CLV_NRD_NRD_1	741	743	PF00675	0.451
CLV_NRD_NRD_1	763	765	PF00675	0.541
CLV_NRD_NRD_1	85	87	PF00675	0.624
CLV_NRD_NRD_1	901	903	PF00675	0.611
CLV_NRD_NRD_1	914	916	PF00675	0.670
CLV_PCSK_KEX2_1	149	151	PF00082	0.664
CLV_PCSK_KEX2_1	214	216	PF00082	0.675
CLV_PCSK_KEX2_1	30	32	PF00082	0.559
CLV_PCSK_KEX2_1	523	525	PF00082	0.674
CLV_PCSK_KEX2_1	536	538	PF00082	0.621
CLV_PCSK_KEX2_1	600	602	PF00082	0.705
CLV_PCSK_KEX2_1	609	611	PF00082	0.632
CLV_PCSK_KEX2_1	741	743	PF00082	0.451
CLV_PCSK_KEX2_1	763	765	PF00082	0.541
CLV_PCSK_KEX2_1	819	821	PF00082	0.737
CLV_PCSK_KEX2_1	83	85	PF00082	0.640
CLV_PCSK_KEX2_1	901	903	PF00082	0.611
CLV_PCSK_KEX2_1	914	916	PF00082	0.670
CLV_PCSK_PC1ET2_1	523	525	PF00082	0.737
CLV_PCSK_PC1ET2_1	600	602	PF00082	0.676
CLV_PCSK_PC1ET2_1	819	821	PF00082	0.737
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.621
CLV_PCSK_SKI1_1	237	241	PF00082	0.803
CLV_PCSK_SKI1_1	249	253	PF00082	0.526
CLV_PCSK_SKI1_1	566	570	PF00082	0.622
CLV_PCSK_SKI1_1	600	604	PF00082	0.707
CLV_PCSK_SKI1_1	764	768	PF00082	0.469
DEG_APCC_DBOX_1	248	256	PF00400	0.677
DEG_SPOP_SBC_1	231	235	PF00917	0.662
DEG_SPOP_SBC_1	426	430	PF00917	0.673
DEG_SPOP_SBC_1	647	651	PF00917	0.660
DEG_SPOP_SBC_1	842	846	PF00917	0.610
DEG_SPOP_SBC_1	864	868	PF00917	0.672
DEG_SPOP_SBC_1	918	922	PF00917	0.748
DOC_CKS1_1	133	138	PF01111	0.574
DOC_CKS1_1	885	890	PF01111	0.586
DOC_CYCLIN_yClb3_PxF_3	884	890	PF00134	0.610
DOC_CYCLIN_yCln2_LP_2	192	198	PF00134	0.615
DOC_CYCLIN_yCln2_LP_2	474	480	PF00134	0.532
DOC_CYCLIN_yCln2_LP_2	550	556	PF00134	0.618
DOC_PP2B_LxvP_1	587	590	PF13499	0.777
DOC_PP2B_PxIxI_1	500	506	PF00149	0.610
DOC_SPAK_OSR1_1	822	826	PF12202	0.511
DOC_USP7_MATH_1	231	235	PF00917	0.611
DOC_USP7_MATH_1	281	285	PF00917	0.671
DOC_USP7_MATH_1	298	302	PF00917	0.681
DOC_USP7_MATH_1	334	338	PF00917	0.529
DOC_USP7_MATH_1	398	402	PF00917	0.664
DOC_USP7_MATH_1	427	431	PF00917	0.682
DOC_USP7_MATH_1	450	454	PF00917	0.533
DOC_USP7_MATH_1	515	519	PF00917	0.737
DOC_USP7_MATH_1	535	539	PF00917	0.501
DOC_USP7_MATH_1	546	550	PF00917	0.600
DOC_USP7_MATH_1	593	597	PF00917	0.692
DOC_USP7_MATH_1	647	651	PF00917	0.604
DOC_USP7_MATH_1	662	666	PF00917	0.706
DOC_USP7_MATH_1	687	691	PF00917	0.701
DOC_USP7_MATH_1	709	713	PF00917	0.500
DOC_USP7_MATH_1	71	75	PF00917	0.615
DOC_USP7_MATH_1	842	846	PF00917	0.619
DOC_USP7_MATH_1	865	869	PF00917	0.772
DOC_WW_Pin1_4	132	137	PF00397	0.591
DOC_WW_Pin1_4	191	196	PF00397	0.592
DOC_WW_Pin1_4	428	433	PF00397	0.773
DOC_WW_Pin1_4	46	51	PF00397	0.583
DOC_WW_Pin1_4	531	536	PF00397	0.705
DOC_WW_Pin1_4	566	571	PF00397	0.688
DOC_WW_Pin1_4	57	62	PF00397	0.644
DOC_WW_Pin1_4	674	679	PF00397	0.754
DOC_WW_Pin1_4	877	882	PF00397	0.629
DOC_WW_Pin1_4	884	889	PF00397	0.616
DOC_WW_Pin1_4	919	924	PF00397	0.685
LIG_14-3-3_CanoR_1	237	246	PF00244	0.624
LIG_14-3-3_CanoR_1	313	318	PF00244	0.583
LIG_14-3-3_CanoR_1	329	334	PF00244	0.445
LIG_14-3-3_CanoR_1	441	446	PF00244	0.628
LIG_14-3-3_CanoR_1	524	528	PF00244	0.697
LIG_14-3-3_CanoR_1	536	542	PF00244	0.609
LIG_14-3-3_CanoR_1	565	573	PF00244	0.552
LIG_14-3-3_CanoR_1	601	608	PF00244	0.787
LIG_14-3-3_CanoR_1	641	647	PF00244	0.646
LIG_14-3-3_CanoR_1	805	815	PF00244	0.740
LIG_14-3-3_CanoR_1	820	826	PF00244	0.499
LIG_14-3-3_CanoR_1	84	90	PF00244	0.681
LIG_14-3-3_CanoR_1	917	923	PF00244	0.702
LIG_BIR_III_2	514	518	PF00653	0.669
LIG_BIR_III_2	532	536	PF00653	0.526
LIG_BIR_III_4	323	327	PF00653	0.482
LIG_BRCT_BRCA1_1	642	646	PF00533	0.508
LIG_BRCT_BRCA1_1	714	718	PF00533	0.430
LIG_CaM_NSCaTE_8	509	516	PF13499	0.585
LIG_DLG_GKlike_1	441	448	PF00625	0.601
LIG_FHA_1	102	108	PF00498	0.702
LIG_FHA_1	150	156	PF00498	0.499
LIG_FHA_1	254	260	PF00498	0.749
LIG_FHA_1	307	313	PF00498	0.591
LIG_FHA_1	392	398	PF00498	0.780
LIG_FHA_1	61	67	PF00498	0.679
LIG_FHA_1	781	787	PF00498	0.485
LIG_FHA_2	133	139	PF00498	0.625
LIG_FHA_2	343	349	PF00498	0.574
LIG_FHA_2	379	385	PF00498	0.604
LIG_FHA_2	409	415	PF00498	0.699
LIG_FHA_2	450	456	PF00498	0.608
LIG_FHA_2	612	618	PF00498	0.652
LIG_FHA_2	732	738	PF00498	0.532
LIG_GBD_Chelix_1	831	839	PF00786	0.613
LIG_GBD_Chelix_1	89	97	PF00786	0.569
LIG_Integrin_RGD_1	403	405	PF01839	0.588
LIG_LIR_Gen_1	165	175	PF02991	0.535
LIG_LIR_Gen_1	369	376	PF02991	0.685
LIG_LIR_Gen_1	4	15	PF02991	0.727
LIG_LIR_Gen_1	628	637	PF02991	0.525
LIG_LIR_Gen_1	711	722	PF02991	0.425
LIG_LIR_Nem_3	165	170	PF02991	0.543
LIG_LIR_Nem_3	21	25	PF02991	0.586
LIG_LIR_Nem_3	26	32	PF02991	0.551
LIG_LIR_Nem_3	369	375	PF02991	0.563
LIG_LIR_Nem_3	4	10	PF02991	0.575
LIG_LIR_Nem_3	628	632	PF02991	0.517
LIG_LIR_Nem_3	635	640	PF02991	0.517
LIG_LIR_Nem_3	711	717	PF02991	0.429
LIG_Pex14_1	936	940	PF04695	0.581
LIG_Pex14_2	892	896	PF04695	0.654
LIG_SH2_CRK	25	29	PF00017	0.559
LIG_SH2_CRK	637	641	PF00017	0.513
LIG_SH2_CRK	714	718	PF00017	0.430
LIG_SH2_NCK_1	714	718	PF00017	0.430
LIG_SH2_PTP2	167	170	PF00017	0.472
LIG_SH2_STAP1	25	29	PF00017	0.588
LIG_SH2_STAP1	714	718	PF00017	0.430
LIG_SH2_STAT5	144	147	PF00017	0.685
LIG_SH2_STAT5	167	170	PF00017	0.472
LIG_SH2_STAT5	22	25	PF00017	0.549
LIG_SH2_STAT5	43	46	PF00017	0.713
LIG_SH2_STAT5	629	632	PF00017	0.535
LIG_SH2_STAT5	639	642	PF00017	0.545
LIG_SH3_3	127	133	PF00018	0.660
LIG_SH3_3	266	272	PF00018	0.670
LIG_SH3_3	301	307	PF00018	0.730
LIG_SH3_3	335	341	PF00018	0.557
LIG_SH3_3	392	398	PF00018	0.699
LIG_SH3_3	613	619	PF00018	0.619
LIG_SH3_3	669	675	PF00018	0.782
LIG_SH3_3	878	884	PF00018	0.671
LIG_SH3_3	900	906	PF00018	0.712
LIG_Sin3_3	357	364	PF02671	0.613
LIG_SUMO_SIM_anti_2	455	461	PF11976	0.458
LIG_SUMO_SIM_par_1	173	179	PF11976	0.489
LIG_SUMO_SIM_par_1	393	399	PF11976	0.667
LIG_SUMO_SIM_par_1	482	487	PF11976	0.492
LIG_TRAF2_1	622	625	PF00917	0.504
LIG_TRAF2_1	678	681	PF00917	0.688
LIG_TRAF2_1	695	698	PF00917	0.659
LIG_TRAF2_1	96	99	PF00917	0.484
MOD_CDC14_SPxK_1	534	537	PF00782	0.673
MOD_CDK_SPK_2	531	536	PF00069	0.589
MOD_CDK_SPxK_1	531	537	PF00069	0.674
MOD_CDK_SPxxK_3	884	891	PF00069	0.585
MOD_CK1_1	222	228	PF00069	0.608
MOD_CK1_1	293	299	PF00069	0.771
MOD_CK1_1	368	374	PF00069	0.679
MOD_CK1_1	399	405	PF00069	0.748
MOD_CK1_1	418	424	PF00069	0.535
MOD_CK1_1	430	436	PF00069	0.637
MOD_CK1_1	596	602	PF00069	0.714
MOD_CK1_1	645	651	PF00069	0.657
MOD_CK1_1	676	682	PF00069	0.607
MOD_CK1_1	712	718	PF00069	0.419
MOD_CK1_1	808	814	PF00069	0.542
MOD_CK1_1	844	850	PF00069	0.738
MOD_CK1_1	877	883	PF00069	0.633
MOD_CK2_1	132	138	PF00069	0.591
MOD_CK2_1	171	177	PF00069	0.578
MOD_CK2_1	342	348	PF00069	0.579
MOD_CK2_1	408	414	PF00069	0.696
MOD_CK2_1	611	617	PF00069	0.672
MOD_CK2_1	692	698	PF00069	0.689
MOD_CK2_1	700	706	PF00069	0.620
MOD_CK2_1	731	737	PF00069	0.535
MOD_CK2_1	93	99	PF00069	0.585
MOD_GlcNHglycan	117	120	PF01048	0.710
MOD_GlcNHglycan	234	237	PF01048	0.584
MOD_GlcNHglycan	260	264	PF01048	0.645
MOD_GlcNHglycan	384	388	PF01048	0.720
MOD_GlcNHglycan	411	414	PF01048	0.716
MOD_GlcNHglycan	525	528	PF01048	0.720
MOD_GlcNHglycan	566	569	PF01048	0.682
MOD_GlcNHglycan	591	594	PF01048	0.696
MOD_GlcNHglycan	595	598	PF01048	0.664
MOD_GlcNHglycan	611	614	PF01048	0.646
MOD_GlcNHglycan	642	645	PF01048	0.671
MOD_GlcNHglycan	651	654	PF01048	0.646
MOD_GlcNHglycan	664	667	PF01048	0.702
MOD_GlcNHglycan	702	705	PF01048	0.598
MOD_GlcNHglycan	73	76	PF01048	0.648
MOD_GlcNHglycan	808	811	PF01048	0.602
MOD_GlcNHglycan	861	864	PF01048	0.677
MOD_GSK3_1	111	118	PF00069	0.694
MOD_GSK3_1	128	135	PF00069	0.581
MOD_GSK3_1	149	156	PF00069	0.514
MOD_GSK3_1	187	194	PF00069	0.626
MOD_GSK3_1	198	205	PF00069	0.698
MOD_GSK3_1	374	381	PF00069	0.644
MOD_GSK3_1	417	424	PF00069	0.693
MOD_GSK3_1	426	433	PF00069	0.639
MOD_GSK3_1	531	538	PF00069	0.718
MOD_GSK3_1	589	596	PF00069	0.693
MOD_GSK3_1	600	607	PF00069	0.615
MOD_GSK3_1	642	649	PF00069	0.627
MOD_GSK3_1	687	694	PF00069	0.796
MOD_GSK3_1	708	715	PF00069	0.475
MOD_GSK3_1	71	78	PF00069	0.692
MOD_GSK3_1	841	848	PF00069	0.661
MOD_GSK3_1	859	866	PF00069	0.582
MOD_GSK3_1	872	879	PF00069	0.641
MOD_GSK3_1	905	912	PF00069	0.698
MOD_GSK3_1	917	924	PF00069	0.639
MOD_N-GLC_1	153	158	PF02516	0.562
MOD_N-GLC_1	203	208	PF02516	0.678
MOD_N-GLC_1	409	414	PF02516	0.712
MOD_N-GLC_1	698	703	PF02516	0.586
MOD_NEK2_1	112	117	PF00069	0.520
MOD_NEK2_1	238	243	PF00069	0.711
MOD_NEK2_1	273	278	PF00069	0.676
MOD_NEK2_1	408	413	PF00069	0.734
MOD_NEK2_1	541	546	PF00069	0.636
MOD_NEK2_1	640	645	PF00069	0.545
MOD_NEK2_1	77	82	PF00069	0.573
MOD_NEK2_1	806	811	PF00069	0.548
MOD_NEK2_1	874	879	PF00069	0.706
MOD_NEK2_2	144	149	PF00069	0.679
MOD_NEK2_2	203	208	PF00069	0.626
MOD_NEK2_2	821	826	PF00069	0.539
MOD_NEK2_2	896	901	PF00069	0.688
MOD_NMyristoyl	1	7	PF02799	0.580
MOD_OFUCOSY	151	157	PF10250	0.564
MOD_PIKK_1	198	204	PF00454	0.663
MOD_PIKK_1	222	228	PF00454	0.631
MOD_PIKK_1	306	312	PF00454	0.579
MOD_PIKK_1	676	682	PF00454	0.574
MOD_PIKK_1	709	715	PF00454	0.542
MOD_PIKK_1	75	81	PF00454	0.723
MOD_PIKK_1	780	786	PF00454	0.492
MOD_PIKK_1	921	927	PF00454	0.703
MOD_PKA_1	149	155	PF00069	0.576
MOD_PKA_1	523	529	PF00069	0.731
MOD_PKA_1	600	606	PF00069	0.697
MOD_PKA_1	609	615	PF00069	0.631
MOD_PKA_1	85	91	PF00069	0.643
MOD_PKA_2	149	155	PF00069	0.522
MOD_PKA_2	222	228	PF00069	0.597
MOD_PKA_2	253	259	PF00069	0.599
MOD_PKA_2	399	405	PF00069	0.742
MOD_PKA_2	523	529	PF00069	0.751
MOD_PKA_2	535	541	PF00069	0.629
MOD_PKA_2	564	570	PF00069	0.547
MOD_PKA_2	600	606	PF00069	0.790
MOD_PKA_2	609	615	PF00069	0.640
MOD_PKA_2	640	646	PF00069	0.556
MOD_PKA_2	821	827	PF00069	0.514
MOD_PKA_2	85	91	PF00069	0.703
MOD_PKB_1	109	117	PF00069	0.510
MOD_PKB_1	915	923	PF00069	0.657
MOD_Plk_1	112	118	PF00069	0.519
MOD_Plk_1	203	209	PF00069	0.658
MOD_Plk_4	171	177	PF00069	0.479
MOD_Plk_4	187	193	PF00069	0.568
MOD_Plk_4	334	340	PF00069	0.502
MOD_Plk_4	371	377	PF00069	0.680
MOD_Plk_4	391	397	PF00069	0.500
MOD_Plk_4	441	447	PF00069	0.567
MOD_Plk_4	546	552	PF00069	0.647
MOD_Plk_4	611	617	PF00069	0.628
MOD_Plk_4	712	718	PF00069	0.447
MOD_Plk_4	731	737	PF00069	0.486
MOD_Plk_4	782	788	PF00069	0.468
MOD_Plk_4	85	91	PF00069	0.643
MOD_ProDKin_1	132	138	PF00069	0.591
MOD_ProDKin_1	191	197	PF00069	0.595
MOD_ProDKin_1	428	434	PF00069	0.773
MOD_ProDKin_1	46	52	PF00069	0.586
MOD_ProDKin_1	531	537	PF00069	0.707
MOD_ProDKin_1	566	572	PF00069	0.690
MOD_ProDKin_1	57	63	PF00069	0.646
MOD_ProDKin_1	674	680	PF00069	0.756
MOD_ProDKin_1	877	883	PF00069	0.627
MOD_ProDKin_1	884	890	PF00069	0.617
MOD_ProDKin_1	919	925	PF00069	0.686
TRG_DiLeu_BaEn_2	627	633	PF01217	0.517
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.634
TRG_DiLeu_BaLyEn_6	247	252	PF01217	0.617
TRG_DiLeu_BaLyEn_6	269	274	PF01217	0.597
TRG_ENDOCYTIC_2	167	170	PF00928	0.472
TRG_ENDOCYTIC_2	25	28	PF00928	0.563
TRG_ENDOCYTIC_2	29	32	PF00928	0.539
TRG_ENDOCYTIC_2	629	632	PF00928	0.535
TRG_ENDOCYTIC_2	637	640	PF00928	0.519
TRG_ENDOCYTIC_2	714	717	PF00928	0.431
TRG_ER_diArg_1	108	111	PF00400	0.554
TRG_ER_diArg_1	213	215	PF00400	0.796
TRG_ER_diArg_1	29	31	PF00400	0.544
TRG_ER_diArg_1	535	537	PF00400	0.587
TRG_ER_diArg_1	608	610	PF00400	0.646
TRG_ER_diArg_1	741	743	PF00400	0.451
TRG_ER_diArg_1	762	764	PF00400	0.559
TRG_ER_diArg_1	820	823	PF00400	0.673
TRG_ER_diArg_1	84	86	PF00400	0.616
TRG_ER_diArg_1	901	903	PF00400	0.611
TRG_ER_diArg_1	914	917	PF00400	0.671
TRG_NES_CRM1_1	310	323	PF08389	0.514
TRG_NLS_MonoCore_2	82	87	PF00514	0.611
TRG_NLS_MonoExtN_4	283	289	PF00514	0.708
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.663
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEZ4	Leptomonas seymouri	37%	100%
A4HGM8	Leishmania braziliensis	63%	98%
A4I3Q2	Leishmania infantum	99%	100%
E9AZZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	97%
Q4Q891	Leishmania major	88%	100%