Copine_i-like_protein/GeneDB:LmjF.28.1190

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

copine i-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7X1G3_LEIDO

TriTrypDb:

LdBPK_281300.1 , LdCL_280017600 , LDHU3_28.1640

Length:

508

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X1G3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1G3

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0010035	response to inorganic substance	3	1
GO:0010038	response to metal ion	4	1
GO:0042221	response to chemical	2	1
GO:0050896	response to stimulus	1	1
GO:0051592	response to calcium ion	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0070887	cellular response to chemical stimulus	3	1
GO:0071241	cellular response to inorganic substance	4	1
GO:0071248	cellular response to metal ion	5	1
GO:0071277	cellular response to calcium ion	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0005543	phospholipid binding	3	9
GO:0005544	calcium-dependent phospholipid binding	4	9
GO:0008289	lipid binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	34	38	PF00656	0.341
CLV_C14_Caspase3-7	387	391	PF00656	0.293
CLV_C14_Caspase3-7	415	419	PF00656	0.265
CLV_NRD_NRD_1	240	242	PF00675	0.416
CLV_NRD_NRD_1	244	246	PF00675	0.455
CLV_NRD_NRD_1	393	395	PF00675	0.269
CLV_NRD_NRD_1	462	464	PF00675	0.284
CLV_PCSK_KEX2_1	244	246	PF00082	0.513
CLV_PCSK_KEX2_1	393	395	PF00082	0.269
CLV_PCSK_KEX2_1	462	464	PF00082	0.280
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.455
CLV_PCSK_SKI1_1	138	142	PF00082	0.300
CLV_PCSK_SKI1_1	308	312	PF00082	0.359
CLV_PCSK_SKI1_1	386	390	PF00082	0.337
DEG_Nend_UBRbox_1	1	4	PF02207	0.429
DOC_MAPK_gen_1	136	145	PF00069	0.275
DOC_MAPK_gen_1	182	192	PF00069	0.352
DOC_MAPK_gen_1	244	253	PF00069	0.391
DOC_MAPK_gen_1	393	403	PF00069	0.359
DOC_MAPK_gen_1	459	468	PF00069	0.264
DOC_MAPK_gen_1	82	91	PF00069	0.305
DOC_MAPK_MEF2A_6	103	111	PF00069	0.300
DOC_MAPK_MEF2A_6	128	135	PF00069	0.359
DOC_MAPK_MEF2A_6	25	32	PF00069	0.277
DOC_MAPK_MEF2A_6	396	405	PF00069	0.359
DOC_MAPK_MEF2A_6	70	77	PF00069	0.341
DOC_PP1_RVXF_1	291	298	PF00149	0.265
DOC_PP2B_LxvP_1	488	491	PF13499	0.269
DOC_PP4_FxxP_1	197	200	PF00568	0.293
DOC_PP4_FxxP_1	297	300	PF00568	0.265
DOC_PP4_FxxP_1	375	378	PF00568	0.300
DOC_USP7_MATH_2	211	217	PF00917	0.269
DOC_USP7_UBL2_3	242	246	PF12436	0.454
DOC_WW_Pin1_4	196	201	PF00397	0.426
DOC_WW_Pin1_4	501	506	PF00397	0.450
LIG_14-3-3_CanoR_1	136	141	PF00244	0.293
LIG_14-3-3_CanoR_1	164	168	PF00244	0.341
LIG_14-3-3_CanoR_1	245	253	PF00244	0.340
LIG_14-3-3_CanoR_1	386	395	PF00244	0.462
LIG_14-3-3_CanoR_1	98	107	PF00244	0.396
LIG_BRCT_BRCA1_1	246	250	PF00533	0.407
LIG_BRCT_BRCA1_1	260	264	PF00533	0.420
LIG_BRCT_BRCA1_1	278	282	PF00533	0.192
LIG_BRCT_BRCA1_1	293	297	PF00533	0.209
LIG_BRCT_BRCA1_1	341	345	PF00533	0.300
LIG_EH1_1	398	406	PF00400	0.265
LIG_EH1_1	66	74	PF00400	0.269
LIG_FHA_1	104	110	PF00498	0.296
LIG_FHA_1	114	120	PF00498	0.354
LIG_FHA_1	128	134	PF00498	0.224
LIG_FHA_1	182	188	PF00498	0.318
LIG_FHA_1	398	404	PF00498	0.265
LIG_FHA_1	44	50	PF00498	0.308
LIG_FHA_1	5	11	PF00498	0.410
LIG_FHA_2	221	227	PF00498	0.413
LIG_FHA_2	252	258	PF00498	0.403
LIG_FHA_2	29	35	PF00498	0.353
LIG_FHA_2	385	391	PF00498	0.293
LIG_FHA_2	407	413	PF00498	0.276
LIG_LIR_Apic_2	196	200	PF02991	0.293
LIG_LIR_Apic_2	294	300	PF02991	0.265
LIG_LIR_Apic_2	372	378	PF02991	0.208
LIG_LIR_Gen_1	234	239	PF02991	0.355
LIG_LIR_Gen_1	247	258	PF02991	0.359
LIG_LIR_Gen_1	26	33	PF02991	0.265
LIG_LIR_Gen_1	261	270	PF02991	0.273
LIG_LIR_Gen_1	439	446	PF02991	0.290
LIG_LIR_Gen_1	470	479	PF02991	0.269
LIG_LIR_LC3C_4	234	239	PF02991	0.355
LIG_LIR_Nem_3	149	155	PF02991	0.265
LIG_LIR_Nem_3	234	238	PF02991	0.398
LIG_LIR_Nem_3	247	253	PF02991	0.323
LIG_LIR_Nem_3	26	32	PF02991	0.265
LIG_LIR_Nem_3	261	267	PF02991	0.304
LIG_LIR_Nem_3	323	329	PF02991	0.300
LIG_LIR_Nem_3	341	347	PF02991	0.300
LIG_LIR_Nem_3	364	369	PF02991	0.359
LIG_LIR_Nem_3	470	474	PF02991	0.269
LIG_LIR_Nem_3	495	500	PF02991	0.300
LIG_LIR_Nem_3	64	69	PF02991	0.400
LIG_MLH1_MIPbox_1	341	345	PF16413	0.359
LIG_NRBOX	95	101	PF00104	0.269
LIG_Pex14_2	278	282	PF04695	0.330
LIG_PTB_Apo_2	51	58	PF02174	0.300
LIG_REV1ctd_RIR_1	64	74	PF16727	0.337
LIG_SH2_CRK	366	370	PF00017	0.359
LIG_SH2_CRK	399	403	PF00017	0.265
LIG_SH2_GRB2like	355	358	PF00017	0.341
LIG_SH2_PTP2	29	32	PF00017	0.337
LIG_SH2_SRC	355	358	PF00017	0.341
LIG_SH2_STAP1	399	403	PF00017	0.265
LIG_SH2_STAT5	11	14	PF00017	0.300
LIG_SH2_STAT5	123	126	PF00017	0.472
LIG_SH2_STAT5	152	155	PF00017	0.308
LIG_SH2_STAT5	258	261	PF00017	0.385
LIG_SH2_STAT5	267	270	PF00017	0.385
LIG_SH2_STAT5	29	32	PF00017	0.337
LIG_SH2_STAT5	306	309	PF00017	0.265
LIG_SH2_STAT5	355	358	PF00017	0.265
LIG_SH2_STAT5	399	402	PF00017	0.265
LIG_SH2_STAT5	65	68	PF00017	0.299
LIG_SH3_3	286	292	PF00018	0.441
LIG_SH3_3	297	303	PF00018	0.209
LIG_SUMO_SIM_anti_2	186	191	PF11976	0.293
LIG_SUMO_SIM_anti_2	223	229	PF11976	0.262
LIG_SUMO_SIM_anti_2	400	407	PF11976	0.265
LIG_SUMO_SIM_anti_2	429	434	PF11976	0.265
LIG_SUMO_SIM_par_1	105	110	PF11976	0.421
LIG_SUMO_SIM_par_1	115	120	PF11976	0.328
LIG_SUMO_SIM_par_1	184	191	PF11976	0.293
LIG_SUMO_SIM_par_1	309	315	PF11976	0.300
LIG_SUMO_SIM_par_1	400	407	PF11976	0.265
LIG_UBA3_1	487	492	PF00899	0.293
LIG_WRC_WIRS_1	217	222	PF05994	0.359
LIG_WRC_WIRS_1	468	473	PF05994	0.310
MOD_CK1_1	102	108	PF00069	0.320
MOD_CK1_1	115	121	PF00069	0.247
MOD_CK1_1	216	222	PF00069	0.293
MOD_CK1_1	3	9	PF00069	0.428
MOD_CK1_1	376	382	PF00069	0.359
MOD_CK2_1	220	226	PF00069	0.331
MOD_CK2_1	228	234	PF00069	0.418
MOD_CK2_1	467	473	PF00069	0.291
MOD_Cter_Amidation	242	245	PF01082	0.480
MOD_GlcNHglycan	160	163	PF01048	0.387
MOD_GlcNHglycan	230	233	PF01048	0.452
MOD_GlcNHglycan	347	350	PF01048	0.403
MOD_GlcNHglycan	375	378	PF01048	0.355
MOD_GlcNHglycan	439	443	PF01048	0.293
MOD_GSK3_1	113	120	PF00069	0.537
MOD_GSK3_1	123	130	PF00069	0.436
MOD_GSK3_1	163	170	PF00069	0.395
MOD_GSK3_1	19	26	PF00069	0.308
MOD_GSK3_1	216	223	PF00069	0.300
MOD_GSK3_1	276	283	PF00069	0.315
MOD_GSK3_1	28	35	PF00069	0.369
MOD_GSK3_1	287	294	PF00069	0.416
MOD_GSK3_1	335	342	PF00069	0.359
MOD_GSK3_1	345	352	PF00069	0.337
MOD_GSK3_1	369	376	PF00069	0.266
MOD_GSK3_1	98	105	PF00069	0.290
MOD_N-GLC_1	338	343	PF02516	0.349
MOD_NEK2_1	107	112	PF00069	0.447
MOD_NEK2_1	119	124	PF00069	0.363
MOD_NEK2_1	153	158	PF00069	0.341
MOD_NEK2_1	220	225	PF00069	0.463
MOD_NEK2_1	228	233	PF00069	0.458
MOD_NEK2_1	282	287	PF00069	0.336
MOD_NEK2_1	311	316	PF00069	0.359
MOD_NEK2_1	373	378	PF00069	0.359
MOD_NEK2_1	99	104	PF00069	0.335
MOD_NEK2_2	28	33	PF00069	0.269
MOD_PIKK_1	123	129	PF00454	0.419
MOD_PKA_1	244	250	PF00069	0.363
MOD_PKA_2	102	108	PF00069	0.303
MOD_PKA_2	127	133	PF00069	0.426
MOD_PKA_2	163	169	PF00069	0.456
MOD_PKA_2	181	187	PF00069	0.163
MOD_PKA_2	244	250	PF00069	0.363
MOD_Plk_1	213	219	PF00069	0.366
MOD_Plk_1	438	444	PF00069	0.300
MOD_Plk_4	119	125	PF00069	0.393
MOD_Plk_4	163	169	PF00069	0.341
MOD_Plk_4	216	222	PF00069	0.300
MOD_Plk_4	28	34	PF00069	0.269
MOD_Plk_4	302	308	PF00069	0.377
MOD_Plk_4	312	318	PF00069	0.331
MOD_Plk_4	397	403	PF00069	0.265
MOD_Plk_4	426	432	PF00069	0.300
MOD_Plk_4	61	67	PF00069	0.361
MOD_ProDKin_1	196	202	PF00069	0.426
MOD_ProDKin_1	501	507	PF00069	0.458
MOD_SUMO_rev_2	470	479	PF00179	0.368
TRG_DiLeu_BaLyEn_6	154	159	PF01217	0.359
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.269
TRG_ENDOCYTIC_2	152	155	PF00928	0.300
TRG_ENDOCYTIC_2	262	265	PF00928	0.382
TRG_ENDOCYTIC_2	29	32	PF00928	0.300
TRG_ENDOCYTIC_2	366	369	PF00928	0.359
TRG_ENDOCYTIC_2	399	402	PF00928	0.265
TRG_ER_diArg_1	135	138	PF00400	0.299
TRG_ER_diArg_1	393	396	PF00400	0.269
TRG_NES_CRM1_1	68	81	PF08389	0.269
TRG_NLS_MonoExtN_4	241	248	PF00514	0.458
TRG_Pf-PMV_PEXEL_1	386	390	PF00026	0.293
TRG_Pf-PMV_PEXEL_1	463	467	PF00026	0.265

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFI3	Leptomonas seymouri	72%	100%
A0A0S4IZ47	Bodo saltans	50%	97%
A0A0S4JTD9	Bodo saltans	46%	95%
A0A0S4KHJ0	Bodo saltans	39%	93%
A4HGG6	Leishmania braziliensis	83%	100%
A4I3J8	Leishmania infantum	100%	100%
A8WMY4	Caenorhabditis briggsae	35%	81%
D4A1R8	Rattus norvegicus	41%	95%
E9AZT8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
H1UBN0	Rattus norvegicus	40%	91%
O75131	Homo sapiens	42%	95%
O95741	Homo sapiens	37%	91%
P59108	Mus musculus	39%	93%
Q08DB4	Bos taurus	41%	95%
Q09219	Caenorhabditis elegans	26%	71%
Q0VE82	Mus musculus	40%	91%
Q1RLL3	Mus musculus	38%	92%
Q1ZXB3	Dictyostelium discoideum	33%	92%
Q2KHY1	Bos taurus	38%	91%
Q4Q8E7	Leishmania major	95%	100%
Q54FY7	Dictyostelium discoideum	39%	88%
Q54P51	Dictyostelium discoideum	34%	94%
Q55GG1	Dictyostelium discoideum	36%	96%
Q5BJS7	Rattus norvegicus	38%	92%
Q5R4W6	Pongo abelii	38%	91%
Q5RAE1	Pongo abelii	42%	95%
Q5S1W2	Arabidopsis thaliana	34%	87%
Q5XQC7	Arabidopsis thaliana	34%	87%
Q7YXU4	Dictyostelium discoideum	40%	85%
Q86K21	Dictyostelium discoideum	39%	96%
Q86YQ8	Homo sapiens	39%	90%
Q8BLR2	Mus musculus	38%	91%
Q8BT60	Mus musculus	42%	95%
Q8C166	Mus musculus	40%	95%
Q8IYJ1	Homo sapiens	38%	92%
Q8JZW4	Mus musculus	38%	86%
Q941L3	Arabidopsis thaliana	35%	88%
Q96A23	Homo sapiens	38%	91%
Q96FN4	Homo sapiens	40%	93%
Q99829	Homo sapiens	41%	95%
Q9DC53	Mus musculus	39%	88%
Q9HCH3	Homo sapiens	39%	86%
Q9UBL6	Homo sapiens	41%	80%
Q9XUB9	Caenorhabditis elegans	35%	80%
Q9Z140	Mus musculus	38%	91%