ATP-grasp domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-grasp domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X1H2_LEIDO

TriTrypDb:

LdBPK_281180.1 , LdCL_280016400 , LDHU3_28.1470

Length:

785

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X1H2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1H2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.410
CLV_C14_Caspase3-7	61	65	PF00656	0.377
CLV_C14_Caspase3-7	705	709	PF00656	0.547
CLV_NRD_NRD_1	385	387	PF00675	0.473
CLV_NRD_NRD_1	411	413	PF00675	0.323
CLV_NRD_NRD_1	439	441	PF00675	0.573
CLV_NRD_NRD_1	452	454	PF00675	0.573
CLV_NRD_NRD_1	585	587	PF00675	0.422
CLV_NRD_NRD_1	697	699	PF00675	0.672
CLV_PCSK_KEX2_1	411	413	PF00082	0.323
CLV_PCSK_KEX2_1	452	454	PF00082	0.649
CLV_PCSK_KEX2_1	585	587	PF00082	0.397
CLV_PCSK_KEX2_1	697	699	PF00082	0.719
CLV_PCSK_SKI1_1	305	309	PF00082	0.411
CLV_PCSK_SKI1_1	452	456	PF00082	0.433
CLV_PCSK_SKI1_1	576	580	PF00082	0.430
CLV_PCSK_SKI1_1	585	589	PF00082	0.440
CLV_PCSK_SKI1_1	645	649	PF00082	0.488
CLV_PCSK_SKI1_1	673	677	PF00082	0.476
DEG_Nend_Nbox_1	1	3	PF02207	0.410
DEG_SPOP_SBC_1	686	690	PF00917	0.485
DOC_CKS1_1	599	604	PF01111	0.526
DOC_CYCLIN_yCln2_LP_2	278	284	PF00134	0.331
DOC_MAPK_gen_1	382	390	PF00069	0.376
DOC_PP1_RVXF_1	303	309	PF00149	0.411
DOC_PP2B_LxvP_1	278	281	PF13499	0.415
DOC_PP4_FxxP_1	599	602	PF00568	0.458
DOC_PP4_FxxP_1	610	613	PF00568	0.457
DOC_USP7_MATH_1	155	159	PF00917	0.454
DOC_USP7_MATH_1	233	237	PF00917	0.421
DOC_USP7_MATH_1	406	410	PF00917	0.507
DOC_USP7_MATH_1	547	551	PF00917	0.645
DOC_USP7_MATH_1	631	635	PF00917	0.519
DOC_USP7_MATH_1	686	690	PF00917	0.648
DOC_USP7_MATH_1	718	722	PF00917	0.422
DOC_USP7_MATH_1	754	758	PF00917	0.514
DOC_USP7_MATH_1	98	102	PF00917	0.584
DOC_USP7_UBL2_3	93	97	PF12436	0.501
DOC_WW_Pin1_4	109	114	PF00397	0.724
DOC_WW_Pin1_4	124	129	PF00397	0.403
DOC_WW_Pin1_4	598	603	PF00397	0.537
DOC_WW_Pin1_4	609	614	PF00397	0.372
LIG_14-3-3_CanoR_1	15	24	PF00244	0.463
LIG_14-3-3_CanoR_1	305	311	PF00244	0.331
LIG_14-3-3_CanoR_1	38	42	PF00244	0.492
LIG_14-3-3_CanoR_1	394	398	PF00244	0.439
LIG_14-3-3_CanoR_1	440	446	PF00244	0.417
LIG_14-3-3_CanoR_1	488	495	PF00244	0.384
LIG_14-3-3_CanoR_1	576	584	PF00244	0.481
LIG_14-3-3_CanoR_1	604	608	PF00244	0.417
LIG_14-3-3_CanoR_1	671	676	PF00244	0.479
LIG_14-3-3_CanoR_1	720	730	PF00244	0.512
LIG_Actin_WH2_2	360	378	PF00022	0.457
LIG_BIR_III_4	422	426	PF00653	0.359
LIG_CSL_BTD_1	537	540	PF09270	0.374
LIG_deltaCOP1_diTrp_1	351	356	PF00928	0.281
LIG_eIF4E_1	135	141	PF01652	0.508
LIG_eIF4E_1	392	398	PF01652	0.468
LIG_eIF4E_1	495	501	PF01652	0.306
LIG_EVH1_1	538	542	PF00568	0.377
LIG_FHA_1	136	142	PF00498	0.550
LIG_FHA_1	275	281	PF00498	0.439
LIG_FHA_1	362	368	PF00498	0.510
LIG_FHA_1	375	381	PF00498	0.468
LIG_FHA_1	488	494	PF00498	0.371
LIG_FHA_1	555	561	PF00498	0.362
LIG_FHA_1	586	592	PF00498	0.536
LIG_FHA_1	604	610	PF00498	0.359
LIG_FHA_1	612	618	PF00498	0.506
LIG_FHA_1	650	656	PF00498	0.529
LIG_FHA_1	732	738	PF00498	0.596
LIG_FHA_2	262	268	PF00498	0.467
LIG_FHA_2	298	304	PF00498	0.360
LIG_FHA_2	440	446	PF00498	0.392
LIG_FHA_2	562	568	PF00498	0.489
LIG_FHA_2	575	581	PF00498	0.540
LIG_FHA_2	652	658	PF00498	0.400
LIG_FHA_2	672	678	PF00498	0.389
LIG_FHA_2	691	697	PF00498	0.788
LIG_FHA_2	703	709	PF00498	0.578
LIG_LIR_Apic_2	354	359	PF02991	0.285
LIG_LIR_Apic_2	608	613	PF02991	0.419
LIG_LIR_Gen_1	115	126	PF02991	0.409
LIG_LIR_Gen_1	153	161	PF02991	0.393
LIG_LIR_Gen_1	163	173	PF02991	0.328
LIG_LIR_Gen_1	220	229	PF02991	0.598
LIG_LIR_Gen_1	292	301	PF02991	0.300
LIG_LIR_Gen_1	496	504	PF02991	0.326
LIG_LIR_Gen_1	769	778	PF02991	0.421
LIG_LIR_Nem_3	115	121	PF02991	0.425
LIG_LIR_Nem_3	153	159	PF02991	0.360
LIG_LIR_Nem_3	163	168	PF02991	0.343
LIG_LIR_Nem_3	220	226	PF02991	0.623
LIG_LIR_Nem_3	292	297	PF02991	0.300
LIG_LIR_Nem_3	340	346	PF02991	0.408
LIG_LIR_Nem_3	496	501	PF02991	0.352
LIG_LIR_Nem_3	535	541	PF02991	0.461
LIG_LIR_Nem_3	583	587	PF02991	0.344
LIG_Rb_pABgroove_1	386	394	PF01858	0.354
LIG_SH2_CRK	156	160	PF00017	0.447
LIG_SH2_CRK	223	227	PF00017	0.487
LIG_SH2_CRK	343	347	PF00017	0.360
LIG_SH2_CRK	498	502	PF00017	0.381
LIG_SH2_GRB2like	152	155	PF00017	0.487
LIG_SH2_GRB2like	184	187	PF00017	0.403
LIG_SH2_GRB2like	764	767	PF00017	0.523
LIG_SH2_GRB2like	79	82	PF00017	0.417
LIG_SH2_NCK_1	152	156	PF00017	0.389
LIG_SH2_NCK_1	223	227	PF00017	0.487
LIG_SH2_SRC	152	155	PF00017	0.509
LIG_SH2_SRC	167	170	PF00017	0.540
LIG_SH2_SRC	184	187	PF00017	0.368
LIG_SH2_SRC	330	333	PF00017	0.266
LIG_SH2_SRC	62	65	PF00017	0.372
LIG_SH2_SRC	79	82	PF00017	0.311
LIG_SH2_STAP1	152	156	PF00017	0.336
LIG_SH2_STAP1	498	502	PF00017	0.352
LIG_SH2_STAT3	392	395	PF00017	0.471
LIG_SH2_STAT5	167	170	PF00017	0.347
LIG_SH2_STAT5	184	187	PF00017	0.309
LIG_SH2_STAT5	223	226	PF00017	0.497
LIG_SH2_STAT5	257	260	PF00017	0.347
LIG_SH2_STAT5	261	264	PF00017	0.355
LIG_SH2_STAT5	330	333	PF00017	0.302
LIG_SH2_STAT5	336	339	PF00017	0.329
LIG_SH2_STAT5	416	419	PF00017	0.310
LIG_SH2_STAT5	503	506	PF00017	0.331
LIG_SH2_STAT5	62	65	PF00017	0.365
LIG_SH2_STAT5	764	767	PF00017	0.410
LIG_SH2_STAT5	79	82	PF00017	0.318
LIG_SH3_3	107	113	PF00018	0.515
LIG_SH3_3	280	286	PF00018	0.371
LIG_SH3_3	534	540	PF00018	0.387
LIG_SH3_3	591	597	PF00018	0.648
LIG_SH3_5	180	184	PF00018	0.321
LIG_SUMO_SIM_par_1	472	477	PF11976	0.349
LIG_SUMO_SIM_par_1	605	612	PF11976	0.416
LIG_TRAF2_1	32	35	PF00917	0.455
LIG_TRAF2_1	370	373	PF00917	0.552
LIG_TRAF2_1	564	567	PF00917	0.496
LIG_TYR_ITIM	341	346	PF00017	0.360
LIG_WRC_WIRS_1	581	586	PF05994	0.356
MOD_CDC14_SPxK_1	127	130	PF00782	0.393
MOD_CDK_SPK_2	124	129	PF00069	0.375
MOD_CDK_SPxK_1	124	130	PF00069	0.373
MOD_CDK_SPxK_1	598	604	PF00069	0.535
MOD_CK1_1	106	112	PF00069	0.568
MOD_CK1_1	193	199	PF00069	0.361
MOD_CK1_1	236	242	PF00069	0.460
MOD_CK1_1	260	266	PF00069	0.383
MOD_CK1_1	317	323	PF00069	0.411
MOD_CK1_1	611	617	PF00069	0.494
MOD_CK1_1	634	640	PF00069	0.405
MOD_CK1_1	709	715	PF00069	0.691
MOD_CK1_1	721	727	PF00069	0.468
MOD_CK1_1	728	734	PF00069	0.471
MOD_CK2_1	367	373	PF00069	0.447
MOD_CK2_1	439	445	PF00069	0.433
MOD_CK2_1	561	567	PF00069	0.487
MOD_CK2_1	574	580	PF00069	0.539
MOD_CK2_1	651	657	PF00069	0.512
MOD_CK2_1	671	677	PF00069	0.522
MOD_CK2_1	686	692	PF00069	0.545
MOD_CMANNOS	353	356	PF00535	0.281
MOD_GlcNHglycan	100	103	PF01048	0.667
MOD_GlcNHglycan	173	176	PF01048	0.470
MOD_GlcNHglycan	18	21	PF01048	0.407
MOD_GlcNHglycan	287	290	PF01048	0.300
MOD_GlcNHglycan	369	372	PF01048	0.504
MOD_GlcNHglycan	408	411	PF01048	0.491
MOD_GlcNHglycan	636	639	PF01048	0.414
MOD_GlcNHglycan	641	644	PF01048	0.368
MOD_GlcNHglycan	682	685	PF01048	0.542
MOD_GSK3_1	108	115	PF00069	0.643
MOD_GSK3_1	217	224	PF00069	0.508
MOD_GSK3_1	22	29	PF00069	0.474
MOD_GSK3_1	232	239	PF00069	0.550
MOD_GSK3_1	257	264	PF00069	0.431
MOD_GSK3_1	285	292	PF00069	0.266
MOD_GSK3_1	293	300	PF00069	0.266
MOD_GSK3_1	313	320	PF00069	0.340
MOD_GSK3_1	361	368	PF00069	0.477
MOD_GSK3_1	512	519	PF00069	0.612
MOD_GSK3_1	576	583	PF00069	0.427
MOD_GSK3_1	608	615	PF00069	0.422
MOD_GSK3_1	651	658	PF00069	0.478
MOD_GSK3_1	686	693	PF00069	0.570
MOD_GSK3_1	702	709	PF00069	0.569
MOD_GSK3_1	718	725	PF00069	0.490
MOD_N-GLC_1	106	111	PF02516	0.762
MOD_N-GLC_1	706	711	PF02516	0.669
MOD_N-GLC_1	80	85	PF02516	0.498
MOD_N-GLC_2	428	430	PF02516	0.416
MOD_NEK2_1	555	560	PF00069	0.419
MOD_NEK2_1	587	592	PF00069	0.487
MOD_NEK2_1	649	654	PF00069	0.460
MOD_NEK2_1	719	724	PF00069	0.489
MOD_NEK2_1	80	85	PF00069	0.529
MOD_NEK2_2	62	67	PF00069	0.363
MOD_PIKK_1	314	320	PF00454	0.314
MOD_PIKK_1	709	715	PF00454	0.511
MOD_PIKK_1	754	760	PF00454	0.439
MOD_PK_1	386	392	PF00069	0.352
MOD_PKA_1	386	392	PF00069	0.533
MOD_PKA_1	585	591	PF00069	0.316
MOD_PKA_2	103	109	PF00069	0.529
MOD_PKA_2	236	242	PF00069	0.530
MOD_PKA_2	314	320	PF00069	0.437
MOD_PKA_2	37	43	PF00069	0.550
MOD_PKA_2	393	399	PF00069	0.392
MOD_PKA_2	439	445	PF00069	0.380
MOD_PKA_2	487	493	PF00069	0.366
MOD_PKA_2	547	553	PF00069	0.505
MOD_PKA_2	585	591	PF00069	0.456
MOD_PKA_2	603	609	PF00069	0.435
MOD_PKA_2	719	725	PF00069	0.501
MOD_PKB_1	546	554	PF00069	0.438
MOD_PKB_1	671	679	PF00069	0.534
MOD_Plk_1	414	420	PF00069	0.406
MOD_Plk_1	728	734	PF00069	0.556
MOD_Plk_1	768	774	PF00069	0.569
MOD_Plk_2-3	702	708	PF00069	0.782
MOD_Plk_4	155	161	PF00069	0.476
MOD_Plk_4	26	32	PF00069	0.490
MOD_Plk_4	274	280	PF00069	0.467
MOD_Plk_4	393	399	PF00069	0.416
MOD_Plk_4	496	502	PF00069	0.354
MOD_Plk_4	555	561	PF00069	0.393
MOD_Plk_4	728	734	PF00069	0.471
MOD_ProDKin_1	109	115	PF00069	0.716
MOD_ProDKin_1	124	130	PF00069	0.401
MOD_ProDKin_1	598	604	PF00069	0.535
MOD_ProDKin_1	609	615	PF00069	0.369
MOD_SUMO_for_1	271	274	PF00179	0.352
MOD_SUMO_for_1	463	466	PF00179	0.550
TRG_DiLeu_BaEn_1	274	279	PF01217	0.363
TRG_DiLeu_BaEn_1	4	9	PF01217	0.472
TRG_ENDOCYTIC_2	156	159	PF00928	0.374
TRG_ENDOCYTIC_2	223	226	PF00928	0.504
TRG_ENDOCYTIC_2	343	346	PF00928	0.360
TRG_ENDOCYTIC_2	498	501	PF00928	0.322
TRG_ENDOCYTIC_2	767	770	PF00928	0.483
TRG_ER_diArg_1	411	413	PF00400	0.315
TRG_ER_diArg_1	452	454	PF00400	0.654
TRG_ER_diArg_1	545	548	PF00400	0.602
TRG_ER_diArg_1	584	586	PF00400	0.383
TRG_Pf-PMV_PEXEL_1	411	415	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	576	580	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P453	Leptomonas seymouri	51%	93%
A0A0S4IPI1	Bodo saltans	31%	100%
A0A1X0NYA4	Trypanosomatidae	34%	100%
A0A422N237	Trypanosoma rangeli	38%	100%
A4HGF3	Leishmania braziliensis	78%	100%
A4I3I4	Leishmania infantum	100%	100%
D0A7V8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AZS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q8F8	Leishmania major	94%	100%
V5BEJ5	Trypanosoma cruzi	34%	94%