Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X1G1_LEIDO

TriTrypDb:

LdBPK_281150.1 , LdCL_280016100 , LDHU3_28.1430

Length:

405

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X1G1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1G1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.787
CLV_NRD_NRD_1	140	142	PF00675	0.660
CLV_NRD_NRD_1	145	147	PF00675	0.649
CLV_NRD_NRD_1	210	212	PF00675	0.757
CLV_NRD_NRD_1	24	26	PF00675	0.641
CLV_NRD_NRD_1	243	245	PF00675	0.772
CLV_NRD_NRD_1	249	251	PF00675	0.799
CLV_NRD_NRD_1	350	352	PF00675	0.718
CLV_NRD_NRD_1	382	384	PF00675	0.566
CLV_NRD_NRD_1	87	89	PF00675	0.675
CLV_PCSK_FUR_1	208	212	PF00082	0.755
CLV_PCSK_KEX2_1	140	142	PF00082	0.660
CLV_PCSK_KEX2_1	19	21	PF00082	0.689
CLV_PCSK_KEX2_1	210	212	PF00082	0.756
CLV_PCSK_KEX2_1	24	26	PF00082	0.616
CLV_PCSK_KEX2_1	243	245	PF00082	0.676
CLV_PCSK_KEX2_1	350	352	PF00082	0.718
CLV_PCSK_KEX2_1	382	384	PF00082	0.566
CLV_PCSK_KEX2_1	86	88	PF00082	0.678
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.717
CLV_PCSK_PC7_1	15	21	PF00082	0.691
CLV_PCSK_PC7_1	239	245	PF00082	0.603
DEG_COP1_1	130	137	PF00400	0.712
DEG_Nend_Nbox_1	1	3	PF02207	0.668
DOC_PP4_FxxP_1	258	261	PF00568	0.748
DOC_USP7_MATH_1	119	123	PF00917	0.791
DOC_USP7_MATH_1	185	189	PF00917	0.653
DOC_USP7_MATH_1	225	229	PF00917	0.815
DOC_USP7_MATH_1	252	256	PF00917	0.734
DOC_USP7_UBL2_3	284	288	PF12436	0.740
DOC_WW_Pin1_4	107	112	PF00397	0.831
DOC_WW_Pin1_4	213	218	PF00397	0.765
DOC_WW_Pin1_4	257	262	PF00397	0.716
DOC_WW_Pin1_4	289	294	PF00397	0.724
DOC_WW_Pin1_4	374	379	PF00397	0.814
LIG_14-3-3_CanoR_1	123	127	PF00244	0.752
LIG_BRCT_BRCA1_1	254	258	PF00533	0.735
LIG_FHA_1	123	129	PF00498	0.658
LIG_FHA_1	176	182	PF00498	0.832
LIG_FHA_1	5	11	PF00498	0.757
LIG_FHA_2	134	140	PF00498	0.670
LIG_LIR_Apic_2	255	261	PF02991	0.730
LIG_LIR_Gen_1	154	163	PF02991	0.670
LIG_LIR_Nem_3	154	159	PF02991	0.661
LIG_SH2_GRB2like	302	305	PF00017	0.718
LIG_SH2_SRC	302	305	PF00017	0.718
LIG_SH2_STAP1	362	366	PF00017	0.739
LIG_SH2_STAP1	395	399	PF00017	0.726
LIG_SH2_STAT3	316	319	PF00017	0.681
LIG_SH2_STAT5	296	299	PF00017	0.669
LIG_SH3_1	201	207	PF00018	0.693
LIG_SH3_3	201	207	PF00018	0.695
LIG_SH3_3	42	48	PF00018	0.756
LIG_SH3_4	284	291	PF00018	0.738
LIG_WW_1	293	296	PF00397	0.623
MOD_CK1_1	122	128	PF00069	0.750
MOD_CK1_1	289	295	PF00069	0.636
MOD_CK2_1	220	226	PF00069	0.810
MOD_CK2_1	306	312	PF00069	0.606
MOD_CK2_1	374	380	PF00069	0.735
MOD_Cter_Amidation	208	211	PF01082	0.755
MOD_Cter_Amidation	22	25	PF01082	0.629
MOD_GlcNHglycan	151	154	PF01048	0.739
MOD_GlcNHglycan	181	184	PF01048	0.798
MOD_GlcNHglycan	21	24	PF01048	0.769
MOD_GlcNHglycan	226	230	PF01048	0.814
MOD_GlcNHglycan	308	311	PF01048	0.652
MOD_GlcNHglycan	75	78	PF01048	0.718
MOD_GlcNHglycan	80	83	PF01048	0.776
MOD_GlcNHglycan	89	92	PF01048	0.586
MOD_GSK3_1	147	154	PF00069	0.677
MOD_GSK3_1	175	182	PF00069	0.832
MOD_GSK3_1	215	222	PF00069	0.765
MOD_GSK3_1	306	313	PF00069	0.673
MOD_GSK3_1	78	85	PF00069	0.816
MOD_GSK3_1	97	104	PF00069	0.507
MOD_N-GLC_1	128	133	PF02516	0.656
MOD_N-GLC_1	219	224	PF02516	0.760
MOD_NEK2_1	195	200	PF00069	0.608
MOD_NEK2_1	34	39	PF00069	0.573
MOD_NEK2_1	361	366	PF00069	0.735
MOD_PIKK_1	122	128	PF00454	0.750
MOD_PKA_1	19	25	PF00069	0.643
MOD_PKA_1	87	93	PF00069	0.725
MOD_PKA_2	122	128	PF00069	0.744
MOD_PKA_2	19	25	PF00069	0.636
MOD_PKA_2	305	311	PF00069	0.782
MOD_PKA_2	87	93	PF00069	0.684
MOD_Plk_1	219	225	PF00069	0.735
MOD_Plk_1	362	368	PF00069	0.701
MOD_Plk_4	63	69	PF00069	0.617
MOD_ProDKin_1	107	113	PF00069	0.833
MOD_ProDKin_1	213	219	PF00069	0.766
MOD_ProDKin_1	257	263	PF00069	0.716
MOD_ProDKin_1	289	295	PF00069	0.725
MOD_ProDKin_1	374	380	PF00069	0.813
TRG_ER_diArg_1	207	210	PF00400	0.770
TRG_ER_diArg_1	242	244	PF00400	0.612
TRG_ER_diArg_1	86	88	PF00400	0.825

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P454	Leptomonas seymouri	40%	100%
A4HGF0	Leishmania braziliensis	61%	100%
A4I3I1	Leishmania infantum	99%	100%
E9AZS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q8G1	Leishmania major	91%	100%