LeishMANIAdb
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Amastin surface glycoprotein, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Amastin surface glycoprotein, putative
Gene product:
Amastin surface glycoprotein, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X1H6_LEIDO
TriTrypDb:
LdBPK_281500.1 , LdCL_280019700 , LDHU3_28.1910
Length:
342

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Amastin, Kinetoplastid host adhesion protein. A host adhesion protein family greatly expanded in Leishmaniids.. Localization: Cell surface (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0020016 ciliary pocket 2 1

Expansion

Sequence features

A0A3S7X1H6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1H6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 128 132 PF00656 0.586
CLV_C14_Caspase3-7 17 21 PF00656 0.712
CLV_C14_Caspase3-7 262 266 PF00656 0.447
CLV_NRD_NRD_1 184 186 PF00675 0.557
CLV_NRD_NRD_1 53 55 PF00675 0.578
CLV_PCSK_KEX2_1 184 186 PF00082 0.567
CLV_PCSK_KEX2_1 42 44 PF00082 0.446
CLV_PCSK_KEX2_1 53 55 PF00082 0.555
CLV_PCSK_KEX2_1 76 78 PF00082 0.509
CLV_PCSK_PC1ET2_1 42 44 PF00082 0.433
CLV_PCSK_PC1ET2_1 76 78 PF00082 0.503
CLV_PCSK_SKI1_1 121 125 PF00082 0.449
CLV_PCSK_SKI1_1 185 189 PF00082 0.543
CLV_PCSK_SKI1_1 196 200 PF00082 0.441
DEG_MDM2_SWIB_1 141 149 PF02201 0.386
DOC_CKS1_1 69 74 PF01111 0.786
DOC_MAPK_gen_1 275 282 PF00069 0.526
DOC_MAPK_HePTP_8 127 139 PF00069 0.622
DOC_MAPK_MEF2A_6 130 139 PF00069 0.612
DOC_MAPK_MEF2A_6 275 284 PF00069 0.523
DOC_PP2B_LxvP_1 113 116 PF13499 0.525
DOC_WW_Pin1_4 233 238 PF00397 0.477
DOC_WW_Pin1_4 53 58 PF00397 0.689
DOC_WW_Pin1_4 68 73 PF00397 0.759
LIG_14-3-3_CanoR_1 184 188 PF00244 0.322
LIG_Actin_WH2_2 215 230 PF00022 0.405
LIG_BIR_III_4 79 83 PF00653 0.660
LIG_CaM_IQ_9 186 202 PF13499 0.299
LIG_FHA_1 122 128 PF00498 0.662
LIG_FHA_1 134 140 PF00498 0.510
LIG_FHA_1 184 190 PF00498 0.270
LIG_FHA_1 217 223 PF00498 0.371
LIG_FHA_1 314 320 PF00498 0.284
LIG_FHA_1 324 330 PF00498 0.280
LIG_FHA_1 63 69 PF00498 0.708
LIG_FHA_2 81 87 PF00498 0.753
LIG_GBD_Chelix_1 282 290 PF00786 0.433
LIG_Integrin_RGD_1 77 79 PF01839 0.507
LIG_LIR_Gen_1 136 146 PF02991 0.325
LIG_LIR_Gen_1 203 212 PF02991 0.410
LIG_LIR_Gen_1 238 248 PF02991 0.477
LIG_LIR_Gen_1 291 300 PF02991 0.342
LIG_LIR_Gen_1 30 40 PF02991 0.706
LIG_LIR_Nem_3 136 141 PF02991 0.325
LIG_LIR_Nem_3 169 173 PF02991 0.271
LIG_LIR_Nem_3 203 208 PF02991 0.410
LIG_LIR_Nem_3 291 296 PF02991 0.337
LIG_PDZ_Class_1 337 342 PF00595 0.356
LIG_Pex14_2 141 145 PF04695 0.439
LIG_SH2_GRB2like 240 243 PF00017 0.543
LIG_SH2_STAP1 33 37 PF00017 0.703
LIG_SH2_STAT5 138 141 PF00017 0.428
LIG_SH2_STAT5 168 171 PF00017 0.281
LIG_SH2_STAT5 182 185 PF00017 0.258
LIG_SH2_STAT5 26 29 PF00017 0.761
LIG_SH2_STAT5 304 307 PF00017 0.285
LIG_SH2_STAT5 309 312 PF00017 0.282
LIG_SH2_STAT5 335 338 PF00017 0.434
LIG_SH3_3 231 237 PF00018 0.487
LIG_SUMO_SIM_anti_2 158 164 PF11976 0.296
LIG_SUMO_SIM_anti_2 206 213 PF11976 0.325
LIG_TRAF2_1 83 86 PF00917 0.689
MOD_CDC14_SPxK_1 73 76 PF00782 0.680
MOD_CDK_SPK_2 53 58 PF00069 0.706
MOD_CDK_SPxK_1 70 76 PF00069 0.772
MOD_CDK_SPxxK_3 70 77 PF00069 0.752
MOD_CK1_1 155 161 PF00069 0.429
MOD_CK1_1 203 209 PF00069 0.376
MOD_CK1_1 213 219 PF00069 0.334
MOD_CK1_1 29 35 PF00069 0.737
MOD_CK1_1 38 44 PF00069 0.717
MOD_CK2_1 18 24 PF00069 0.766
MOD_CK2_1 29 35 PF00069 0.640
MOD_CK2_1 80 86 PF00069 0.669
MOD_GlcNHglycan 127 130 PF01048 0.484
MOD_GlcNHglycan 154 157 PF01048 0.469
MOD_GlcNHglycan 202 205 PF01048 0.579
MOD_GlcNHglycan 212 215 PF01048 0.351
MOD_GlcNHglycan 237 240 PF01048 0.355
MOD_GlcNHglycan 29 32 PF01048 0.560
MOD_GlcNHglycan 46 49 PF01048 0.532
MOD_GSK3_1 121 128 PF00069 0.697
MOD_GSK3_1 129 136 PF00069 0.588
MOD_GSK3_1 14 21 PF00069 0.737
MOD_GSK3_1 151 158 PF00069 0.398
MOD_GSK3_1 176 183 PF00069 0.282
MOD_GSK3_1 190 197 PF00069 0.249
MOD_GSK3_1 206 213 PF00069 0.394
MOD_GSK3_1 22 29 PF00069 0.727
MOD_GSK3_1 309 316 PF00069 0.291
MOD_GSK3_1 31 38 PF00069 0.690
MOD_LATS_1 233 239 PF00433 0.477
MOD_N-GLC_1 259 264 PF02516 0.306
MOD_N-GLC_1 62 67 PF02516 0.437
MOD_NEK2_1 217 222 PF00069 0.381
MOD_NEK2_1 310 315 PF00069 0.311
MOD_NEK2_1 323 328 PF00069 0.290
MOD_PIKK_1 129 135 PF00454 0.600
MOD_PIKK_1 14 20 PF00454 0.718
MOD_PIKK_1 155 161 PF00454 0.316
MOD_PIKK_1 259 265 PF00454 0.466
MOD_PIKK_1 80 86 PF00454 0.669
MOD_PK_1 194 200 PF00069 0.223
MOD_PKA_2 129 135 PF00069 0.576
MOD_PKA_2 183 189 PF00069 0.322
MOD_PKA_2 190 196 PF00069 0.307
MOD_PKB_1 119 127 PF00069 0.668
MOD_Plk_1 22 28 PF00069 0.805
MOD_Plk_1 288 294 PF00069 0.464
MOD_Plk_4 133 139 PF00069 0.562
MOD_Plk_4 166 172 PF00069 0.301
MOD_Plk_4 213 219 PF00069 0.417
MOD_ProDKin_1 233 239 PF00069 0.477
MOD_ProDKin_1 53 59 PF00069 0.688
MOD_ProDKin_1 68 74 PF00069 0.757
MOD_SUMO_for_1 57 60 PF00179 0.699
MOD_SUMO_rev_2 270 277 PF00179 0.445
TRG_ENDOCYTIC_2 138 141 PF00928 0.416
TRG_ENDOCYTIC_2 240 243 PF00928 0.549
TRG_ENDOCYTIC_2 33 36 PF00928 0.728
TRG_ENDOCYTIC_2 335 338 PF00928 0.442
TRG_ER_diArg_1 53 55 PF00400 0.701
TRG_NLS_Bipartite_1 76 98 PF00514 0.700
TRG_Pf-PMV_PEXEL_1 196 200 PF00026 0.445
TRG_Pf-PMV_PEXEL_1 66 70 PF00026 0.562

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7I8 Leptomonas seymouri 44% 100%
A0A1X0NYN9 Trypanosomatidae 33% 100%
A0A422MVT4 Trypanosoma rangeli 28% 100%
A4HDI3 Leishmania braziliensis 26% 100%
A4HGJ1 Leishmania braziliensis 64% 100%
A4I0W6 Leishmania infantum 23% 100%
A4I3L8 Leishmania infantum 100% 100%
E9AZV8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 99%
Q4Q8C7 Leishmania major 92% 100%
V5AQB9 Trypanosoma cruzi 37% 100%
V5D669 Trypanosoma cruzi 26% 88%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS