Tc-38 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X1B1_LEIDO

TriTrypDb:

LdBPK_280930.1 , LdCL_280013900 , LDHU3_28.1110

Length:

870

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X1B1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1B1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	451	455	PF00656	0.525
CLV_C14_Caspase3-7	792	796	PF00656	0.630
CLV_NRD_NRD_1	203	205	PF00675	0.604
CLV_NRD_NRD_1	283	285	PF00675	0.458
CLV_NRD_NRD_1	291	293	PF00675	0.533
CLV_NRD_NRD_1	576	578	PF00675	0.368
CLV_NRD_NRD_1	594	596	PF00675	0.540
CLV_NRD_NRD_1	680	682	PF00675	0.396
CLV_NRD_NRD_1	719	721	PF00675	0.581
CLV_NRD_NRD_1	83	85	PF00675	0.362
CLV_NRD_NRD_1	94	96	PF00675	0.261
CLV_PCSK_KEX2_1	283	285	PF00082	0.515
CLV_PCSK_KEX2_1	291	293	PF00082	0.674
CLV_PCSK_KEX2_1	576	578	PF00082	0.368
CLV_PCSK_KEX2_1	594	596	PF00082	0.540
CLV_PCSK_KEX2_1	680	682	PF00082	0.396
CLV_PCSK_KEX2_1	83	85	PF00082	0.362
CLV_PCSK_SKI1_1	148	152	PF00082	0.479
CLV_PCSK_SKI1_1	506	510	PF00082	0.401
CLV_PCSK_SKI1_1	513	517	PF00082	0.385
CLV_PCSK_SKI1_1	63	67	PF00082	0.316
CLV_PCSK_SKI1_1	733	737	PF00082	0.573
CLV_PCSK_SKI1_1	95	99	PF00082	0.376
DEG_APCC_DBOX_1	575	583	PF00400	0.341
DEG_Nend_UBRbox_1	1	4	PF02207	0.630
DEG_SCF_FBW7_1	32	37	PF00400	0.636
DOC_CDC14_PxL_1	419	427	PF14671	0.428
DOC_CYCLIN_RxL_1	503	511	PF00134	0.413
DOC_MAPK_gen_1	465	473	PF00069	0.453
DOC_MAPK_gen_1	694	702	PF00069	0.380
DOC_MAPK_gen_1	83	93	PF00069	0.303
DOC_MAPK_HePTP_8	338	350	PF00069	0.458
DOC_MAPK_MEF2A_6	341	350	PF00069	0.445
DOC_PP1_RVXF_1	455	462	PF00149	0.403
DOC_PP1_RVXF_1	504	511	PF00149	0.413
DOC_PP1_RVXF_1	538	545	PF00149	0.566
DOC_PP2B_LxvP_1	162	165	PF13499	0.614
DOC_PP4_FxxP_1	248	251	PF00568	0.556
DOC_PP4_FxxP_1	476	479	PF00568	0.434
DOC_PP4_FxxP_1	725	728	PF00568	0.556
DOC_SPAK_OSR1_1	806	810	PF12202	0.472
DOC_USP7_MATH_1	22	26	PF00917	0.623
DOC_USP7_MATH_1	227	231	PF00917	0.633
DOC_USP7_MATH_1	393	397	PF00917	0.391
DOC_USP7_MATH_1	601	605	PF00917	0.532
DOC_USP7_MATH_1	608	612	PF00917	0.630
DOC_USP7_MATH_1	667	671	PF00917	0.378
DOC_USP7_MATH_1	773	777	PF00917	0.446
DOC_USP7_MATH_1	786	790	PF00917	0.748
DOC_WW_Pin1_4	118	123	PF00397	0.264
DOC_WW_Pin1_4	160	165	PF00397	0.548
DOC_WW_Pin1_4	218	223	PF00397	0.611
DOC_WW_Pin1_4	30	35	PF00397	0.769
DOC_WW_Pin1_4	44	49	PF00397	0.535
DOC_WW_Pin1_4	604	609	PF00397	0.594
DOC_WW_Pin1_4	680	685	PF00397	0.374
DOC_WW_Pin1_4	723	728	PF00397	0.535
LIG_14-3-3_CanoR_1	291	296	PF00244	0.526
LIG_14-3-3_CanoR_1	345	351	PF00244	0.420
LIG_14-3-3_CanoR_1	576	580	PF00244	0.440
LIG_14-3-3_CanoR_1	615	624	PF00244	0.589
LIG_14-3-3_CanoR_1	697	703	PF00244	0.364
LIG_14-3-3_CanoR_1	822	826	PF00244	0.578
LIG_Actin_WH2_2	620	638	PF00022	0.387
LIG_BRCT_BRCA1_1	207	211	PF00533	0.649
LIG_BRCT_BRCA1_1	229	233	PF00533	0.539
LIG_BRCT_BRCA1_1	395	399	PF00533	0.374
LIG_CaM_IQ_9	459	474	PF13499	0.453
LIG_CaMK_CASK_1	90	95	PF00069	0.362
LIG_CSL_BTD_1	91	94	PF09270	0.299
LIG_deltaCOP1_diTrp_1	239	248	PF00928	0.549
LIG_deltaCOP1_diTrp_1	90	98	PF00928	0.362
LIG_EVH1_2	569	573	PF00568	0.439
LIG_FHA_1	128	134	PF00498	0.299
LIG_FHA_1	219	225	PF00498	0.628
LIG_FHA_1	263	269	PF00498	0.542
LIG_FHA_1	31	37	PF00498	0.636
LIG_FHA_1	319	325	PF00498	0.400
LIG_FHA_1	327	333	PF00498	0.409
LIG_FHA_1	357	363	PF00498	0.472
LIG_FHA_1	607	613	PF00498	0.610
LIG_FHA_1	64	70	PF00498	0.299
LIG_FHA_2	112	118	PF00498	0.352
LIG_FHA_2	161	167	PF00498	0.752
LIG_FHA_2	399	405	PF00498	0.392
LIG_FHA_2	449	455	PF00498	0.489
LIG_FHA_2	681	687	PF00498	0.437
LIG_FHA_2	71	77	PF00498	0.264
LIG_FHA_2	857	863	PF00498	0.636
LIG_IBAR_NPY_1	308	310	PF08397	0.465
LIG_LIR_Apic_2	503	507	PF02991	0.403
LIG_LIR_Gen_1	152	162	PF02991	0.679
LIG_LIR_Gen_1	239	248	PF02991	0.549
LIG_LIR_Gen_1	319	328	PF02991	0.437
LIG_LIR_Gen_1	344	353	PF02991	0.418
LIG_LIR_Nem_3	152	157	PF02991	0.525
LIG_LIR_Nem_3	230	236	PF02991	0.562
LIG_LIR_Nem_3	239	245	PF02991	0.564
LIG_LIR_Nem_3	275	281	PF02991	0.495
LIG_LIR_Nem_3	294	298	PF02991	0.349
LIG_LIR_Nem_3	319	323	PF02991	0.400
LIG_LIR_Nem_3	344	350	PF02991	0.383
LIG_LIR_Nem_3	548	553	PF02991	0.333
LIG_LIR_Nem_3	688	693	PF02991	0.466
LIG_LYPXL_yS_3	422	425	PF13949	0.418
LIG_LYPXL_yS_3	690	693	PF13949	0.384
LIG_MLH1_MIPbox_1	207	211	PF16413	0.649
LIG_MYND_1	234	238	PF01753	0.574
LIG_NRBOX	424	430	PF00104	0.435
LIG_NRBOX	862	868	PF00104	0.558
LIG_Pex14_1	622	626	PF04695	0.406
LIG_Pex14_1	678	682	PF04695	0.453
LIG_Pex14_2	618	622	PF04695	0.443
LIG_PTB_Apo_2	305	312	PF02174	0.489
LIG_PTB_Apo_2	319	326	PF02174	0.355
LIG_PTB_Apo_2	760	767	PF02174	0.465
LIG_REV1ctd_RIR_1	459	469	PF16727	0.457
LIG_REV1ctd_RIR_1	507	517	PF16727	0.420
LIG_SH2_CRK	320	324	PF00017	0.418
LIG_SH2_GRB2like	320	323	PF00017	0.403
LIG_SH2_NCK_1	682	686	PF00017	0.354
LIG_SH2_PTP2	108	111	PF00017	0.362
LIG_SH2_PTP2	644	647	PF00017	0.519
LIG_SH2_SRC	315	318	PF00017	0.370
LIG_SH2_SRC	432	435	PF00017	0.547
LIG_SH2_STAP1	320	324	PF00017	0.390
LIG_SH2_STAT5	108	111	PF00017	0.362
LIG_SH2_STAT5	210	213	PF00017	0.653
LIG_SH2_STAT5	310	313	PF00017	0.560
LIG_SH2_STAT5	315	318	PF00017	0.531
LIG_SH2_STAT5	320	323	PF00017	0.339
LIG_SH2_STAT5	342	345	PF00017	0.411
LIG_SH2_STAT5	373	376	PF00017	0.409
LIG_SH2_STAT5	387	390	PF00017	0.353
LIG_SH2_STAT5	485	488	PF00017	0.437
LIG_SH2_STAT5	626	629	PF00017	0.553
LIG_SH2_STAT5	644	647	PF00017	0.355
LIG_SH2_STAT5	682	685	PF00017	0.353
LIG_SH3_3	231	237	PF00018	0.566
LIG_SH3_3	29	35	PF00018	0.693
LIG_SH3_3	409	415	PF00018	0.396
LIG_SH3_3	640	646	PF00018	0.410
LIG_SH3_3	751	757	PF00018	0.457
LIG_SH3_3	791	797	PF00018	0.516
LIG_SH3_3	88	94	PF00018	0.299
LIG_TRAF2_1	785	788	PF00917	0.535
LIG_TYR_ITIM	642	647	PF00017	0.500
LIG_UBA3_1	729	737	PF00899	0.530
LIG_WRC_WIRS_1	151	156	PF05994	0.437
MOD_CK1_1	160	166	PF00069	0.594
MOD_CK1_1	212	218	PF00069	0.670
MOD_CK1_1	294	300	PF00069	0.510
MOD_CK1_1	44	50	PF00069	0.688
MOD_CK1_1	604	610	PF00069	0.587
MOD_CK1_1	611	617	PF00069	0.544
MOD_CK1_1	816	822	PF00069	0.529
MOD_CK2_1	160	166	PF00069	0.680
MOD_CK2_1	212	218	PF00069	0.680
MOD_CK2_1	398	404	PF00069	0.360
MOD_CK2_1	786	792	PF00069	0.781
MOD_CK2_1	821	827	PF00069	0.573
MOD_GlcNHglycan	197	200	PF01048	0.711
MOD_GlcNHglycan	211	214	PF01048	0.595
MOD_GlcNHglycan	229	232	PF01048	0.574
MOD_GlcNHglycan	415	418	PF01048	0.407
MOD_GlcNHglycan	441	444	PF01048	0.575
MOD_GlcNHglycan	618	621	PF01048	0.527
MOD_GlcNHglycan	741	744	PF01048	0.601
MOD_GlcNHglycan	750	753	PF01048	0.450
MOD_GlcNHglycan	788	791	PF01048	0.785
MOD_GlcNHglycan	802	805	PF01048	0.451
MOD_GlcNHglycan	810	813	PF01048	0.423
MOD_GlcNHglycan	815	818	PF01048	0.388
MOD_GlcNHglycan	859	862	PF01048	0.606
MOD_GSK3_1	195	202	PF00069	0.666
MOD_GSK3_1	205	212	PF00069	0.672
MOD_GSK3_1	294	301	PF00069	0.509
MOD_GSK3_1	30	37	PF00069	0.638
MOD_GSK3_1	394	401	PF00069	0.603
MOD_GSK3_1	435	442	PF00069	0.576
MOD_GSK3_1	602	609	PF00069	0.530
MOD_GSK3_1	821	828	PF00069	0.568
MOD_GSK3_1	857	864	PF00069	0.608
MOD_N-GLC_1	205	210	PF02516	0.651
MOD_N-GLC_1	254	259	PF02516	0.536
MOD_N-GLC_1	551	556	PF02516	0.392
MOD_N-GLC_1	616	621	PF02516	0.585
MOD_N-GLC_2	586	588	PF02516	0.401
MOD_NEK2_1	150	155	PF00069	0.518
MOD_NEK2_1	157	162	PF00069	0.563
MOD_NEK2_1	254	259	PF00069	0.536
MOD_NEK2_1	346	351	PF00069	0.406
MOD_NEK2_1	356	361	PF00069	0.347
MOD_NEK2_1	36	41	PF00069	0.789
MOD_NEK2_1	381	386	PF00069	0.447
MOD_NEK2_1	486	491	PF00069	0.432
MOD_NEK2_1	508	513	PF00069	0.404
MOD_NEK2_1	551	556	PF00069	0.392
MOD_NEK2_1	628	633	PF00069	0.455
MOD_NEK2_1	741	746	PF00069	0.589
MOD_NEK2_1	747	752	PF00069	0.500
MOD_NEK2_1	799	804	PF00069	0.526
MOD_NEK2_1	821	826	PF00069	0.526
MOD_NEK2_1	834	839	PF00069	0.626
MOD_NEK2_2	394	399	PF00069	0.448
MOD_NEK2_2	667	672	PF00069	0.442
MOD_NEK2_2	728	733	PF00069	0.450
MOD_PIKK_1	182	188	PF00454	0.631
MOD_PIKK_1	199	205	PF00454	0.627
MOD_PIKK_1	22	28	PF00454	0.627
MOD_PIKK_1	551	557	PF00454	0.403
MOD_PIKK_1	741	747	PF00454	0.535
MOD_PKA_1	291	297	PF00069	0.534
MOD_PKA_2	12	18	PF00069	0.627
MOD_PKA_2	199	205	PF00069	0.637
MOD_PKA_2	291	297	PF00069	0.513
MOD_PKA_2	575	581	PF00069	0.438
MOD_PKA_2	821	827	PF00069	0.586
MOD_Plk_1	116	122	PF00069	0.299
MOD_Plk_1	381	387	PF00069	0.443
MOD_Plk_1	448	454	PF00069	0.501
MOD_Plk_1	551	557	PF00069	0.403
MOD_Plk_1	667	673	PF00069	0.449
MOD_Plk_1	861	867	PF00069	0.558
MOD_Plk_2-3	836	842	PF00069	0.638
MOD_Plk_2-3	849	855	PF00069	0.512
MOD_Plk_4	241	247	PF00069	0.598
MOD_Plk_4	254	260	PF00069	0.511
MOD_Plk_4	291	297	PF00069	0.534
MOD_Plk_4	357	363	PF00069	0.478
MOD_Plk_4	394	400	PF00069	0.441
MOD_Plk_4	448	454	PF00069	0.478
MOD_Plk_4	816	822	PF00069	0.529
MOD_Plk_4	862	868	PF00069	0.487
MOD_ProDKin_1	118	124	PF00069	0.264
MOD_ProDKin_1	160	166	PF00069	0.550
MOD_ProDKin_1	218	224	PF00069	0.612
MOD_ProDKin_1	30	36	PF00069	0.772
MOD_ProDKin_1	44	50	PF00069	0.533
MOD_ProDKin_1	604	610	PF00069	0.594
MOD_ProDKin_1	680	686	PF00069	0.371
MOD_ProDKin_1	723	729	PF00069	0.528
MOD_SUMO_rev_2	430	438	PF00179	0.562
TRG_DiLeu_BaEn_2	687	693	PF01217	0.470
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.604
TRG_DiLeu_BaLyEn_6	420	425	PF01217	0.365
TRG_DiLeu_BaLyEn_6	725	730	PF01217	0.549
TRG_DiLeu_BaLyEn_6	743	748	PF01217	0.409
TRG_DiLeu_BaLyEn_6	794	799	PF01217	0.548
TRG_ENDOCYTIC_2	310	313	PF00928	0.494
TRG_ENDOCYTIC_2	320	323	PF00928	0.374
TRG_ENDOCYTIC_2	422	425	PF00928	0.418
TRG_ENDOCYTIC_2	644	647	PF00928	0.519
TRG_ENDOCYTIC_2	682	685	PF00928	0.353
TRG_ENDOCYTIC_2	690	693	PF00928	0.384
TRG_ER_diArg_1	282	284	PF00400	0.446
TRG_ER_diArg_1	290	292	PF00400	0.548
TRG_ER_diArg_1	333	336	PF00400	0.392
TRG_ER_diArg_1	57	60	PF00400	0.541
TRG_ER_diArg_1	633	636	PF00400	0.436
TRG_ER_diArg_1	679	681	PF00400	0.399
TRG_ER_FFAT_2	208	215	PF00635	0.574
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	427	431	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	694	698	PF00026	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7T3	Leptomonas seymouri	44%	100%
A4I3G1	Leishmania infantum	100%	100%
E9AZQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q8I3	Leishmania major	90%	100%