Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X1G0_LEIDO

TriTrypDb:

LdBPK_281320.1 , LdCL_280017800 , LDHU3_28.1670

Length:

785

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X1G0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1G0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.733
CLV_C14_Caspase3-7	480	484	PF00656	0.724
CLV_C14_Caspase3-7	492	496	PF00656	0.723
CLV_NRD_NRD_1	162	164	PF00675	0.634
CLV_NRD_NRD_1	220	222	PF00675	0.740
CLV_NRD_NRD_1	259	261	PF00675	0.711
CLV_NRD_NRD_1	293	295	PF00675	0.512
CLV_NRD_NRD_1	386	388	PF00675	0.794
CLV_NRD_NRD_1	519	521	PF00675	0.625
CLV_NRD_NRD_1	569	571	PF00675	0.748
CLV_NRD_NRD_1	596	598	PF00675	0.569
CLV_NRD_NRD_1	72	74	PF00675	0.668
CLV_PCSK_FUR_1	291	295	PF00082	0.633
CLV_PCSK_FUR_1	569	573	PF00082	0.729
CLV_PCSK_FUR_1	594	598	PF00082	0.618
CLV_PCSK_KEX2_1	162	164	PF00082	0.634
CLV_PCSK_KEX2_1	220	222	PF00082	0.740
CLV_PCSK_KEX2_1	259	261	PF00082	0.688
CLV_PCSK_KEX2_1	293	295	PF00082	0.512
CLV_PCSK_KEX2_1	385	387	PF00082	0.742
CLV_PCSK_KEX2_1	569	571	PF00082	0.756
CLV_PCSK_KEX2_1	596	598	PF00082	0.569
CLV_PCSK_KEX2_1	72	74	PF00082	0.668
CLV_PCSK_PC1ET2_1	385	387	PF00082	0.742
CLV_PCSK_PC1ET2_1	571	573	PF00082	0.737
CLV_PCSK_SKI1_1	174	178	PF00082	0.780
CLV_PCSK_SKI1_1	230	234	PF00082	0.663
CLV_PCSK_SKI1_1	286	290	PF00082	0.503
CLV_PCSK_SKI1_1	322	326	PF00082	0.760
DEG_Nend_UBRbox_3	1	3	PF02207	0.689
DEG_SPOP_SBC_1	145	149	PF00917	0.671
DEG_SPOP_SBC_1	185	189	PF00917	0.688
DEG_SPOP_SBC_1	231	235	PF00917	0.831
DEG_SPOP_SBC_1	37	41	PF00917	0.818
DEG_SPOP_SBC_1	549	553	PF00917	0.701
DEG_SPOP_SBC_1	559	563	PF00917	0.700
DEG_SPOP_SBC_1	583	587	PF00917	0.751
DEG_SPOP_SBC_1	81	85	PF00917	0.709
DOC_ANK_TNKS_1	630	637	PF00023	0.753
DOC_CYCLIN_yCln2_LP_2	690	696	PF00134	0.716
DOC_MAPK_gen_1	594	603	PF00069	0.597
DOC_MAPK_gen_1	72	78	PF00069	0.679
DOC_MAPK_RevD_3	60	73	PF00069	0.716
DOC_PP2B_LxvP_1	690	693	PF13499	0.753
DOC_PP2B_LxvP_1	696	699	PF13499	0.682
DOC_PP2B_LxvP_1	78	81	PF13499	0.587
DOC_USP7_MATH_1	123	127	PF00917	0.749
DOC_USP7_MATH_1	186	190	PF00917	0.716
DOC_USP7_MATH_1	215	219	PF00917	0.835
DOC_USP7_MATH_1	232	236	PF00917	0.690
DOC_USP7_MATH_1	331	335	PF00917	0.670
DOC_USP7_MATH_1	346	350	PF00917	0.763
DOC_USP7_MATH_1	35	39	PF00917	0.816
DOC_USP7_MATH_1	431	435	PF00917	0.727
DOC_USP7_MATH_1	534	538	PF00917	0.694
DOC_USP7_MATH_1	549	553	PF00917	0.729
DOC_USP7_MATH_1	55	59	PF00917	0.496
DOC_USP7_MATH_1	582	586	PF00917	0.734
DOC_USP7_MATH_1	699	703	PF00917	0.749
DOC_USP7_MATH_1	720	724	PF00917	0.682
DOC_USP7_MATH_1	725	729	PF00917	0.797
DOC_USP7_MATH_1	740	744	PF00917	0.605
DOC_USP7_MATH_1	81	85	PF00917	0.730
DOC_WW_Pin1_4	224	229	PF00397	0.668
DOC_WW_Pin1_4	27	32	PF00397	0.815
DOC_WW_Pin1_4	33	38	PF00397	0.730
DOC_WW_Pin1_4	389	394	PF00397	0.776
DOC_WW_Pin1_4	44	49	PF00397	0.842
DOC_WW_Pin1_4	504	509	PF00397	0.735
DOC_WW_Pin1_4	552	557	PF00397	0.702
DOC_WW_Pin1_4	564	569	PF00397	0.712
DOC_WW_Pin1_4	84	89	PF00397	0.737
LIG_14-3-3_CanoR_1	144	151	PF00244	0.718
LIG_14-3-3_CanoR_1	163	173	PF00244	0.676
LIG_14-3-3_CanoR_1	174	179	PF00244	0.649
LIG_14-3-3_CanoR_1	230	238	PF00244	0.691
LIG_14-3-3_CanoR_1	245	251	PF00244	0.635
LIG_14-3-3_CanoR_1	269	276	PF00244	0.626
LIG_14-3-3_CanoR_1	370	379	PF00244	0.695
LIG_14-3-3_CanoR_1	386	395	PF00244	0.570
LIG_14-3-3_CanoR_1	520	526	PF00244	0.816
LIG_14-3-3_CanoR_1	558	568	PF00244	0.782
LIG_14-3-3_CanoR_1	733	741	PF00244	0.726
LIG_BIR_III_4	195	199	PF00653	0.619
LIG_FHA_1	140	146	PF00498	0.828
LIG_FHA_1	400	406	PF00498	0.707
LIG_FHA_1	473	479	PF00498	0.804
LIG_FHA_1	763	769	PF00498	0.673
LIG_FHA_2	165	171	PF00498	0.605
LIG_FHA_2	414	420	PF00498	0.630
LIG_FHA_2	485	491	PF00498	0.744
LIG_FHA_2	772	778	PF00498	0.705
LIG_LIR_Apic_2	607	612	PF02991	0.578
LIG_LIR_Nem_3	284	288	PF02991	0.526
LIG_LIR_Nem_3	411	417	PF02991	0.602
LIG_SH2_CRK	598	602	PF00017	0.622
LIG_SH2_STAP1	208	212	PF00017	0.613
LIG_SH2_STAT3	3	6	PF00017	0.668
LIG_SH2_STAT3	616	619	PF00017	0.686
LIG_SH2_STAT5	538	541	PF00017	0.643
LIG_SH3_3	31	37	PF00018	0.795
LIG_SH3_3	321	327	PF00018	0.549
LIG_SH3_3	375	381	PF00018	0.684
LIG_SH3_3	456	462	PF00018	0.727
LIG_SH3_3	553	559	PF00018	0.675
LIG_SH3_3	656	662	PF00018	0.709
LIG_SH3_3	681	687	PF00018	0.650
LIG_SH3_3	695	701	PF00018	0.799
LIG_SUMO_SIM_par_1	475	484	PF11976	0.721
LIG_SxIP_EBH_1	126	137	PF03271	0.618
LIG_TRAF2_1	774	777	PF00917	0.662
MOD_CDC14_SPxK_1	227	230	PF00782	0.661
MOD_CDC14_SPxK_1	555	558	PF00782	0.789
MOD_CDC14_SPxK_1	567	570	PF00782	0.685
MOD_CDK_SPK_2	564	569	PF00069	0.851
MOD_CDK_SPxK_1	224	230	PF00069	0.667
MOD_CDK_SPxK_1	552	558	PF00069	0.786
MOD_CDK_SPxK_1	564	570	PF00069	0.686
MOD_CDK_SPxxK_3	564	571	PF00069	0.815
MOD_CK1_1	109	115	PF00069	0.761
MOD_CK1_1	136	142	PF00069	0.834
MOD_CK1_1	168	174	PF00069	0.641
MOD_CK1_1	237	243	PF00069	0.777
MOD_CK1_1	249	255	PF00069	0.619
MOD_CK1_1	265	271	PF00069	0.624
MOD_CK1_1	29	35	PF00069	0.733
MOD_CK1_1	334	340	PF00069	0.741
MOD_CK1_1	36	42	PF00069	0.784
MOD_CK1_1	408	414	PF00069	0.506
MOD_CK1_1	484	490	PF00069	0.677
MOD_CK1_1	496	502	PF00069	0.724
MOD_CK1_1	504	510	PF00069	0.493
MOD_CK1_1	537	543	PF00069	0.700
MOD_CK1_1	544	550	PF00069	0.713
MOD_CK1_1	551	557	PF00069	0.732
MOD_CK1_1	561	567	PF00069	0.524
MOD_CK1_1	585	591	PF00069	0.677
MOD_CK1_1	703	709	PF00069	0.668
MOD_CK1_1	710	716	PF00069	0.684
MOD_CK1_1	84	90	PF00069	0.684
MOD_CK2_1	164	170	PF00069	0.602
MOD_CK2_1	370	376	PF00069	0.696
MOD_CK2_1	413	419	PF00069	0.626
MOD_CK2_1	431	437	PF00069	0.502
MOD_CK2_1	771	777	PF00069	0.657
MOD_Cter_Amidation	291	294	PF01082	0.550
MOD_Cter_Amidation	70	73	PF01082	0.656
MOD_GlcNHglycan	108	111	PF01048	0.593
MOD_GlcNHglycan	114	117	PF01048	0.488
MOD_GlcNHglycan	170	173	PF01048	0.642
MOD_GlcNHglycan	209	213	PF01048	0.793
MOD_GlcNHglycan	234	237	PF01048	0.759
MOD_GlcNHglycan	24	27	PF01048	0.820
MOD_GlcNHglycan	255	258	PF01048	0.833
MOD_GlcNHglycan	264	267	PF01048	0.604
MOD_GlcNHglycan	270	273	PF01048	0.480
MOD_GlcNHglycan	306	309	PF01048	0.646
MOD_GlcNHglycan	367	370	PF01048	0.767
MOD_GlcNHglycan	372	375	PF01048	0.698
MOD_GlcNHglycan	40	43	PF01048	0.833
MOD_GlcNHglycan	410	413	PF01048	0.494
MOD_GlcNHglycan	433	436	PF01048	0.686
MOD_GlcNHglycan	468	471	PF01048	0.709
MOD_GlcNHglycan	53	56	PF01048	0.683
MOD_GlcNHglycan	547	550	PF01048	0.701
MOD_GlcNHglycan	57	60	PF01048	0.713
MOD_GlcNHglycan	654	657	PF01048	0.820
MOD_GlcNHglycan	69	72	PF01048	0.570
MOD_GlcNHglycan	690	693	PF01048	0.672
MOD_GlcNHglycan	705	708	PF01048	0.634
MOD_GlcNHglycan	712	715	PF01048	0.666
MOD_GlcNHglycan	722	725	PF01048	0.694
MOD_GlcNHglycan	727	730	PF01048	0.702
MOD_GlcNHglycan	750	753	PF01048	0.657
MOD_GlcNHglycan	84	87	PF01048	0.750
MOD_GlcNHglycan	94	97	PF01048	0.819
MOD_GSK3_1	102	109	PF00069	0.728
MOD_GSK3_1	133	140	PF00069	0.781
MOD_GSK3_1	164	171	PF00069	0.744
MOD_GSK3_1	180	187	PF00069	0.652
MOD_GSK3_1	215	222	PF00069	0.773
MOD_GSK3_1	22	29	PF00069	0.659
MOD_GSK3_1	226	233	PF00069	0.659
MOD_GSK3_1	234	241	PF00069	0.663
MOD_GSK3_1	246	253	PF00069	0.555
MOD_GSK3_1	261	268	PF00069	0.636
MOD_GSK3_1	299	306	PF00069	0.519
MOD_GSK3_1	33	40	PF00069	0.778
MOD_GSK3_1	346	353	PF00069	0.806
MOD_GSK3_1	381	388	PF00069	0.815
MOD_GSK3_1	404	411	PF00069	0.528
MOD_GSK3_1	468	475	PF00069	0.727
MOD_GSK3_1	479	486	PF00069	0.828
MOD_GSK3_1	491	498	PF00069	0.706
MOD_GSK3_1	500	507	PF00069	0.830
MOD_GSK3_1	51	58	PF00069	0.692
MOD_GSK3_1	533	540	PF00069	0.696
MOD_GSK3_1	541	548	PF00069	0.703
MOD_GSK3_1	558	565	PF00069	0.521
MOD_GSK3_1	582	589	PF00069	0.672
MOD_GSK3_1	636	643	PF00069	0.777
MOD_GSK3_1	699	706	PF00069	0.781
MOD_GSK3_1	720	727	PF00069	0.669
MOD_GSK3_1	80	87	PF00069	0.683
MOD_GSK3_1	9	16	PF00069	0.730
MOD_N-GLC_1	44	49	PF02516	0.778
MOD_N-GLC_1	466	471	PF02516	0.629
MOD_N-GLC_1	484	489	PF02516	0.688
MOD_N-GLC_1	649	654	PF02516	0.751
MOD_N-GLC_1	763	768	PF02516	0.478
MOD_NEK2_1	121	126	PF00069	0.697
MOD_NEK2_1	405	410	PF00069	0.634
MOD_NEK2_1	468	473	PF00069	0.696
MOD_NEK2_1	502	507	PF00069	0.749
MOD_NEK2_1	734	739	PF00069	0.756
MOD_NEK2_1	82	87	PF00069	0.749
MOD_NEK2_2	272	277	PF00069	0.535
MOD_NEK2_2	452	457	PF00069	0.667
MOD_PIKK_1	215	221	PF00454	0.760
MOD_PIKK_1	405	411	PF00454	0.658
MOD_PIKK_1	444	450	PF00454	0.729
MOD_PIKK_1	615	621	PF00454	0.600
MOD_PIKK_1	677	683	PF00454	0.661
MOD_PKA_1	385	391	PF00069	0.745
MOD_PKA_2	156	162	PF00069	0.606
MOD_PKA_2	219	225	PF00069	0.744
MOD_PKA_2	253	259	PF00069	0.703
MOD_PKA_2	261	267	PF00069	0.771
MOD_PKA_2	268	274	PF00069	0.675
MOD_PKA_2	334	340	PF00069	0.749
MOD_PKA_2	385	391	PF00069	0.819
MOD_PKA_2	51	57	PF00069	0.628
MOD_PKA_2	576	582	PF00069	0.670
MOD_PKA_2	630	636	PF00069	0.759
MOD_PKA_2	657	663	PF00069	0.597
MOD_PKB_1	260	268	PF00069	0.816
MOD_Plk_1	346	352	PF00069	0.799
MOD_Plk_1	540	546	PF00069	0.615
MOD_Plk_2-3	413	419	PF00069	0.626
MOD_Plk_4	29	35	PF00069	0.742
MOD_Plk_4	534	540	PF00069	0.671
MOD_Plk_4	541	547	PF00069	0.629
MOD_Plk_4	707	713	PF00069	0.794
MOD_ProDKin_1	224	230	PF00069	0.670
MOD_ProDKin_1	27	33	PF00069	0.816
MOD_ProDKin_1	389	395	PF00069	0.775
MOD_ProDKin_1	44	50	PF00069	0.843
MOD_ProDKin_1	504	510	PF00069	0.735
MOD_ProDKin_1	552	558	PF00069	0.704
MOD_ProDKin_1	564	570	PF00069	0.711
MOD_ProDKin_1	84	90	PF00069	0.737
TRG_DiLeu_BaEn_1	413	418	PF01217	0.598
TRG_DiLeu_BaEn_4	776	782	PF01217	0.726
TRG_DiLeu_BaLyEn_6	730	735	PF01217	0.670
TRG_ENDOCYTIC_2	285	288	PF00928	0.544
TRG_ENDOCYTIC_2	598	601	PF00928	0.631
TRG_ER_diArg_1	161	163	PF00400	0.613
TRG_ER_diArg_1	220	223	PF00400	0.741
TRG_ER_diArg_1	242	245	PF00400	0.774
TRG_ER_diArg_1	259	262	PF00400	0.720
TRG_ER_diArg_1	291	294	PF00400	0.652
TRG_ER_diArg_1	340	343	PF00400	0.789
TRG_ER_diArg_1	568	570	PF00400	0.804
TRG_ER_diArg_1	594	597	PF00400	0.545
TRG_ER_diArg_1	72	74	PF00400	0.668
TRG_NLS_MonoExtC_3	569	574	PF00514	0.744
TRG_NLS_MonoExtN_4	568	575	PF00514	0.749
TRG_Pf-PMV_PEXEL_1	415	419	PF00026	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I844	Leptomonas seymouri	35%	100%
A4HGG8	Leishmania braziliensis	60%	98%
A4I3K0	Leishmania infantum	99%	100%
E9AZU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q8E5	Leishmania major	87%	100%