Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X1F4_LEIDO

TriTrypDb:

LdBPK_281360.1 , LdCL_280018200 , LDHU3_28.1720

Length:

438

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X1F4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1F4

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0030030	cell projection organization	4	1
GO:0044782	cilium organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005509	calcium ion binding	5	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	274	278	PF00656	0.522
CLV_NRD_NRD_1	332	334	PF00675	0.460
CLV_NRD_NRD_1	345	347	PF00675	0.283
CLV_NRD_NRD_1	409	411	PF00675	0.481
CLV_NRD_NRD_1	41	43	PF00675	0.404
CLV_NRD_NRD_1	95	97	PF00675	0.415
CLV_PCSK_FUR_1	409	413	PF00082	0.487
CLV_PCSK_KEX2_1	332	334	PF00082	0.455
CLV_PCSK_KEX2_1	409	411	PF00082	0.476
CLV_PCSK_KEX2_1	41	43	PF00082	0.389
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.515
CLV_PCSK_SKI1_1	326	330	PF00082	0.582
DEG_APCC_DBOX_1	32	40	PF00400	0.494
DEG_APCC_DBOX_1	331	339	PF00400	0.399
DEG_SCF_FBW7_1	127	134	PF00400	0.475
DEG_SCF_FBW7_1	208	214	PF00400	0.519
DEG_SPOP_SBC_1	212	216	PF00917	0.539
DOC_CKS1_1	128	133	PF01111	0.495
DOC_CKS1_1	208	213	PF01111	0.520
DOC_MAPK_gen_1	12	22	PF00069	0.395
DOC_MAPK_gen_1	397	407	PF00069	0.570
DOC_MAPK_MEF2A_6	12	20	PF00069	0.382
DOC_PP2B_LxvP_1	110	113	PF13499	0.578
DOC_PP4_FxxP_1	119	122	PF00568	0.572
DOC_PP4_FxxP_1	128	131	PF00568	0.693
DOC_PP4_FxxP_1	22	25	PF00568	0.463
DOC_USP7_MATH_1	113	117	PF00917	0.460
DOC_USP7_MATH_1	131	135	PF00917	0.661
DOC_USP7_MATH_1	157	161	PF00917	0.702
DOC_USP7_MATH_1	162	166	PF00917	0.681
DOC_USP7_MATH_1	176	180	PF00917	0.740
DOC_USP7_MATH_1	213	217	PF00917	0.609
DOC_USP7_MATH_1	283	287	PF00917	0.388
DOC_USP7_MATH_1	31	35	PF00917	0.484
DOC_USP7_UBL2_3	380	384	PF12436	0.408
DOC_USP7_UBL2_3	97	101	PF12436	0.496
DOC_WW_Pin1_4	127	132	PF00397	0.734
DOC_WW_Pin1_4	155	160	PF00397	0.681
DOC_WW_Pin1_4	166	171	PF00397	0.691
DOC_WW_Pin1_4	185	190	PF00397	0.645
DOC_WW_Pin1_4	207	212	PF00397	0.682
DOC_WW_Pin1_4	221	226	PF00397	0.531
DOC_WW_Pin1_4	421	426	PF00397	0.678
LIG_14-3-3_CanoR_1	114	122	PF00244	0.340
LIG_14-3-3_CanoR_1	254	259	PF00244	0.485
LIG_14-3-3_CanoR_1	33	37	PF00244	0.514
LIG_14-3-3_CanoR_1	96	104	PF00244	0.563
LIG_BIR_II_1	1	5	PF00653	0.410
LIG_BRCT_BRCA1_1	115	119	PF00533	0.453
LIG_BRCT_BRCA1_1	213	217	PF00533	0.543
LIG_BRCT_BRCA1_1	256	260	PF00533	0.335
LIG_eIF4E_1	89	95	PF01652	0.262
LIG_EVH1_1	208	212	PF00568	0.521
LIG_FHA_2	221	227	PF00498	0.475
LIG_FHA_2	272	278	PF00498	0.542
LIG_FHA_2	79	85	PF00498	0.452
LIG_FHA_2	98	104	PF00498	0.338
LIG_Integrin_RGD_1	275	277	PF01839	0.623
LIG_LIR_Apic_2	116	122	PF02991	0.570
LIG_LIR_Apic_2	19	25	PF02991	0.447
LIG_LIR_Gen_1	2	11	PF02991	0.430
LIG_LIR_Gen_1	246	256	PF02991	0.442
LIG_LIR_Gen_1	267	273	PF02991	0.444
LIG_LIR_Gen_1	399	407	PF02991	0.457
LIG_LIR_Gen_1	50	61	PF02991	0.588
LIG_LIR_Gen_1	74	85	PF02991	0.431
LIG_LIR_Gen_1	88	95	PF02991	0.333
LIG_LIR_Nem_3	246	252	PF02991	0.388
LIG_LIR_Nem_3	267	272	PF02991	0.492
LIG_LIR_Nem_3	292	296	PF02991	0.391
LIG_LIR_Nem_3	399	405	PF02991	0.438
LIG_LIR_Nem_3	74	80	PF02991	0.432
LIG_LIR_Nem_3	88	92	PF02991	0.333
LIG_MLH1_MIPbox_1	115	119	PF16413	0.473
LIG_Pex14_2	249	253	PF04695	0.375
LIG_Pex14_2	293	297	PF04695	0.410
LIG_PTB_Apo_2	299	306	PF02174	0.483
LIG_PTB_Phospho_1	299	305	PF10480	0.480
LIG_Rb_pABgroove_1	263	271	PF01858	0.286
LIG_SH2_CRK	305	309	PF00017	0.455
LIG_SH2_CRK	89	93	PF00017	0.369
LIG_SH2_NCK_1	120	124	PF00017	0.417
LIG_SH2_SRC	120	123	PF00017	0.406
LIG_SH2_SRC	364	367	PF00017	0.374
LIG_SH2_STAP1	364	368	PF00017	0.553
LIG_SH2_STAP1	402	406	PF00017	0.462
LIG_SH2_STAP1	89	93	PF00017	0.388
LIG_SH2_STAT5	230	233	PF00017	0.470
LIG_SH2_STAT5	296	299	PF00017	0.521
LIG_SH2_STAT5	374	377	PF00017	0.577
LIG_SH2_STAT5	53	56	PF00017	0.637
LIG_SH2_STAT5	93	96	PF00017	0.373
LIG_SH3_3	119	125	PF00018	0.533
LIG_SH3_3	15	21	PF00018	0.385
LIG_SH3_3	183	189	PF00018	0.703
LIG_SH3_3	206	212	PF00018	0.699
LIG_SH3_3	255	261	PF00018	0.518
LIG_SUMO_SIM_anti_2	81	88	PF11976	0.381
LIG_TRAF2_1	396	399	PF00917	0.494
LIG_TYR_ITIM	303	308	PF00017	0.445
LIG_WW_3	111	115	PF00397	0.396
MOD_CDC14_SPxK_1	169	172	PF00782	0.714
MOD_CDK_SPxK_1	166	172	PF00069	0.729
MOD_CDK_SPxK_1	221	227	PF00069	0.555
MOD_CK1_1	165	171	PF00069	0.663
MOD_CK1_1	233	239	PF00069	0.467
MOD_CK2_1	103	109	PF00069	0.460
MOD_CK2_1	185	191	PF00069	0.510
MOD_CK2_1	220	226	PF00069	0.481
MOD_CK2_1	24	30	PF00069	0.471
MOD_CK2_1	31	37	PF00069	0.451
MOD_CK2_1	393	399	PF00069	0.507
MOD_DYRK1A_RPxSP_1	421	425	PF00069	0.698
MOD_GlcNHglycan	149	152	PF01048	0.681
MOD_GlcNHglycan	164	167	PF01048	0.690
MOD_GlcNHglycan	178	181	PF01048	0.700
MOD_GlcNHglycan	197	200	PF01048	0.748
MOD_GlcNHglycan	203	206	PF01048	0.571
MOD_GlcNHglycan	416	419	PF01048	0.499
MOD_GSK3_1	127	134	PF00069	0.674
MOD_GSK3_1	153	160	PF00069	0.595
MOD_GSK3_1	162	169	PF00069	0.654
MOD_GSK3_1	174	181	PF00069	0.659
MOD_GSK3_1	207	214	PF00069	0.594
MOD_GSK3_1	238	245	PF00069	0.396
MOD_GSK3_1	279	286	PF00069	0.500
MOD_GSK3_1	47	54	PF00069	0.515
MOD_N-GLC_1	139	144	PF02516	0.625
MOD_N-GLC_1	238	243	PF02516	0.616
MOD_N-GLC_1	97	102	PF02516	0.515
MOD_NEK2_1	1	6	PF00069	0.464
MOD_NEK2_2	213	218	PF00069	0.537
MOD_PIKK_1	103	109	PF00454	0.526
MOD_PIKK_1	157	163	PF00454	0.767
MOD_PIKK_1	233	239	PF00454	0.418
MOD_PIKK_1	283	289	PF00454	0.529
MOD_PIKK_1	71	77	PF00454	0.483
MOD_PK_1	254	260	PF00069	0.322
MOD_PK_1	384	390	PF00069	0.463
MOD_PKA_1	96	102	PF00069	0.577
MOD_PKA_2	113	119	PF00069	0.433
MOD_PKA_2	162	168	PF00069	0.740
MOD_PKA_2	306	312	PF00069	0.440
MOD_PKA_2	32	38	PF00069	0.464
MOD_PKA_2	393	399	PF00069	0.482
MOD_Plk_1	238	244	PF00069	0.605
MOD_Plk_1	364	370	PF00069	0.378
MOD_Plk_1	384	390	PF00069	0.346
MOD_Plk_1	78	84	PF00069	0.387
MOD_Plk_2-3	73	79	PF00069	0.453
MOD_Plk_4	213	219	PF00069	0.685
MOD_Plk_4	292	298	PF00069	0.441
MOD_Plk_4	384	390	PF00069	0.463
MOD_ProDKin_1	127	133	PF00069	0.737
MOD_ProDKin_1	155	161	PF00069	0.683
MOD_ProDKin_1	166	172	PF00069	0.691
MOD_ProDKin_1	185	191	PF00069	0.648
MOD_ProDKin_1	207	213	PF00069	0.680
MOD_ProDKin_1	221	227	PF00069	0.521
MOD_ProDKin_1	421	427	PF00069	0.678
MOD_SUMO_rev_2	373	382	PF00179	0.541
TRG_ENDOCYTIC_2	296	299	PF00928	0.534
TRG_ENDOCYTIC_2	305	308	PF00928	0.394
TRG_ENDOCYTIC_2	402	405	PF00928	0.466
TRG_ENDOCYTIC_2	53	56	PF00928	0.612
TRG_ENDOCYTIC_2	89	92	PF00928	0.370
TRG_ER_diArg_1	40	42	PF00400	0.419
TRG_ER_diArg_1	409	412	PF00400	0.476
TRG_ER_diArg_1	431	434	PF00400	0.723
TRG_NLS_MonoExtN_4	409	414	PF00514	0.595
TRG_Pf-PMV_PEXEL_1	333	337	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J6	Leptomonas seymouri	63%	94%
A0A0N1II86	Leptomonas seymouri	24%	74%
A0A0S4JFD7	Bodo saltans	24%	71%
A0A0S4KKB5	Bodo saltans	27%	100%
A0A1X0NMV7	Trypanosomatidae	26%	74%
A0A1X0NYM5	Trypanosomatidae	35%	99%
A0A3R7KQJ5	Trypanosoma rangeli	35%	100%
A0A3S5H6A9	Leishmania donovani	23%	100%
A0A422NE50	Trypanosoma rangeli	26%	75%
A4H5I7	Leishmania braziliensis	24%	100%
A4HGH2	Leishmania braziliensis	78%	100%
A4HTS8	Leishmania infantum	23%	100%
A4I3K4	Leishmania infantum	99%	100%
D0A836	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
D0A989	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	75%
E9AML1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AZU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q8E1	Leishmania major	92%	100%
Q4QI25	Leishmania major	24%	100%
V5DJB6	Trypanosoma cruzi	25%	68%