Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum attachment zone protein 20

Species:

Leishmania donovani

UniProt:

A0A3S7X1L3_LEIDO

TriTrypDb:

LdBPK_281780.1 , LdCL_280022800 , LDHU3_28.2340

Length:

850

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3S7X1L3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1L3

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	836	840	PF00656	0.412
CLV_NRD_NRD_1	161	163	PF00675	0.422
CLV_NRD_NRD_1	2	4	PF00675	0.418
CLV_NRD_NRD_1	229	231	PF00675	0.438
CLV_NRD_NRD_1	31	33	PF00675	0.382
CLV_NRD_NRD_1	414	416	PF00675	0.529
CLV_NRD_NRD_1	472	474	PF00675	0.534
CLV_NRD_NRD_1	498	500	PF00675	0.482
CLV_NRD_NRD_1	510	512	PF00675	0.428
CLV_NRD_NRD_1	537	539	PF00675	0.506
CLV_NRD_NRD_1	56	58	PF00675	0.317
CLV_NRD_NRD_1	807	809	PF00675	0.366
CLV_PCSK_KEX2_1	229	231	PF00082	0.438
CLV_PCSK_KEX2_1	31	33	PF00082	0.382
CLV_PCSK_KEX2_1	414	416	PF00082	0.521
CLV_PCSK_KEX2_1	472	474	PF00082	0.546
CLV_PCSK_KEX2_1	509	511	PF00082	0.501
CLV_PCSK_KEX2_1	55	57	PF00082	0.332
CLV_PCSK_KEX2_1	805	807	PF00082	0.405
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.332
CLV_PCSK_PC1ET2_1	805	807	PF00082	0.405
CLV_PCSK_SKI1_1	131	135	PF00082	0.384
CLV_PCSK_SKI1_1	235	239	PF00082	0.435
CLV_PCSK_SKI1_1	4	8	PF00082	0.409
CLV_PCSK_SKI1_1	539	543	PF00082	0.486
CLV_PCSK_SKI1_1	634	638	PF00082	0.555
CLV_PCSK_SKI1_1	691	695	PF00082	0.507
CLV_PCSK_SKI1_1	740	744	PF00082	0.525
CLV_PCSK_SKI1_1	767	771	PF00082	0.432
CLV_PCSK_SKI1_1	808	812	PF00082	0.404
CLV_Separin_Metazoa	496	500	PF03568	0.679
DEG_APCC_DBOX_1	234	242	PF00400	0.630
DEG_APCC_DBOX_1	519	527	PF00400	0.694
DEG_APCC_DBOX_1	762	770	PF00400	0.611
DEG_Nend_Nbox_1	1	3	PF02207	0.616
DEG_SPOP_SBC_1	280	284	PF00917	0.743
DEG_SPOP_SBC_1	351	355	PF00917	0.732
DOC_CKS1_1	635	640	PF01111	0.756
DOC_CYCLIN_RxL_1	229	239	PF00134	0.601
DOC_CYCLIN_RxL_1	520	530	PF00134	0.678
DOC_CYCLIN_RxL_1	805	814	PF00134	0.607
DOC_CYCLIN_yCln2_LP_2	146	152	PF00134	0.574
DOC_MAPK_gen_1	162	171	PF00069	0.637
DOC_MAPK_gen_1	3	9	PF00069	0.614
DOC_MAPK_gen_1	55	64	PF00069	0.583
DOC_MAPK_gen_1	808	818	PF00069	0.574
DOC_MAPK_HePTP_8	159	171	PF00069	0.629
DOC_MAPK_MEF2A_6	162	171	PF00069	0.637
DOC_MAPK_RevD_3	148	163	PF00069	0.595
DOC_PP2B_LxvP_1	146	149	PF13499	0.573
DOC_PP2B_LxvP_1	150	153	PF13499	0.549
DOC_PP2B_LxvP_1	698	701	PF13499	0.754
DOC_USP7_MATH_1	185	189	PF00917	0.675
DOC_USP7_MATH_1	192	196	PF00917	0.678
DOC_USP7_MATH_1	228	232	PF00917	0.642
DOC_USP7_MATH_1	272	276	PF00917	0.696
DOC_USP7_MATH_1	289	293	PF00917	0.664
DOC_USP7_MATH_1	295	299	PF00917	0.729
DOC_USP7_MATH_1	306	310	PF00917	0.699
DOC_USP7_MATH_1	408	412	PF00917	0.737
DOC_USP7_MATH_1	644	648	PF00917	0.783
DOC_USP7_MATH_1	665	669	PF00917	0.747
DOC_USP7_MATH_1	710	714	PF00917	0.721
DOC_USP7_MATH_1	731	735	PF00917	0.754
DOC_USP7_MATH_1	742	746	PF00917	0.697
DOC_USP7_UBL2_3	805	809	PF12436	0.575
DOC_WW_Pin1_4	346	351	PF00397	0.745
DOC_WW_Pin1_4	356	361	PF00397	0.727
DOC_WW_Pin1_4	375	380	PF00397	0.643
DOC_WW_Pin1_4	383	388	PF00397	0.735
DOC_WW_Pin1_4	392	397	PF00397	0.672
DOC_WW_Pin1_4	426	431	PF00397	0.733
DOC_WW_Pin1_4	439	444	PF00397	0.691
DOC_WW_Pin1_4	465	470	PF00397	0.777
DOC_WW_Pin1_4	504	509	PF00397	0.740
DOC_WW_Pin1_4	617	622	PF00397	0.774
DOC_WW_Pin1_4	634	639	PF00397	0.680
DOC_WW_Pin1_4	645	650	PF00397	0.699
DOC_WW_Pin1_4	692	697	PF00397	0.782
DOC_WW_Pin1_4	719	724	PF00397	0.810
LIG_14-3-3_CanoR_1	373	379	PF00244	0.745
LIG_14-3-3_CanoR_1	457	464	PF00244	0.788
LIG_14-3-3_CanoR_1	551	558	PF00244	0.724
LIG_14-3-3_CanoR_1	691	696	PF00244	0.748
LIG_14-3-3_CanoR_1	763	767	PF00244	0.610
LIG_Actin_WH2_2	483	501	PF00022	0.682
LIG_Actin_WH2_2	823	840	PF00022	0.498
LIG_APCC_ABBA_1	47	52	PF00400	0.591
LIG_EVH1_1	698	702	PF00568	0.735
LIG_EVH1_2	575	579	PF00568	0.760
LIG_FHA_1	13	19	PF00498	0.587
LIG_FHA_1	139	145	PF00498	0.601
LIG_FHA_1	393	399	PF00498	0.811
LIG_FHA_1	458	464	PF00498	0.734
LIG_FHA_1	482	488	PF00498	0.728
LIG_FHA_1	64	70	PF00498	0.583
LIG_FHA_1	85	91	PF00498	0.617
LIG_FHA_2	203	209	PF00498	0.593
LIG_FHA_2	357	363	PF00498	0.744
LIG_FHA_2	594	600	PF00498	0.758
LIG_FHA_2	777	783	PF00498	0.608
LIG_FHA_2	834	840	PF00498	0.404
LIG_FHA_2	86	92	PF00498	0.593
LIG_IRF3_LxIS_1	783	788	PF10401	0.586
LIG_LIR_Gen_1	418	428	PF02991	0.686
LIG_LIR_Gen_1	71	81	PF02991	0.579
LIG_LIR_Nem_3	418	423	PF02991	0.683
LIG_LIR_Nem_3	578	582	PF02991	0.739
LIG_LIR_Nem_3	71	76	PF02991	0.580
LIG_MYND_1	696	700	PF01753	0.760
LIG_NRBOX	765	771	PF00104	0.623
LIG_NRBOX	806	812	PF00104	0.601
LIG_PCNA_PIPBox_1	534	543	PF02747	0.684
LIG_PTB_Apo_2	118	125	PF02174	0.585
LIG_SH2_CRK	156	160	PF00017	0.604
LIG_SH2_STAP1	656	660	PF00017	0.737
LIG_SH2_STAT3	155	158	PF00017	0.604
LIG_SH3_1	697	703	PF00018	0.721
LIG_SH3_3	145	151	PF00018	0.571
LIG_SH3_3	268	274	PF00018	0.656
LIG_SH3_3	358	364	PF00018	0.753
LIG_SH3_3	384	390	PF00018	0.777
LIG_SH3_3	570	576	PF00018	0.751
LIG_SH3_3	595	601	PF00018	0.696
LIG_SH3_3	620	626	PF00018	0.746
LIG_SH3_3	632	638	PF00018	0.695
LIG_SH3_3	693	699	PF00018	0.776
LIG_SH3_3	702	708	PF00018	0.711
LIG_SUMO_SIM_anti_2	564	570	PF11976	0.734
LIG_SUMO_SIM_anti_2	71	79	PF11976	0.576
LIG_SUMO_SIM_par_1	13	22	PF11976	0.580
LIG_SUMO_SIM_par_1	216	221	PF11976	0.584
LIG_SUMO_SIM_par_1	65	72	PF11976	0.593
LIG_TRAF2_1	39	42	PF00917	0.609
LIG_TRAF2_1	588	591	PF00917	0.677
LIG_TRAF2_1	673	676	PF00917	0.797
LIG_TRAF2_1	779	782	PF00917	0.606
LIG_TRAF2_1	97	100	PF00917	0.609
LIG_TYR_ITIM	154	159	PF00017	0.475
MOD_CDC14_SPxK_1	429	432	PF00782	0.704
MOD_CDC14_SPxK_1	470	473	PF00782	0.703
MOD_CDC14_SPxK_1	507	510	PF00782	0.622
MOD_CDK_SPK_2	439	444	PF00069	0.548
MOD_CDK_SPK_2	467	472	PF00069	0.727
MOD_CDK_SPK_2	504	509	PF00069	0.567
MOD_CDK_SPK_2	634	639	PF00069	0.748
MOD_CDK_SPK_2	692	697	PF00069	0.687
MOD_CDK_SPxK_1	426	432	PF00069	0.675
MOD_CDK_SPxK_1	467	473	PF00069	0.705
MOD_CDK_SPxK_1	504	510	PF00069	0.627
MOD_CDK_SPxxK_3	465	472	PF00069	0.680
MOD_CDK_SPxxK_3	504	511	PF00069	0.674
MOD_CDK_SPxxK_3	634	641	PF00069	0.749
MOD_CK1_1	195	201	PF00069	0.602
MOD_CK1_1	251	257	PF00069	0.460
MOD_CK1_1	282	288	PF00069	0.705
MOD_CK1_1	290	296	PF00069	0.627
MOD_CK1_1	353	359	PF00069	0.718
MOD_CK1_1	375	381	PF00069	0.724
MOD_CK1_1	392	398	PF00069	0.615
MOD_CK1_1	613	619	PF00069	0.701
MOD_CK1_1	668	674	PF00069	0.672
MOD_CK1_1	713	719	PF00069	0.726
MOD_CK1_1	72	78	PF00069	0.434
MOD_CK1_1	724	730	PF00069	0.730
MOD_CK1_1	79	85	PF00069	0.405
MOD_CK2_1	444	450	PF00069	0.742
MOD_CK2_1	593	599	PF00069	0.703
MOD_CK2_1	670	676	PF00069	0.721
MOD_CK2_1	750	756	PF00069	0.544
MOD_CK2_1	776	782	PF00069	0.492
MOD_CK2_1	785	791	PF00069	0.435
MOD_CK2_1	85	91	PF00069	0.482
MOD_CK2_1	94	100	PF00069	0.467
MOD_DYRK1A_RPxSP_1	634	638	PF00069	0.745
MOD_GlcNHglycan	12	15	PF01048	0.472
MOD_GlcNHglycan	164	167	PF01048	0.495
MOD_GlcNHglycan	187	190	PF01048	0.640
MOD_GlcNHglycan	194	197	PF01048	0.628
MOD_GlcNHglycan	199	202	PF01048	0.491
MOD_GlcNHglycan	230	233	PF01048	0.525
MOD_GlcNHglycan	284	287	PF01048	0.712
MOD_GlcNHglycan	289	292	PF01048	0.695
MOD_GlcNHglycan	306	309	PF01048	0.580
MOD_GlcNHglycan	312	315	PF01048	0.644
MOD_GlcNHglycan	319	322	PF01048	0.591
MOD_GlcNHglycan	326	329	PF01048	0.546
MOD_GlcNHglycan	374	377	PF01048	0.830
MOD_GlcNHglycan	391	394	PF01048	0.613
MOD_GlcNHglycan	41	46	PF01048	0.387
MOD_GlcNHglycan	614	618	PF01048	0.611
MOD_GlcNHglycan	630	633	PF01048	0.644
MOD_GlcNHglycan	660	663	PF01048	0.718
MOD_GlcNHglycan	685	688	PF01048	0.708
MOD_GlcNHglycan	715	719	PF01048	0.793
MOD_GlcNHglycan	733	736	PF01048	0.704
MOD_GlcNHglycan	740	743	PF01048	0.673
MOD_GlcNHglycan	752	755	PF01048	0.493
MOD_GlcNHglycan	841	844	PF01048	0.592
MOD_GSK3_1	218	225	PF00069	0.496
MOD_GSK3_1	251	258	PF00069	0.461
MOD_GSK3_1	272	279	PF00069	0.655
MOD_GSK3_1	306	313	PF00069	0.721
MOD_GSK3_1	336	343	PF00069	0.714
MOD_GSK3_1	346	353	PF00069	0.632
MOD_GSK3_1	368	375	PF00069	0.722
MOD_GSK3_1	378	385	PF00069	0.745
MOD_GSK3_1	439	446	PF00069	0.778
MOD_GSK3_1	463	470	PF00069	0.713
MOD_GSK3_1	613	620	PF00069	0.697
MOD_GSK3_1	630	637	PF00069	0.610
MOD_GSK3_1	654	661	PF00069	0.711
MOD_GSK3_1	667	674	PF00069	0.589
MOD_GSK3_1	68	75	PF00069	0.466
MOD_GSK3_1	710	717	PF00069	0.691
MOD_GSK3_1	738	745	PF00069	0.676
MOD_GSK3_1	833	840	PF00069	0.542
MOD_N-GLC_1	10	15	PF02516	0.444
MOD_N-GLC_1	185	190	PF02516	0.622
MOD_N-GLC_1	192	197	PF02516	0.638
MOD_N-GLC_1	324	329	PF02516	0.730
MOD_N-GLC_1	426	431	PF02516	0.666
MOD_N-GLC_1	724	729	PF02516	0.658
MOD_NEK2_1	456	461	PF00069	0.700
MOD_NEK2_1	463	468	PF00069	0.629
MOD_NEK2_1	68	73	PF00069	0.482
MOD_NEK2_1	785	790	PF00069	0.477
MOD_NEK2_1	833	838	PF00069	0.506
MOD_PIKK_1	154	160	PF00454	0.427
MOD_PIKK_1	368	374	PF00454	0.738
MOD_PIKK_1	602	608	PF00454	0.660
MOD_PIKK_1	671	677	PF00454	0.728
MOD_PIKK_1	785	791	PF00454	0.479
MOD_PK_1	5	11	PF00069	0.504
MOD_PKA_1	162	168	PF00069	0.489
MOD_PKA_1	472	478	PF00069	0.686
MOD_PKA_2	228	234	PF00069	0.518
MOD_PKA_2	248	254	PF00069	0.363
MOD_PKA_2	372	378	PF00069	0.679
MOD_PKA_2	402	408	PF00069	0.788
MOD_PKA_2	456	462	PF00069	0.805
MOD_PKA_2	472	478	PF00069	0.603
MOD_PKA_2	519	525	PF00069	0.563
MOD_PKA_2	550	556	PF00069	0.648
MOD_PKA_2	658	664	PF00069	0.743
MOD_PKA_2	665	671	PF00069	0.666
MOD_PKA_2	711	717	PF00069	0.652
MOD_PKA_2	762	768	PF00069	0.496
MOD_PKA_2	837	843	PF00069	0.585
MOD_PKB_1	455	463	PF00069	0.708
MOD_Plk_1	408	414	PF00069	0.620
MOD_Plk_1	594	600	PF00069	0.593
MOD_Plk_1	755	761	PF00069	0.516
MOD_Plk_1	833	839	PF00069	0.474
MOD_Plk_1	84	90	PF00069	0.492
MOD_Plk_1	99	105	PF00069	0.308
MOD_Plk_2-3	85	91	PF00069	0.482
MOD_Plk_2-3	94	100	PF00069	0.467
MOD_Plk_4	12	18	PF00069	0.467
MOD_Plk_4	251	257	PF00069	0.509
MOD_Plk_4	63	69	PF00069	0.446
MOD_Plk_4	72	78	PF00069	0.342
MOD_Plk_4	85	91	PF00069	0.370
MOD_Plk_4	99	105	PF00069	0.304
MOD_ProDKin_1	346	352	PF00069	0.681
MOD_ProDKin_1	356	362	PF00069	0.661
MOD_ProDKin_1	375	381	PF00069	0.541
MOD_ProDKin_1	383	389	PF00069	0.667
MOD_ProDKin_1	392	398	PF00069	0.585
MOD_ProDKin_1	426	432	PF00069	0.675
MOD_ProDKin_1	439	445	PF00069	0.607
MOD_ProDKin_1	465	471	PF00069	0.722
MOD_ProDKin_1	504	510	PF00069	0.675
MOD_ProDKin_1	617	623	PF00069	0.724
MOD_ProDKin_1	634	640	PF00069	0.593
MOD_ProDKin_1	645	651	PF00069	0.618
MOD_ProDKin_1	692	698	PF00069	0.736
MOD_ProDKin_1	719	725	PF00069	0.774
MOD_SUMO_rev_2	157	165	PF00179	0.460
MOD_SUMO_rev_2	513	518	PF00179	0.633
TRG_DiLeu_BaEn_1	418	423	PF01217	0.596
TRG_DiLeu_BaEn_1	493	498	PF01217	0.585
TRG_DiLeu_BaEn_2	781	787	PF01217	0.502
TRG_DiLeu_BaEn_4	93	99	PF01217	0.535
TRG_ENDOCYTIC_2	156	159	PF00928	0.486
TRG_ENDOCYTIC_2	50	53	PF00928	0.459
TRG_ER_diArg_1	30	32	PF00400	0.463
TRG_ER_diArg_1	471	473	PF00400	0.668
TRG_ER_diArg_1	508	511	PF00400	0.615
TRG_ER_diArg_1	56	59	PF00400	0.370
TRG_ER_diArg_1	770	773	PF00400	0.541
TRG_ER_diArg_1	847	850	PF00400	0.625
TRG_NLS_MonoExtC_3	54	59	PF00514	0.373
TRG_NLS_MonoExtC_3	804	809	PF00514	0.440
TRG_Pf-PMV_PEXEL_1	485	489	PF00026	0.652
TRG_Pf-PMV_PEXEL_1	524	529	PF00026	0.693
TRG_Pf-PMV_PEXEL_1	773	778	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	808	813	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HGL9	Leishmania braziliensis	74%	100%
A4I3P4	Leishmania infantum	99%	100%
E9AZY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
Q4Q8A0	Leishmania major	92%	100%