Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X1I5_LEIDO

TriTrypDb:

LdBPK_281650.1 , LdCL_280021200 , LDHU3_28.2120

Length:

642

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X1I5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1I5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.575
CLV_NRD_NRD_1	151	153	PF00675	0.625
CLV_NRD_NRD_1	256	258	PF00675	0.679
CLV_NRD_NRD_1	273	275	PF00675	0.567
CLV_NRD_NRD_1	35	37	PF00675	0.555
CLV_NRD_NRD_1	399	401	PF00675	0.598
CLV_NRD_NRD_1	426	428	PF00675	0.610
CLV_NRD_NRD_1	583	585	PF00675	0.722
CLV_PCSK_FUR_1	149	153	PF00082	0.626
CLV_PCSK_FUR_1	33	37	PF00082	0.539
CLV_PCSK_KEX2_1	112	114	PF00082	0.575
CLV_PCSK_KEX2_1	151	153	PF00082	0.625
CLV_PCSK_KEX2_1	256	258	PF00082	0.541
CLV_PCSK_KEX2_1	273	275	PF00082	0.519
CLV_PCSK_KEX2_1	32	34	PF00082	0.511
CLV_PCSK_KEX2_1	35	37	PF00082	0.507
CLV_PCSK_KEX2_1	399	401	PF00082	0.590
CLV_PCSK_KEX2_1	426	428	PF00082	0.584
CLV_PCSK_KEX2_1	583	585	PF00082	0.722
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.511
CLV_PCSK_SKI1_1	151	155	PF00082	0.559
CLV_PCSK_SKI1_1	256	260	PF00082	0.534
CLV_PCSK_SKI1_1	290	294	PF00082	0.575
CLV_PCSK_SKI1_1	326	330	PF00082	0.605
CLV_PCSK_SKI1_1	451	455	PF00082	0.676
CLV_PCSK_SKI1_1	522	526	PF00082	0.658
CLV_PCSK_SKI1_1	557	561	PF00082	0.555
CLV_PCSK_SKI1_1	620	624	PF00082	0.532
CLV_PCSK_SKI1_1	91	95	PF00082	0.445
DEG_APCC_DBOX_1	216	224	PF00400	0.650
DEG_APCC_DBOX_1	582	590	PF00400	0.495
DOC_CYCLIN_RxL_1	625	639	PF00134	0.703
DOC_CYCLIN_yClb5_NLxxxL_5	368	376	PF00134	0.563
DOC_MAPK_gen_1	583	591	PF00069	0.493
DOC_MAPK_MEF2A_6	572	579	PF00069	0.669
DOC_USP7_MATH_1	158	162	PF00917	0.551
DOC_USP7_MATH_1	185	189	PF00917	0.556
DOC_USP7_MATH_1	492	496	PF00917	0.642
DOC_USP7_UBL2_3	326	330	PF12436	0.666
LIG_14-3-3_CanoR_1	112	121	PF00244	0.506
LIG_14-3-3_CanoR_1	173	178	PF00244	0.465
LIG_14-3-3_CanoR_1	273	282	PF00244	0.562
LIG_14-3-3_CanoR_1	295	301	PF00244	0.654
LIG_14-3-3_CanoR_1	347	355	PF00244	0.583
LIG_14-3-3_CanoR_1	407	416	PF00244	0.536
LIG_14-3-3_CanoR_1	433	439	PF00244	0.584
LIG_14-3-3_CanoR_1	594	599	PF00244	0.624
LIG_Actin_WH2_2	107	124	PF00022	0.532
LIG_Actin_WH2_2	582	598	PF00022	0.478
LIG_APCC_ABBA_1	25	30	PF00400	0.492
LIG_APCC_ABBAyCdc20_2	620	626	PF00400	0.602
LIG_BIR_II_1	1	5	PF00653	0.638
LIG_CaM_IQ_9	588	603	PF13499	0.675
LIG_Clathr_ClatBox_1	387	391	PF01394	0.647
LIG_eIF4E_1	138	144	PF01652	0.603
LIG_FHA_1	291	297	PF00498	0.589
LIG_FHA_1	433	439	PF00498	0.609
LIG_FHA_1	53	59	PF00498	0.472
LIG_FHA_1	531	537	PF00498	0.545
LIG_FHA_1	566	572	PF00498	0.601
LIG_FHA_1	630	636	PF00498	0.617
LIG_FHA_2	14	20	PF00498	0.539
LIG_FHA_2	198	204	PF00498	0.583
LIG_FHA_2	274	280	PF00498	0.613
LIG_FHA_2	297	303	PF00498	0.589
LIG_FHA_2	376	382	PF00498	0.576
LIG_FHA_2	408	414	PF00498	0.505
LIG_FHA_2	553	559	PF00498	0.687
LIG_GBD_Chelix_1	58	66	PF00786	0.497
LIG_LIR_Gen_1	360	366	PF02991	0.598
LIG_LIR_Nem_3	134	138	PF02991	0.533
LIG_LIR_Nem_3	360	365	PF02991	0.604
LIG_NRBOX	266	272	PF00104	0.624
LIG_PCNA_yPIPBox_3	257	271	PF02747	0.658
LIG_PCNA_yPIPBox_3	26	38	PF02747	0.565
LIG_PDZ_Class_2	637	642	PF00595	0.743
LIG_SH2_PTP2	362	365	PF00017	0.574
LIG_SH2_STAT3	624	627	PF00017	0.586
LIG_SH2_STAT5	13	16	PF00017	0.521
LIG_SH2_STAT5	138	141	PF00017	0.581
LIG_SH2_STAT5	362	365	PF00017	0.574
LIG_SUMO_SIM_anti_2	219	224	PF11976	0.612
LIG_SUMO_SIM_anti_2	458	464	PF11976	0.589
LIG_SUMO_SIM_anti_2	5	10	PF11976	0.557
LIG_SUMO_SIM_par_1	284	291	PF11976	0.557
LIG_SUMO_SIM_par_1	386	393	PF11976	0.568
LIG_SUMO_SIM_par_1	481	487	PF11976	0.647
LIG_SUMO_SIM_par_1	573	578	PF11976	0.669
LIG_TRAF2_1	180	183	PF00917	0.574
LIG_TRAF2_1	200	203	PF00917	0.428
LIG_TRAF2_1	277	280	PF00917	0.596
LIG_TRAF2_1	299	302	PF00917	0.692
LIG_TRAF2_1	350	353	PF00917	0.617
LIG_TRAF2_1	389	392	PF00917	0.536
LIG_TRAF2_1	410	413	PF00917	0.595
LIG_TRAF2_1	44	47	PF00917	0.508
MOD_CK1_1	304	310	PF00069	0.701
MOD_CK1_1	377	383	PF00069	0.630
MOD_CK1_1	495	501	PF00069	0.492
MOD_CK1_1	566	572	PF00069	0.707
MOD_CK2_1	13	19	PF00069	0.542
MOD_CK2_1	197	203	PF00069	0.622
MOD_CK2_1	273	279	PF00069	0.556
MOD_CK2_1	296	302	PF00069	0.584
MOD_CK2_1	336	342	PF00069	0.637
MOD_CK2_1	347	353	PF00069	0.623
MOD_CK2_1	375	381	PF00069	0.575
MOD_CK2_1	386	392	PF00069	0.469
MOD_CK2_1	407	413	PF00069	0.521
MOD_CK2_1	552	558	PF00069	0.684
MOD_CK2_1	570	576	PF00069	0.526
MOD_CK2_1	89	95	PF00069	0.537
MOD_CMANNOS	193	196	PF00535	0.669
MOD_GlcNHglycan	114	117	PF01048	0.536
MOD_GlcNHglycan	155	159	PF01048	0.569
MOD_GlcNHglycan	301	306	PF01048	0.664
MOD_GlcNHglycan	381	384	PF01048	0.548
MOD_GlcNHglycan	611	614	PF01048	0.549
MOD_GlcNHglycan	79	82	PF01048	0.479
MOD_GSK3_1	139	146	PF00069	0.602
MOD_GSK3_1	154	161	PF00069	0.360
MOD_GSK3_1	375	382	PF00069	0.510
MOD_GSK3_1	386	393	PF00069	0.524
MOD_GSK3_1	566	573	PF00069	0.653
MOD_N-GLC_1	563	568	PF02516	0.617
MOD_NEK2_1	139	144	PF00069	0.534
MOD_NEK2_1	154	159	PF00069	0.310
MOD_NEK2_1	322	327	PF00069	0.649
MOD_NEK2_1	439	444	PF00069	0.685
MOD_NEK2_1	57	62	PF00069	0.498
MOD_PIKK_1	197	203	PF00454	0.577
MOD_PIKK_1	260	266	PF00454	0.540
MOD_PIKK_1	347	353	PF00454	0.623
MOD_PIKK_1	408	414	PF00454	0.607
MOD_PIKK_1	439	445	PF00454	0.682
MOD_PIKK_1	492	498	PF00454	0.708
MOD_PIKK_1	52	58	PF00454	0.606
MOD_PIKK_1	72	78	PF00454	0.280
MOD_PK_1	386	392	PF00069	0.629
MOD_PK_1	594	600	PF00069	0.549
MOD_PKA_1	112	118	PF00069	0.494
MOD_PKA_1	273	279	PF00069	0.637
MOD_PKA_2	112	118	PF00069	0.450
MOD_PKA_2	203	209	PF00069	0.596
MOD_PKA_2	273	279	PF00069	0.552
MOD_PKA_2	322	328	PF00069	0.601
MOD_PKA_2	346	352	PF00069	0.594
MOD_PKA_2	408	414	PF00069	0.527
MOD_PKA_2	432	438	PF00069	0.568
MOD_PKA_2	446	452	PF00069	0.653
MOD_PKA_2	474	480	PF00069	0.511
MOD_PKA_2	95	101	PF00069	0.579
MOD_Plk_1	154	160	PF00069	0.567
MOD_Plk_1	38	44	PF00069	0.566
MOD_Plk_1	390	396	PF00069	0.555
MOD_Plk_1	566	572	PF00069	0.653
MOD_Plk_1	575	581	PF00069	0.693
MOD_Plk_1	636	642	PF00069	0.664
MOD_Plk_2-3	336	342	PF00069	0.691
MOD_Plk_2-3	89	95	PF00069	0.520
MOD_Plk_4	139	145	PF00069	0.561
MOD_Plk_4	173	179	PF00069	0.499
MOD_Plk_4	566	572	PF00069	0.653
MOD_SUMO_for_1	463	466	PF00179	0.701
MOD_SUMO_for_1	539	542	PF00179	0.638
MOD_SUMO_rev_2	255	263	PF00179	0.602
MOD_SUMO_rev_2	29	34	PF00179	0.461
TRG_DiLeu_BaEn_4	301	307	PF01217	0.696
TRG_DiLeu_BaEn_4	458	464	PF01217	0.464
TRG_DiLeu_BaLyEn_6	600	605	PF01217	0.667
TRG_ENDOCYTIC_2	362	365	PF00928	0.566
TRG_ER_diArg_1	111	113	PF00400	0.573
TRG_ER_diArg_1	272	274	PF00400	0.658
TRG_ER_diArg_1	321	324	PF00400	0.595
TRG_ER_diArg_1	33	36	PF00400	0.540
TRG_ER_diArg_1	425	427	PF00400	0.612
TRG_ER_diArg_1	601	604	PF00400	0.668
TRG_NLS_MonoExtC_3	31	36	PF00514	0.542
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	370	375	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	603	607	PF00026	0.660
TRG_Pf-PMV_PEXEL_1	91	95	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9P5	Leptomonas seymouri	50%	100%
A0A1X0P087	Trypanosomatidae	25%	100%
A4HGK5	Leishmania braziliensis	80%	100%
A4I3N1	Leishmania infantum	100%	100%
E9AZX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q8B3	Leishmania major	92%	100%
V5B7Y0	Trypanosoma cruzi	27%	100%