Thiamine pyrophosphate enzyme, N-terminal TPP binding domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphonopyruvate decarboxylase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7X1I1_LEIDO

TriTrypDb:

LdBPK_281710.1 , LdCL_280022000 , LDHU3_28.2240

Length:

415

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X1I1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1I1

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006790	sulfur compound metabolic process	3	1
GO:0008152	metabolic process	1	5
GO:0009058	biosynthetic process	2	5
GO:0009987	cellular process	1	5
GO:0016053	organic acid biosynthetic process	4	1
GO:0019295	coenzyme M biosynthetic process	5	1
GO:0019296	coenzyme M metabolic process	4	1
GO:0044237	cellular metabolic process	2	5
GO:0044249	cellular biosynthetic process	3	5
GO:0044272	sulfur compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0071704	organic substance metabolic process	2	5
GO:1901576	organic substance biosynthetic process	3	5
GO:0006793	phosphorus metabolic process	3	4
GO:0019634	organic phosphonate metabolic process	4	4
GO:0019637	organophosphate metabolic process	3	4
GO:0032923	organic phosphonate biosynthetic process	4	4
GO:0090407	organophosphate biosynthetic process	4	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0016829	lyase activity	2	10
GO:0019842	vitamin binding	3	11
GO:0030976	thiamine pyrophosphate binding	3	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0043169	cation binding	3	11
GO:0050997	quaternary ammonium group binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:1901681	sulfur compound binding	2	11
GO:0016830	carbon-carbon lyase activity	3	5
GO:0016831	carboxy-lyase activity	4	5
GO:0050545	sulfopyruvate decarboxylase activity	5	1
GO:0033980	phosphonopyruvate decarboxylase activity	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	194	196	PF00675	0.638
CLV_NRD_NRD_1	237	239	PF00675	0.445
CLV_NRD_NRD_1	396	398	PF00675	0.526
CLV_NRD_NRD_1	6	8	PF00675	0.570
CLV_PCSK_KEX2_1	194	196	PF00082	0.638
CLV_PCSK_KEX2_1	237	239	PF00082	0.445
CLV_PCSK_KEX2_1	396	398	PF00082	0.577
CLV_PCSK_KEX2_1	6	8	PF00082	0.701
CLV_PCSK_SKI1_1	22	26	PF00082	0.236
CLV_PCSK_SKI1_1	300	304	PF00082	0.410
CLV_PCSK_SKI1_1	6	10	PF00082	0.610
DEG_APCC_DBOX_1	271	279	PF00400	0.335
DEG_Nend_Nbox_1	1	3	PF02207	0.529
DOC_MAPK_MEF2A_6	353	360	PF00069	0.385
DOC_PP1_RVXF_1	401	407	PF00149	0.365
DOC_PP2B_LxvP_1	77	80	PF13499	0.303
DOC_PP4_FxxP_1	33	36	PF00568	0.254
DOC_USP7_MATH_1	241	245	PF00917	0.492
DOC_USP7_MATH_1	42	46	PF00917	0.455
DOC_WW_Pin1_4	13	18	PF00397	0.416
DOC_WW_Pin1_4	174	179	PF00397	0.319
DOC_WW_Pin1_4	254	259	PF00397	0.474
DOC_WW_Pin1_4	386	391	PF00397	0.385
LIG_14-3-3_CanoR_1	135	141	PF00244	0.349
LIG_14-3-3_CanoR_1	405	413	PF00244	0.341
LIG_Actin_WH2_2	392	407	PF00022	0.424
LIG_BIR_III_2	199	203	PF00653	0.604
LIG_BRCT_BRCA1_1	29	33	PF00533	0.389
LIG_eIF4E_1	105	111	PF01652	0.273
LIG_FHA_1	201	207	PF00498	0.614
LIG_FHA_1	42	48	PF00498	0.385
LIG_FHA_1	74	80	PF00498	0.244
LIG_FHA_2	119	125	PF00498	0.385
LIG_LIR_Apic_2	103	108	PF02991	0.312
LIG_LIR_Apic_2	30	36	PF02991	0.298
LIG_LIR_Apic_2	37	42	PF02991	0.298
LIG_LIR_Gen_1	166	175	PF02991	0.366
LIG_LIR_Gen_1	177	185	PF02991	0.286
LIG_LIR_Nem_3	166	172	PF02991	0.412
LIG_LIR_Nem_3	177	182	PF02991	0.307
LIG_MLH1_MIPbox_1	29	33	PF16413	0.335
LIG_PCNA_PIPBox_1	93	102	PF02747	0.385
LIG_PDZ_Class_2	410	415	PF00595	0.336
LIG_PTAP_UEV_1	201	206	PF05743	0.495
LIG_SH2_CRK	105	109	PF00017	0.310
LIG_SH2_STAT5	19	22	PF00017	0.451
LIG_SH2_STAT5	349	352	PF00017	0.385
LIG_SH2_STAT5	39	42	PF00017	0.122
LIG_SH2_STAT5	46	49	PF00017	0.305
LIG_SH2_STAT5	56	59	PF00017	0.249
LIG_SH2_STAT5	73	76	PF00017	0.428
LIG_SH3_3	141	147	PF00018	0.433
LIG_SH3_3	199	205	PF00018	0.598
LIG_SUMO_SIM_par_1	354	362	PF11976	0.389
LIG_TRAF2_1	231	234	PF00917	0.382
LIG_TRFH_1	38	42	PF08558	0.335
LIG_UBA3_1	110	118	PF00899	0.272
MOD_CK1_1	174	180	PF00069	0.428
MOD_CK1_1	228	234	PF00069	0.413
MOD_CK1_1	244	250	PF00069	0.536
MOD_CK1_1	271	277	PF00069	0.379
MOD_CK2_1	118	124	PF00069	0.403
MOD_CK2_1	20	26	PF00069	0.272
MOD_CK2_1	228	234	PF00069	0.385
MOD_GlcNHglycan	243	246	PF01048	0.521
MOD_GlcNHglycan	29	32	PF01048	0.335
MOD_GlcNHglycan	86	89	PF01048	0.278
MOD_GSK3_1	228	235	PF00069	0.372
MOD_GSK3_1	259	266	PF00069	0.197
MOD_GSK3_1	381	388	PF00069	0.550
MOD_N-GLC_1	219	224	PF02516	0.445
MOD_NEK2_1	111	116	PF00069	0.322
MOD_NEK2_1	20	25	PF00069	0.373
MOD_NEK2_1	225	230	PF00069	0.439
MOD_NEK2_1	336	341	PF00069	0.307
MOD_NEK2_1	84	89	PF00069	0.254
MOD_NEK2_2	73	78	PF00069	0.385
MOD_NEK2_2	95	100	PF00069	0.385
MOD_PKA_2	134	140	PF00069	0.353
MOD_PKA_2	271	277	PF00069	0.335
MOD_PKA_2	404	410	PF00069	0.327
MOD_Plk_1	161	167	PF00069	0.341
MOD_Plk_1	336	342	PF00069	0.287
MOD_Plk_4	42	48	PF00069	0.301
MOD_Plk_4	95	101	PF00069	0.385
MOD_ProDKin_1	13	19	PF00069	0.416
MOD_ProDKin_1	174	180	PF00069	0.315
MOD_ProDKin_1	254	260	PF00069	0.475
MOD_ProDKin_1	386	392	PF00069	0.399
MOD_SUMO_rev_2	389	395	PF00179	0.605
TRG_DiLeu_BaEn_1	359	364	PF01217	0.385
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.273
TRG_ENDOCYTIC_2	148	151	PF00928	0.340
TRG_ENDOCYTIC_2	169	172	PF00928	0.364
TRG_ENDOCYTIC_2	349	352	PF00928	0.385
TRG_ER_diArg_1	194	196	PF00400	0.532
TRG_ER_diArg_1	236	238	PF00400	0.438
TRG_ER_diArg_1	395	397	PF00400	0.602
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.303
TRG_Pf-PMV_PEXEL_1	397	402	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I285	Leptomonas seymouri	67%	100%
A0A1X0NSM8	Trypanosomatidae	40%	100%
A0A422NZ60	Trypanosoma rangeli	39%	100%
A4HGL1	Leishmania braziliensis	85%	100%
A4I3N7	Leishmania infantum	99%	100%
D0A8C7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AZX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O86938	Streptomyces viridochromogenes (strain DSM 40736 / JCM 4977 / BCRC 1201 / Tue 494)	28%	100%
Q4Q8A7	Leishmania major	94%	100%
Q54271	Streptomyces hygroscopicus	27%	100%
V5DBD1	Trypanosoma cruzi	41%	92%