Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X1A2_LEIDO

TriTrypDb:

LdBPK_280830.1 , LdCL_280012900 , LDHU3_28.1000

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X1A2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1A2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	147	153	PF00089	0.442
CLV_NRD_NRD_1	129	131	PF00675	0.503
CLV_NRD_NRD_1	174	176	PF00675	0.537
CLV_NRD_NRD_1	27	29	PF00675	0.565
CLV_NRD_NRD_1	66	68	PF00675	0.534
CLV_PCSK_KEX2_1	128	130	PF00082	0.469
CLV_PCSK_KEX2_1	176	178	PF00082	0.464
CLV_PCSK_KEX2_1	27	29	PF00082	0.524
CLV_PCSK_KEX2_1	88	90	PF00082	0.597
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.464
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.588
CLV_PCSK_SKI1_1	122	126	PF00082	0.506
CLV_PCSK_SKI1_1	130	134	PF00082	0.471
CLV_PCSK_SKI1_1	144	148	PF00082	0.427
DEG_APCC_DBOX_1	174	182	PF00400	0.520
DEG_APCC_KENBOX_2	106	110	PF00400	0.517
DOC_CDC14_PxL_1	43	51	PF14671	0.556
DOC_CKS1_1	90	95	PF01111	0.434
DOC_MAPK_MEF2A_6	56	63	PF00069	0.579
DOC_PP1_RVXF_1	120	127	PF00149	0.484
DOC_PP4_FxxP_1	90	93	PF00568	0.464
DOC_USP7_MATH_1	73	77	PF00917	0.679
DOC_USP7_MATH_1	79	83	PF00917	0.573
DOC_USP7_MATH_1	98	102	PF00917	0.444
DOC_WW_Pin1_4	54	59	PF00397	0.653
DOC_WW_Pin1_4	89	94	PF00397	0.517
LIG_14-3-3_CanoR_1	128	133	PF00244	0.592
LIG_14-3-3_CanoR_1	150	156	PF00244	0.462
LIG_14-3-3_CanoR_1	185	189	PF00244	0.477
LIG_14-3-3_CanoR_1	89	93	PF00244	0.600
LIG_BIR_II_1	1	5	PF00653	0.625
LIG_Clathr_ClatBox_1	136	140	PF01394	0.490
LIG_DLG_GKlike_1	128	136	PF00625	0.462
LIG_FHA_1	151	157	PF00498	0.497
LIG_FHA_2	136	142	PF00498	0.507
LIG_FHA_2	18	24	PF00498	0.469
LIG_FHA_2	184	190	PF00498	0.417
LIG_FHA_2	34	40	PF00498	0.543
LIG_FHA_2	76	82	PF00498	0.594
LIG_FHA_2	8	14	PF00498	0.610
LIG_GBD_Chelix_1	102	110	PF00786	0.400
LIG_LIR_Gen_1	131	139	PF02991	0.469
LIG_LIR_Nem_3	131	136	PF02991	0.457
LIG_PDZ_Class_2	185	190	PF00595	0.451
LIG_Pex14_2	133	137	PF04695	0.435
LIG_SH2_STAT5	30	33	PF00017	0.623
LIG_SH2_STAT5	34	37	PF00017	0.668
LIG_SH3_3	110	116	PF00018	0.544
LIG_SH3_3	41	47	PF00018	0.587
LIG_SUMO_SIM_anti_2	38	44	PF11976	0.551
LIG_TRAF2_1	10	13	PF00917	0.555
LIG_TRAF2_1	138	141	PF00917	0.611
MOD_CK1_1	135	141	PF00069	0.527
MOD_CK1_1	170	176	PF00069	0.504
MOD_CK1_1	6	12	PF00069	0.572
MOD_CK1_1	82	88	PF00069	0.588
MOD_CK1_1	91	97	PF00069	0.475
MOD_CK2_1	135	141	PF00069	0.579
MOD_CK2_1	166	172	PF00069	0.500
MOD_CK2_1	7	13	PF00069	0.561
MOD_CK2_1	75	81	PF00069	0.575
MOD_GlcNHglycan	161	164	PF01048	0.539
MOD_GlcNHglycan	80	84	PF01048	0.556
MOD_GlcNHglycan	93	96	PF01048	0.462
MOD_GSK3_1	128	135	PF00069	0.463
MOD_GSK3_1	155	162	PF00069	0.461
MOD_GSK3_1	164	171	PF00069	0.516
MOD_GSK3_1	3	10	PF00069	0.567
MOD_GSK3_1	75	82	PF00069	0.694
MOD_GSK3_1	94	101	PF00069	0.419
MOD_NEK2_1	132	137	PF00069	0.480
MOD_NEK2_1	17	22	PF00069	0.485
MOD_NEK2_1	3	8	PF00069	0.660
MOD_PIKK_1	8	14	PF00454	0.613
MOD_PK_1	155	161	PF00069	0.406
MOD_PKA_1	128	134	PF00069	0.462
MOD_PKA_1	88	94	PF00069	0.578
MOD_PKA_2	128	134	PF00069	0.462
MOD_PKA_2	149	155	PF00069	0.457
MOD_PKA_2	184	190	PF00069	0.441
MOD_PKA_2	88	94	PF00069	0.606
MOD_Plk_1	164	170	PF00069	0.467
MOD_Plk_1	73	79	PF00069	0.663
MOD_Plk_4	132	138	PF00069	0.505
MOD_Plk_4	155	161	PF00069	0.516
MOD_Plk_4	98	104	PF00069	0.508
MOD_ProDKin_1	54	60	PF00069	0.654
MOD_ProDKin_1	89	95	PF00069	0.507
TRG_ER_diArg_1	128	130	PF00400	0.505
TRG_ER_diArg_1	174	177	PF00400	0.535
TRG_NES_CRM1_1	104	118	PF08389	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7T0	Leptomonas seymouri	41%	95%
A4HGB9	Leishmania braziliensis	70%	100%
E9ADJ8	Leishmania major	85%	100%
E9AHH7	Leishmania infantum	98%	100%
E9AZP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%