UmuC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA polymerase kappa, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X1H5_LEIDO

TriTrypDb:

LdBPK_281540.1 , LdCL_280020200 , LDHU3_28.1980

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X1H5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1H5

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	4
GO:0006259	DNA metabolic process	4	4
GO:0006260	DNA replication	5	1
GO:0006281	DNA repair	5	4
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0006950	response to stress	2	4
GO:0006974	DNA damage response	4	4
GO:0008152	metabolic process	1	4
GO:0009987	cellular process	1	4

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003677	DNA binding	4	4
GO:0003684	damaged DNA binding	5	4
GO:0003824	catalytic activity	1	2
GO:0003887	DNA-directed DNA polymerase activity	5	2
GO:0005488	binding	1	4
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016779	nucleotidyltransferase activity	4	2
GO:0034061	DNA polymerase activity	4	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	401	405	PF00656	0.562
CLV_NRD_NRD_1	189	191	PF00675	0.482
CLV_NRD_NRD_1	23	25	PF00675	0.600
CLV_NRD_NRD_1	295	297	PF00675	0.808
CLV_NRD_NRD_1	353	355	PF00675	0.558
CLV_PCSK_KEX2_1	22	24	PF00082	0.598
CLV_PCSK_KEX2_1	295	297	PF00082	0.808
CLV_PCSK_KEX2_1	532	534	PF00082	0.571
CLV_PCSK_PC1ET2_1	532	534	PF00082	0.571
CLV_PCSK_PC7_1	528	534	PF00082	0.573

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A4I3M2	Leishmania infantum	94%	100%
E9AZW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%

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