Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X1C2_LEIDO

TriTrypDb:

LdBPK_280990.1 , LdCL_280014500 , LDHU3_28.1180

Length:

303

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X1C2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1C2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.668
CLV_NRD_NRD_1	149	151	PF00675	0.655
CLV_NRD_NRD_1	227	229	PF00675	0.631
CLV_NRD_NRD_1	3	5	PF00675	0.712
CLV_NRD_NRD_1	38	40	PF00675	0.620
CLV_NRD_NRD_1	74	76	PF00675	0.673
CLV_PCSK_FUR_1	104	108	PF00082	0.640
CLV_PCSK_KEX2_1	106	108	PF00082	0.561
CLV_PCSK_KEX2_1	149	151	PF00082	0.660
CLV_PCSK_KEX2_1	2	4	PF00082	0.717
CLV_PCSK_KEX2_1	271	273	PF00082	0.559
CLV_PCSK_KEX2_1	278	280	PF00082	0.623
CLV_PCSK_KEX2_1	74	76	PF00082	0.673
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.577
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.559
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.623
CLV_PCSK_PC7_1	102	108	PF00082	0.578
CLV_PCSK_SKI1_1	39	43	PF00082	0.564
CLV_PCSK_SKI1_1	79	83	PF00082	0.507
CLV_Separin_Metazoa	261	265	PF03568	0.524
DEG_APCC_DBOX_1	83	91	PF00400	0.555
DEG_Nend_UBRbox_1	1	4	PF02207	0.622
DOC_CYCLIN_RxL_1	260	273	PF00134	0.439
DOC_MAPK_gen_1	104	112	PF00069	0.560
DOC_MAPK_gen_1	186	196	PF00069	0.568
DOC_MAPK_gen_1	37	46	PF00069	0.568
DOC_MAPK_MEF2A_6	189	198	PF00069	0.574
DOC_MAPK_MEF2A_6	37	46	PF00069	0.568
DOC_MAPK_NFAT4_5	39	47	PF00069	0.641
DOC_PP1_RVXF_1	37	44	PF00149	0.559
DOC_WW_Pin1_4	61	66	PF00397	0.705
LIG_14-3-3_CanoR_1	2	9	PF00244	0.711
LIG_14-3-3_CanoR_1	207	211	PF00244	0.541
LIG_14-3-3_CanoR_1	231	235	PF00244	0.647
LIG_Actin_WH2_2	123	141	PF00022	0.553
LIG_Actin_WH2_2	191	209	PF00022	0.542
LIG_Actin_WH2_2	255	273	PF00022	0.561
LIG_APCC_ABBAyCdc20_2	39	45	PF00400	0.566
LIG_Clathr_ClatBox_1	41	45	PF01394	0.566
LIG_FHA_1	17	23	PF00498	0.633
LIG_FHA_2	197	203	PF00498	0.554
LIG_FHA_2	213	219	PF00498	0.521
LIG_FHA_2	25	31	PF00498	0.545
LIG_FHA_2	62	68	PF00498	0.748
LIG_LIR_Gen_1	185	194	PF02991	0.534
LIG_LIR_Nem_3	185	190	PF02991	0.511
LIG_LIR_Nem_3	236	242	PF02991	0.582
LIG_LIR_Nem_3	273	277	PF02991	0.583
LIG_LRP6_Inhibitor_1	31	37	PF00058	0.548
LIG_NRBOX	258	264	PF00104	0.515
LIG_SH2_CRK	239	243	PF00017	0.579
LIG_SH2_GRB2like	97	100	PF00017	0.580
LIG_SH2_STAT5	274	277	PF00017	0.580
LIG_SH3_3	12	18	PF00018	0.552
LIG_SH3_3	281	287	PF00018	0.649
LIG_SH3_3	60	66	PF00018	0.674
LIG_SUMO_SIM_anti_2	27	33	PF11976	0.562
LIG_TRAF2_1	253	256	PF00917	0.556
LIG_TRAF2_1	69	72	PF00917	0.592
MOD_CK2_1	212	218	PF00069	0.559
MOD_CK2_1	230	236	PF00069	0.622
MOD_CK2_1	61	67	PF00069	0.755
MOD_GlcNHglycan	220	223	PF01048	0.503
MOD_GlcNHglycan	288	291	PF01048	0.659
MOD_GlcNHglycan	52	55	PF01048	0.721
MOD_GSK3_1	141	148	PF00069	0.660
MOD_N-GLC_1	218	223	PF02516	0.534
MOD_NEK2_1	270	275	PF00069	0.498
MOD_PIKK_1	157	163	PF00454	0.433
MOD_PKA_1	2	8	PF00069	0.605
MOD_PKA_2	2	8	PF00069	0.715
MOD_PKA_2	206	212	PF00069	0.541
MOD_PKA_2	230	236	PF00069	0.528
MOD_PKB_1	2	10	PF00069	0.606
MOD_Plk_1	58	64	PF00069	0.712
MOD_ProDKin_1	61	67	PF00069	0.706
MOD_SUMO_rev_2	267	273	PF00179	0.540
MOD_SUMO_rev_2	33	42	PF00179	0.549
MOD_SUMO_rev_2	85	90	PF00179	0.555
TRG_DiLeu_BaEn_1	295	300	PF01217	0.611
TRG_DiLeu_BaEn_3	236	242	PF01217	0.508
TRG_DiLeu_BaEn_4	171	177	PF01217	0.534
TRG_DiLeu_BaEn_4	254	260	PF01217	0.555
TRG_DiLeu_BaEn_4	71	77	PF01217	0.572
TRG_ENDOCYTIC_2	239	242	PF00928	0.580
TRG_ENDOCYTIC_2	274	277	PF00928	0.535
TRG_ER_diArg_1	1	4	PF00400	0.622
TRG_ER_diArg_1	101	104	PF00400	0.637
TRG_ER_diArg_1	149	152	PF00400	0.590
TRG_ER_diArg_1	166	169	PF00400	0.500
TRG_ER_diArg_1	74	76	PF00400	0.678

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM76	Leptomonas seymouri	54%	97%
A0A1X0NYF4	Trypanosomatidae	33%	100%
A4HGD4	Leishmania braziliensis	72%	100%
A4I3G7	Leishmania infantum	100%	100%
E9AZQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q8H7	Leishmania major	92%	100%