Archaic translocase outer mitochondrial membrane 46 kDa subunit, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial import receptor subunit ATOM46, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X1C8_LEIDO

TriTrypDb:

LdBPK_281020.1 , LdCL_280014800 , LDHU3_28.1230

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005741	mitochondrial outer membrane	5	1
GO:0005742	mitochondrial outer membrane translocase complex	4	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0032991	protein-containing complex	1	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098799	outer mitochondrial membrane protein complex	3	1

Expansion

Sequence features

A0A3S7X1C8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1C8

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006626	protein targeting to mitochondrion	5	1
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0030150	protein import into mitochondrial matrix	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0044743	protein transmembrane import into intracellular organelle	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0055085	transmembrane transport	2	1
GO:0065002	intracellular protein transmembrane transport	4	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071806	protein transmembrane transport	3	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:1990542	mitochondrial transmembrane transport	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.355
CLV_NRD_NRD_1	249	251	PF00675	0.603
CLV_NRD_NRD_1	376	378	PF00675	0.581
CLV_NRD_NRD_1	47	49	PF00675	0.418
CLV_NRD_NRD_1	73	75	PF00675	0.444
CLV_PCSK_FUR_1	374	378	PF00082	0.655
CLV_PCSK_KEX2_1	249	251	PF00082	0.603
CLV_PCSK_KEX2_1	374	376	PF00082	0.563
CLV_PCSK_KEX2_1	73	75	PF00082	0.474
CLV_PCSK_SKI1_1	11	15	PF00082	0.454
CLV_PCSK_SKI1_1	110	114	PF00082	0.385
CLV_PCSK_SKI1_1	133	137	PF00082	0.318
CLV_PCSK_SKI1_1	260	264	PF00082	0.528
CLV_PCSK_SKI1_1	348	352	PF00082	0.599
CLV_PCSK_SKI1_1	41	45	PF00082	0.381
CLV_PCSK_SKI1_1	56	60	PF00082	0.288
CLV_Separin_Metazoa	70	74	PF03568	0.646
DEG_APCC_DBOX_1	122	130	PF00400	0.533
DEG_Nend_UBRbox_2	1	3	PF02207	0.411
DOC_MAPK_MEF2A_6	106	115	PF00069	0.571
DOC_MAPK_MEF2A_6	84	92	PF00069	0.603
DOC_PP1_RVXF_1	9	15	PF00149	0.307
DOC_PP2B_LxvP_1	351	354	PF13499	0.420
DOC_USP7_MATH_1	176	180	PF00917	0.611
DOC_USP7_MATH_1	200	204	PF00917	0.552
DOC_USP7_MATH_1	335	339	PF00917	0.418
DOC_USP7_MATH_1	78	82	PF00917	0.594
DOC_WW_Pin1_4	331	336	PF00397	0.406
LIG_14-3-3_CanoR_1	187	193	PF00244	0.561
LIG_14-3-3_CanoR_1	352	358	PF00244	0.436
LIG_14-3-3_CanoR_1	79	85	PF00244	0.571
LIG_BIR_III_4	119	123	PF00653	0.532
LIG_BRCT_BRCA1_1	324	328	PF00533	0.314
LIG_FHA_1	18	24	PF00498	0.440
LIG_FHA_1	297	303	PF00498	0.313
LIG_FHA_1	354	360	PF00498	0.289
LIG_FHA_2	136	142	PF00498	0.513
LIG_FHA_2	160	166	PF00498	0.543
LIG_FHA_2	217	223	PF00498	0.435
LIG_FHA_2	324	330	PF00498	0.320
LIG_FHA_2	98	104	PF00498	0.563
LIG_LIR_Gen_1	211	221	PF02991	0.316
LIG_LIR_Gen_1	238	244	PF02991	0.286
LIG_LIR_Nem_3	130	135	PF02991	0.593
LIG_LIR_Nem_3	211	217	PF02991	0.316
LIG_LIR_Nem_3	238	243	PF02991	0.289
LIG_LIR_Nem_3	312	318	PF02991	0.360
LIG_NRBOX	345	351	PF00104	0.305
LIG_Pex14_1	10	14	PF04695	0.256
LIG_REV1ctd_RIR_1	237	246	PF16727	0.378
LIG_SH2_CRK	132	136	PF00017	0.522
LIG_SH2_CRK	85	89	PF00017	0.590
LIG_SH2_SRC	114	117	PF00017	0.581
LIG_SH2_STAT3	382	385	PF00017	0.482
LIG_SH2_STAT5	114	117	PF00017	0.581
LIG_SH3_3	1	7	PF00018	0.393
LIG_SUMO_SIM_anti_2	203	209	PF11976	0.405
LIG_SUMO_SIM_anti_2	22	28	PF11976	0.250
LIG_SUMO_SIM_anti_2	296	302	PF11976	0.278
LIG_SUMO_SIM_par_1	290	296	PF11976	0.376
MOD_CDC14_SPxK_1	334	337	PF00782	0.526
MOD_CDK_SPxK_1	331	337	PF00069	0.515
MOD_CK1_1	235	241	PF00069	0.357
MOD_CK1_1	296	302	PF00069	0.363
MOD_CK1_1	338	344	PF00069	0.509
MOD_CK2_1	135	141	PF00069	0.379
MOD_CK2_1	216	222	PF00069	0.434
MOD_CK2_1	323	329	PF00069	0.358
MOD_CK2_1	338	344	PF00069	0.383
MOD_CK2_1	97	103	PF00069	0.529
MOD_GlcNHglycan	228	231	PF01048	0.397
MOD_GlcNHglycan	234	237	PF01048	0.340
MOD_GlcNHglycan	315	318	PF01048	0.465
MOD_GlcNHglycan	37	40	PF01048	0.515
MOD_GlcNHglycan	76	79	PF01048	0.423
MOD_GlcNHglycan	80	83	PF01048	0.374
MOD_GSK3_1	202	209	PF00069	0.394
MOD_GSK3_1	313	320	PF00069	0.464
MOD_GSK3_1	331	338	PF00069	0.486
MOD_GSK3_1	74	81	PF00069	0.489
MOD_GSK3_1	97	104	PF00069	0.428
MOD_N-GLC_1	276	281	PF02516	0.483
MOD_N-GLC_2	216	218	PF02516	0.316
MOD_NEK2_1	135	140	PF00069	0.375
MOD_NEK2_1	206	211	PF00069	0.392
MOD_NEK2_1	244	249	PF00069	0.454
MOD_NEK2_1	304	309	PF00069	0.418
MOD_NEK2_2	335	340	PF00069	0.517
MOD_PKA_2	78	84	PF00069	0.385
MOD_Plk_1	276	282	PF00069	0.481
MOD_Plk_1	335	341	PF00069	0.522
MOD_Plk_2-3	159	165	PF00069	0.512
MOD_Plk_4	202	208	PF00069	0.364
MOD_Plk_4	235	241	PF00069	0.372
MOD_Plk_4	25	31	PF00069	0.301
MOD_Plk_4	293	299	PF00069	0.330
MOD_Plk_4	323	329	PF00069	0.338
MOD_Plk_4	405	411	PF00069	0.627
MOD_ProDKin_1	331	337	PF00069	0.515
TRG_DiLeu_BaLyEn_6	239	244	PF01217	0.343
TRG_DiLeu_BaLyEn_6	345	350	PF01217	0.473
TRG_ENDOCYTIC_2	132	135	PF00928	0.397
TRG_ER_diArg_1	249	251	PF00400	0.506
TRG_ER_diArg_1	339	342	PF00400	0.498
TRG_ER_diArg_1	374	377	PF00400	0.528
TRG_ER_diArg_1	72	74	PF00400	0.590
TRG_NES_CRM1_1	276	290	PF08389	0.441
TRG_NES_CRM1_1	393	406	PF08389	0.570
TRG_Pf-PMV_PEXEL_1	196	201	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7T6	Leptomonas seymouri	81%	100%
A0A0S4IQ39	Bodo saltans	41%	99%
A0A1X0NZX9	Trypanosomatidae	50%	98%
A0A3R7JYC9	Trypanosoma rangeli	52%	100%
A4HGD7	Leishmania braziliensis	89%	100%
A4I3H0	Leishmania infantum	99%	100%
D0A7W6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	98%
E9AZQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q8H4	Leishmania major	97%	100%
V5B0R0	Trypanosoma cruzi	52%	100%