UmuC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA polymerase kappa, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X1H5_LEIDO

TriTrypDb:

LdBPK_281540.1 , LdCL_280020200 , LDHU3_28.1980

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X1H5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1H5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	4
GO:0006259	DNA metabolic process	4	4
GO:0006281	DNA repair	5	4
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0006950	response to stress	2	4
GO:0006974	DNA damage response	4	4
GO:0008152	metabolic process	1	4
GO:0009987	cellular process	1	4
GO:0033554	cellular response to stress	3	4
GO:0034641	cellular nitrogen compound metabolic process	3	4
GO:0043170	macromolecule metabolic process	3	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044260	obsolete cellular macromolecule metabolic process	3	4
GO:0046483	heterocycle metabolic process	3	4
GO:0050896	response to stimulus	1	4
GO:0051716	cellular response to stimulus	2	4
GO:0071704	organic substance metabolic process	2	4
GO:0090304	nucleic acid metabolic process	4	4
GO:1901360	organic cyclic compound metabolic process	3	4
GO:0006260	DNA replication	5	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003677	DNA binding	4	4
GO:0003684	damaged DNA binding	5	4
GO:0005488	binding	1	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4
GO:0003824	catalytic activity	1	2
GO:0003887	DNA-directed DNA polymerase activity	5	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016779	nucleotidyltransferase activity	4	2
GO:0034061	DNA polymerase activity	4	2
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0140097	catalytic activity, acting on DNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	401	405	PF00656	0.562
CLV_NRD_NRD_1	189	191	PF00675	0.482
CLV_NRD_NRD_1	23	25	PF00675	0.600
CLV_NRD_NRD_1	295	297	PF00675	0.808
CLV_NRD_NRD_1	353	355	PF00675	0.558
CLV_PCSK_KEX2_1	22	24	PF00082	0.598
CLV_PCSK_KEX2_1	295	297	PF00082	0.808
CLV_PCSK_KEX2_1	532	534	PF00082	0.571
CLV_PCSK_PC1ET2_1	532	534	PF00082	0.571
CLV_PCSK_PC7_1	528	534	PF00082	0.573
CLV_PCSK_SKI1_1	210	214	PF00082	0.439
CLV_PCSK_SKI1_1	296	300	PF00082	0.547
CLV_PCSK_SKI1_1	99	103	PF00082	0.546
DEG_ODPH_VHL_1	444	456	PF01847	0.501
DOC_MAPK_DCC_7	282	291	PF00069	0.384
DOC_MAPK_gen_1	272	281	PF00069	0.579
DOC_MAPK_gen_1	282	291	PF00069	0.483
DOC_MAPK_MEF2A_6	274	283	PF00069	0.574
DOC_MAPK_MEF2A_6	77	84	PF00069	0.600
DOC_PP1_RVXF_1	226	233	PF00149	0.541
DOC_PP2B_LxvP_1	509	512	PF13499	0.496
DOC_USP7_MATH_1	171	175	PF00917	0.712
DOC_USP7_MATH_1	185	189	PF00917	0.400
DOC_USP7_MATH_1	238	242	PF00917	0.468
DOC_USP7_MATH_1	251	255	PF00917	0.341
DOC_USP7_MATH_1	31	35	PF00917	0.450
DOC_USP7_MATH_1	366	370	PF00917	0.554
DOC_USP7_MATH_1	386	390	PF00917	0.533
DOC_USP7_MATH_1	461	465	PF00917	0.499
DOC_USP7_UBL2_3	187	191	PF12436	0.614
DOC_USP7_UBL2_3	308	312	PF12436	0.698
DOC_WW_Pin1_4	167	172	PF00397	0.730
DOC_WW_Pin1_4	342	347	PF00397	0.618
DOC_WW_Pin1_4	37	42	PF00397	0.427
DOC_WW_Pin1_4	427	432	PF00397	0.503
DOC_WW_Pin1_4	481	486	PF00397	0.559
DOC_WW_Pin1_4	494	499	PF00397	0.541
DOC_WW_Pin1_4	507	512	PF00397	0.493
LIG_14-3-3_CanoR_1	190	196	PF00244	0.568
LIG_14-3-3_CanoR_1	210	219	PF00244	0.273
LIG_14-3-3_CanoR_1	354	359	PF00244	0.647
LIG_14-3-3_CanoR_1	420	426	PF00244	0.505
LIG_14-3-3_CanoR_1	492	498	PF00244	0.607
LIG_14-3-3_CterR_2	533	536	PF00244	0.570
LIG_Actin_WH2_2	161	179	PF00022	0.636
LIG_BIR_II_1	1	5	PF00653	0.433
LIG_BIR_III_2	404	408	PF00653	0.560
LIG_BRCT_BRCA1_1	235	239	PF00533	0.594
LIG_BRCT_BRCA1_1	417	421	PF00533	0.507
LIG_CtBP_PxDLS_1	391	395	PF00389	0.525
LIG_EVH1_2	468	472	PF00568	0.425
LIG_FHA_1	2	8	PF00498	0.603
LIG_FHA_1	225	231	PF00498	0.544
LIG_FHA_2	366	372	PF00498	0.622
LIG_FHA_2	61	67	PF00498	0.489
LIG_FHA_2	95	101	PF00498	0.539
LIG_LIR_Gen_1	252	262	PF02991	0.557
LIG_LIR_Gen_1	40	50	PF02991	0.587
LIG_LIR_Nem_3	114	120	PF02991	0.578
LIG_LIR_Nem_3	203	209	PF02991	0.556
LIG_LIR_Nem_3	252	258	PF02991	0.565
LIG_LIR_Nem_3	275	279	PF02991	0.577
LIG_LIR_Nem_3	40	46	PF02991	0.582
LIG_MYND_1	507	511	PF01753	0.496
LIG_OCRL_FandH_1	268	280	PF00620	0.480
LIG_SH2_STAT5	110	113	PF00017	0.471
LIG_SH2_STAT5	120	123	PF00017	0.452
LIG_SH2_STAT5	233	236	PF00017	0.552
LIG_SH2_STAT5	442	445	PF00017	0.526
LIG_SH2_STAT5	455	458	PF00017	0.465
LIG_SH3_2	487	492	PF14604	0.569
LIG_SH3_3	139	145	PF00018	0.638
LIG_SH3_3	262	268	PF00018	0.576
LIG_SH3_3	440	446	PF00018	0.529
LIG_SH3_3	47	53	PF00018	0.604
LIG_SH3_3	480	486	PF00018	0.560
LIG_SH3_3	501	507	PF00018	0.540
LIG_SH3_4	52	59	PF00018	0.603
LIG_SUMO_SIM_par_1	57	63	PF11976	0.616
LIG_TRAF2_1	339	342	PF00917	0.551
LIG_TRAF2_1	63	66	PF00917	0.622
LIG_TRFH_1	442	446	PF08558	0.521
MOD_CDK_SPxxK_3	485	492	PF00069	0.568
MOD_CK1_1	162	168	PF00069	0.628
MOD_CK1_1	2	8	PF00069	0.416
MOD_CK1_1	249	255	PF00069	0.532
MOD_CK1_1	362	368	PF00069	0.581
MOD_CK1_1	430	436	PF00069	0.520
MOD_CK1_1	497	503	PF00069	0.554
MOD_CK2_1	132	138	PF00069	0.714
MOD_CK2_1	336	342	PF00069	0.542
MOD_CK2_1	365	371	PF00069	0.623
MOD_CK2_1	60	66	PF00069	0.604
MOD_Cter_Amidation	293	296	PF01082	0.766
MOD_Cter_Amidation	352	355	PF01082	0.554
MOD_DYRK1A_RPxSP_1	427	431	PF00069	0.499
MOD_GlcNHglycan	146	149	PF01048	0.772
MOD_GlcNHglycan	155	158	PF01048	0.619
MOD_GlcNHglycan	173	176	PF01048	0.492
MOD_GlcNHglycan	296	299	PF01048	0.595
MOD_GlcNHglycan	33	36	PF01048	0.553
MOD_GlcNHglycan	364	367	PF01048	0.621
MOD_GlcNHglycan	371	375	PF01048	0.631
MOD_GlcNHglycan	394	397	PF01048	0.609
MOD_GlcNHglycan	437	440	PF01048	0.548
MOD_GSK3_1	140	147	PF00069	0.760
MOD_GSK3_1	167	174	PF00069	0.639
MOD_GSK3_1	186	193	PF00069	0.346
MOD_GSK3_1	2	9	PF00069	0.535
MOD_GSK3_1	354	361	PF00069	0.581
MOD_GSK3_1	362	369	PF00069	0.528
MOD_GSK3_1	370	377	PF00069	0.506
MOD_GSK3_1	386	393	PF00069	0.524
MOD_GSK3_1	411	418	PF00069	0.519
MOD_GSK3_1	481	488	PF00069	0.565
MOD_GSK3_1	493	500	PF00069	0.565
MOD_GSK3_1	507	514	PF00069	0.505
MOD_LATS_1	208	214	PF00433	0.427
MOD_N-GLC_1	132	137	PF02516	0.594
MOD_N-GLC_1	366	371	PF02516	0.549
MOD_NEK2_1	119	124	PF00069	0.526
MOD_NEK2_1	232	237	PF00069	0.560
MOD_NEK2_1	358	363	PF00069	0.542
MOD_NEK2_1	411	416	PF00069	0.519
MOD_NEK2_1	425	430	PF00069	0.585
MOD_NEK2_1	6	11	PF00069	0.413
MOD_NEK2_2	94	99	PF00069	0.555
MOD_PIKK_1	210	216	PF00454	0.405
MOD_PIKK_1	26	32	PF00454	0.611
MOD_PIKK_1	432	438	PF00454	0.536
MOD_PIKK_1	461	467	PF00454	0.493
MOD_PKA_1	190	196	PF00069	0.487
MOD_PKA_1	354	360	PF00069	0.552
MOD_PKA_2	162	168	PF00069	0.727
MOD_PKA_2	294	300	PF00069	0.652
MOD_PKA_2	358	364	PF00069	0.551
MOD_PKA_2	419	425	PF00069	0.503
MOD_Plk_1	113	119	PF00069	0.571
MOD_Plk_1	473	479	PF00069	0.485
MOD_Plk_2-3	399	405	PF00069	0.559
MOD_Plk_4	2	8	PF00069	0.416
MOD_Plk_4	497	503	PF00069	0.554
MOD_ProDKin_1	167	173	PF00069	0.732
MOD_ProDKin_1	342	348	PF00069	0.616
MOD_ProDKin_1	37	43	PF00069	0.425
MOD_ProDKin_1	427	433	PF00069	0.506
MOD_ProDKin_1	481	487	PF00069	0.563
MOD_ProDKin_1	494	500	PF00069	0.541
MOD_ProDKin_1	507	513	PF00069	0.499
TRG_DiLeu_BaLyEn_6	274	279	PF01217	0.593
TRG_ENDOCYTIC_2	120	123	PF00928	0.503
TRG_ENDOCYTIC_2	259	262	PF00928	0.411
TRG_ER_diArg_1	21	24	PF00400	0.549
TRG_ER_diArg_1	61	64	PF00400	0.631
TRG_ER_diArg_1	7	10	PF00400	0.430
TRG_NES_CRM1_1	66	78	PF08389	0.594
TRG_Pf-PMV_PEXEL_1	210	214	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I3M2	Leishmania infantum	94%	100%
E9AZW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%