Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X1F6_LEIDO

TriTrypDb:

LdBPK_280970.1 , LdCL_280014300 , LDHU3_28.1150

Length:

176

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X1F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1F6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.544
CLV_NRD_NRD_1	123	125	PF00675	0.673
CLV_NRD_NRD_1	77	79	PF00675	0.534
CLV_NRD_NRD_1	9	11	PF00675	0.567
CLV_PCSK_KEX2_1	106	108	PF00082	0.531
CLV_PCSK_KEX2_1	125	127	PF00082	0.660
CLV_PCSK_KEX2_1	77	79	PF00082	0.544
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.531
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.660
CLV_PCSK_SKI1_1	46	50	PF00082	0.580
DEG_APCC_DBOX_1	76	84	PF00400	0.567
DEG_Nend_UBRbox_1	1	4	PF02207	0.705
DEG_SPOP_SBC_1	96	100	PF00917	0.681
DOC_CYCLIN_RxL_1	46	57	PF00134	0.484
DOC_MAPK_gen_1	10	18	PF00069	0.570
DOC_MAPK_gen_1	106	112	PF00069	0.519
DOC_MAPK_gen_1	22	30	PF00069	0.566
DOC_MAPK_gen_1	46	54	PF00069	0.552
DOC_PP1_RVXF_1	12	19	PF00149	0.547
DOC_PP1_RVXF_1	22	28	PF00149	0.550
DOC_PP1_RVXF_1	48	55	PF00149	0.465
DOC_PP2B_LxvP_1	118	121	PF13499	0.673
DOC_PP2B_PxIxI_1	57	63	PF00149	0.489
DOC_USP7_MATH_1	105	109	PF00917	0.512
DOC_USP7_MATH_1	12	16	PF00917	0.666
DOC_USP7_MATH_1	95	99	PF00917	0.642
DOC_WW_Pin1_4	83	88	PF00397	0.594
LIG_14-3-3_CanoR_1	13	19	PF00244	0.548
LIG_14-3-3_CanoR_1	69	79	PF00244	0.458
LIG_BRCT_BRCA1_1	14	18	PF00533	0.662
LIG_FHA_1	113	119	PF00498	0.579
LIG_FHA_1	42	48	PF00498	0.470
LIG_LIR_Gen_1	108	117	PF02991	0.530
LIG_LIR_Gen_1	127	137	PF02991	0.245
LIG_LIR_Nem_3	108	112	PF02991	0.502
LIG_LIR_Nem_3	127	132	PF02991	0.343
LIG_PDZ_Class_3	171	176	PF00595	0.555
LIG_Pex14_2	165	169	PF04695	0.410
LIG_RPA_C_Fungi	17	29	PF08784	0.666
LIG_SH2_PTP2	109	112	PF00017	0.500
LIG_SH2_SRC	109	112	PF00017	0.422
LIG_SH2_STAT5	109	112	PF00017	0.476
LIG_SH3_3	142	148	PF00018	0.432
LIG_ULM_U2AF65_1	124	130	PF00076	0.639
LIG_WW_3	30	34	PF00397	0.551
MOD_CK1_1	100	106	PF00069	0.603
MOD_CK2_1	105	111	PF00069	0.481
MOD_GlcNHglycan	5	8	PF01048	0.493
MOD_GlcNHglycan	99	102	PF01048	0.537
MOD_GSK3_1	96	103	PF00069	0.670
MOD_NEK2_1	41	46	PF00069	0.551
MOD_NEK2_1	70	75	PF00069	0.406
MOD_PIKK_1	31	37	PF00454	0.605
MOD_PIKK_1	41	47	PF00454	0.583
MOD_PIKK_1	78	84	PF00454	0.638
MOD_PKA_2	12	18	PF00069	0.593
MOD_Plk_1	112	118	PF00069	0.468
MOD_ProDKin_1	83	89	PF00069	0.595
TRG_ENDOCYTIC_2	109	112	PF00928	0.512
TRG_ER_diArg_1	152	155	PF00400	0.498
TRG_ER_diArg_1	77	79	PF00400	0.509
TRG_NLS_MonoExtC_3	9	14	PF00514	0.642
TRG_NLS_MonoExtN_4	9	14	PF00514	0.648
TRG_Pf-PMV_PEXEL_1	78	82	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM05	Leptomonas seymouri	74%	100%
A0A0S4IWE5	Bodo saltans	28%	100%
A0A0S4IZV2	Bodo saltans	28%	100%
A0A1X0NYD0	Trypanosomatidae	39%	99%
A0A3R7KRX2	Trypanosoma rangeli	41%	96%
A4HGD2	Leishmania braziliensis	88%	100%
A4I3G5	Leishmania infantum	99%	100%
D0A7X5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AZQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q8H9	Leishmania major	98%	100%