EF-hand domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calmodulin-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7X1A1_LEIDO

TriTrypDb:

LdBPK_280860.1 , LdCL_280013200 , LDHU3_28.1030

Length:

154

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X1A1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X1A1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005509	calcium ion binding	5	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.519
CLV_PCSK_KEX2_1	97	99	PF00082	0.403
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.403
CLV_PCSK_SKI1_1	107	111	PF00082	0.297
CLV_PCSK_SKI1_1	74	78	PF00082	0.297
CLV_PCSK_SKI1_1	87	91	PF00082	0.325
DEG_APCC_DBOX_1	106	114	PF00400	0.355
DOC_CKS1_1	100	105	PF01111	0.326
DOC_MAPK_gen_1	74	81	PF00069	0.518
DOC_USP7_MATH_1	56	60	PF00917	0.449
DOC_WW_Pin1_4	146	151	PF00397	0.528
DOC_WW_Pin1_4	40	45	PF00397	0.257
DOC_WW_Pin1_4	79	84	PF00397	0.576
DOC_WW_Pin1_4	99	104	PF00397	0.411
LIG_14-3-3_CanoR_1	107	117	PF00244	0.322
LIG_14-3-3_CanoR_1	61	67	PF00244	0.337
LIG_BRCT_BRCA1_1	62	66	PF00533	0.297
LIG_BRCT_BRCA1_1	9	13	PF00533	0.484
LIG_BRCT_BRCA1_2	9	15	PF00533	0.444
LIG_FHA_2	100	106	PF00498	0.326
LIG_FHA_2	110	116	PF00498	0.297
LIG_FHA_2	41	47	PF00498	0.321
LIG_LIR_Gen_1	31	39	PF02991	0.424
LIG_LIR_Gen_1	63	73	PF02991	0.331
LIG_LIR_LC3C_4	136	141	PF02991	0.514
LIG_LIR_Nem_3	31	36	PF02991	0.456
LIG_LIR_Nem_3	63	69	PF02991	0.279
LIG_LIR_Nem_3	88	93	PF02991	0.322
LIG_MLH1_MIPbox_1	9	13	PF16413	0.442
LIG_NBox_RRM_1	69	79	PF00076	0.331
LIG_OCRL_FandH_1	11	23	PF00620	0.300
LIG_Pex14_2	13	17	PF04695	0.436
LIG_REV1ctd_RIR_1	10	19	PF16727	0.454
LIG_SH2_STAT5	108	111	PF00017	0.278
LIG_SUMO_SIM_par_1	50	57	PF11976	0.328
LIG_TRAF2_1	118	121	PF00917	0.496
LIG_TRAF2_1	82	85	PF00917	0.604
MOD_CK2_1	115	121	PF00069	0.479
MOD_CK2_1	40	46	PF00069	0.291
MOD_CK2_1	79	85	PF00069	0.574
MOD_CK2_1	99	105	PF00069	0.297
MOD_GlcNHglycan	117	120	PF01048	0.452
MOD_GlcNHglycan	9	12	PF01048	0.491
MOD_GSK3_1	56	63	PF00069	0.460
MOD_NEK2_1	109	114	PF00069	0.368
MOD_NEK2_1	77	82	PF00069	0.571
MOD_PKA_2	60	66	PF00069	0.303
MOD_Plk_1	45	51	PF00069	0.395
MOD_Plk_2-3	128	134	PF00069	0.476
MOD_Plk_4	141	147	PF00069	0.471
MOD_Plk_4	32	38	PF00069	0.395
MOD_ProDKin_1	146	152	PF00069	0.529
MOD_ProDKin_1	40	46	PF00069	0.257
MOD_ProDKin_1	79	85	PF00069	0.575
MOD_ProDKin_1	99	105	PF00069	0.411
TRG_DiLeu_BaEn_2	104	110	PF01217	0.355
TRG_DiLeu_BaEn_3	120	126	PF01217	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P206	Leptomonas seymouri	36%	100%
A0A0N0P4B4	Leptomonas seymouri	27%	100%
A0A0N0P7S6	Leptomonas seymouri	60%	100%
A0A0N0P8Y6	Leptomonas seymouri	29%	85%
A0A0N1I2Q3	Leptomonas seymouri	29%	100%
A0A0N1PDC0	Leptomonas seymouri	27%	100%
A0A0S4INC8	Bodo saltans	30%	82%
A0A0S4IQZ8	Bodo saltans	44%	100%
A0A0S4IS38	Bodo saltans	36%	100%
A0A0S4IUE7	Bodo saltans	28%	99%
A0A0S4IXG9	Bodo saltans	28%	100%
A0A0S4J7U6	Bodo saltans	28%	95%
A0A0S4JFC8	Bodo saltans	36%	91%
A0A0S4JFY6	Bodo saltans	31%	100%
A0A0S4JGV2	Bodo saltans	29%	99%
A0A1X0NMM5	Trypanosomatidae	36%	100%
A0A1X0NTH2	Trypanosomatidae	30%	100%
A0A1X0NXC6	Trypanosomatidae	30%	97%
A0A1X0NYH1	Trypanosomatidae	55%	100%
A0A1X0P607	Trypanosomatidae	25%	100%
A0A1X0P9X3	Trypanosomatidae	28%	85%
A0A3Q8IHK5	Leishmania donovani	29%	100%
A0A3R7M547	Trypanosoma rangeli	29%	100%
A0A3R7NB96	Trypanosoma rangeli	50%	100%
A0A3R7RDM4	Trypanosoma rangeli	26%	98%
A0A3S7WW96	Leishmania donovani	31%	100%
A0A3S7WXD9	Leishmania donovani	30%	100%
A0A3S7X9Z4	Leishmania donovani	27%	100%
A0A422MQ47	Trypanosoma rangeli	35%	100%
A0A422N447	Trypanosoma rangeli	28%	100%
A0A422N487	Trypanosoma rangeli	31%	100%
A0A422NIM0	Trypanosoma rangeli	27%	100%
A0A422P0I1	Trypanosoma rangeli	27%	85%
A0T2M3	Hesperocyparis arizonica	27%	93%
A2WN93	Oryza sativa subsp. indica	34%	100%
A2WNH1	Oryza sativa subsp. indica	34%	100%
A2Y609	Oryza sativa subsp. indica	35%	100%
A3E3H0	Pfiesteria piscicida	34%	100%
A3E4D8	Prorocentrum minimum	34%	100%
A3E4F9	Karlodinium veneficum	34%	100%
A4H5R9	Leishmania braziliensis	36%	100%
A4HAV0	Leishmania braziliensis	29%	100%
A4HBM1	Leishmania braziliensis	33%	100%
A4HCI2	Leishmania braziliensis	29%	100%
A4HGC2	Leishmania braziliensis	83%	100%
A4HN60	Leishmania braziliensis	28%	100%
A4HU13	Leishmania infantum	36%	100%
A4HZA9	Leishmania infantum	31%	100%
A4I000	Leishmania infantum	30%	100%
A4I3F5	Leishmania infantum	99%	100%
A4IA04	Leishmania infantum	29%	100%
A4IBS7	Leishmania infantum	27%	100%
A4IF97	Bos taurus	27%	90%
A4UHC0	Alexandrium fundyense	34%	100%
A8CEP3	Saccharina japonica	36%	100%
A8I1Q0	Heterocapsa triquetra	34%	100%
B1PSN3	Leishmania donovani	36%	100%
C9ZML6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	85%
C9ZSQ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZYU5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0A7Y5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
D0A9H8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
D0A9H9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
D2DGW3	Tyrophagus putrescentiae	34%	100%
E9AFL3	Leishmania major	26%	100%
E9AMU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AUY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AVX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AZP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B525	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B6R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
O00897	Dictyostelium discoideum	25%	100%
O02367	Ciona intestinalis	36%	100%
O14950	Homo sapiens	26%	90%
O15182	Homo sapiens	29%	92%
O16305	Caenorhabditis elegans	37%	100%
O23184	Arabidopsis thaliana	28%	92%
O23320	Arabidopsis thaliana	35%	100%
O35648	Mus musculus	29%	92%
O60041	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	33%	100%
O82018	Mougeotia scalaris	34%	100%
O82659	Arabidopsis thaliana	29%	91%
O94739	Pleurotus ostreatus	34%	100%
O96081	Halocynthia roretzi	37%	100%
O96102	Physarum polycephalum	37%	100%
O97341	Suberites domuncula	34%	100%
P02585	Homo sapiens	29%	96%
P02586	Oryctolagus cuniculus	28%	96%
P02587	Sus scrofa	28%	97%
P02588	Gallus gallus	25%	94%
P02589	Pelophylax lessonae	29%	95%
P02594	Electrophorus electricus	38%	100%
P02595	Patinopecten sp.	37%	100%
P02597	Gallus gallus	36%	100%
P02598	Tetrahymena pyriformis	36%	100%
P02599	Dictyostelium discoideum	35%	100%
P02612	Gallus gallus	26%	90%
P04352	Chlamydomonas reinhardtii	33%	94%
P04353	Spinacia oleracea	34%	100%
P04464	Triticum aestivum	34%	100%
P04630	Caenorhabditis elegans	35%	96%
P05419	Gallus gallus	36%	100%
P05434	Chlamydomonas reinhardtii	30%	91%
P05932	Arbacia punctulata	36%	100%
P05933	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
P06704	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	96%
P06787	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
P07290	Mizuhopecten yessoensis	29%	99%
P07291	Argopecten irradians	30%	98%
P07463	Paramecium tetraurelia	36%	100%
P08053	Physarum polycephalum	28%	100%
P09402	Dictyostelium discoideum	33%	100%
P0DH95	Arabidopsis thaliana	35%	100%
P0DH96	Arabidopsis thaliana	35%	100%
P0DH97	Arabidopsis thaliana	35%	100%
P0DH98	Arabidopsis thaliana	35%	100%
P0DP23	Homo sapiens	37%	100%
P0DP24	Homo sapiens	37%	100%
P0DP25	Homo sapiens	37%	100%
P0DP26	Mus musculus	37%	100%
P0DP27	Mus musculus	37%	100%
P0DP28	Mus musculus	37%	100%
P0DP29	Rattus norvegicus	37%	100%
P0DP30	Rattus norvegicus	37%	100%
P0DP31	Rattus norvegicus	37%	100%
P0DP33	Xenopus laevis	37%	100%
P0DP34	Xenopus laevis	37%	100%
P0DP35	Xenopus laevis	37%	100%
P10246	Meleagris gallopavo	26%	95%
P11118	Euglena gracilis	34%	100%
P11120	Pleurotus cornucopiae	35%	100%
P11121	Pyuridae sp.	37%	100%
P13833	Dictyostelium discoideum	29%	96%
P13868	Solanum tuberosum	37%	100%
P14533	Doryteuthis pealeii	30%	100%
P15094	Achlya klebsiana	37%	100%
P15159	Tachypleus tridentatus	35%	100%
P15845	Schistosoma mansoni	30%	100%
P17928	Medicago sativa	33%	100%
P18061	Trypanosoma cruzi	36%	100%
P18666	Rattus norvegicus	26%	90%
P19105	Homo sapiens	26%	90%
P20801	Mus musculus	28%	96%
P21251	Stichopus japonicus	37%	100%
P21797	Balanus nubilus	29%	97%
P21798	Balanus nubilus	27%	100%
P23286	Candida albicans	30%	100%
P24032	Gallus gallus	26%	90%
P24044	Plasmodium falciparum	35%	100%
P24844	Homo sapiens	26%	90%
P27161	Solanum lycopersicum	36%	100%
P27163	Petunia hybrida	33%	100%
P27164	Petunia hybrida	33%	84%
P27165	Phytophthora infestans	36%	100%
P27166	Stylonychia lemnae	35%	100%
P27482	Homo sapiens	33%	100%
P29269	Sus scrofa	26%	90%
P29289	Homarus americanus	25%	100%
P30187	Arabidopsis thaliana	27%	81%
P35622	Mizuhopecten yessoensis	27%	100%
P40423	Drosophila melanogaster	26%	89%
P41040	Zea mays	33%	100%
P41041	Pneumocystis carinii	35%	100%
P41208	Homo sapiens	30%	90%
P41209	Mus musculus	32%	90%
P41210	Atriplex nummularia	26%	92%
P43645	Spermatozopsis similis	30%	100%
P43646	Tetraselmis striata	30%	100%
P47947	Drosophila melanogaster	29%	100%
P47948	Drosophila melanogaster	29%	99%
P47949	Drosophila melanogaster	30%	99%
P48976	Malus domestica	34%	100%
P49258	Drosophila melanogaster	36%	100%
P53440	Naegleria gruberi	35%	99%
P53441	Naegleria gruberi	31%	90%
P54213	Dunaliella salina	30%	91%
P54357	Drosophila melanogaster	30%	100%
P59220	Arabidopsis thaliana	35%	100%
P60204	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	31%	100%
P60205	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	31%	100%
P60206	Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)	31%	100%
P61859	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	32%	100%
P61860	Colletotrichum trifolii	32%	100%
P61861	Colletotrichum gloeosporioides	32%	100%
P62144	Anas platyrhynchos	37%	100%
P62145	Aplysia californica	37%	100%
P62146	Arbacia punctulata	37%	100%
P62147	Branchiostoma floridae	37%	100%
P62148	Branchiostoma lanceolatum	37%	100%
P62149	Gallus gallus	37%	100%
P62150	Oryzias latipes	37%	100%
P62151	Tetronarce californica	37%	100%
P62152	Drosophila melanogaster	37%	100%
P62153	Halocynthia roretzi	37%	100%
P62154	Locusta migratoria	37%	100%
P62156	Oncorhynchus sp.	37%	100%
P62157	Bos taurus	37%	100%
P62160	Oryctolagus cuniculus	37%	100%
P62162	Hordeum vulgare	34%	100%
P62163	Glycine max	34%	100%
P62184	Renilla reniformis	37%	100%
P62199	Petunia hybrida	35%	100%
P62200	Daucus carota	35%	100%
P62201	Lilium longiflorum	35%	100%
P62202	Bryonia dioica	35%	100%
P62203	Plasmodium falciparum (isolate 3D7)	35%	100%
P69097	Trypanosoma brucei brucei	36%	100%
P69098	Trypanosoma brucei gambiense	36%	100%
P80322	Branchiostoma lanceolatum	28%	94%
P81660	Anguilla anguilla	27%	96%
P84339	Agaricus bisporus	34%	100%
P93087	Capsicum annuum	35%	100%
P93171	Helianthus annuus	35%	100%
Q03509	Arabidopsis thaliana	36%	100%
Q06827	Scherffelia dubia	29%	92%
Q09196	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
Q09510	Caenorhabditis elegans	27%	90%
Q09665	Caenorhabditis elegans	31%	96%
Q0IQB6	Oryza sativa subsp. japonica	33%	84%
Q0IUU4	Oryza sativa subsp. japonica	34%	84%
Q0JNL7	Oryza sativa subsp. japonica	35%	100%
Q0JNS6	Oryza sativa subsp. japonica	34%	100%
Q11083	Caenorhabditis elegans	31%	67%
Q12798	Homo sapiens	31%	90%
Q17133	Branchiostoma floridae	31%	100%
Q1A7B1	Blattella germanica	30%	100%
Q1A7B2	Blattella germanica	32%	100%
Q1A7B3	Blattella germanica	32%	100%
Q24956	Giardia intestinalis	28%	88%
Q2R1Z5	Oryza sativa subsp. japonica	29%	91%
Q2TBN3	Bos taurus	31%	90%
Q32LE3	Bos taurus	33%	90%
Q338P8	Oryza sativa subsp. japonica	25%	81%
Q39752	Fagus sylvatica	34%	100%
Q3SB08	Pseudechis porphyriacus	25%	99%
Q3SB09	Pseudechis australis	25%	99%
Q3SB10	Hoplocephalus stephensii	25%	99%
Q3SB11	Tropidechis carinatus	25%	99%
Q3SB12	Notechis scutatus scutatus	25%	99%
Q3SB13	Pseudonaja textilis	25%	99%
Q3SB14	Oxyuranus microlepidotus	25%	99%
Q3SB15	Oxyuranus scutellatus scutellatus	25%	99%
Q3T0E8	Bos taurus	26%	100%
Q3THE2	Mus musculus	26%	90%
Q40302	Macrocystis pyrifera	36%	100%
Q40642	Oryza sativa subsp. indica	33%	82%
Q41420	Solanum tuberosum	30%	100%
Q4Q2W1	Leishmania major	29%	100%
Q4Q8I9	Leishmania major	95%	100%
Q4QBK6	Leishmania major	30%	100%
Q4QCJ3	Leishmania major	32%	100%
Q4QHT2	Leishmania major	36%	100%
Q5E9E2	Bos taurus	26%	90%
Q5RAD2	Pongo abelii	37%	100%
Q5RBA4	Pongo abelii	26%	90%
Q5RC34	Pongo abelii	26%	90%
Q5U206	Rattus norvegicus	33%	100%
Q64122	Rattus norvegicus	28%	90%
Q682T9	Arabidopsis thaliana	35%	100%
Q6F332	Oryza sativa subsp. japonica	35%	100%
Q6IT78	Ctenopharyngodon idella	37%	100%
Q6L5F4	Oryza sativa subsp. japonica	28%	89%
Q6PI52	Danio rerio	37%	100%
Q6R520	Oreochromis mossambicus	37%	100%
Q6YNX6	Ovis aries	37%	100%
Q71UH5	Globisporangium splendens	36%	100%
Q71UH6	Perca flavescens	37%	100%
Q7DMN9	Solanum tuberosum	35%	100%
Q7DMP0	Solanum tuberosum	34%	100%
Q7F0J0	Oryza sativa subsp. japonica	28%	91%
Q7T3T2	Epinephelus akaara	37%	100%
Q7Y052	Euphorbia characias	35%	100%
Q7Z2B8	Dictyostelium discoideum	27%	100%
Q84MN0	Oryza sativa subsp. japonica	31%	100%
Q84VG0	Oryza sativa subsp. japonica	29%	100%
Q8AY75	Bothrops insularis	26%	99%
Q8K4K1	Mus musculus	29%	92%
Q8S1Y9	Oryza sativa subsp. japonica	33%	82%
Q8STF0	Strongylocentrotus intermedius	37%	99%
Q8TD86	Homo sapiens	25%	85%
Q8VZ50	Arabidopsis thaliana	26%	100%
Q8X187	Paxillus involutus	33%	100%
Q948R0	Oryza sativa subsp. japonica	32%	93%
Q94AZ4	Arabidopsis thaliana	26%	100%
Q95NI4	Halichondria okadai	35%	100%
Q95NR9	Metridium senile	37%	100%
Q96GE6	Homo sapiens	25%	79%
Q9BLG0	Todarodes pacificus	25%	100%
Q9C9U8	Arabidopsis thaliana	26%	94%
Q9CQ19	Mus musculus	26%	90%
Q9CQ46	Mus musculus	29%	94%
Q9D6P8	Mus musculus	32%	100%
Q9FZ75	Arabidopsis thaliana	28%	98%
Q9GRJ1	Lumbricus rubellus	37%	100%
Q9HFY6	Blastocladiella emersonii	36%	100%
Q9JLK3	Mus musculus	31%	89%
Q9JLK4	Mus musculus	31%	71%
Q9JM83	Mus musculus	30%	100%
Q9LE22	Arabidopsis thaliana	28%	91%
Q9LI84	Arabidopsis thaliana	32%	96%
Q9LIK5	Arabidopsis thaliana	33%	89%
Q9LQN4	Arabidopsis thaliana	30%	93%
Q9M7R0	Olea europaea	26%	90%
Q9M8U1	Arabidopsis thaliana	29%	93%
Q9N1Q8	Bos taurus	33%	89%
Q9N1Q9	Bos taurus	32%	94%
Q9NP86	Homo sapiens	32%	89%
Q9NZT1	Homo sapiens	32%	100%
Q9R1K9	Mus musculus	30%	90%
Q9S744	Arabidopsis thaliana	28%	100%
Q9SU00	Arabidopsis thaliana	27%	100%
Q9U6D3	Myxine glutinosa	36%	100%
Q9UB37	Branchiostoma lanceolatum	37%	100%
Q9UWF0	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	32%	100%
Q9XVI9	Caenorhabditis elegans	30%	100%
Q9XZP2	Branchiostoma floridae	35%	100%
Q9ZQE6	Arabidopsis thaliana	29%	82%