Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S7X1D3_LEIDO

TriTrypDb:

LdCL_280015900 , LDHU3_28.1380

Length:

844

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X1D3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1D3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	309	313	PF00656	0.613
CLV_C14_Caspase3-7	434	438	PF00656	0.643
CLV_C14_Caspase3-7	477	481	PF00656	0.559
CLV_C14_Caspase3-7	581	585	PF00656	0.702
CLV_NRD_NRD_1	287	289	PF00675	0.604
CLV_NRD_NRD_1	371	373	PF00675	0.594
CLV_PCSK_KEX2_1	287	289	PF00082	0.604
CLV_PCSK_KEX2_1	370	372	PF00082	0.591
CLV_PCSK_KEX2_1	55	57	PF00082	0.712
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.525
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.712
CLV_PCSK_SKI1_1	186	190	PF00082	0.572
CLV_PCSK_SKI1_1	217	221	PF00082	0.618
CLV_PCSK_SKI1_1	256	260	PF00082	0.589
CLV_PCSK_SKI1_1	27	31	PF00082	0.706
CLV_PCSK_SKI1_1	386	390	PF00082	0.584
CLV_PCSK_SKI1_1	395	399	PF00082	0.497
CLV_PCSK_SKI1_1	403	407	PF00082	0.464
CLV_PCSK_SKI1_1	56	60	PF00082	0.836
CLV_PCSK_SKI1_1	564	568	PF00082	0.630
CLV_PCSK_SKI1_1	630	634	PF00082	0.661
CLV_PCSK_SKI1_1	745	749	PF00082	0.722
CLV_PCSK_SKI1_1	82	86	PF00082	0.705
CLV_Separin_Metazoa	525	529	PF03568	0.659
DEG_APCC_DBOX_1	394	402	PF00400	0.540
DEG_Nend_UBRbox_1	1	4	PF02207	0.696
DEG_SPOP_SBC_1	527	531	PF00917	0.693
DEG_SPOP_SBC_1	699	703	PF00917	0.705
DEG_SPOP_SBC_1	720	724	PF00917	0.743
DOC_CKS1_1	545	550	PF01111	0.696
DOC_CKS1_1	603	608	PF01111	0.680
DOC_MAPK_DCC_7	4	14	PF00069	0.734
DOC_MAPK_MEF2A_6	169	177	PF00069	0.684
DOC_MAPK_MEF2A_6	661	670	PF00069	0.554
DOC_PP2B_LxvP_1	175	178	PF13499	0.654
DOC_PP2B_LxvP_1	682	685	PF13499	0.704
DOC_PP2B_LxvP_1	748	751	PF13499	0.713
DOC_PP2B_LxvP_1	774	777	PF13499	0.744
DOC_USP7_MATH_1	108	112	PF00917	0.577
DOC_USP7_MATH_1	188	192	PF00917	0.584
DOC_USP7_MATH_1	195	199	PF00917	0.544
DOC_USP7_MATH_1	23	27	PF00917	0.760
DOC_USP7_MATH_1	29	33	PF00917	0.702
DOC_USP7_MATH_1	290	294	PF00917	0.626
DOC_USP7_MATH_1	300	304	PF00917	0.606
DOC_USP7_MATH_1	36	40	PF00917	0.736
DOC_USP7_MATH_1	484	488	PF00917	0.586
DOC_USP7_MATH_1	527	531	PF00917	0.745
DOC_USP7_MATH_1	555	559	PF00917	0.684
DOC_USP7_MATH_1	586	590	PF00917	0.580
DOC_USP7_MATH_1	637	641	PF00917	0.721
DOC_USP7_MATH_1	643	647	PF00917	0.682
DOC_USP7_MATH_1	654	658	PF00917	0.612
DOC_USP7_MATH_1	706	710	PF00917	0.719
DOC_USP7_MATH_1	720	724	PF00917	0.619
DOC_USP7_MATH_1	768	772	PF00917	0.705
DOC_USP7_MATH_1	99	103	PF00917	0.672
DOC_USP7_UBL2_3	449	453	PF12436	0.466
DOC_USP7_UBL2_3	82	86	PF12436	0.600
DOC_WW_Pin1_4	106	111	PF00397	0.660
DOC_WW_Pin1_4	410	415	PF00397	0.763
DOC_WW_Pin1_4	48	53	PF00397	0.649
DOC_WW_Pin1_4	533	538	PF00397	0.655
DOC_WW_Pin1_4	544	549	PF00397	0.739
DOC_WW_Pin1_4	602	607	PF00397	0.681
DOC_WW_Pin1_4	700	705	PF00397	0.735
DOC_WW_Pin1_4	733	738	PF00397	0.749
LIG_14-3-3_CanoR_1	160	170	PF00244	0.646
LIG_14-3-3_CanoR_1	305	311	PF00244	0.645
LIG_14-3-3_CanoR_1	4	9	PF00244	0.698
LIG_14-3-3_CanoR_1	528	533	PF00244	0.660
LIG_14-3-3_CanoR_1	822	831	PF00244	0.673
LIG_BIR_III_2	515	519	PF00653	0.661
LIG_BIR_III_2	779	783	PF00653	0.589
LIG_BRCT_BRCA1_1	383	387	PF00533	0.582
LIG_Clathr_ClatBox_1	170	174	PF01394	0.712
LIG_CtBP_PxDLS_1	761	765	PF00389	0.653
LIG_EVH1_1	774	778	PF00568	0.719
LIG_FHA_1	226	232	PF00498	0.555
LIG_FHA_1	274	280	PF00498	0.529
LIG_FHA_1	336	342	PF00498	0.489
LIG_FHA_1	452	458	PF00498	0.576
LIG_FHA_1	467	473	PF00498	0.505
LIG_FHA_1	474	480	PF00498	0.694
LIG_FHA_1	537	543	PF00498	0.660
LIG_FHA_1	603	609	PF00498	0.791
LIG_FHA_1	631	637	PF00498	0.702
LIG_FHA_1	812	818	PF00498	0.651
LIG_FHA_2	110	116	PF00498	0.739
LIG_FHA_2	192	198	PF00498	0.679
LIG_FHA_2	260	266	PF00498	0.544
LIG_FHA_2	307	313	PF00498	0.634
LIG_FHA_2	426	432	PF00498	0.690
LIG_FHA_2	465	471	PF00498	0.533
LIG_FHA_2	520	526	PF00498	0.645
LIG_FHA_2	557	563	PF00498	0.672
LIG_LIR_Gen_1	384	394	PF02991	0.584
LIG_LIR_Gen_1	522	527	PF02991	0.693
LIG_LIR_Gen_1	529	538	PF02991	0.707
LIG_LIR_Nem_3	318	322	PF02991	0.510
LIG_LIR_Nem_3	384	390	PF02991	0.583
LIG_LIR_Nem_3	522	526	PF02991	0.695
LIG_LIR_Nem_3	529	535	PF02991	0.709
LIG_LIR_Nem_3	563	569	PF02991	0.680
LIG_MYND_1	606	610	PF01753	0.688
LIG_MYND_1	762	766	PF01753	0.747
LIG_RPA_C_Fungi	800	812	PF08784	0.600
LIG_SH2_CRK	380	384	PF00017	0.587
LIG_SH2_STAT3	320	323	PF00017	0.569
LIG_SH2_STAT3	379	382	PF00017	0.592
LIG_SH3_1	62	68	PF00018	0.632
LIG_SH3_3	408	414	PF00018	0.684
LIG_SH3_3	540	546	PF00018	0.690
LIG_SH3_3	62	68	PF00018	0.632
LIG_SH3_3	669	675	PF00018	0.705
LIG_SH3_3	711	717	PF00018	0.779
LIG_SH3_3	726	732	PF00018	0.611
LIG_SH3_3	753	759	PF00018	0.668
LIG_SH3_3	762	768	PF00018	0.697
LIG_SH3_3	772	778	PF00018	0.638
LIG_SH3_3	780	786	PF00018	0.551
LIG_SH3_3	787	793	PF00018	0.565
LIG_Sin3_3	461	468	PF02671	0.596
LIG_SUMO_SIM_anti_2	115	120	PF11976	0.602
LIG_SUMO_SIM_anti_2	460	467	PF11976	0.600
LIG_SUMO_SIM_par_1	169	174	PF11976	0.608
LIG_TRAF2_1	289	292	PF00917	0.514
LIG_TRAF2_1	45	48	PF00917	0.676
LIG_TRAF2_1	522	525	PF00917	0.701
LIG_UBA3_1	220	229	PF00899	0.605
MOD_CDC14_SPxK_1	413	416	PF00782	0.772
MOD_CDK_SPxK_1	410	416	PF00069	0.765
MOD_CDK_SPxxK_3	48	55	PF00069	0.652
MOD_CK1_1	102	108	PF00069	0.675
MOD_CK1_1	109	115	PF00069	0.636
MOD_CK1_1	150	156	PF00069	0.672
MOD_CK1_1	191	197	PF00069	0.629
MOD_CK1_1	303	309	PF00069	0.643
MOD_CK1_1	507	513	PF00069	0.653
MOD_CK1_1	558	564	PF00069	0.732
MOD_CK1_1	646	652	PF00069	0.721
MOD_CK1_1	709	715	PF00069	0.703
MOD_CK1_1	723	729	PF00069	0.594
MOD_CK1_1	826	832	PF00069	0.649
MOD_CK2_1	109	115	PF00069	0.720
MOD_CK2_1	191	197	PF00069	0.609
MOD_CK2_1	259	265	PF00069	0.544
MOD_CK2_1	41	47	PF00069	0.708
MOD_CK2_1	425	431	PF00069	0.701
MOD_CK2_1	464	470	PF00069	0.531
MOD_CK2_1	519	525	PF00069	0.668
MOD_CK2_1	527	533	PF00069	0.651
MOD_CK2_1	622	628	PF00069	0.654
MOD_DYRK1A_RPxSP_1	410	414	PF00069	0.691
MOD_GlcNHglycan	157	160	PF01048	0.703
MOD_GlcNHglycan	21	24	PF01048	0.600
MOD_GlcNHglycan	38	41	PF01048	0.742
MOD_GlcNHglycan	390	393	PF01048	0.481
MOD_GlcNHglycan	43	46	PF01048	0.727
MOD_GlcNHglycan	476	479	PF01048	0.658
MOD_GlcNHglycan	508	512	PF01048	0.705
MOD_GlcNHglycan	592	595	PF01048	0.702
MOD_GlcNHglycan	6	9	PF01048	0.737
MOD_GlcNHglycan	639	642	PF01048	0.783
MOD_GlcNHglycan	655	659	PF01048	0.518
MOD_GlcNHglycan	677	680	PF01048	0.776
MOD_GlcNHglycan	69	72	PF01048	0.721
MOD_GlcNHglycan	753	756	PF01048	0.664
MOD_GlcNHglycan	770	773	PF01048	0.683
MOD_GSK3_1	102	109	PF00069	0.724
MOD_GSK3_1	139	146	PF00069	0.625
MOD_GSK3_1	169	176	PF00069	0.642
MOD_GSK3_1	189	196	PF00069	0.484
MOD_GSK3_1	19	26	PF00069	0.706
MOD_GSK3_1	295	302	PF00069	0.648
MOD_GSK3_1	335	342	PF00069	0.560
MOD_GSK3_1	382	389	PF00069	0.554
MOD_GSK3_1	464	471	PF00069	0.580
MOD_GSK3_1	586	593	PF00069	0.538
MOD_GSK3_1	642	649	PF00069	0.672
MOD_GSK3_1	650	657	PF00069	0.694
MOD_GSK3_1	719	726	PF00069	0.737
MOD_GSK3_1	78	85	PF00069	0.766
MOD_N-GLC_1	150	155	PF02516	0.647
MOD_N-GLC_1	265	270	PF02516	0.531
MOD_NEK2_1	114	119	PF00069	0.574
MOD_NEK2_1	12	17	PF00069	0.821
MOD_NEK2_1	143	148	PF00069	0.614
MOD_NEK2_1	259	264	PF00069	0.530
MOD_NEK2_1	464	469	PF00069	0.595
MOD_NEK2_1	816	821	PF00069	0.584
MOD_NEK2_2	290	295	PF00069	0.534
MOD_NEK2_2	99	104	PF00069	0.581
MOD_PIKK_1	143	149	PF00454	0.478
MOD_PIKK_1	29	35	PF00454	0.703
MOD_PIKK_1	312	318	PF00454	0.597
MOD_PIKK_1	354	360	PF00454	0.475
MOD_PIKK_1	364	370	PF00454	0.465
MOD_PIKK_1	826	832	PF00454	0.649
MOD_PK_1	169	175	PF00069	0.681
MOD_PKA_2	147	153	PF00069	0.747
MOD_PKA_2	23	29	PF00069	0.579
MOD_PKA_2	259	265	PF00069	0.530
MOD_PKA_2	304	310	PF00069	0.599
MOD_PKA_2	364	370	PF00069	0.518
MOD_PKA_2	432	438	PF00069	0.647
MOD_PKA_2	527	533	PF00069	0.669
MOD_PKA_2	712	718	PF00069	0.734
MOD_PKA_2	78	84	PF00069	0.628
MOD_PKA_2	824	830	PF00069	0.645
MOD_PKB_1	2	10	PF00069	0.697
MOD_Plk_1	114	120	PF00069	0.642
MOD_Plk_1	173	179	PF00069	0.654
MOD_Plk_1	215	221	PF00069	0.620
MOD_Plk_1	265	271	PF00069	0.532
MOD_Plk_1	290	296	PF00069	0.638
MOD_Plk_1	425	431	PF00069	0.701
MOD_Plk_1	507	513	PF00069	0.571
MOD_Plk_1	628	634	PF00069	0.699
MOD_Plk_2-3	628	634	PF00069	0.699
MOD_Plk_4	114	120	PF00069	0.589
MOD_Plk_4	233	239	PF00069	0.529
MOD_Plk_4	760	766	PF00069	0.568
MOD_ProDKin_1	106	112	PF00069	0.652
MOD_ProDKin_1	410	416	PF00069	0.765
MOD_ProDKin_1	48	54	PF00069	0.651
MOD_ProDKin_1	533	539	PF00069	0.656
MOD_ProDKin_1	544	550	PF00069	0.739
MOD_ProDKin_1	602	608	PF00069	0.682
MOD_ProDKin_1	700	706	PF00069	0.730
MOD_ProDKin_1	733	739	PF00069	0.751
MOD_SUMO_rev_2	41	51	PF00179	0.662
MOD_SUMO_rev_2	558	566	PF00179	0.637
MOD_SUMO_rev_2	625	632	PF00179	0.674
TRG_DiLeu_BaEn_1	216	221	PF01217	0.618
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.634
TRG_DiLeu_BaLyEn_6	275	280	PF01217	0.530
TRG_DiLeu_BaLyEn_6	54	59	PF01217	0.714
TRG_ENDOCYTIC_2	319	322	PF00928	0.578
TRG_ENDOCYTIC_2	380	383	PF00928	0.589
TRG_ER_diArg_1	1	4	PF00400	0.678
TRG_ER_diArg_1	286	288	PF00400	0.602
TRG_Pf-PMV_PEXEL_1	278	283	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	75	80	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HGE8	Leishmania braziliensis	52%	100%
A4I3H9	Leishmania infantum	98%	100%
E9AZS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q8G3	Leishmania major	90%	99%