Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X1K0_LEIDO

TriTrypDb:

LdBPK_281690.1 , LdCL_280021600 , LDHU3_28.2180

Length:

561

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X1K0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1K0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	303	307	PF00656	0.671
CLV_C14_Caspase3-7	311	315	PF00656	0.668
CLV_C14_Caspase3-7	552	556	PF00656	0.811
CLV_NRD_NRD_1	21	23	PF00675	0.777
CLV_NRD_NRD_1	223	225	PF00675	0.686
CLV_NRD_NRD_1	415	417	PF00675	0.770
CLV_NRD_NRD_1	429	431	PF00675	0.561
CLV_PCSK_KEX2_1	109	111	PF00082	0.850
CLV_PCSK_KEX2_1	223	225	PF00082	0.686
CLV_PCSK_KEX2_1	429	431	PF00082	0.657
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.850
CLV_PCSK_SKI1_1	231	235	PF00082	0.570
CLV_PCSK_SKI1_1	82	86	PF00082	0.754
DEG_APCC_DBOX_1	47	55	PF00400	0.766
DEG_Nend_UBRbox_2	1	3	PF02207	0.755
DEG_SPOP_SBC_1	148	152	PF00917	0.617
DEG_SPOP_SBC_1	249	253	PF00917	0.692
DEG_SPOP_SBC_1	254	258	PF00917	0.730
DEG_SPOP_SBC_1	518	522	PF00917	0.749
DOC_CKS1_1	90	95	PF01111	0.617
DOC_CYCLIN_yCln2_LP_2	396	402	PF00134	0.619
DOC_MAPK_DCC_7	392	402	PF00069	0.618
DOC_MAPK_gen_1	350	357	PF00069	0.511
DOC_MAPK_gen_1	390	398	PF00069	0.581
DOC_MAPK_MEF2A_6	350	357	PF00069	0.661
DOC_MAPK_MEF2A_6	392	400	PF00069	0.574
DOC_MAPK_NFAT4_5	350	358	PF00069	0.579
DOC_PP2B_LxvP_1	396	399	PF13499	0.660
DOC_PP4_FxxP_1	246	249	PF00568	0.693
DOC_PP4_FxxP_1	78	81	PF00568	0.608
DOC_USP7_MATH_1	113	117	PF00917	0.734
DOC_USP7_MATH_1	148	152	PF00917	0.676
DOC_USP7_MATH_1	254	258	PF00917	0.755
DOC_USP7_MATH_1	263	267	PF00917	0.620
DOC_USP7_MATH_1	295	299	PF00917	0.750
DOC_USP7_MATH_1	32	36	PF00917	0.613
DOC_USP7_MATH_1	373	377	PF00917	0.676
DOC_USP7_MATH_1	518	522	PF00917	0.786
DOC_WW_Pin1_4	144	149	PF00397	0.804
DOC_WW_Pin1_4	158	163	PF00397	0.525
DOC_WW_Pin1_4	250	255	PF00397	0.690
DOC_WW_Pin1_4	33	38	PF00397	0.758
DOC_WW_Pin1_4	77	82	PF00397	0.721
DOC_WW_Pin1_4	89	94	PF00397	0.627
LIG_14-3-3_CanoR_1	275	282	PF00244	0.729
LIG_14-3-3_CanoR_1	48	58	PF00244	0.703
LIG_14-3-3_CanoR_1	523	533	PF00244	0.822
LIG_14-3-3_CanoR_1	82	90	PF00244	0.760
LIG_BIR_III_4	443	447	PF00653	0.741
LIG_BRCT_BRCA1_1	151	155	PF00533	0.775
LIG_BRCT_BRCA1_1	451	455	PF00533	0.805
LIG_eIF4E_1	19	25	PF01652	0.596
LIG_FHA_1	134	140	PF00498	0.777
LIG_FHA_1	216	222	PF00498	0.569
LIG_FHA_1	230	236	PF00498	0.693
LIG_FHA_1	545	551	PF00498	0.629
LIG_FHA_1	74	80	PF00498	0.609
LIG_FHA_2	141	147	PF00498	0.740
LIG_FHA_2	163	169	PF00498	0.724
LIG_FHA_2	173	179	PF00498	0.707
LIG_FHA_2	232	238	PF00498	0.464
LIG_FHA_2	301	307	PF00498	0.742
LIG_FHA_2	550	556	PF00498	0.830
LIG_FHA_2	68	74	PF00498	0.613
LIG_Integrin_RGD_1	478	480	PF01839	0.722
LIG_LIR_Apic_2	243	249	PF02991	0.660
LIG_LIR_Apic_2	76	81	PF02991	0.647
LIG_LIR_Gen_1	452	463	PF02991	0.648
LIG_LIR_Nem_3	227	233	PF02991	0.530
LIG_LIR_Nem_3	376	382	PF02991	0.679
LIG_LIR_Nem_3	452	458	PF02991	0.641
LIG_MYND_1	119	123	PF01753	0.767
LIG_SH2_GRB2like	11	14	PF00017	0.686
LIG_SH2_STAP1	11	15	PF00017	0.724
LIG_SH2_STAP1	533	537	PF00017	0.732
LIG_SH2_STAT5	14	17	PF00017	0.586
LIG_SH2_STAT5	19	22	PF00017	0.596
LIG_SH2_STAT5	38	41	PF00017	0.686
LIG_SH3_1	157	163	PF00018	0.841
LIG_SH3_1	26	32	PF00018	0.596
LIG_SH3_1	91	97	PF00018	0.758
LIG_SH3_2	29	34	PF14604	0.608
LIG_SH3_3	142	148	PF00018	0.670
LIG_SH3_3	157	163	PF00018	0.511
LIG_SH3_3	166	172	PF00018	0.686
LIG_SH3_3	257	263	PF00018	0.621
LIG_SH3_3	26	32	PF00018	0.596
LIG_SH3_3	326	332	PF00018	0.645
LIG_SH3_3	91	97	PF00018	0.745
LIG_SUMO_SIM_par_1	231	237	PF11976	0.534
LIG_TRAF2_1	489	492	PF00917	0.755
LIG_TYR_ITSM	375	382	PF00017	0.637
MOD_CDK_SPK_2	77	82	PF00069	0.755
MOD_CK1_1	147	153	PF00069	0.769
MOD_CK1_1	250	256	PF00069	0.692
MOD_CK1_1	33	39	PF00069	0.715
MOD_CK1_1	433	439	PF00069	0.660
MOD_CK1_1	449	455	PF00069	0.716
MOD_CK1_1	483	489	PF00069	0.755
MOD_CK1_1	527	533	PF00069	0.827
MOD_CK1_1	535	541	PF00069	0.694
MOD_CK1_1	542	548	PF00069	0.582
MOD_CK1_1	57	63	PF00069	0.697
MOD_CK2_1	140	146	PF00069	0.767
MOD_CK2_1	162	168	PF00069	0.754
MOD_CK2_1	172	178	PF00069	0.713
MOD_CK2_1	485	491	PF00069	0.783
MOD_CK2_1	67	73	PF00069	0.616
MOD_GlcNHglycan	114	118	PF01048	0.762
MOD_GlcNHglycan	151	154	PF01048	0.686
MOD_GlcNHglycan	178	181	PF01048	0.651
MOD_GlcNHglycan	276	279	PF01048	0.626
MOD_GlcNHglycan	308	311	PF01048	0.733
MOD_GlcNHglycan	432	435	PF01048	0.743
MOD_GlcNHglycan	459	462	PF01048	0.810
MOD_GlcNHglycan	480	485	PF01048	0.603
MOD_GlcNHglycan	488	491	PF01048	0.498
MOD_GlcNHglycan	512	515	PF01048	0.692
MOD_GlcNHglycan	541	544	PF01048	0.597
MOD_GlcNHglycan	62	65	PF01048	0.742
MOD_GSK3_1	113	120	PF00069	0.735
MOD_GSK3_1	140	147	PF00069	0.720
MOD_GSK3_1	149	156	PF00069	0.658
MOD_GSK3_1	158	165	PF00069	0.746
MOD_GSK3_1	172	179	PF00069	0.560
MOD_GSK3_1	249	256	PF00069	0.656
MOD_GSK3_1	296	303	PF00069	0.671
MOD_GSK3_1	32	39	PF00069	0.812
MOD_GSK3_1	449	456	PF00069	0.771
MOD_GSK3_1	457	464	PF00069	0.679
MOD_GSK3_1	482	489	PF00069	0.742
MOD_GSK3_1	50	57	PF00069	0.733
MOD_GSK3_1	524	531	PF00069	0.802
MOD_GSK3_1	533	540	PF00069	0.664
MOD_GSK3_1	541	548	PF00069	0.548
MOD_GSK3_1	551	558	PF00069	0.600
MOD_GSK3_1	73	80	PF00069	0.658
MOD_N-GLC_1	338	343	PF02516	0.768
MOD_N-GLC_1	446	451	PF02516	0.651
MOD_N-GLC_1	555	560	PF02516	0.747
MOD_N-GLC_1	60	65	PF02516	0.801
MOD_N-GLC_1	74	79	PF02516	0.604
MOD_NEK2_1	155	160	PF00069	0.692
MOD_NEK2_1	274	279	PF00069	0.653
MOD_NEK2_1	537	542	PF00069	0.697
MOD_NEK2_1	54	59	PF00069	0.691
MOD_NEK2_1	546	551	PF00069	0.716
MOD_PIKK_1	140	146	PF00454	0.767
MOD_PIKK_1	453	459	PF00454	0.571
MOD_PKA_2	200	206	PF00069	0.677
MOD_PKA_2	274	280	PF00069	0.730
MOD_PKA_2	524	530	PF00069	0.819
MOD_Plk_1	172	178	PF00069	0.785
MOD_Plk_1	341	347	PF00069	0.729
MOD_Plk_1	374	380	PF00069	0.640
MOD_Plk_1	446	452	PF00069	0.716
MOD_Plk_1	453	459	PF00069	0.615
MOD_Plk_1	74	80	PF00069	0.753
MOD_Plk_4	461	467	PF00069	0.756
MOD_Plk_4	50	56	PF00069	0.724
MOD_Plk_4	74	80	PF00069	0.779
MOD_ProDKin_1	144	150	PF00069	0.806
MOD_ProDKin_1	158	164	PF00069	0.526
MOD_ProDKin_1	250	256	PF00069	0.692
MOD_ProDKin_1	33	39	PF00069	0.759
MOD_ProDKin_1	77	83	PF00069	0.720
MOD_ProDKin_1	89	95	PF00069	0.628
MOD_SUMO_for_1	349	352	PF00179	0.500
MOD_SUMO_rev_2	17	25	PF00179	0.649
TRG_DiLeu_BaEn_1	129	134	PF01217	0.615
TRG_ENDOCYTIC_2	379	382	PF00928	0.685
TRG_ER_diArg_1	223	226	PF00400	0.685
TRG_ER_diArg_1	494	497	PF00400	0.717
TRG_ER_diArg_1	5	8	PF00400	0.728
TRG_ER_diArg_1	502	505	PF00400	0.603
TRG_ER_diArg_1	523	526	PF00400	0.814
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.683
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HGK9	Leishmania braziliensis	69%	100%
A4I3N5	Leishmania infantum	99%	100%
E9AZX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q8A9	Leishmania major	89%	100%