Zinc_finger_C3HC4_type_(RING_finger)_containing_p rotein_putative/Pfam:PF00097

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X1G5_LEIDO

TriTrypDb:

LdBPK_281410.1 , LdCL_280018700 , LDHU3_28.1770

Length:

398

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X1G5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1G5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	44	48	PF00656	0.629
CLV_NRD_NRD_1	10	12	PF00675	0.628
CLV_NRD_NRD_1	104	106	PF00675	0.464
CLV_NRD_NRD_1	15	17	PF00675	0.792
CLV_NRD_NRD_1	171	173	PF00675	0.532
CLV_PCSK_KEX2_1	104	106	PF00082	0.421
CLV_PCSK_KEX2_1	114	116	PF00082	0.456
CLV_PCSK_KEX2_1	125	127	PF00082	0.404
CLV_PCSK_KEX2_1	171	173	PF00082	0.501
CLV_PCSK_KEX2_1	63	65	PF00082	0.531
CLV_PCSK_KEX2_1	9	11	PF00082	0.638
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.607
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.519
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.586
CLV_PCSK_SKI1_1	104	108	PF00082	0.478
CLV_PCSK_SKI1_1	122	126	PF00082	0.380
CLV_PCSK_SKI1_1	3	7	PF00082	0.750
CLV_PCSK_SKI1_1	330	334	PF00082	0.378
CLV_PCSK_SKI1_1	95	99	PF00082	0.642
DEG_APCC_DBOX_1	243	251	PF00400	0.473
DEG_Nend_UBRbox_3	1	3	PF02207	0.549
DOC_CDC14_PxL_1	298	306	PF14671	0.271
DOC_CYCLIN_RxL_1	122	132	PF00134	0.462
DOC_MAPK_gen_1	208	217	PF00069	0.500
DOC_PP1_RVXF_1	123	130	PF00149	0.620
DOC_PP4_FxxP_1	290	293	PF00568	0.383
DOC_USP7_UBL2_3	110	114	PF12436	0.435
DOC_USP7_UBL2_3	330	334	PF12436	0.410
DOC_WW_Pin1_4	377	382	PF00397	0.634
LIG_14-3-3_CanoR_1	177	181	PF00244	0.490
LIG_14-3-3_CanoR_1	363	371	PF00244	0.424
LIG_Actin_WH2_2	357	374	PF00022	0.538
LIG_BRCT_BRCA1_1	314	318	PF00533	0.439
LIG_FHA_1	221	227	PF00498	0.460
LIG_FHA_1	259	265	PF00498	0.451
LIG_FHA_1	267	273	PF00498	0.284
LIG_FHA_1	32	38	PF00498	0.625
LIG_FHA_1	54	60	PF00498	0.585
LIG_FHA_2	199	205	PF00498	0.488
LIG_FHA_2	20	26	PF00498	0.616
LIG_FHA_2	39	45	PF00498	0.605
LIG_GBD_Chelix_1	68	76	PF00786	0.405
LIG_LIR_Apic_2	289	293	PF02991	0.377
LIG_LIR_Apic_2	303	308	PF02991	0.218
LIG_LIR_Nem_3	394	398	PF02991	0.561
LIG_LRP6_Inhibitor_1	343	349	PF00058	0.430
LIG_PCNA_yPIPBox_3	114	128	PF02747	0.545
LIG_Rb_LxCxE_1	289	309	PF01857	0.335
LIG_SH2_CRK	212	216	PF00017	0.488
LIG_SH2_CRK	305	309	PF00017	0.404
LIG_SH2_GRB2like	277	280	PF00017	0.270
LIG_SH2_SRC	277	280	PF00017	0.371
LIG_SH2_STAT3	225	228	PF00017	0.525
LIG_SH2_STAT5	174	177	PF00017	0.505
LIG_SH2_STAT5	225	228	PF00017	0.543
LIG_SH3_3	347	353	PF00018	0.465
LIG_SUMO_SIM_par_1	389	394	PF11976	0.560
LIG_TRAF2_1	106	109	PF00917	0.532
LIG_TRAF2_1	201	204	PF00917	0.492
LIG_UBA3_1	127	135	PF00899	0.425
LIG_UBA3_1	137	141	PF00899	0.434
LIG_UBA3_1	152	157	PF00899	0.481
MOD_CDC14_SPxK_1	380	383	PF00782	0.637
MOD_CDK_SPxK_1	377	383	PF00069	0.627
MOD_CK1_1	312	318	PF00069	0.416
MOD_CK1_1	359	365	PF00069	0.368
MOD_CK2_1	19	25	PF00069	0.614
MOD_CK2_1	198	204	PF00069	0.486
MOD_CK2_1	38	44	PF00069	0.711
MOD_DYRK1A_RPxSP_1	377	381	PF00069	0.474
MOD_GlcNHglycan	25	29	PF01048	0.791
MOD_GlcNHglycan	373	376	PF01048	0.619
MOD_GSK3_1	194	201	PF00069	0.440
MOD_GSK3_1	264	271	PF00069	0.402
MOD_GSK3_1	38	45	PF00069	0.745
MOD_NEK2_1	129	134	PF00069	0.462
MOD_NEK2_1	145	150	PF00069	0.272
MOD_NEK2_1	193	198	PF00069	0.502
MOD_NEK2_1	263	268	PF00069	0.513
MOD_NEK2_1	324	329	PF00069	0.459
MOD_NEK2_1	59	64	PF00069	0.515
MOD_NEK2_1	72	77	PF00069	0.354
MOD_PIKK_1	117	123	PF00454	0.548
MOD_PIKK_1	129	135	PF00454	0.532
MOD_PIKK_1	158	164	PF00454	0.386
MOD_PIKK_1	338	344	PF00454	0.463
MOD_PIKK_1	362	368	PF00454	0.522
MOD_PK_1	356	362	PF00069	0.360
MOD_PKA_2	176	182	PF00069	0.497
MOD_PKA_2	362	368	PF00069	0.517
MOD_PKA_2	371	377	PF00069	0.510
MOD_PKB_1	354	362	PF00069	0.552
MOD_PKB_1	9	17	PF00069	0.609
MOD_Plk_1	194	200	PF00069	0.449
MOD_Plk_1	264	270	PF00069	0.434
MOD_Plk_1	72	78	PF00069	0.477
MOD_Plk_2-3	155	161	PF00069	0.507
MOD_Plk_2-3	38	44	PF00069	0.589
MOD_Plk_4	300	306	PF00069	0.285
MOD_ProDKin_1	377	383	PF00069	0.639
MOD_SUMO_for_1	106	109	PF00179	0.523
MOD_SUMO_for_1	113	116	PF00179	0.504
MOD_SUMO_for_1	140	143	PF00179	0.429
MOD_SUMO_rev_2	154	159	PF00179	0.455
TRG_DiLeu_BaEn_4	154	160	PF01217	0.457
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.455
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.557
TRG_DiLeu_BaLyEn_6	245	250	PF01217	0.421
TRG_ENDOCYTIC_2	212	215	PF00928	0.491
TRG_ER_diArg_1	103	105	PF00400	0.577
TRG_ER_diArg_1	149	152	PF00400	0.596
TRG_ER_diArg_1	170	172	PF00400	0.485
TRG_ER_diArg_1	8	11	PF00400	0.634
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	369	373	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6L8	Leptomonas seymouri	65%	100%
A0A1X0P3W0	Trypanosomatidae	47%	100%
A0A3R7KVC5	Trypanosoma rangeli	46%	100%
A4HGH7	Leishmania braziliensis	79%	100%
A4I3K9	Leishmania infantum	100%	100%
C9ZPW1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	98%
E9AZU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q8D6	Leishmania major	92%	100%
V5AUY7	Trypanosoma cruzi	50%	88%