CNH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X1B3_LEIDO

TriTrypDb:

LdBPK_280960.1 , LdCL_280014200 , LDHU3_28.1140

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A0A3S7X1B3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1B3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.445
CLV_NRD_NRD_1	195	197	PF00675	0.515
CLV_NRD_NRD_1	234	236	PF00675	0.342
CLV_PCSK_FUR_1	232	236	PF00082	0.317
CLV_PCSK_KEX2_1	118	120	PF00082	0.462
CLV_PCSK_KEX2_1	195	197	PF00082	0.515
CLV_PCSK_KEX2_1	234	236	PF00082	0.340
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.462
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.314
CLV_PCSK_PC7_1	114	120	PF00082	0.372
CLV_PCSK_SKI1_1	206	210	PF00082	0.468
CLV_PCSK_SKI1_1	258	262	PF00082	0.392
CLV_PCSK_SKI1_1	384	388	PF00082	0.331
CLV_PCSK_SKI1_1	503	507	PF00082	0.397
CLV_PCSK_SKI1_1	55	59	PF00082	0.453
CLV_PCSK_SKI1_1	567	571	PF00082	0.353
CLV_Separin_Metazoa	500	504	PF03568	0.547
DEG_Nend_Nbox_1	1	3	PF02207	0.463
DEG_SCF_TRCP1_1	405	410	PF00400	0.481
DEG_SPOP_SBC_1	360	364	PF00917	0.594
DOC_CKS1_1	458	463	PF01111	0.685
DOC_CKS1_1	464	469	PF01111	0.613
DOC_CYCLIN_yClb3_PxF_3	433	441	PF00134	0.624
DOC_MAPK_gen_1	422	430	PF00069	0.480
DOC_MAPK_MEF2A_6	210	219	PF00069	0.574
DOC_MAPK_MEF2A_6	441	448	PF00069	0.626
DOC_PP1_SILK_1	206	211	PF00149	0.596
DOC_PP4_FxxP_1	430	433	PF00568	0.628
DOC_PP4_FxxP_1	569	572	PF00568	0.581
DOC_USP7_MATH_1	137	141	PF00917	0.611
DOC_USP7_MATH_1	154	158	PF00917	0.694
DOC_USP7_MATH_1	169	173	PF00917	0.684
DOC_USP7_MATH_1	222	226	PF00917	0.513
DOC_USP7_MATH_1	360	364	PF00917	0.605
DOC_USP7_MATH_1	73	77	PF00917	0.291
DOC_USP7_UBL2_3	123	127	PF12436	0.721
DOC_USP7_UBL2_3	15	19	PF12436	0.385
DOC_USP7_UBL2_3	156	160	PF12436	0.651
DOC_USP7_UBL2_3	367	371	PF12436	0.577
DOC_WW_Pin1_4	194	199	PF00397	0.740
DOC_WW_Pin1_4	218	223	PF00397	0.492
DOC_WW_Pin1_4	457	462	PF00397	0.685
DOC_WW_Pin1_4	463	468	PF00397	0.660
DOC_WW_Pin1_4	570	575	PF00397	0.620
LIG_14-3-3_CanoR_1	235	240	PF00244	0.556
LIG_14-3-3_CanoR_1	258	267	PF00244	0.618
LIG_14-3-3_CanoR_1	296	304	PF00244	0.477
LIG_14-3-3_CanoR_1	326	332	PF00244	0.584
LIG_14-3-3_CanoR_1	333	337	PF00244	0.557
LIG_14-3-3_CanoR_1	424	431	PF00244	0.516
LIG_14-3-3_CanoR_1	567	572	PF00244	0.490
LIG_Actin_WH2_2	410	426	PF00022	0.494
LIG_AP2alpha_1	297	301	PF02296	0.549
LIG_APCC_ABBA_1	20	25	PF00400	0.346
LIG_APCC_ABBA_1	444	449	PF00400	0.493
LIG_APCC_ABBAyCdc20_2	19	25	PF00400	0.406
LIG_FHA_1	24	30	PF00498	0.390
LIG_FHA_1	266	272	PF00498	0.567
LIG_FHA_1	287	293	PF00498	0.596
LIG_FHA_1	347	353	PF00498	0.602
LIG_FHA_1	5	11	PF00498	0.511
LIG_FHA_2	195	201	PF00498	0.697
LIG_FHA_2	452	458	PF00498	0.529
LIG_FHA_2	511	517	PF00498	0.537
LIG_LIR_Gen_1	257	267	PF02991	0.511
LIG_LIR_Gen_1	298	306	PF02991	0.552
LIG_LIR_Gen_1	440	448	PF02991	0.478
LIG_LIR_Gen_1	60	69	PF02991	0.363
LIG_LIR_Nem_3	225	229	PF02991	0.591
LIG_LIR_Nem_3	257	263	PF02991	0.501
LIG_LIR_Nem_3	298	304	PF02991	0.484
LIG_LIR_Nem_3	440	446	PF02991	0.482
LIG_LIR_Nem_3	60	64	PF02991	0.295
LIG_PCNA_PIPBox_1	528	537	PF02747	0.502
LIG_PCNA_yPIPBox_3	309	318	PF02747	0.557
LIG_Pex14_2	297	301	PF04695	0.624
LIG_Rb_pABgroove_1	529	537	PF01858	0.541
LIG_SH2_CRK	443	447	PF00017	0.510
LIG_SH2_STAP1	280	284	PF00017	0.533
LIG_SH2_STAT3	280	283	PF00017	0.536
LIG_SH2_STAT3	456	459	PF00017	0.568
LIG_SH2_STAT3	535	538	PF00017	0.532
LIG_SH2_STAT5	21	24	PF00017	0.420
LIG_SH2_STAT5	226	229	PF00017	0.501
LIG_SH3_3	430	436	PF00018	0.586
LIG_SH3_3	455	461	PF00018	0.530
LIG_SH3_3	480	486	PF00018	0.576
LIG_SH3_3	69	75	PF00018	0.217
LIG_SUMO_SIM_anti_2	214	221	PF11976	0.481
LIG_SUMO_SIM_anti_2	340	347	PF11976	0.516
LIG_SUMO_SIM_anti_2	351	356	PF11976	0.460
LIG_SUMO_SIM_anti_2	412	418	PF11976	0.505
LIG_SUMO_SIM_anti_2	60	66	PF11976	0.400
LIG_SUMO_SIM_par_1	25	30	PF11976	0.279
LIG_SUMO_SIM_par_1	340	347	PF11976	0.525
LIG_SUMO_SIM_par_1	70	76	PF11976	0.298
LIG_UBA3_1	568	576	PF00899	0.596
MOD_CDC14_SPxK_1	573	576	PF00782	0.607
MOD_CDK_SPxK_1	570	576	PF00069	0.573
MOD_CK1_1	194	200	PF00069	0.732
MOD_CK1_1	307	313	PF00069	0.583
MOD_CK1_1	341	347	PF00069	0.541
MOD_CK1_1	4	10	PF00069	0.432
MOD_CK2_1	107	113	PF00069	0.558
MOD_CK2_1	510	516	PF00069	0.536
MOD_CK2_1	91	97	PF00069	0.578
MOD_GlcNHglycan	128	131	PF01048	0.393
MOD_GlcNHglycan	151	154	PF01048	0.623
MOD_GlcNHglycan	156	159	PF01048	0.496
MOD_GlcNHglycan	171	174	PF01048	0.424
MOD_GlcNHglycan	3	6	PF01048	0.609
MOD_GlcNHglycan	306	309	PF01048	0.373
MOD_GlcNHglycan	357	360	PF01048	0.476
MOD_GlcNHglycan	373	376	PF01048	0.374
MOD_GlcNHglycan	405	408	PF01048	0.338
MOD_GlcNHglycan	425	428	PF01048	0.293
MOD_GlcNHglycan	470	473	PF01048	0.393
MOD_GlcNHglycan	50	53	PF01048	0.620
MOD_GlcNHglycan	516	520	PF01048	0.482
MOD_GlcNHglycan	557	560	PF01048	0.327
MOD_GSK3_1	137	144	PF00069	0.661
MOD_GSK3_1	190	197	PF00069	0.723
MOD_GSK3_1	218	225	PF00069	0.605
MOD_GSK3_1	23	30	PF00069	0.338
MOD_GSK3_1	282	289	PF00069	0.533
MOD_GSK3_1	312	319	PF00069	0.527
MOD_GSK3_1	355	362	PF00069	0.533
MOD_GSK3_1	403	410	PF00069	0.488
MOD_GSK3_1	459	466	PF00069	0.739
MOD_GSK3_1	87	94	PF00069	0.520
MOD_LATS_1	565	571	PF00433	0.491
MOD_N-GLC_1	23	28	PF02516	0.581
MOD_N-GLC_1	312	317	PF02516	0.278
MOD_N-GLC_1	510	515	PF02516	0.286
MOD_NEK2_1	1	6	PF00069	0.451
MOD_NEK2_1	190	195	PF00069	0.717
MOD_NEK2_1	286	291	PF00069	0.541
MOD_NEK2_1	297	302	PF00069	0.474
MOD_NEK2_1	304	309	PF00069	0.452
MOD_NEK2_1	327	332	PF00069	0.572
MOD_NEK2_1	35	40	PF00069	0.424
MOD_NEK2_1	387	392	PF00069	0.541
MOD_NEK2_1	423	428	PF00069	0.486
MOD_NEK2_1	555	560	PF00069	0.516
MOD_NEK2_2	451	456	PF00069	0.544
MOD_NEK2_2	510	515	PF00069	0.562
MOD_PIKK_1	107	113	PF00454	0.631
MOD_PIKK_1	27	33	PF00454	0.326
MOD_PIKK_1	312	318	PF00454	0.508
MOD_PIKK_1	460	466	PF00454	0.670
MOD_PK_1	92	98	PF00069	0.532
MOD_PKA_1	235	241	PF00069	0.585
MOD_PKA_2	295	301	PF00069	0.481
MOD_PKA_2	332	338	PF00069	0.512
MOD_PKA_2	395	401	PF00069	0.595
MOD_PKA_2	423	429	PF00069	0.515
MOD_Plk_1	23	29	PF00069	0.375
MOD_Plk_1	286	292	PF00069	0.541
MOD_Plk_1	312	318	PF00069	0.475
MOD_Plk_1	510	516	PF00069	0.499
MOD_Plk_4	204	210	PF00069	0.568
MOD_Plk_4	222	228	PF00069	0.528
MOD_Plk_4	235	241	PF00069	0.559
MOD_Plk_4	297	303	PF00069	0.523
MOD_Plk_4	338	344	PF00069	0.599
MOD_Plk_4	387	393	PF00069	0.532
MOD_Plk_4	451	457	PF00069	0.547
MOD_Plk_4	510	516	PF00069	0.514
MOD_ProDKin_1	194	200	PF00069	0.741
MOD_ProDKin_1	218	224	PF00069	0.492
MOD_ProDKin_1	457	463	PF00069	0.694
MOD_ProDKin_1	570	576	PF00069	0.629
TRG_DiLeu_BaEn_1	214	219	PF01217	0.541
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.452
TRG_ENDOCYTIC_2	226	229	PF00928	0.528
TRG_ENDOCYTIC_2	443	446	PF00928	0.465
TRG_ENDOCYTIC_2	498	501	PF00928	0.611
TRG_ER_diArg_1	119	121	PF00400	0.662
TRG_NLS_Bipartite_1	103	122	PF00514	0.601
TRG_NLS_MonoCore_2	117	122	PF00514	0.627
TRG_NLS_MonoExtN_4	232	238	PF00514	0.505
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.332
TRG_Pf-PMV_PEXEL_1	55	60	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7S9	Leptomonas seymouri	62%	100%
A0A1X0NYG1	Trypanosomatidae	42%	100%
A0A422N3T8	Trypanosoma rangeli	42%	100%
A4HGD1	Leishmania braziliensis	76%	100%
E9AZQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q8I0	Leishmania major	92%	100%