Hydrolase_alpha/beta_fold_family_putative/GeneDB: LmjF.28.1570

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrolase, alpha/beta fold family, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X1K2_LEIDO

TriTrypDb:

LdBPK_281700.1 , LdCL_280021800 , LDHU3_28.2200

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 34
NetGPI	no	yes: 0, no: 34

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7X1K2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1K2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	33
GO:0016787	hydrolase activity	2	33

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.623
CLV_NRD_NRD_1	279	281	PF00675	0.355
CLV_PCSK_KEX2_1	54	56	PF00082	0.400
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.420
CLV_PCSK_SKI1_1	245	249	PF00082	0.316
CLV_PCSK_SKI1_1	33	37	PF00082	0.481
CLV_PCSK_SKI1_1	54	58	PF00082	0.434
DOC_MAPK_gen_1	20	28	PF00069	0.385
DOC_MAPK_MEF2A_6	181	189	PF00069	0.359
DOC_MAPK_MEF2A_6	280	289	PF00069	0.248
DOC_MAPK_MEF2A_6	319	328	PF00069	0.386
DOC_PP1_RVXF_1	311	318	PF00149	0.356
DOC_PP2B_LxvP_1	124	127	PF13499	0.295
DOC_PP4_FxxP_1	116	119	PF00568	0.389
DOC_PP4_FxxP_1	63	66	PF00568	0.340
DOC_SPAK_OSR1_1	207	211	PF12202	0.193
DOC_USP7_MATH_1	12	16	PF00917	0.645
DOC_USP7_MATH_1	27	31	PF00917	0.582
DOC_USP7_MATH_1	6	10	PF00917	0.636
DOC_USP7_UBL2_3	277	281	PF12436	0.202
LIG_14-3-3_CanoR_1	123	127	PF00244	0.380
LIG_14-3-3_CanoR_1	181	186	PF00244	0.298
LIG_14-3-3_CanoR_1	20	28	PF00244	0.386
LIG_14-3-3_CanoR_1	280	285	PF00244	0.337
LIG_Actin_WH2_2	74	89	PF00022	0.175
LIG_AP2alpha_1	39	43	PF02296	0.437
LIG_APCC_ABBA_1	89	94	PF00400	0.184
LIG_BIR_II_1	1	5	PF00653	0.640
LIG_BRCT_BRCA1_1	109	113	PF00533	0.366
LIG_BRCT_BRCA1_1	84	88	PF00533	0.395
LIG_DLG_GKlike_1	181	188	PF00625	0.346
LIG_eIF4E_1	303	309	PF01652	0.389
LIG_FHA_1	2	8	PF00498	0.457
LIG_FHA_1	284	290	PF00498	0.246
LIG_FHA_2	109	115	PF00498	0.338
LIG_FHA_2	60	66	PF00498	0.366
LIG_FXI_DFP_1	113	117	PF00024	0.350
LIG_GBD_Chelix_1	73	81	PF00786	0.433
LIG_LIR_Apic_2	114	119	PF02991	0.394
LIG_LIR_Apic_2	62	66	PF02991	0.368
LIG_LIR_Gen_1	110	121	PF02991	0.202
LIG_LIR_Gen_1	40	50	PF02991	0.418
LIG_LIR_Gen_1	57	66	PF02991	0.254
LIG_LIR_Gen_1	85	93	PF02991	0.357
LIG_LIR_Nem_3	110	116	PF02991	0.396
LIG_LIR_Nem_3	40	46	PF02991	0.405
LIG_LIR_Nem_3	57	63	PF02991	0.276
LIG_LIR_Nem_3	85	91	PF02991	0.319
LIG_LIR_Nem_3	94	100	PF02991	0.284
LIG_MYND_2	118	122	PF01753	0.184
LIG_Pex14_1	226	230	PF04695	0.389
LIG_Pex14_2	39	43	PF04695	0.343
LIG_Pex14_2	88	92	PF04695	0.404
LIG_SH2_GRB2like	102	105	PF00017	0.300
LIG_SH2_STAP1	205	209	PF00017	0.406
LIG_SH2_STAP1	84	88	PF00017	0.175
LIG_SH2_STAT3	230	233	PF00017	0.389
LIG_SH2_STAT5	138	141	PF00017	0.314
LIG_SH2_STAT5	230	233	PF00017	0.388
LIG_SH2_STAT5	246	249	PF00017	0.270
LIG_SH2_STAT5	98	101	PF00017	0.270
LIG_SH3_3	194	200	PF00018	0.396
LIG_SH3_3	279	285	PF00018	0.293
LIG_SH3_3	292	298	PF00018	0.289
LIG_SH3_3	312	318	PF00018	0.322
LIG_SH3_3	63	69	PF00018	0.411
LIG_UBA3_1	337	344	PF00899	0.271
LIG_WRC_WIRS_1	60	65	PF05994	0.328
MOD_CK1_1	22	28	PF00069	0.430
MOD_CK1_1	283	289	PF00069	0.297
MOD_CK2_1	128	134	PF00069	0.350
MOD_CK2_1	246	252	PF00069	0.442
MOD_Cter_Amidation	52	55	PF01082	0.422
MOD_GlcNHglycan	1	4	PF01048	0.432
MOD_GlcNHglycan	215	218	PF01048	0.312
MOD_GSK3_1	1	8	PF00069	0.692
MOD_GSK3_1	104	111	PF00069	0.380
MOD_GSK3_1	12	19	PF00069	0.696
MOD_GSK3_1	22	29	PF00069	0.573
MOD_GSK3_1	45	52	PF00069	0.487
MOD_N-GLC_1	22	27	PF02516	0.511
MOD_N-GLC_1	338	343	PF02516	0.396
MOD_NEK2_1	1	6	PF00069	0.488
MOD_NEK2_1	162	167	PF00069	0.349
MOD_NEK2_1	26	31	PF00069	0.494
MOD_NEK2_1	338	343	PF00069	0.388
MOD_NEK2_1	77	82	PF00069	0.375
MOD_PIKK_1	108	114	PF00454	0.184
MOD_PIKK_1	229	235	PF00454	0.389
MOD_PIKK_1	27	33	PF00454	0.286
MOD_PKA_1	280	286	PF00069	0.373
MOD_PKA_1	54	60	PF00069	0.443
MOD_PKA_2	104	110	PF00069	0.388
MOD_PKA_2	122	128	PF00069	0.185
MOD_PKA_2	19	25	PF00069	0.424
MOD_PKA_2	54	60	PF00069	0.431
MOD_Plk_1	22	28	PF00069	0.510
MOD_Plk_1	338	344	PF00069	0.481
MOD_Plk_4	198	204	PF00069	0.338
MOD_Plk_4	283	289	PF00069	0.262
MOD_Plk_4	338	344	PF00069	0.550
MOD_Plk_4	77	83	PF00069	0.410
MOD_SUMO_rev_2	34	44	PF00179	0.487
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.394
TRG_ENDOCYTIC_2	205	208	PF00928	0.389
TRG_ENDOCYTIC_2	60	63	PF00928	0.336
TRG_ENDOCYTIC_2	97	100	PF00928	0.310
TRG_NES_CRM1_1	146	158	PF08389	0.253

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D3	Leptomonas seymouri	29%	80%
A0A0N0P3S4	Leptomonas seymouri	38%	95%
A0A0N1PA10	Leptomonas seymouri	70%	100%
A0A0N1PCQ2	Leptomonas seymouri	48%	100%
A0A0S4JQB3	Bodo saltans	40%	100%
A0A1X0NSR3	Trypanosomatidae	37%	77%
A0A1X0NSS6	Trypanosomatidae	44%	100%
A0A3Q8IAY1	Leishmania donovani	36%	100%
A0A3R7KKJ0	Trypanosoma rangeli	43%	100%
A0A3S5IRR1	Trypanosoma rangeli	33%	85%
A0A3S7WUJ3	Leishmania donovani	41%	100%
A0A3S7WUK0	Leishmania donovani	31%	100%
A0A422NS41	Trypanosoma rangeli	37%	80%
A4H956	Leishmania braziliensis	45%	100%
A4H959	Leishmania braziliensis	31%	100%
A4H960	Leishmania braziliensis	40%	100%
A4HGL0	Leishmania braziliensis	81%	100%
A4HXH8	Leishmania infantum	41%	100%
A4HXI1	Leishmania infantum	31%	100%
A4HXI2	Leishmania infantum	37%	100%
A4I3N6	Leishmania infantum	100%	100%
A4JPX5	Burkholderia vietnamiensis (strain G4 / LMG 22486)	26%	100%
B2JQW2	Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815)	27%	100%
C9ZP69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	86%
C9ZP70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AR73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AR76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AR77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AZX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O05235	Bacillus subtilis (strain 168)	23%	100%
P00632	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	27%	100%
P47229	Paraburkholderia xenovorans (strain LB400)	24%	100%
Q4Q8A8	Leishmania major	94%	100%
Q4QE86	Leishmania major	38%	100%
Q4QE87	Leishmania major	31%	100%
Q4QE90	Leishmania major	42%	100%
Q52011	Pseudomonas furukawaii	24%	100%
Q52532	Pseudomonas sp.	24%	100%
Q54528	Streptomyces purpurascens	30%	100%
Q54809	Streptomyces peucetius	29%	100%
Q55217	Streptomyces sp. (strain C5)	29%	100%
Q59093	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	24%	100%
Q59695	Pseudomonas putida	27%	94%
Q83WC8	Acinetobacter calcoaceticus	23%	100%
V5AZB9	Trypanosoma cruzi	39%	81%
V5BER0	Trypanosoma cruzi	45%	100%
V5BNU9	Trypanosoma cruzi	30%	85%